Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure.

abstract：:Nucleocytoplasmic transport of transcription factors is essential in eukaryotes. We previously reported the presence of two functional NLSs in the homeodomain protein, aristaless-related homeobox (Arx) protein, which is a key transcriptional repressor of LMO1, SHOX2, and PAX4 during development. NLS2, that overlaps th...

journal_title：Molecular and cellular biochemistry

authors： Ye W,Lin W,Tartakoff AM,Ma Q,Tao T

更新日期：2013-09-01 00:00:00

abstract：:Some properties of a submitochondrial cell-free system for protein synthesis are described. The system was prepared from rat liver mitochondria lysed with Triton X-100, and the lysate was characterized by a linear rate of [14C]amino acid incorporation for 15-20 min with subsequent decline in activity. The incorporatio...

journal_title：Molecular and cellular biochemistry

authors： Kisselev OI,Gaitskhoki VS,Neifakh SA

更新日期：1977-02-04 00:00:00

abstract：:Pre-purified preparations of myoinositol-1-phosphate synthase (E.C. 5.5.1.4) from rat testes can be purified to homogeneity by first crystallizing the enzyme according to JAKOBY and then recrystallizing it at a pH value close to the isoelectric point while slowly increasing the temperature from 0 to 15 degrees C. This...

journal_title：Molecular and cellular biochemistry

authors： Pittner F,Hoffmann-Ostenhof O

更新日期：1979-12-14 00:00:00

abstract：:In this study, we examined changes in the biochemical and inotropic events of the alpha(1)-adrenoceptor signaling pathway in hypothyroid rat hearts. Hypothyroidism was induced by treating experimental animals with 0.05% 6-n-propyl-2-thiouracil (PTU) in drinking water for 7 weeks. A significant decrease of beta- and an...

journal_title：Molecular and cellular biochemistry

authors： Jalali S,Durston M,Panagia V,Mesaeli N

更新日期：2006-02-01 00:00:00

abstract：:Both reactive oxygen- and nitrogen-derived reactive species play important roles in physiological and pathophysiological conditions. Flavones, luteolin and luteolin-7-O-glucoside along with a rich plant source of both flavones, namely dandelion (Taraxacum officinale) flower extract were studied for antioxidant activit...

journal_title：Molecular and cellular biochemistry

authors： Hu C,Kitts DD

更新日期：2004-10-01 00:00:00

abstract：:In this paper we review some of the large quantities of information currently available concerning the identification, structure and function of Ca(2+)-binding proteins of endoplasmic and sarcoplasmic reticulum membranes. The review places particular emphasis on identification and discussion of Ca2+ 'storage' proteins...

journal_title：Molecular and cellular biochemistry

authors： Milner RE,Famulski KS,Michalak M

更新日期：1992-05-13 00:00:00

abstract：:The aim of the work was to study the influence of vaspin on oxidative stress-induced apoptosis of mouse mesenchymal stem cells (MSCs). MSCs originated from bone marrow of C57BL/6 mouse were treated with vaspin and/or H2O2 in a dose-dependent manner. Cellular viability detected by CCK-8 and cell apoptosis studied by fl...

journal_title：Molecular and cellular biochemistry

authors： Zhu X,Zhang L,Chen Y,Chen B,Huang H,Lv J,Hu S,Shen J

更新日期：2019-12-01 00:00:00

abstract：:Gastrointestinal symptoms are fairly common in diabetes mellitus. Glimepride, is a latest second generation sulfonylurea used for the treatment of type II diabetes mellitus, is a insulin secrectagogue; indirectly, it also increases insulin secretion and its specific effect on pancreatic ATP-dependent K(+) channel inhi...

journal_title：Molecular and cellular biochemistry

authors： Phadatare PD,Chandrashekhar VM

更新日期：2011-08-01 00:00:00

abstract：:Ran-binding protein in microtubule-organizing center (RanBPM) has been reported to interact with the neurotrophin receptors p75NTR and TrkA, meanwhile p75NTR and TrkA can also interact with TRAF6. Whether RanBPM interacts directly with TRAF6 has not yet been established. In this study, using a yeast two-hybrid system ...

journal_title：Molecular and cellular biochemistry

authors： Wang L,Fu C,Cui Y,Xie Y,Yuan Y,Wang X,Chen H,Huang BR

更新日期：2012-01-01 00:00:00

abstract：:In this study, we aimed to study the role of miRNAs in intrauterine adhesion (IUA) disease. An IUA cell model was constructed by TGF-β1. Smad3 inhibitor (SIS3) can inhibit the Smad3 signaling pathway and affect the role of TGF-β1; thus, it was used to identify the role of Smad3 and related miRNAs in IUA. Cell number s...

