Inhibition of respiration in mitochondria and in digitonin-treated rat hepatocytes by podophyllotoxin.

abstract：:Recent studies have shown that allogeneic bone marrow (BM)-mesenchymal stem cell transplantation (MSCT) appears to be effective in systemic lupus erythematosus (SLE) patients and lupus-prone mice, contrary to studies in syngeneic BM-MSCT. These studies indicated that the abnormalities of BM-MSCs may be involved in the...

journal_title：Molecular and cellular biochemistry

authors： Gu Z,Tan W,Feng G,Meng Y,Shen B,Liu H,Cheng C

更新日期：2014-02-01 00:00:00

abstract：:Recently it has been demonstrated that hydroxylamine is an activator of triglyceride catabolism. We have studied the effect of hydroxylamine on isocitrate lyase activity and lipid catabolism and have noted a stimulation of isocitrate lyase biosynthesis by 5 mM hydroxylamine. The specificity of this effect was tested w...

journal_title：Molecular and cellular biochemistry

authors： Vanni P,Vincenzini MT,Vincieri F,Baccari V

更新日期：1977-04-12 00:00:00

abstract：:Calpain inhibitors show the potential to serve as non-surgical alternatives in treating diabetic cataract and other types of these disorders. Here, we have tested the recently developed calpain inhibitor, SJA6017, for its ability to inhibit cataractogenesis in porcine lenses. These lenses were incubated in increasing ...

journal_title：Molecular and cellular biochemistry

authors： Biswas S,Harris F,Singh J,Phoenix DA

更新日期：2004-06-01 00:00:00

abstract：:Cutaneous changes like rash and hair loss, as well as other neurogenic inflammation side effects, occur frequently during anticancer treatment with the epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), erlotinib. These adverse events may be so severe that they impair the patient's compliance with ...

journal_title：Molecular and cellular biochemistry

authors： Chmielinska JJ,Kramer JH,Mak IT,Spurney CF,Weglicki WB

更新日期：2020-02-01 00:00:00

abstract：:Ran-binding protein in microtubule-organizing center (RanBPM) has been reported to interact with the neurotrophin receptors p75NTR and TrkA, meanwhile p75NTR and TrkA can also interact with TRAF6. Whether RanBPM interacts directly with TRAF6 has not yet been established. In this study, using a yeast two-hybrid system ...

journal_title：Molecular and cellular biochemistry

authors： Wang L,Fu C,Cui Y,Xie Y,Yuan Y,Wang X,Chen H,Huang BR

更新日期：2012-01-01 00:00:00

abstract：:Nitric oxide (NO) is a messenger molecule which regulates many physiological functions like immunity, vascular tone and serves as a neurotransmitter. Although it is known to participate in healing process, its role in collagen synthesis is not clear. Therefore, the present investigation was done to study the role of N...

journal_title：Molecular and cellular biochemistry

authors： Shukla A,Rasik AM,Shankar R

更新日期：1999-10-01 00:00:00

abstract：:In the past decades, a greater understanding of acute pancreatitis has led to improvement in mortality rates. Nevertheless, this disease continues to be a health care system problem due to its economical costs. Future strategies such as antioxidant supplementation could be very promising, regarding to beginning and pr...

journal_title：Molecular and cellular biochemistry

authors： Carrasco C,Holguín-Arévalo MS,Martín-Partido G,Rodríguez AB,Pariente JA

更新日期：2014-02-01 00:00:00

abstract：:Proteins which are major substrates of epidermal transglutaminases can be identified in cultured keratinocytes of human, cow, and new-born rat. Cow and human keratinocytes both contain substrate proteins which are 30 000 to 50 000 daltons in size but dissociable in SDS to 12 000 daltons or less. In both species these ...

journal_title：Molecular and cellular biochemistry

authors： Kubilus J,Baden HP

更新日期：1984-01-01 00:00:00

abstract：:Glucocorticoid hormones (GCH) are anti-inflammatory and immunosuppressive agents that inhibit T-cell growth and activation. Since the T-cell receptor (TCR)/CD3 complex mediates T-lymphocyte activation, we studied the effect of in vitro dexamethasone (DEX), a synthetic GCH, on TCR/CD3 expression. DEX-treatment of a hyb...

journal_title：Molecular and cellular biochemistry

authors： Migliorati G,Bartoli A,Nocentini G,Ronchetti S,Moraca R,Riccardi C

更新日期：1997-02-01 00:00:00

abstract：:To evaluate the role of lipid oxidation in atherogenesis the levels of lipid- and protein-bound products of peroxidation in normal and atherosclerotic areas of human aorta were investigated. The level of fluorescent (360/430 nm) lipid products was measured in chloroform-methanol extracts of aortic tissue. Normal intim...

journal_title：Molecular and cellular biochemistry

authors： Tertov VV,Kaplun VV,Mikhailova IA,Suprun IV,Orekhov AN

更新日期：2001-09-01 00:00:00

abstract：:Piperine is a major component of black (Piper nigrum Linn) and long pepper (Piper longum Linn) used widely in various systems of traditional medicine. We have evaluated the effect of piperine on mitochondrial tricarboxylic acid cycle and phase I and glutathione-metabolizing enzymes in Benzo(a)pyrene induced experiment...

