The relation between the action potential duration, the increase in resting tension, and ATP content during metabolic inhibition in guinea pig ventricular muscles.

abstract：:Glioblastoma is the most common and deadly type of brain cancer. The poor prognosis may be largely attributed to inadequate disease response to current chemotherapeutic agents. Activation of p38 is associated with deleterious outcomes in glioblastoma patients, as its signaling mediates chemoresistance mechanisms. Anti...

journal_title：Molecular and cellular biochemistry

authors： Su BC,Chen JY

更新日期：2020-01-01 00:00:00

abstract：:Nocturnin has been identified as a clock-controlled gene based on its rhythmic expression and night-time peak of transcript level in Xenopus retina. Further studies show that the widespread expression and rhythmicity of nocturnin mRNA level parallel the expression of clock genes. In Xenopus, nocturnin transcription is...

journal_title：Molecular and cellular biochemistry

authors： Li R,Yue J,Zhang Y,Zhou L,Hao W,Yuan J,Qiang B,Ding JM,Peng X,Cao JM

更新日期：2008-10-01 00:00:00

abstract：:In addition to the classical genomic steroid actions on modulation of transcription and protein synthesis, rapid, nongenomic effects have been described for various steroids. These effects on cellular signaling and function are supposed to be transmitted by membrane binding sites unrelated to the classical intracellul...

journal_title：Molecular and cellular biochemistry

authors： Falkenstein E,Eisen C,Schmieding K,Krautkrämer M,Stein C,Lösel R,Wehling M

更新日期：2001-02-01 00:00:00

abstract：:Cyclophosphamide (CP), an alkylating agent widely used in cancer chemotherapy causes cardiac membrane damage. Lupeol, a pentacyclic triterpene, isolated from Crataeva nurvala stem bark and its ester, lupeol linoleate possess a wide range of medicinal properties. The effect of lupeol and its ester was evaluated in CP i...

journal_title：Molecular and cellular biochemistry

authors： Sudharsan PT,Mythili Y,Selvakumar E,Varalakshmi P

更新日期：2006-11-01 00:00:00

abstract：:A high molecular weight protein has been isolated as a major polypeptide comprising 85% of the total extractable proteins in the fruit pericarp of the plant Impatiens balsamina. The protein has been purified to homogeneity following fractionation of the crude cell supernatant with ammonium sulphate, chromatography on ...

journal_title：Molecular and cellular biochemistry

authors： Pal M,Biswas S

更新日期：1994-01-26 00:00:00

abstract：:Obesity-induced low-grade inflammation (metaflammation) impairs insulin receptor signaling. This has been implicated in the development of insulin resistance. Insulin signaling in the target tissues is mediated by stress kinases such as p38 mitogen-activated protein kinase, c-Jun NH2-terminal kinase, inhibitor of NF-k...

journal_title：Molecular and cellular biochemistry

authors： Nandipati KC,Subramanian S,Agrawal DK

更新日期：2017-02-01 00:00:00

abstract：:The naturally occurring flavonoid, quercetin, in the presence of Cu(II) and molecular oxygen caused breakage of calf thymus DNA, supercoiled pBR322 plasmid DNA and single stranded M13 phage DNA. In the case of the plasmid, the product(s) were relaxed circles or a mixture of these and linear molecules depending upon th...

journal_title：Molecular and cellular biochemistry

authors： Rahman A,Fazal F,Greensill J,Ainley K,Parish JH,Hadi SM

更新日期：1992-04-01 00:00:00

abstract：:Hydrogen sulfide (H2S) has been investigated widely in recent years. H2S plays a variety of roles in different biological systems, including cardiovascular system. It is the final product of amino acids metabolism, which contains sulfur-cysteine and homocysteine (Hcy). In human plasma, there are several various forms ...

journal_title：Molecular and cellular biochemistry

authors： Olas B,Kontek B

更新日期：2015-06-01 00:00:00

abstract：:N-Methyl-N-nitrosourea (MNU)-induced rat mammary adenocarcinomas contain high levels of a novel leupeptin-sensitive serine endopeptidase. Its properties apparently differ from those of other similar endopeptidases reported to be present in various normal and malignant mammalian tissues. The same leupeptinsensitive ser...

journal_title：Molecular and cellular biochemistry

authors： Eto I,Bandy MD

更新日期：1990-04-18 00:00:00

abstract：:The angiotensin converting enzyme (ACE) is a key factor in the production of angiotensin II and in the degradation of bradykinin. Chronic exposure to high levels of circulating and tissue ACE predispose to vascular wall thickening and atherosclerosis. Factor VII (FACTOR VII) is the first enzyme in the extrinsic pathwa...