journal_title：Molecular and cellular biochemistry

authors： Liu S,Huang X,Liu Y,Song D,Xiao Y

更新日期：2020-07-01 00:00:00

abstract：:Inadequate migration and invasion of the trophoblast cells during embryo implantation is one of the reasons for pregnancy-related complications such as intrauterine growth restriction and preeclampsia. In the present study, relevance of WNT ligands and integrins associated with hepatocyte growth factor (HGF)-mediated ...

journal_title：Molecular and cellular biochemistry

authors： Chaudhary P,Malhotra SS,Babu GS,Sobti RC,Gupta SK

更新日期：2019-03-01 00:00:00

abstract：:Biochemical and ultrastructural studies indicate that the atrophy of adrenal cortex in hypoyhysectomized rats involves the following changes: (1) One to two days after hypophysectomy, there is loss of "template activity" resulting from cumulative DNA-damage and heterochromatinization. In vivo ACTH-administration led t...

journal_title：Molecular and cellular biochemistry

authors： Tchen TT,Chan SW,Kuo TH,Mostafapour KM,Drzewiecki VH

更新日期：1977-04-12 00:00:00

abstract：:Overexpressed cysteine-rich protein 61 (Cyr61) is believed to enhance osteosarcoma (OS) cell metastasis, but the mechanism of Cyr61 overexpression in OS is not clear so far. In this study 33 OS samples were analyzed by immunostaining and focused on two parts: the correlation between overexpression of Cyr61 and OS meta...

journal_title：Molecular and cellular biochemistry

authors： Chen J,Song Y,Yang J,Gong L,Zhao P,Zhang Y,Su H

更新日期：2013-12-01 00:00:00

abstract：:Many recent studies have suggested that bergapten (BP), a class of native compound with numerous biological activities such as anti-resorptive properties, may exert protective effects against postmenopausal bone loss. However, it remains unknown whether BP regulates or improves the osteogenic function of bone marrow s...

journal_title：Molecular and cellular biochemistry

authors： Xiao JJ,Zhao WJ,Zhang XT,Zhao WL,Wang XX,Yin SH,Jiang F,Zhao YX,Chen FN,Li SL

更新日期：2015-11-01 00:00:00

abstract：:The major protein in the sarcoplasmic reticulum (SR) membrane is the Ca2+ transporting ATPase which carries out active Ca2+ pumping at the expense of ATP hydrolysis. The aim of this work was to elucidate the mechanisms by which oxidative stress induced by Fenton's reaction (Fe(2+)+H2O2-->HO.+OH-+Fe3+) alters the funct...

journal_title：Molecular and cellular biochemistry

authors： Castilho RF,Carvalho-Alves PC,Vercesi AE,Ferreira ST

更新日期：1996-06-21 00:00:00

abstract：:The TIS11 gene is an immediate early gene that is induced rapidly and transiently by phorbol 12-myristate 13-acetate and various growth factors. To study transcriptional regulation of the gene, a genomic clone of rat TIS11 was isolated, and the organization of exon-intron structure and transcriptional initiation site ...

journal_title：Molecular and cellular biochemistry

authors： Kaneda N,Murata T,Niimi Y,Minamiyama M

更新日期：2000-10-01 00:00:00

abstract：:The aim of this study was to investigate estrogen's effect on age-related changes in bladder function. Female Wistar rats were divided into three groups that included young rats (3-month-old) (YR), old rats (13-month-old) (OR), and old rats given subcutaneous treatments of estradiol for 6 weeks (OR + E). The groups we...

journal_title：Molecular and cellular biochemistry

authors： Watanabe T,Matsumoto M,Toji S,Miyagawa I

更新日期：2008-11-01 00:00:00

abstract：:In addition of being an important inflammatory biomarker and a risk factor for cardiovascular disease, much evidence indicates that the C-reactive protein (CRP) contributes to the atherosclerosis development process. This plasmatic protein synthesized by hepatocytes in response to inflammation and tissue injury induce...

journal_title：Molecular and cellular biochemistry

authors： Cossette É,Cloutier I,Tardif K,DonPierre G,Tanguay JF

更新日期：2013-01-01 00:00:00

abstract：:This review describes a comprehensive analysis of a surface plasmon resonance (SPR)-based biosensor study of molecular interactions in the insulin-like growth factor (IGF) molecular axis. In this study, we focus on the interaction between the polypeptide growth factors IGF-I and IGF-II with six soluble IGF binding pro...

journal_title：Molecular and cellular biochemistry

authors： Beattie J,Phillips K,Shand JH,Szymanowska M,Flint DJ,Allan GJ

更新日期：2008-01-01 00:00:00

abstract：:The molecular mechanisms potentially responsible for cadmium carcinogenesis were investigated by differential gene expression analysis of Balb/c-3T3 cells morphologically transformed with cadmium chloride. Differential display analysis of gene expression revealed overexpression of mouse Translation Initiation Factor 3...