journal_title：Molecular and cellular biochemistry

authors： Selvendiran K,Thirunavukkarasu C,Singh JP,Padmavathi R,Sakthisekaran D

更新日期：2005-03-01 00:00:00

abstract：:It has been shown that elevation of plasma methionine (Met) and its metabolites may occur in several genetic abnormalities. In this study we investigated the in vitro and in vivo effects of the Met and methionine sulfoxide (MetO) on oxidative stress parameters in the liver of rats. For in vitro studies, liver homogena...

journal_title：Molecular and cellular biochemistry

authors： Costa MZ,da Silva TM,Flores NP,Schmitz F,da Silva Scherer EB,Viau CM,Saffi J,Barschak AG,de Souza Wyse AT,Spanevello RM,Stefanello FM

更新日期：2013-12-01 00:00:00

abstract：:Migration and invasion are important characteristics of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs), which are involved in joint damage and contribute to rheumatoid arthritis (RA) pathology. However, the underlying mechanisms remain unclear. Because epithelial-mesenchymal transition (EMT) is a key mech...

journal_title：Molecular and cellular biochemistry

authors： Zhu D,Zhao J,Lou A,Huang Q,OuYang Q,Zhu J,Fan M,He Y,Ren H,Yang M

更新日期：2019-09-01 00:00:00

abstract：:Pathophysiology of polyunsaturated fatty acids (PUFAs) is associated with aberrant lipid and oxygen metabolism. In particular, under oxidative stress, PUFAs are prone to autocatalytic degradation via peroxidation, leading to formation of reactive aldehydes with numerous potentially harmful effects. However, the pathol...

journal_title：Molecular and cellular biochemistry

authors： Andrisic L,Collinson EJ,Tehlivets O,Perak E,Zarkovic T,Dawes IW,Zarkovic N,Cipak Gasparovic A

更新日期：2015-01-01 00:00:00

abstract：:Bone-morphogenetic proteins (BMPs) play an important role in development and many cellular processes. However, their functional role in the development and progression of breast cancer is not clearly understood. In the present study, we performed a systematic expression analysis of the 14 types of BMPs in 10 human bre...

journal_title：Molecular and cellular biochemistry

authors： Guo D,Huang J,Gong J

更新日期：2012-04-01 00:00:00

abstract：:Cervical cancer is the most common cancer in Indian females and is associated with infection with high risk Human papillomaviruses (HPVs). Curcumin (Diferuloyl methane), a chemopreventive agent, is a natural compound extracted from Curcuma longa that allows suppression of carcinogenesis. The objective of this study wa...

journal_title：Molecular and cellular biochemistry

authors： Singh M,Singh N

更新日期：2009-05-01 00:00:00

abstract：:In rat cardiac sarcolemmal membranes a phosphoinositide-specific phospholipase C (PLC) was found to be present. The enzyme hydrolysed exogenous [3H-]phosphatidylinositol 4,5-biphosphate ([3H-]PtdIns(4,5)P2) in an optimized assay mixture containing 15 micrograms SL protein, 100 mM NaCl, 1 mM free Ca2+, 14 mM Na-cholate...

journal_title：Molecular and cellular biochemistry

authors： Meij JT,Panagia V

更新日期：1992-10-21 00:00:00

abstract：:Despite its wide range of known substrates, the signaling function of protein kinase CK2 is still enigmatic. Mounting evidence suggests that CK2alpha, the catalytic subunit of holoenzymic CK2, may exist free of its usual regulatory partner CK2beta, raising the possibility that 'free' CK2alpha has regulation and functi...

journal_title：Molecular and cellular biochemistry

authors： Lebrin F,Bianchini L,Rabilloud T,Chambaz EM,Goldberg Y

更新日期：1999-01-01 00:00:00

abstract：:MAP/Microtubule affinity-regulating kinase 4 (MARK4), a Ser/Thr protein kinases, is related to the Par-1 (partitioning-defective) gene products, and is the human ortholog of Par-1. MARK4 shows its role in the cell polarity at the time of embryonic development. It is mostly located at the basal region of cells, providi...

journal_title：Molecular and cellular biochemistry

authors： Naz F,Islam A,Ahmad F,Hassan MI

更新日期：2015-12-01 00:00:00

abstract：:The present study was aimed to get the nucleotide sequences of a part of COII mitochondrial gene amplified from individuals of five species of Termites (Isoptera: Termitidae: Macrotermitinae). Four of them belonged to the genus Odontotermes (O. obesus, O. horni, O. bhagwatii and Odontotermes sp.) and one to Microterme...

