CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter.

abstract：:Chronic aristolochic acid (AA) nephropathy (CAAN) caused by intake of AA-containing herbs is difficult to treat. We evaluated the therapeutic effect of bone marrow (BM) mesenchymal stem cells (MSCs) on a rat model of CAAN. Female Wistar rats were fed with decoction of Caulis Aristolochia manshuriensis by intragastric ...

journal_title：Molecular and cellular biochemistry

authors： Li W,Jiang H,Feng JM

更新日期：2012-09-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is a devastating disease that results in irreversible central vision loss. TLRs signaling pathway has been found to play an important role in AMD pathogenesis as evidenced by several studies. The objective of the study was to determine the single nucleotide polymorphism (SNP) cha...

journal_title：Molecular and cellular biochemistry

authors： Sharma NK,Sharma K,Gupta A,Prabhakar S,Singh R,Gupta PK,Anand A

更新日期：2014-08-01 00:00:00

abstract：:Respiratory muscle injury may result from excessive loading due to a decrease in respiratory muscle strength, an increase in the work of breathing, or an increase in the rate of ventilation. Other conditions such as hypoxemia, hypercapnia, aging, decreased nutrition, and immobilization may potentiate respiratory muscl...

journal_title：Molecular and cellular biochemistry

authors： Reid WD,MacGowan NA

更新日期：1998-02-01 00:00:00

abstract：:Proteins which are major substrates of epidermal transglutaminases can be identified in cultured keratinocytes of human, cow, and new-born rat. Cow and human keratinocytes both contain substrate proteins which are 30 000 to 50 000 daltons in size but dissociable in SDS to 12 000 daltons or less. In both species these ...

journal_title：Molecular and cellular biochemistry

authors： Kubilus J,Baden HP

更新日期：1984-01-01 00:00:00

abstract：:Gram negative sepsis and septic shock continue to be a major medical problem, with a complex physiopathology and it is associated with high mortality. Although secretion of cytokines such as tumor necrosis factor-alpha by macrophages is the principal host mediator of septic shock, other characteristic functions of mac...

journal_title：Molecular and cellular biochemistry

authors： Víctor VM,Miñano M,Guayerbas N,Del Río M,Medina S,De la Fuente M

更新日期：1998-12-01 00:00:00

abstract：:Insulin and vanadate function as complete mitogens for SV40-transformed murine 3T3T (CSV3-1) cells but not for nontransformed 3T3T cells. Mitogenesis induced by insulin and vanadate in CSV3-1 cells is associated with the induction of the expression of protooncogenes c-jun and junB, two major AP-1 transcription factor ...

journal_title：Molecular and cellular biochemistry

authors： Wang H,Xie Z,Scott RE

更新日期：1997-03-01 00:00:00

abstract：:In mammalian cells, increases in calcium concentration cause increases in oxidative phosphorylation. This effect is mediated by the activation of four mitochondrial dehydrogenases by calcium ions; FAD-glycerol 3-phosphate dehydrogenase, pyruvate dehydrogenase, NAD-isocitrate dehydrogenase and oxoglutarate dehydrogenas...

journal_title：Molecular and cellular biochemistry

authors： Nichols BJ,Denton RM

更新日期：1995-08-01 00:00:00

abstract：:Diabetes-induced changes in glucose formation, intracellular and mitochondrial glutathione redox states as well as hydroxyl free radicals (HFR) generation have been investigated in rabbit kidney-cortex tubules. In contrast to renal tubules of control animals, diabetes-evoked increase in glucose formation in the presen...

journal_title：Molecular and cellular biochemistry

authors： Winiarska K,Drozak J,Wegrzynowicz M,Fraczyk T,Bryla J

更新日期：2004-06-01 00:00:00

abstract：:Winter survival for many insect species relies on the ability to endure the freezing of extracellular body fluids. Because freezing impedes oxygen delivery to tissues, one component of natural freeze tolerance is a well-developed anoxia/ischemia resistance. The present study explores the responses of the hypoxia-induc...

journal_title：Molecular and cellular biochemistry

authors： Morin P Jr,McMullen DC,Storey KB

更新日期：2005-12-01 00:00:00

abstract：:NF45, also referred to as nuclear factor of activated T cells, has been reported to promote the progression of multiple cancer types. However, the expression and physiological significance of NF45 in pancreatic ductal adenocarcinoma (PDAC) remain largely elusive. In this study, we investigated the clinical relevance a...

journal_title：Molecular and cellular biochemistry

authors： Wan C,Gong C,Ji L,Liu X,Wang Y,Wang L,Shao M,Yang L,Fan S,Xiao Y,Wang X,Li M,Zhou G,Zhang Y

