Chemopreventive potential of esculetin in 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch carcinogenesis.

abstract：:A rapid growth of the coronary vasculature occurs during prenatal and early postnatal periods as precursor cells from the epi- and sub-epicardium differentiate, migrate and form vascular structures (vasculogenesis) which then fuse, branch and in some cases recruit cells to form three tunics (angiogenesis). These proce...

journal_title：Molecular and cellular biochemistry

authors： Tomanek RJ,Zheng W,Yue X

更新日期：2004-09-01 00:00:00

abstract：:Advanced glycation end products (AGEs) are formed from the non-enzymatic glycation reaction of reducing sugars or their metabolites with the free amino groups of several biomolecules and are known to play pathophysiological roles in various inflammatory diseases. In an earlier study, it was suggested that tumor necros...

journal_title：Molecular and cellular biochemistry

authors： Watanabe M,Toyomura T,Wake H,Liu K,Teshigawara K,Takahashi H,Nishibori M,Mori S

更新日期：2017-10-01 00:00:00

abstract：:When severe ischemia, such as that resulting from a sudden and complete coronary artery occlusion, is prolonged for more than 20-40 min, myocardial infarction develops, and there is irreversible loss of contractile function. When myocardial ischemia is less severe but nevertheless prolonged, the myocardium is dysfunct...

journal_title：Molecular and cellular biochemistry

authors： Heusch G,Schulz R

更新日期：1998-09-01 00:00:00

abstract：:Long-chain fatty acids (e.g. arachidonic acid) have been implicated in physiological control of insulin secretion. We previously reported histidine phosphorylation of at least two islet proteins (e.g., NDP kinase and the beta subunit of trimeric G-proteins), and suggested that such a signalling step may have regulator...

journal_title：Molecular and cellular biochemistry

authors： Kowluru A

更新日期：2004-11-01 00:00:00

abstract：:In mammalian cells, increases in calcium concentration cause increases in oxidative phosphorylation. This effect is mediated by the activation of four mitochondrial dehydrogenases by calcium ions; FAD-glycerol 3-phosphate dehydrogenase, pyruvate dehydrogenase, NAD-isocitrate dehydrogenase and oxoglutarate dehydrogenas...

journal_title：Molecular and cellular biochemistry

authors： Nichols BJ,Denton RM

更新日期：1995-08-01 00:00:00

abstract：:We have investigated how diabetes affects the expression of adropin (ADR) in rat brain, cerebellum, kidneys, heart, liver, and pancreas tissues. The rats in the diabetic group were administered an intraperitoneal (i.p.) injection of a single dose of 60 mg/kg streptozotocin (STZ) dissolved in a 0.1 M phosphate-citrate ...

journal_title：Molecular and cellular biochemistry

authors： Aydin S,Kuloglu T,Aydin S,Eren MN,Yilmaz M,Kalayci M,Sahin I,Kocaman N,Citil C,Kendir Y

更新日期：2013-08-01 00:00:00

abstract：:Hypertrophic scarring (HSc) which frequently develops in patients following severe thermal injury is characterized by accumulation of extracellular matrix (ECM) proteins including type I and type III collagen. In this study, we examined the presence and quantity of IGF-1 mRNA transcripts in post-burn HSc. The results ...

journal_title：Molecular and cellular biochemistry

authors： Ghahary A,Shen YJ,Nedelec B,Scott PG,Tredget EE

更新日期：1995-07-05 00:00:00

abstract：:Heat shock factor 1 (HSF1) is the major heat shock transcription factor and plays an essential role in mediating the cellular response to physiological and environmental stress. We found that LPS-induced expression of the granulocyte-colony stimulating factor (G-CSF) gene was upregulated in HSF1 knock-out (HSF1(-/-)) ...

journal_title：Molecular and cellular biochemistry

authors： Zhang L,Yang M,Wang Q,Liu M,Liang Q,Zhang H,Xiao X

更新日期：2011-06-01 00:00:00

abstract：:TGR(mREN2)27 is a transgenic rat harboring the murine Ren-2 gene and exhibit fulminant hypertension and marked heart hypertrophy. In order to study the role of angiotensin II in the increase of cardiac mass, these animals were treated with antihypertensive and non-antihypertensive doses of the angiotensin II receptor ...

journal_title：Molecular and cellular biochemistry

authors： Böhm M,Lippoldt A,Wienen W,Ganten D,Bader M

更新日期：1996-10-01 00:00:00

abstract：:Insulin elicits its divergent metabolic and mitogenic effects by binding to its specific receptor, which belongs to the family of receptor tyrosine kinases. The activated insulin receptor phosphorylates the intracellular substrate IRS-1, which then binds various signalling molecules that contain SRC homology 2 domains...

journal_title：Molecular and cellular biochemistry

authors： Ogawa W,Matozaki T,Kasuga M

更新日期：1998-05-01 00:00:00

abstract：:Recent studies have shown that allogeneic bone marrow (BM)-mesenchymal stem cell transplantation (MSCT) appears to be effective in systemic lupus erythematosus (SLE) patients and lupus-prone mice, contrary to studies in syngeneic BM-MSCT. These studies indicated that the abnormalities of BM-MSCs may be involved in the...