journal_title：Molecular and cellular biochemistry

authors： Sobti RC,Kumari M,Sharma VL,Sodhi M,Mukesh M,Shouche Y

更新日期：2009-11-01 00:00:00

abstract：:Enhancer of zeste homolog 2 (EZH2) is a highly conserved histone methyltransferase, which is overexpressed in different types of cancers such as breast and prostate cancer. It is reported that EZH2 can directly down-regulate RUNX3 by increasing histone H3 methylation. However, the role of EZH2 in the development and p...

journal_title：Molecular and cellular biochemistry

authors： Lian R,Ma H,Wu Z,Zhang G,Jiao L,Miao W,Jin Q,Li R,Chen P,Shi H,Yu W

更新日期：2018-02-01 00:00:00

abstract：:Primary cultures of skeletal muscle cells secrete plasminogen activator (PA) activity to the conditioning medium and display membrane-bound PA. Growth of these cells in culture in presence of 10(-7) M dexamethasone resulted in a marked reduction of the membranal and secreted PA activity. The hormone also reduced cytos...

journal_title：Molecular and cellular biochemistry

authors： Mayer M,Finci Z,Chaouat M,Sasson S

更新日期：1986-02-01 00:00:00

abstract：:Female rats at weaning (30 days age) were maintained on vitamin E-deficient diet for 70 days. The vitamin E-deficient and control animals were sacrificed on 100 days of age. To study recovery a group of animals were supplemented with normal diet for last 25 days after initial 45 days of deficient diet or vice versa. T...

journal_title：Molecular and cellular biochemistry

authors： Das P,Chowdhury M

更新日期：1999-08-01 00:00:00

abstract：:Previous studies reported that estrogen receptor β (ERβ) is localized to mitochondria, whereas little is known about the physiological functions of mitochondrial ERβ. In the present study, we explored the role of mitochondrial ERβ in regulating apoptosis using stable ERβ-expressing and ERβ knockdown cells lines. We fo...

journal_title：Molecular and cellular biochemistry

authors： Liang J,Xie Q,Li P,Zhong X,Chen Y

更新日期：2015-03-01 00:00:00

abstract：:The ex vivo and in vitro effects of quercetin on NTPDase, adenosine deaminase (ADA), and acetycholinesterase (AChE) activities in lymphocytes, as well as the effects of quercetin on butyrylcholinesterase (BChE) activity in serum and myeloperoxidase (MPO) activity in plasma were determined in rats. For the ex vivo expe...

journal_title：Molecular and cellular biochemistry

authors： Abdalla FH,Cardoso AM,Schmatz R,Gonçalves JF,Baldissarelli J,Martins CC,Zanini D,de Oliveira LS,da Costa P,Pimentel VC,Pereira LB,Lhamas CL,Schetinger MR,Morsch VM,Mazzanti CM

更新日期：2014-11-01 00:00:00

abstract：:Formation of foam cells from macrophages, which are formed by the differentiation of blood-borne monocytes, is a critical early event in atherogenesis. To examine how pre-exposure of monocytes to modified proteins, such as oxLDL, influences their differentiation to macrophages, an in vitro model system using isolated ...

journal_title：Molecular and cellular biochemistry

authors： Radhika A,Sudhakaran PR

更新日期：2013-01-01 00:00:00

abstract：:The occurrence of the 'whey' protein, alpha-lactalbumin, in pig (Sus scrofus) milk samples from 904 sows is examined. A semi-discontinuous buffer system has been developed to detect the existence of genetic polymorphism. There are two homozygous variants, designated A and B. Both variants are isolated and it is shown ...

journal_title：Molecular and cellular biochemistry

authors： Bell K,McKenzie HA,Shaw DC

更新日期：1981-03-13 00:00:00

abstract：:Lens epithelial cells are the metabolic unit of the lens and antioxidant enzymes are mainly concentrated here. The purpose of this study was to maintain human lens epithelial cells (HLEC) in culture and examine the status of antioxidant enzymes (glutathione peroxidase (GSHPx), catalase (CAT), glutathione-S-transferase...

journal_title：Molecular and cellular biochemistry

authors： Mohanty I,Joshi S,Trivedi D,Srivastava S,Tandon R,Gupta SK

更新日期：2002-09-01 00:00:00

abstract：:The capacity of noradrenaline (NA) and its end metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) to modulate the chemotaxis of lymphocytes from a primary immunocompetent organ (thymus) and a secondary one (spleen) was investigated over a range of concentrations from 10(-12) M to 10(-5) M. Lymphocyte chemotaxis was eva...

journal_title：Molecular and cellular biochemistry

authors： García JJ,del Carmen Sáez M,De la Fuente M,Ortega E

更新日期：2003-12-01 00:00:00

abstract：:The antioxidant efficacy of vitamin E on Perchloroethylene (PER) induced cytotoxicity has been studied in rats. Feeding PER to rats for 42 days using sesame oil as vehicle alters total protein and protein bound carbohydrate components in liver and kidney of experimental animals. Supplementation of vitamin E prevented ...

journal_title：Molecular and cellular biochemistry

authors： Ebrahim AS,Gopalakrishnan R,Murugesan A,Sakthisekaran D

更新日期：1995-03-09 00:00:00