Abstract:
:TGR(mREN2)27 is a transgenic rat harboring the murine Ren-2 gene and exhibit fulminant hypertension and marked heart hypertrophy. In order to study the role of angiotensin II in the increase of cardiac mass, these animals were treated with antihypertensive and non-antihypertensive doses of the angiotensin II receptor AT1 antagonist Telmisartan for 9 weeks. All doses led to significant reductions of heart hypertrophy detected by the evaluation of the diameter of cardiac muscle bundles. We conclude from this study that cardiac hypertrophy in TGR(mREN2)27 is characterized by an increased volume of cardiomyocytes and an unchanged amount of fibrous tissue and that angiotensin II plays an important role in the mechanisms leading to this phenotype.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Böhm M,Lippoldt A,Wienen W,Ganten D,Bader Mdoi
10.1007/BF00408661subject
Has Abstractpub_date
1996-10-01 00:00:00pages
217-21eissn
0300-8177issn
1573-4919journal_volume
163-164pub_type
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