journal_title：Molecular and cellular biochemistry

authors： Gu Z,Tan W,Feng G,Meng Y,Shen B,Liu H,Cheng C

更新日期：2014-02-01 00:00:00

abstract：:MicroRNAs have been implicated in regulating diverse cellular pathways. Emerging evidence indicates that miR-143 plays causal roles in cancer tumorigenesis as a tumor suppress gene; however, its role in prostate cancer tumorigenesis remains largely unknown. The aims of this study were to verify the effect of miR-143 o...

journal_title：Molecular and cellular biochemistry

authors： Xu B,Niu X,Zhang X,Tao J,Wu D,Wang Z,Li P,Zhang W,Wu H,Feng N,Wang Z,Hua L,Wang X

更新日期：2011-04-01 00:00:00

abstract：:The angiotensin converting enzyme (ACE) is a key factor in the production of angiotensin II and in the degradation of bradykinin. Chronic exposure to high levels of circulating and tissue ACE predispose to vascular wall thickening and atherosclerosis. Factor VII (FACTOR VII) is the first enzyme in the extrinsic pathwa...

journal_title：Molecular and cellular biochemistry

authors： Sobti RC,Maithil N,Thakur H,Sharma Y,Talwar KK

更新日期：2010-08-01 00:00:00

abstract：:Parkinson disease (PD) is a neurodegenerative disease characterized by progressive dopaminergic neurodegeneration in the substantia nigra pars compacta (SNc) area. The present study was undertaken to evaluate the neuroprotective effect of β-caryophyllene (BCP) against rotenone-induced oxidative stress and neuroinflamm...

journal_title：Molecular and cellular biochemistry

authors： Ojha S,Javed H,Azimullah S,Haque ME

更新日期：2016-07-01 00:00:00

abstract：:Poly(ADP-ribose) polymerases or PARPs are a family of NAD(+)-dependent enzymes that modify themselves and other substrate proteins with ADP-ribose polymers. The founding member PARP 1 is localized predominantly in the nucleus and is activated by binding to DNA lesions. Excessive PARP 1 activation following genotoxin t...

journal_title：Molecular and cellular biochemistry

authors： Yeh TY,Sbodio JI,Nguyen MT,Meyer TN,Lee RM,Chi NW

更新日期：2005-08-01 00:00:00

abstract：:The ubiquitin specific peptidase 22 (USP22) is a positive regulator of the growth of tumors. However, little is known about the impact of USP22 knockdown on the growth of human bladder cells. In the present study, we designed a series of asymmetric interfering RNAs (aiRNAs) and compared the efficacy of aiRNA and conve...

journal_title：Molecular and cellular biochemistry

authors： Lv L,Xiao XY,Gu ZH,Zeng FQ,Huang LQ,Jiang GS

更新日期：2011-01-01 00:00:00

abstract：:Carbohydrate has been removed from a number of glycoproteins without major effect on the structure or enzyme activity of the protein. Thus carbohydrate has been suggested to underly a non-primary function for proteins, such as in relatively non-specific interactions with other carbohydrates or macromolecules, stabiliz...

journal_title：Molecular and cellular biochemistry

authors： West CM

更新日期：1986-11-01 00:00:00

abstract：:Recent reports considered that it was the disturbance of calcium homeostasis and the accumulation of misfolded proteins in the endoplasmic reticulum (ER) that activated hepatic stellate cells (HSCs) apoptosis and promoted fibrosis resolution. However, the signal-transducing events that are activated by ER stress after...

journal_title：Molecular and cellular biochemistry

authors： Huang Y,Li X,Wang Y,Wang H,Huang C,Li J

更新日期：2014-09-01 00:00:00

abstract：:Metabolic syndrome (MetS) is associated with alterations in coronary vascular smooth muscle and endothelial function. The current study examined the contractile response of the isolated coronary arterioles to serotonin in pigs with and without MetS and investigated the signaling pathways responsible for serotonin-indu...

journal_title：Molecular and cellular biochemistry

authors： Lawandy I,Liu Y,Shi G,Zhang Z,Scrimgeour LA,Pavlov V,Jaworski R,Sellke FW,Feng J

更新日期：2019-11-01 00:00:00

abstract：:Interleukin-12 (IL-12), a member of interleukin family, plays a critical role in immune responses and anti-tumor activity. In this study, the effects of IL-12 on monocytic tumor cell lines differentiation to macrophagocyte and its likely mechanism was investigated. We examined the differentiation markers, morphologica...

journal_title：Molecular and cellular biochemistry

authors： Ma TT,Wu BT,Lin Y,Xiong HY,Wang Q,Li ZW,Cheng F,Tu ZG

更新日期：2015-04-01 00:00:00

abstract：:Young female Zucker fa/fa rats of 370-430 g were implanted with osmotic minipumps releasing 3.5 micromol/day-kg of estrone oleate in liposomes (Merlin-2) into the bloodstream for up to 14 days. Merlin-2 induced a sustained loss of appetite, and a decrease in body weight of 3.5%, which contrasts with the 8.2% increase ...