journal_title：Molecular and cellular biochemistry

authors： Sobti RC,Maithil N,Thakur H,Sharma Y,Talwar KK

更新日期：2010-08-01 00:00:00

abstract：:The homeodomain-containing Msx3 gene, the newest member of the Msx family, encodes two mRNAs, with an unknown relationship to each other. To elucidate how Msx3 gene generates the two transcripts, we cloned their corresponding cDNAs from an E10.5 mouse embryo cDNA library. The alignment of sequences of the two Msx3-spe...

journal_title：Molecular and cellular biochemistry

authors： Matsui H,Takahashi T,Raghow R

更新日期：2004-12-01 00:00:00

abstract：:We evaluated the effects of Rubus tereticaulis in healing process by determining the total carbonyl content, collagen synthesis, and total protein level on rat wounded tissues. Wounds were performed in the back of 54 Wistar rats, using a biopsy punch instrument with 0.6 mm in diameter. Rats were randomly divided into ...

journal_title：Molecular and cellular biochemistry

authors： Aksoy H,Demirbağ Ç,Şen A,Şekerler T,Özakpınar Ö,Şener A,Ahmad S,Tetik S

更新日期：2020-09-01 00:00:00

abstract：:Peroxisome proliferator activated receptor gamma coactivator 1α (PGC-1α) induced by hypoxia regulates mitochondrial biogenesis and oxidative stress. However, the potential role of PGC-1α in hypoxia-promoted proliferation of pulmonary arterial vascular smooth muscle cells (PASMCs) is completely unknown. In this study, ...

journal_title：Molecular and cellular biochemistry

authors： Rao J,Li J,Liu Y,Lu P,Sun X,Sugumaran PK,Zhu D

更新日期：2012-08-01 00:00:00

abstract：:Poly(ADP-ribose) polymerases or PARPs are a family of NAD(+)-dependent enzymes that modify themselves and other substrate proteins with ADP-ribose polymers. The founding member PARP 1 is localized predominantly in the nucleus and is activated by binding to DNA lesions. Excessive PARP 1 activation following genotoxin t...

journal_title：Molecular and cellular biochemistry

authors： Yeh TY,Sbodio JI,Nguyen MT,Meyer TN,Lee RM,Chi NW

更新日期：2005-08-01 00:00:00

abstract：:1. Two different molecular forms of dopamine-beta-hydroxylase were isolated from human serum; a major component (Peak I enzyme) with a molecular weight of 368000 and with a higher specific activity and a minor component (Peak II enzyme) with a molecular weight of 188000 and with a lower specific activity. 2. Both form...

journal_title：Molecular and cellular biochemistry

authors： Ikeno T,Hashimoto S,Kuzuya H,Nagatsu T

更新日期：1977-12-29 00:00:00

abstract：:Growth hormone (GH) has been reported to be useful to treat heart failure. To elucidate whether GH has direct beneficial effects on the heart, we examined effects of GH on oxidative stress-induced apoptosis in cardiac myocytes. TUNEL staining and DNA ladder analysis revealed that hydrogen peroxide (H2O2)-induced apopt...

journal_title：Molecular and cellular biochemistry

authors： Gu Y,Zou Y,Aikawa R,Hayashi D,Kudoh S,Yamauchi T,Uozumi H,Zhu W,Kadowaki T,Yazaki Y,Komuro I

更新日期：2001-07-01 00:00:00

abstract：:It has been recently shown that long-term thyroxine administration increases the tolerance of the heart to ischaemia. The present study investigated whether thyroxine induced cardioprotection involves alterations in the pattern of p38 mitogen activated protein kinase (p38MAPK) and c-Jun NH2-terminal kinases (JNKs) act...

journal_title：Molecular and cellular biochemistry

authors： Pantos C,Malliopoulou V,Paizis I,Moraitis P,Mourouzis I,Tzeis S,Karamanoli E,Cokkinos DD,Carageorgiou H,Varonos D,Cokkinos DV

更新日期：2003-01-01 00:00:00

abstract：:S-glutathionylation, the formation of mixed disulfides of glutathione with cysteine residues of proteins, is a broadly observed physiological modification that occurs in response to oxidative stress. Since cysteine residues are particularly susceptible to oxidative modification by reactive oxygen species, S-glutathion...

journal_title：Molecular and cellular biochemistry

authors： Leonberg AK,Chai YC

更新日期：2007-10-01 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) and renin-angiotensin system (RAS) play critical roles in the process of renal diseases, but their interaction has not been comprehensively discussed. In the present studies, we investigated the renoprotective effects of MPAK inhibitors on renal diseases in type 1 diabetic mouse...

journal_title：Molecular and cellular biochemistry

authors： Hong Z,Hong Z,Wu D,Nie H

更新日期：2016-08-01 00:00:00

abstract：:Higher order chromatin degradation (HOCD) is a stepwise dismantling of the genome through the excision of chromatin loops and their oligomers at matrix attachment regions (MARs) during the early stages of programmed cell death. Although HOCD ultimately leads to the inactivation of the genome and cell death, a partial ...

