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Studies on the adrenal cortex of hypophysectomized rats: a model for abnormal cellular atrophy and death.

Abstract：

:Biochemical and ultrastructural studies indicate that the atrophy of adrenal cortex in hypoyhysectomized rats involves the following changes: (1) One to two days after hypophysectomy, there is loss of "template activity" resulting from cumulative DNA-damage and heterochromatinization. In vivo ACTH-administration led to recuperation of these cells, indicating damage during hypophysectomized state to be reversible. (2) If the duration of hypophysectomy is prolonged, some of the cells become irreversibly damaged and can no longer recuperate after in vivo ACTH administration. (3) The period of most rapid cell death is from the third to seventh day after hypophysectomy. The cause of cell death is probably due to membrane damage in the absence of protein synthesis, leading to lysis of the cells. Lysozomes and macrophages are apparently not involved.

journal_name

Mol Cell Biochem

journal_title

Molecular and cellular biochemistry

authors

Tchen TT,Chan SW,Kuo TH,Mostafapour KM,Drzewiecki VH

doi

10.1007/BF01793330

subject

Has Abstract

pub_date

1977-04-12 00:00:00

pages

79-87

issue

2

eissn

0300-8177

issn

1573-4919

journal_volume

15

pub_type

杂志文章

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