更新日期：2015-12-01 00:00:00

abstract：:Whereas in rat liver mitochondria the hyperthyroid state causes an increase both in fatty acid unsaturation and in the Ea of D-3-hydroxybutyrate dehydrogenase and a decrease in phase transition temperature, in hyperthyroid rat heart mitochondria these changes are negligible. D-3-hydroxybutyrate dehydrogenase in both t...

journal_title：Molecular and cellular biochemistry

authors： Lippolis R,Morini P,Conserva AR,Casalino E,Landriscina C

更新日期：1990-03-27 00:00:00

abstract：:Angiotensin II induces the expression of platelet-derived growth factor A-chain and B-chain in cultured vascular smooth muscle cells at the level of transcription. The renin-angiotensin system has also been implicated in the increased expression of platelet-derived growth factor in the mechanically-injured artery wall...

journal_title：Molecular and cellular biochemistry

authors： Khachigian LM,Takuwa Y,Collins T

更新日期：2000-09-01 00:00:00

abstract：:Chemical and enzymatic properties of four collagenases newly isolated from anaerobic Clostridium histolyticum, aerobic Achromobacter iophagus, and from two lower eucaryotes, the fungus Entomophthora coronata and the insect Hypoderma lineatum are reviewed. The problems of their biosynthesis and precursors, namely the e...

journal_title：Molecular and cellular biochemistry

authors： Keil B

更新日期：1979-01-26 00:00:00

abstract：:Apoptosis is a physiological mechanism for the control of DNA integrity in mammalian cells. Vanadium induces both DNA damage and apoptosis. It is suggested that vanadium-induced apoptosis serves to eliminate DNA-damaged cells. This study is designed to clarify a role of reactive oxygen species in the mechanism of apop...

journal_title：Molecular and cellular biochemistry

authors： Ye J,Ding M,Leonard SS,Robinson VA,Millecchia L,Zhang X,Castranova V,Vallyathan V,Shi X

更新日期：1999-12-01 00:00:00

abstract：:Migration and proliferation of smooth muscle cells (SMC) are important events during arteriogenesis, but the underlying mechanism is still only partially understood. The present study investigates the expression of integrins alpha 5 beta 1 and v beta 3 as well as focal adhesion kinase (FAK) and phosphorylated FAK (pY3...

journal_title：Molecular and cellular biochemistry

authors： Cai WJ,Li MB,Wu X,Wu S,Zhu W,Chen D,Luo M,Eitenmüller I,Kampmann A,Schaper J,Schaper W

更新日期：2009-02-01 00:00:00

abstract：:ADP-ribosylation factors (ARFs) comprise a family of approximately 20 kDa guanine nucleotide-binding proteins that were discovered as one of several cofactors required in cholera toxin-catalyzed ADP-ribosylation of Gs alpha, the guanine nucleotide-binding protein responsible for stimulation of adenylyl cyclase, and wa...

journal_title：Molecular and cellular biochemistry

authors： Welsh CF,Moss J,Vaughan M

更新日期：1994-09-01 00:00:00

abstract：:Nicotinic acid administration, which depletes liver glycogen, leads to an increase of both pyruvate kinase L and phosphoenolypyruvate carboxykinase in liver by a factor of nearly two. The former is not prevented by either cycloheximide or actinomycin D. L-Cysteine, an allosteric inhibitor of pyruvate kinase L, favors ...

journal_title：Molecular and cellular biochemistry

authors： Moreno FJ,Benito M,Sánchez-Medina F,Medina JM,Mayor F

更新日期：1976-11-30 00:00:00

abstract：:This study examined the role of the protein kinase C (PKC) signalling pathway in the regulation of expression of human complement factor I (CFI) gene. The production of CFI by Hep G2 cells was enhanced in a dose- and time-dependent fashion by 12-O-tetradecanoyl-1,2-phorbol 13-acetate (TPA), a potent PKC activator. 4Al...

journal_title：Molecular and cellular biochemistry

authors： Minta J,Fung M

更新日期：1999-11-01 00:00:00

abstract：:Liver glucose 6-phosphate dehydrogenase and phosphogluconate dehydrogenase activities were significantly decreased in both diabetic and fasted rats. Treatment of diabetic rats with insulin resulted in liver glucose 6-phosphate dehydrogenase and phosphogluconate dehydrogenase activities that were significantly greater ...

journal_title：Molecular and cellular biochemistry

authors： Martins RN,Stokes GB,Masters CL

更新日期：1986-05-01 00:00:00

abstract：:β-Adrenergic receptor (β-AR) stimulation induces cardiac myocyte apoptosis and plays an important role in myocardial remodeling. Here we investigated expression of various apoptosis-related genes affected by β-AR stimulation, and examined first time the role of ataxia telangiectasia mutated kinase (ATM) in cardiac myo...