journal_title：Molecular and cellular biochemistry

authors： Adán C,Grasa MM,Cabot C,Esteve M,Vilà R,Masanés R,Estruch J,Fernández-López JA,Remesar X,Alemany M

更新日期：1999-07-01 00:00:00

abstract：:Recruitment of the protein kinase C (PKC) family of isozymes is an integral component of the signaling events that direct cardiac phenotype expressed during postnatal development and in response to pathologic stimuli. Hyperglycemia is a potent activating signal for cardiac PKC isozymes and induces the apoptosis progra...

journal_title：Molecular and cellular biochemistry

authors： Malhotra A,Kang BP,Hashmi S,Meggs LG

更新日期：2005-01-01 00:00:00

abstract：:The astonishing growth rate of deer antlers offers a valuable model for the discovery of novel factors and regulatory systems controlling rapid tissue growth. Numerous molecules have been identified in growing antlers using a variety of techniques. However, little is known about the spatial distribution of these molec...

journal_title：Molecular and cellular biochemistry

authors： Deb-Choudhury S,Wang W,Clerens S,McMahon C,Dyer JM,Li C

更新日期：2015-11-01 00:00:00

abstract：:Studies have shown that long noncoding RNA Zinc finger E-box-binding homeobox 2 antisense RNA 1 (ZEB2-AS1) is involved in the progression of lung cancer, bladder cancer, and hepatocellular carcinoma. However, its role in the pathogenesis of gastric cancer remains unknown. The Wnt/β-catenin pathway contributes to the d...

journal_title：Molecular and cellular biochemistry

authors： Wang F,Zhu W,Yang R,Xie W,Wang D

更新日期：2019-06-01 00:00:00

abstract：:We have previously demonstrated that Cationic Arginine-Rich Peptides (CARPs) and in particular poly-arginine-18 (R18; 18-mer of arginine) exhibit potent neuroprotective properties in both in vitro and in vivo neuronal injury models. Based on the current literature, there is a consensus that arginine residues by virtue...

journal_title：Molecular and cellular biochemistry

authors： MacDougall G,Anderton RS,Ouliel E,Gao J,Redmond SL,Knuckey NW,Meloni BP

更新日期：2020-01-01 00:00:00

abstract：:Hepatocyte cell adhesion molecule (HepaCAM) plays a crucial role in tumor progression and has been recognized as a novel tumor suppressor gene. The high protein expression level of protein kinase Cε (PKCε) has been discovered in many tumor types. In the present study, we determined HepaCAM and PKCε protein levels in h...

journal_title：Molecular and cellular biochemistry

authors： Tan B,Tan J,Du H,Quan Z,Xu X,Jiang X,Luo C,Wu X

更新日期：2014-06-01 00:00:00

abstract：:We have focused on the roles of PARP and poly(ADP-ribosyl)ation early in apoptosis, as well as during the early stages of differentiation-linked DNA replication. In both nuclear processes, a transient burst of PAR synthesis and PARP expression occurs early, prior to internucleosomal DNA cleavage before commitment to a...

journal_title：Molecular and cellular biochemistry

authors： Simbulan-Rosenthal CM,Rosenthal DS,Iyer S,Boulares H,Smulson ME

更新日期：1999-03-01 00:00:00

abstract：:Comparison of Ca2+ uptake by isolated mouse liver mitochondria, and mitochondria prepared from mastocytoma cells grown with and without N6,O2'-dibutyryladenosine 3',5' cyclic monophosphate (DB cyclic AMP) and theophylline showed several differences in their capacity to take up and retain calcium. In particular mitocho...

journal_title：Molecular and cellular biochemistry

authors： McHardy JE,Ralph RK

更新日期：1980-03-20 00:00:00

abstract：:Accumulating data have shown that microRNAs are involved in the pathogenesis of cancer. miR-202 has been confirmed to be downregulated in several types of human cancer. However, the expression and biological role of miR-202 in osteosarcoma (OS) carcinogenesis and progression remain unclear. In this study, we demonstra...

journal_title：Molecular and cellular biochemistry

authors： Sun Z,Zhang T,Hong H,Liu Q,Zhang H

更新日期：2014-12-01 00:00:00

abstract：:Growth hormone (GH) has been reported to be useful to treat heart failure. To elucidate whether GH has direct beneficial effects on the heart, we examined effects of GH on oxidative stress-induced apoptosis in cardiac myocytes. TUNEL staining and DNA ladder analysis revealed that hydrogen peroxide (H2O2)-induced apopt...

journal_title：Molecular and cellular biochemistry

authors： Gu Y,Zou Y,Aikawa R,Hayashi D,Kudoh S,Yamauchi T,Uozumi H,Zhu W,Kadowaki T,Yazaki Y,Komuro I

更新日期：2001-07-01 00:00:00