journal_title：Molecular and cellular biochemistry

authors： Joseph P,Lei YX,Ong TM

更新日期：2004-01-01 00:00:00

abstract：:Pig coronary artery cultured smooth muscle cells were skinned using saponin. In the presence of an ATP-regenerating system and oxalate, the skinned cells showed an ATP-dependent azide insensitive Ca(2+)-uptake which increased linearly with time for > 1 h. The Ca(2+)-uptake occurred with Km values of 0.20 +/- 0.03 micr...

journal_title：Molecular and cellular biochemistry

authors： Elmoselhi AB,Blennerhassett M,Samson SE,Grover AK

更新日期：1995-10-18 00:00:00

abstract：:Tumor suppressor p53 plays important roles in cell cycle regulation, apoptosis and DNA repair in different cell types including lung cancer. There are different p53 apoptotic pathways in high and low metastatic ability lung cancer cells. However, the exactly mechanism in the pathway is still unclear. Here we found tha...

journal_title：Molecular and cellular biochemistry

authors： Huang Y,Jin Y,Yan CH,Yu Y,Bai J,Chen F,Zhao YZ,Fu SB

更新日期：2008-02-01 00:00:00

abstract：:This study investigated the anticancer effects of embelin in human gastric cancer cells and the underlying molecular mechanisms. Gastric cancer cells were treated with embelin and 5-FU for methyl-thiazolyl-tetrazolium bromide cell viability assay and flow cytometric detection of cell viability and apoptosis. Protein p...

journal_title：Molecular and cellular biochemistry

authors： Wang DG,Sun YB,Ye F,Li W,Kharbuja P,Gao L,Zhang DY,Suo J

更新日期：2014-01-01 00:00:00

abstract：:From pharmacological investigations and clinical studies, it is known that angiotensin converting enzyme (ACE) inhibitors exhibit additional local actions, which are not related to hemodynamic changes and which cannot be explained only by interference with the renin angiotensin system (RAS) by means of an inhibition o...

journal_title：Molecular and cellular biochemistry

authors： Linz W,Wiemer G,Schaper J,Zimmermann R,Nagasawa K,Gohlke P,Unger T,Schölkens BA

更新日期：1995-06-07 00:00:00

abstract：:In hypertensive animals and patients, oxidative stress represents the primary risk factor for progression of left ventricular hypertrophy. Recently, it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals and peroxynitrite anion to exert therapeutic antioxidant activity...

journal_title：Molecular and cellular biochemistry

authors： Yu YS,Zheng H

更新日期：2012-06-01 00:00:00

abstract：:Both early diagnostic and prognostic assessment of the acute abdomen in preterm infants are hampered by the lack of a sensitive and specific parameter for intestinal injury. In this prospective clinical study we wanted to estimate the value of intestinal (I-) and liver (L-) fatty acid binding protein (FABP) in diagnos...

journal_title：Molecular and cellular biochemistry

authors： Guthmann F,Börchers T,Wolfrum C,Wustrack T,Bartholomäus S,Spener F

更新日期：2002-10-01 00:00:00

abstract：:As a m6A methylation modifier, METTL3 is functionally involved in various biological processes. Nevertheless, the role of METTL3 in osteogenesis is not determined up to date. In the current study, METTL3 is identified as a crucial regulator in the progression of osteogenic differentiation. Loss of METTL3 significantly...

journal_title：Molecular and cellular biochemistry

authors： Yu J,Shen L,Liu Y,Ming H,Zhu X,Chu M,Lin J

更新日期：2020-01-01 00:00:00

abstract：:Original studies with rat adrenocortical carcinoma identified a 180 kDa cell-surface protein which contained both guanylate cyclase and atrial natriuretic factor (ANF) receptor, representing a potentially new type of bifunctional receptor protein. It is both a receptor and a guanylate cyclase. This critical conclusion...

journal_title：Molecular and cellular biochemistry

authors： Marala RB,Sharma RK

更新日期：1991-01-16 00:00:00

abstract：:Higher order chromatin degradation (HOCD) is a stepwise dismantling of the genome through the excision of chromatin loops and their oligomers at matrix attachment regions (MARs) during the early stages of programmed cell death. Although HOCD ultimately leads to the inactivation of the genome and cell death, a partial ...

journal_title：Molecular and cellular biochemistry

authors： Banaszewska M,Konat GW

更新日期：2006-01-01 00:00:00

abstract：:In rat adipocytes, the insulin stimulation of the rate of glucose uptake is due, at least partially, to the recruitment of glucose transporter proteins from an intracellular compartment to the plasma membrane. Vanadate is a known insulin mimetic agent and causes an increase in the rate of glucose transport in rat adip...

journal_title：Molecular and cellular biochemistry

authors： Päquet MR,Romanek RJ,Sargeant RJ

更新日期：1992-02-12 00:00:00