journal_title：Molecular and cellular biochemistry

authors： Banaszewska M,Konat GW

更新日期：2006-01-01 00:00:00

abstract：:The aim of the research was to study the role played by extracellular O2-radicals, which are implicated in cardiac cell damage and the protective effect by cell-permeable, nitroxide, superoxide dismutase-mimics. Cardiomyocytes cultures from 1-day-old rats served as the test-system. Experiments were performed since 5th...

journal_title：Molecular and cellular biochemistry

authors： Mohsen M,Pinson A,Zhang R,Samuni A

更新日期：1995-04-26 00:00:00

abstract：:Thrombospondin-1 (TSP-1) is a homotrimeric glycoprotein synthesized in a variety of normal and transformed cells, and secreted into the extracellular matrix. Based on its known effects on the tumor and endothelial cells, TSP-1 was implicated in the tumor growth and metastasis. In the present study, we have demonstrate...

journal_title：Molecular and cellular biochemistry

authors： Kim SA,Um SJ,Kang JH,Hong KJ

更新日期：2001-01-01 00:00:00

abstract：:The effects of the microtubular inhibitor, podophyllotoxin, on mitochondrial respiration were determined using isolated, digitonin-permeabilized hepatocytes and isolated mitochondria. In hepatocytes, podophyllotoxin (1.5 mM) inhibited coupled and uncoupled respiration of both FAD and NAD-linked substrates. In mitochon...

journal_title：Molecular and cellular biochemistry

authors： Horrum MA,Jennett RB,Ecklund RE,Tobin RB

更新日期：1986-06-01 00:00:00

abstract：:Immunoassays such as rocket immunoelectrophoresis, western dot blot hybridization, and competitive ELISA analysis were used to estimate and compare homology among fishes (several species), crab, toad, chicken and rodent metallothioneins. The relative abundance of tissue-specific metallothionein in catfish was highest ...

journal_title：Molecular and cellular biochemistry

authors： Chatterjee A,Maiti IB

更新日期：1990-05-10 00:00:00

abstract：:The aim of our study is to explore the regulation of C1QTNF1-AS1 on its target miR-221-3p/SOCS3 in human hepatocellular carcinoma (HCC). To explore the underlying molecular regulation of non-coding RNA for HCC, differentially expressed patterns of lncRNAs and genes were examined by RNA-seq. GO and KEGG pathway analysi...

journal_title：Molecular and cellular biochemistry

authors： Han W,Yu G,Meng X,Hong H,Zheng L,Wu X,Zhang D,Yan B,Ma Y,Li X,Wang Q

更新日期：2019-10-01 00:00:00

abstract：:Sensitive to Apoptosis Gene (SAG), a RING component of SCF E3 ubiquitin ligase, was shown to be phosphorylated by protein kinase CK2 at the Thr10 residue. It is, however, unknown whether this phosphorylation is stress-responsive or whether the phosphorylation changes its E3 ubiquitin ligase activity. To address these,...

journal_title：Molecular and cellular biochemistry

authors： He H,Tan M,Pamarthy D,Wang G,Ahmed K,Sun Y

更新日期：2007-01-01 00:00:00

abstract：:Using a synthetic peptide that encompasses the zinc finger domain of the eukaryotic transcription factor Sp1, we produced a number of monoclonal antibodies that specifically reacted with the target antigen. Analysis by competitive inhibition assay of five of the monoclonal antibodies revealed that they all recognized ...

journal_title：Molecular and cellular biochemistry

authors： Katai H,Terato K,Raghow R

更新日期：1991-02-27 00:00:00

abstract：:Adipose-derived stem cells (ADSCs) have been considered as the optimal cells for regenerative medicine because ADSCs have the potential of multi-directional differentiation. To study the mechanisms of ADSCs differentiation, we analyzed microarray of GSE37329. GSE37329 was downloaded from Gene Expression Omnibus includ...

journal_title：Molecular and cellular biochemistry

authors： Ren Y,Han C,Wang J,Jia Y,Kong L,Eerdun T,Wu L,Jiang D

更新日期：2015-02-01 00:00:00

abstract：:Human cardiomyopathy has been extensively studied in the last decade, and knowledge of the functional and structural alterations of the heart has grown. However, understanding of the pathogenesis has come mostly from experimental studies. A number of work have been designed to elucidate if alterations of the contracti...

journal_title：Molecular and cellular biochemistry

authors： Veksler V,Ventura-Clapier R

更新日期：1994-04-01 00:00:00

abstract：:The effects of chloroperoxidase [EC 1.1.1.10] and hydrogen peroxide on the viabilities of quiescent and germinating conidiospores of an aflatoxigenic fungus, Aspergillus flavus, were determined. Hydrogen peroxide was found moderately lethal and chloroperoxidase produced a 30-fold increase in the lethality of hydrogen ...

journal_title：Molecular and cellular biochemistry

authors： Jacks TJ,De Lucca AJ,Morris NM

更新日期：1999-05-01 00:00:00