Structural, genetic and pharmacological identity of the rat alpha 2-adrenergic receptor subtype cA2-47 and its molecular characterization in rat adrenal, adrenocortical carcinoma and bovine retina.

abstract：:The AP-1 consensus sequences (TGAGTCA) are the major 12-O-tetradecanoylphorbol113-acetate (TPA) responsive elements shared by several TPA inducible genes, such as c-sis, c-fos, c-myc, collagenase, stromelysin, hMTIIA and SV40. However, the role of AP-1 binding sites, which are present in the introns 3, 5, and 11 of OD...

journal_title：Molecular and cellular biochemistry

authors： Tseng CP,Verma AK

更新日期：1995-05-10 00:00:00

abstract：:The (Ca2+ + Mg2+) ATPase which serves as a Ca2+ pump in the kidney basolateral membranes is essential to the maintenance of an intracellular Ca2+ concentration optimal for kidney function. Since atrial natriuretic peptide (ANP) is known to participate in the Ca2+ homeostasis mechanism, altered levels of ANP in diabete...

journal_title：Molecular and cellular biochemistry

authors： Sahai A,Ganguly PK

更新日期：1991-06-26 00:00:00

abstract：:Highly sensitive and specific synthetic substrates were used to quantitate cathepsin B and D activity in peritoneal macrophages in response to stimulation in vivo with mineral oil and thioglycollate. After intraperitoneal instillation of mineral oil the activity of cathepsin B increased significantly (to 15 300 units/...

journal_title：Molecular and cellular biochemistry

authors： Lesser M,Chang JC,Orlowski M

更新日期：1985-11-01 00:00:00

abstract：:Ischemic heart disease is the leading cause of death for both men and women worldwide, accruing 7.4 million deaths in 2012. There has been a continued search for better cardioprotective modalities that would reduce myocardial ischemia-reperfusion injury. Among these attempts, a more convenient model of ischemic precon...

journal_title：Molecular and cellular biochemistry

authors： Gill R,Kuriakose R,Gertz ZM,Salloum FN,Xi L,Kukreja RC

更新日期：2015-04-01 00:00:00

abstract：:Tyrosine levels are abnormally elevated in tissues and body fluids of patients with inborn errors of tyrosine metabolism. Tyrosinemia type II, which is caused by tyrosine aminotransferase deficiency, provokes eyes, skin, and central nervous system disturbances in affected patients. However, the mechanisms of brain dam...

journal_title：Molecular and cellular biochemistry

authors： Streck EL,De Prá SDT,Ferro PR,Carvalho-Silva M,Gomes LM,Agostini JF,Damiani A,Andrade VM,Schuck PF,Ferreira GC,Scaini G

更新日期：2017-11-01 00:00:00

abstract：:Phospholipase Cε (PLCε), a downstream effector of small GTPase superfamily, has been identified to play a crucial role in tumorigenesis. Previously, our studies have showed that PLCε promotes proliferation of renal cell carcinoma (RCC) cells. However, the molecular mechanisms by which PLCε enhances the survival phenot...

journal_title：Molecular and cellular biochemistry

authors： Du HF,Ou LP,Song XD,Fan YR,Yang X,Tan B,Quan Z,Luo CL,Wu XH

更新日期：2014-04-01 00:00:00

abstract：:There is general agreement that the connexin43 gap junction protein is a substrate for phosphorylation by protein kinase C but there is no similar consensus regarding the action of protein kinase A. Our previous studies demonstrated that channels formed by connexin43 were reversibly gated in response to microinjected ...

journal_title：Molecular and cellular biochemistry

authors： Shah MM,Martinez AM,Fletcher WH

更新日期：2002-09-01 00:00:00

abstract：:The involvement of the p53 gene in apoptosis of many cell types towards y-radiation is well established. However, little information is available on the relationship between p53 status and cells' ability to undergo apoptosis following exposure to fast neutrons. The aim of this study was to characterize the apoptotic p...

journal_title：Molecular and cellular biochemistry

authors： Jee YH,Jeong WI,Kim TH,Hwang IS,Ahn MJ,Joo HG,Hong SH,Jeong KS

更新日期：2005-02-01 00:00:00

abstract：:Insulin elicits its divergent metabolic and mitogenic effects by binding to its specific receptor, which belongs to the family of receptor tyrosine kinases. The activated insulin receptor phosphorylates the intracellular substrate IRS-1, which then binds various signalling molecules that contain SRC homology 2 domains...

journal_title：Molecular and cellular biochemistry

authors： Ogawa W,Matozaki T,Kasuga M

更新日期：1998-05-01 00:00:00

abstract：:In this article, we discuss our attempts to establish the existence in the cytoplasm of regulatory molecules involved in translational control. Our studies have revealed the presence of cAMP independent protein kinase in the free mRNP complex capable of phosphorylating a Mr = 38 000 polypeptide, also part of the same ...