journal_title：Molecular and cellular biochemistry

authors： Foster CR,Singh M,Subramanian V,Singh K

更新日期：2011-07-01 00:00:00

abstract：:The IL-6-related cytokines, LIF and cardiotrophin-1, are important growth promoting and cardioprotective agents for cardiomyocytes. However, factors that regulate their actions in the heart are poorly understood. In this study, we tested the hypothesis that endothelin-1, a peptide hormone that produces a pattern of ca...

journal_title：Molecular and cellular biochemistry

authors： Booz GW,Day JN,Speth R,Baker KM

更新日期：2002-11-01 00:00:00

abstract：:We evaluated the effects of Rubus tereticaulis in healing process by determining the total carbonyl content, collagen synthesis, and total protein level on rat wounded tissues. Wounds were performed in the back of 54 Wistar rats, using a biopsy punch instrument with 0.6 mm in diameter. Rats were randomly divided into ...

journal_title：Molecular and cellular biochemistry

authors： Aksoy H,Demirbağ Ç,Şen A,Şekerler T,Özakpınar Ö,Şener A,Ahmad S,Tetik S

更新日期：2020-09-01 00:00:00

abstract：:By qualitative and quantitative PCR, we evaluated the expression of three messengers coding for SAT-1, SAT-2 and GalNAcT-1 in human samples of intestinal cancer and some cell lines (breast cancer and melanomas). Qualitative PCR demonstrated, in human tissues but not in the cell lines examined, the presence of an mRNA ...

journal_title：Molecular and cellular biochemistry

authors： Gornati R,Chini V,Rimoldi S,Meregalli M,Schiaffino E,Bernardini G

更新日期：2007-04-01 00:00:00

abstract：:The effects of Mg2+ concentration (Mg2+o, 0, 1.2, 2.4, and 4.8 mM) on the incidence of reperfusion arrhythmias and on the cellular electrical activity were studied in spontaneously beating rat hearts. The surface electrogram and the membrane potential were recorded in control conditions, during 10 min of regional isch...

journal_title：Molecular and cellular biochemistry

authors： Ponce Zumino A,Risler NR,Schanne OF,Ruiz Petrich E,Carrión A

更新日期：1997-06-01 00:00:00

abstract：:Rat pancreatic acinar cells AR 4-2J respond to dexamethasone by differentiation and a decreased proliferation rate. Protein labelling by [3H]-mevalonolactone, used as a precursor of farnesyl and geranylgeranyl isoprenoid groups, was increased in the presence of dexamethasone. In these same conditions, dexamethasone de...

journal_title：Molecular and cellular biochemistry

authors： Lambert M,Bui ND

更新日期：1999-12-01 00:00:00

abstract：:Sodium cyanide (NaCN)-induced chemical hypoxia is known to increase intracellular free calcium concentration and reduce cell survival, but its effect on gene expression has not been studied. In this study, we designed primers to conduct a rapid and reliable assay for the expression of mRNA of inducible nitric oxide sy...

journal_title：Molecular and cellular biochemistry

authors： Kiang JG,Warke VG,Tsokos GC

更新日期：2003-12-01 00:00:00

abstract：:Myostatin belongs to the Transforming Growth Factor-beta (TGF-beta) superfamily and is expressed in developing and mature skeletal muscle. Biologically, the role of myostatin seems to be extremely well conserved during evolution since inactivating mutations in myostatin gene cause similar phenotype of heavy muscling i...

journal_title：Molecular and cellular biochemistry

authors： Jeanplong F,Sharma M,Somers WG,Bass JJ,Kambadur R

更新日期：2001-04-01 00:00:00

abstract：:In order to study the mechanism of entry and localization of bilirubin (BR) into cell membrane, binding of BR to sealed and human serum albumin (HSA)-entrapped sealed membranes was studied by CD spectroscopy. An induced bisignate CD cotton effects (CDCEs) of BR-bound sealed membranes were observed with maxima at 515 n...

journal_title：Molecular and cellular biochemistry

authors： Rashid H,Khan MM,Tayyab S

更新日期：2005-09-01 00:00:00

abstract：:We have tested the hypothesis that activation of the insulin receptor tyrosine kinase is due to autophosphorylation of tyrosines 1146, 1150 and 1151 within a putative autoinhibitory domain. A synthetic peptide corresponding to residues 1134-1162, with tyrosines substituted by alanine or phenylalanine, of the insulin r...

journal_title：Molecular and cellular biochemistry

authors： Filipek A,Soderling TR

更新日期：1993-03-24 00:00:00

abstract：:In this study, indirect immunofluorescence labeling was used to examine the cellular dynamic distribution of Thr11 phosphorylated H3 at mitosis in MCF-7 cells. The Thr11 phosphorylation was observed beginning at prophase at centromeres. Upon progression of mitosis, fluorescence signal was enhanced in the central regio...

journal_title：Molecular and cellular biochemistry

authors： Zhou H,Li D,Song L,Liu R,Chen J,Huang X

更新日期：2008-04-01 00:00:00