Abstract:
:Visceral leishmaniasis has been found to be associated with severe anemia and premature lysis of erythrocytes. Peroxidative damage of red cells has been noted in several hemolytic anemias. Present study shows enhanced formation of methemoglobin in hamsters infected with Leishmania donovani. Increased formation of malonyldialdehyde and diene conjugate has been noted in the erythrocytes of the infected animals with the progress of anemia. Results showed decreased activities of protective enzymes like superoxide dismutase, catalase and glutathione reductase against peroxidative attack. An increase in the membrane cholesterol/phospholipid ratio and a decrease in membrane fluidity of erythrocytes were observed under the diseased condition. Densitometric scan after SDS-PAGE of red cell membrane of the infected animals revealed significant degradation of band 3 and band 4.1 proteins. The results suggest that alteration in the membrane may lead to reduced life span of the red cells in experimental visceral leishmaniasis.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Biswas T,Pal JK,Naskar K,Ghosh DK,Ghosal Jdoi
10.1007/BF00944601subject
Has Abstractpub_date
1995-05-24 00:00:00pages
99-105issue
2eissn
0300-8177issn
1573-4919journal_volume
146pub_type
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