journal_title：Molecular and cellular biochemistry

authors： Bag J,Sells BH

更新日期：1981-11-13 00:00:00

abstract：:Peroxisomes and peroxisomal enzyme expression were investigated biochemically and morphometrically in guinea pig intestinal epithelial cells at different stages of their migration along the crypt-villus axis. Epithelial cells were sequentially isolated along the axis and the specific activities of the peroxisomal enzy...

journal_title：Molecular and cellular biochemistry

authors： Phipps AN,Connock MJ,Johnson P,Burdett K

更新日期：2000-01-01 00:00:00

abstract：:The clearance of thrombin seems to occur at more than one site and by different mechanisms. This contributes to maintaining thrombin at the right concentrations to act optimally on its various substrates, and thus, to produce the proper amount of proteolytic conversions so that coagulation is precisely controlled. The...

journal_title：Molecular and cellular biochemistry

authors： Carlson TH

更新日期：1986-08-01 00:00:00

abstract：:Limited proteolysis of rabbit muscle phosphorylase kinase catalyzed by chymotrypsin generates a 33 kD product whose kinase activity is independent of both calcium and pH over the range of 6.8 to 8.3 (Malencik, D.A. & Fischer, E.H. Calcium and Cell Function III: 161-188, 1982). This active preparation consists of three...

journal_title：Molecular and cellular biochemistry

authors： Malencik DA,Zhao Z,Anderson SR

更新日期：1993-11-01 00:00:00

abstract：:Young female Zucker fa/fa rats of 370-430 g were implanted with osmotic minipumps releasing 3.5 micromol/day-kg of estrone oleate in liposomes (Merlin-2) into the bloodstream for up to 14 days. Merlin-2 induced a sustained loss of appetite, and a decrease in body weight of 3.5%, which contrasts with the 8.2% increase ...

journal_title：Molecular and cellular biochemistry

authors： Adán C,Grasa MM,Cabot C,Esteve M,Vilà R,Masanés R,Estruch J,Fernández-López JA,Remesar X,Alemany M

更新日期：1999-07-01 00:00:00

abstract：:Liver-X-Receptor alpha (LXR-alpha) that belongs to nuclear receptor/transcriptional factor family has been recognized to play crucial role in the regulation of lipid metabolism and inflammation. Consequently, the present study was addressed to explore the functional genomics of LXR-alpha within human blood immunomodul...

journal_title：Molecular and cellular biochemistry

authors： Kaul D,Gautam A,Sikand K

更新日期：2006-11-01 00:00:00

abstract：:Beta-arrestin-2 is an adaptor protein that terminates G protein activation and seems to be involved in the modulation of the inflammatory response. Small hyaluronan (HA) fragments, such as 4-mer HA oligosaccharides, are known to interact with the toll-like receptor-4 (TLR-4) with consequent activation of the nuclear f...

journal_title：Molecular and cellular biochemistry

authors： Campo GM,Avenoso A,D'Ascola A,Scuruchi M,Calatroni A,Campo S

更新日期：2015-01-01 00:00:00

abstract：:The TIS11 gene is an immediate early gene that is induced rapidly and transiently by phorbol 12-myristate 13-acetate and various growth factors. To study transcriptional regulation of the gene, a genomic clone of rat TIS11 was isolated, and the organization of exon-intron structure and transcriptional initiation site ...

journal_title：Molecular and cellular biochemistry

authors： Kaneda N,Murata T,Niimi Y,Minamiyama M

更新日期：2000-10-01 00:00:00

abstract：:SAP155 is an essential component of the spliceosome and its phosphorylation is required for splicing catalysis, but little is known concerning its function and regulation during spermatogenesis in postnatal murine testes. We report that inhibition of dual-specificity tyrosine-phosphorylation regulated kinase (DYRK) IA...

journal_title：Molecular and cellular biochemistry

authors： Eto K,Sonoda Y,Abe S

更新日期：2011-09-01 00:00:00

abstract：:Modulation of Ca(2+) homoeostasis in cardiac myocytes plays a major role in beat-to-beat regulation of heart function. Previous studies suggest that sphingosine-1-phosphate (S1P), a biologically active sphingomyelin metabolite, regulates Ca(2+) handling in cardiac myocytes, but the underlying mechanism is unclear. In ...

journal_title：Molecular and cellular biochemistry

authors： Egom EE,Bae JS,Capel R,Richards M,Ke Y,Pharithi RB,Maher V,Kruzliak P,Lei M

更新日期：2016-08-01 00:00:00

abstract：:One of the atrial natriuretic factor (ANF) receptors is a 180 kDa protein (180 kDa mGC) which possesses the extraordinary characteristic of being bifunctional: it is both a receptor and a guanylate cyclase. In addition to the 180 kDa mGC, there exists another 120-130 kDa protein which is also bifunctional and a 120 kD...

journal_title：Molecular and cellular biochemistry

authors： Marala RB,Sharma RK

更新日期：1992-01-15 00:00:00

abstract：:The TP53 signal transduction pathway is an attractive target for cancer treatments. In this study, we conducted a comprehensive molecular evaluation of 907 patients with cancer in Japan to identify genomic alterations in the TP53 pathway. TP53 mutations were frequently detected in many cancers, except melanoma, thymic...

journal_title：Molecular and cellular biochemistry

authors： Ohnami S,Ohshima K,Nagashima T,Urakami K,Shimoda Y,Saito J,Naruoka A,Hatakeyama K,Mochizuki T,Serizawa M,Ohnami S,Kusuhara M,Yamaguchi K

更新日期：2017-07-01 00:00:00

abstract：:Plants in the form of food or other remedial forms have been used for the treatment of various human ailments. Diabetes is one such disorder in which various form of plants and herbal remedies have been tried. Brassicajuncea (BJ) seeds (Rai) are consumed in India as a spice in various food items. Previous studies have...

journal_title：Molecular and cellular biochemistry

authors： Grover JK,Yadav S,Vats V

更新日期：2002-12-01 00:00:00

abstract：UNLABELLED:Carnosic acid is a well-known antioxidant. Recently, it has been identified as modulator of nuclear factor erythroid 2-related factor 2 (Nrf2). The effect of carnosic acid in the context of cardiovascular disorders has not been studied. In the present study, we investigated the beneficial effect and the unde...

journal_title：Molecular and cellular biochemistry

authors： Sahu BD,Putcha UK,Kuncha M,Rachamalla SS,Sistla R

更新日期：2014-09-01 00:00:00

abstract：:S-glutathionylation, the formation of mixed disulfides of glutathione with cysteine residues of proteins, is a broadly observed physiological modification that occurs in response to oxidative stress. Since cysteine residues are particularly susceptible to oxidative modification by reactive oxygen species, S-glutathion...

journal_title：Molecular and cellular biochemistry

authors： Leonberg AK,Chai YC

更新日期：2007-10-01 00:00:00

abstract：:Though, it is quite well-known how retinoic acid (RA) is able to induce neuritogenesis in different in vitro models, the putative role exerted by reactive oxygen species (ROS) during this process still need to be further studied. For such purpose, we used a neuronal-like cell line (SH-SY5Y cells) in order to investiga...

journal_title：Molecular and cellular biochemistry

authors： da Frota Junior ML,Pires AS,Zeidán-Chuliá F,Bristot IJ,Lopes FM,de Bittencourt Pasquali MA,Zanotto-Filho A,Behr GA,Klamt F,Gelain DP,Moreira JC

更新日期：2011-12-01 00:00:00

abstract：:This article summarizes recent ultrastructure findings from our laboratory and documents some of the information accumulated primarily since 1975 from many laboratories. Special attention is given to documentation by scanning electron microscopy which affords insight into platelet activation (adhesion, aggregation, re...

journal_title：Molecular and cellular biochemistry

authors： Barnhart MI

更新日期：1978-12-22 00:00:00

abstract：:In the context of high human consumption of fructose diets, there is an imperative need to understand how dietary fructose intake influence cellular and molecular mechanisms and thereby affect β-cell dysfunction and insulin resistance. While evidence exists for a relationship between high-fat-induced insulin resistanc...

journal_title：Molecular and cellular biochemistry

authors： Balakumar M,Raji L,Prabhu D,Sathishkumar C,Prabu P,Mohan V,Balasubramanyam M

更新日期：2016-12-01 00:00:00

abstract：:There is a wealth of information regarding the import and export of nuclear proteins in general. Nevertheless, the available data that deals with the nucleocytoplasmic movement of steroid hormone receptors remains highly limited. Some research findings reported during the past five years have succeeded in identifying ...

journal_title：Molecular and cellular biochemistry

authors： Sebastian T,Sreeja S,Thampan RV

更新日期：2004-05-01 00:00:00

abstract：:The results of our experiments demonstrated that one hour of ischemia followed by one hour of reflow in the kidney caused a reduction in (Na+K+)ATPase activity and microsomal sulfhydryl content as well as an increase in microsomal lipid peroxidation. Renal venous malondialdehyde concentration was increased soon after ...

journal_title：Molecular and cellular biochemistry

authors： Kato M,Kako KJ

更新日期：1987-12-01 00:00:00

abstract：:The fatty acid binding proteins (FAPBs) function as intracellular carriers of fatty acid (FA) and related compounds. During the digestion of lipids, the local concentration of FA exceeds their critical micellar concentration; the excess ratio of FA/FABP can be as high as approximately 1,000/1, consequently building mi...

journal_title：Molecular and cellular biochemistry

authors： Levin LB,Nachliel E,Gutman M,Tsfadia Y

更新日期：2009-06-01 00:00:00