Dexamethasone-induced decrease in HMG-CoA reductase and protein-farnesyl transferase activities does not impair ras processing in AR 4-2J cells.

abstract：:Migration and proliferation of smooth muscle cells (SMC) are important events during arteriogenesis, but the underlying mechanism is still only partially understood. The present study investigates the expression of integrins alpha 5 beta 1 and v beta 3 as well as focal adhesion kinase (FAK) and phosphorylated FAK (pY3...

journal_title：Molecular and cellular biochemistry

authors： Cai WJ,Li MB,Wu X,Wu S,Zhu W,Chen D,Luo M,Eitenmüller I,Kampmann A,Schaper J,Schaper W

更新日期：2009-02-01 00:00:00

abstract：:In order to compare the role of the Ca(2+)-receptive protein (troponin), in the characteristic myofibrillar contractile response of chicken fast and slow skeletal muscles, the troponin in both kinds of myofibrils were partially exchanged, under slightly acidic conditions. The Ca(2+)- or Sr(2+)-activation of the ATPase...

journal_title：Molecular and cellular biochemistry

authors： Kawashima A,Shiraishi F,Ohtsuki I,Yamamoto K

更新日期：1994-03-30 00:00:00

abstract：:Histone H1 of rat alveolar macrophages, neutrophilic granulocytes and monocytes extracted with 5% (v/v) perchloric acid was studied in order to see whether a protein similar to histone H1 degrees of rat liver exists in these specialized cells. The biochemical methods used involved SDS and acid-urea polyacrylamide gel ...

journal_title：Molecular and cellular biochemistry

authors： Ghadam P,Rabbani A

更新日期：2002-07-01 00:00:00

abstract：:Many glomerular diseases are associated with changes in the expression and distribution in the components of extracellular matrix. A remarkable feature in acute renal failure induced by mercuric chloride in rats was large fibronectin (Fn) deposits in kidneys 1 h post-HgCl2 injection (5 mg/kg body wt., s.c.). Our study...

journal_title：Molecular and cellular biochemistry

authors： Saball E,Salvarrey M,Serra E,Picó G,Elías MM

更新日期：2001-10-01 00:00:00

abstract：:There is general agreement that the connexin43 gap junction protein is a substrate for phosphorylation by protein kinase C but there is no similar consensus regarding the action of protein kinase A. Our previous studies demonstrated that channels formed by connexin43 were reversibly gated in response to microinjected ...

journal_title：Molecular and cellular biochemistry

authors： Shah MM,Martinez AM,Fletcher WH

更新日期：2002-09-01 00:00:00

abstract：:Gram negative sepsis and septic shock continue to be a major medical problem, with a complex physiopathology and it is associated with high mortality. Although secretion of cytokines such as tumor necrosis factor-alpha by macrophages is the principal host mediator of septic shock, other characteristic functions of mac...

journal_title：Molecular and cellular biochemistry

authors： Víctor VM,Miñano M,Guayerbas N,Del Río M,Medina S,De la Fuente M

更新日期：1998-12-01 00:00:00

abstract：:The present study examines the time dependent effects of n-6 and n-3 polyunsaturated fatty acids on liver microsomal lipid metabolism in FVB mice fed a diet supplemented with a mixture of free fatty acids (mainly 18:3n-6 and 20:5n-3) at 25 mg/g diet. Significant changes in the fatty acid composition of total liver and...

journal_title：Molecular and cellular biochemistry

authors： de Antueno RJ,Cantrill RC,Huang YS,Raha SK,Elliot M,Horrobin DF

更新日期：1992-12-16 00:00:00

abstract：:Differentiation of 3T3-L1 preadipocytes, induced by methyl-isobutylxanthine (MIX), dexamethasone (DEX), and insulin, results in cells with the morphological and biochemical characteristics of adipocytes. Following incubation of 3T3-L1 cells with MIX, DEX, and insulin, poly(ADP-ribose) synthetase activity decreased abr...

journal_title：Molecular and cellular biochemistry

authors： Pekala PH,Moss J

更新日期：1983-01-01 00:00:00

abstract：:Fibrates and WY-14643 are widely used as lipid-lowering drugs via modulation of peroxisome proliferator-activated receptor alpha (PPAR α) for the treatment of a wide range of metabolic disorders. Here, to address the question whether PPAR α agonists can affect the enzymatic activity of 11beta-hydroxysteroid dehydrogen...

journal_title：Molecular and cellular biochemistry

authors： Kim CH,Ramu R,Ahn JH,Bae MA,Cho YS

更新日期：2010-11-01 00:00:00

abstract：:The purified Ca2+/Mg2+ ATPase from rat heart plasma membrane was activated by Ca2+ and Mg2+ with Ka values of 1.47 mM and 2.51 mM, respectively; other divalent cations also activated the enzyme but to a lesser extent. Divalent cations like Cu2+, Zn2+, Ni2+, Cd2+ were potent inhibitors of the enzyme activity in the pre...

journal_title：Molecular and cellular biochemistry

authors： Zhao D,Elimban V,Dhalla NS

更新日期：1991-10-16 00:00:00

abstract：:Fat cells were preincubated for 2 h in the presence and absence of growth hormone (GH) and Dexamethasone (Dex) before the addition of increasing concentrations of either epinephrine, theophylline or glucagon and final incubation of the cells for an additional 5 minutes. GH and Dex increased by 85%, 28% and 72%, respec...

journal_title：Molecular and cellular biochemistry

authors： Harris R,Bennun A

更新日期：1976-12-10 00:00:00

abstract：:Antimycin A (AMA) inhibits succinate oxidase, NADH oxidase, and mitochondrial electron transport chain between cytochrome b and c. We recently demonstrated that AMA inhibited the growth of Calu-6 lung cancer cells through apoptosis. Here, we investigated the effects of AMA and/or MAPK inhibitors on Calu-6 lung cancer ...

journal_title：Molecular and cellular biochemistry

authors： Han YH,Park WH

更新日期：2010-01-01 00:00:00

abstract：:A systematic comparison of the impact of some potential endocrine disruptors (EDs) on modulation of androgen receptor (AR) and pregnane and xenobiotic receptor (PXR) function was conducted in a multi-step analysis. Promoter-reporter-based transcription assays were performed in conjunction with receptor dynamic studies...

journal_title：Molecular and cellular biochemistry

authors： Chaturvedi NK,Kumar S,Negi S,Tyagi RK

更新日期：2010-12-01 00:00:00

abstract：:Eukaryotic protein synthesis initiation factor eIF-2 is usually isolated as a heterotrimer (alphabeta gamma). By use of Sephacryl S-300 fractionation an alpha subunit-deficient form of eIF-2 was identified in impure preparations from rabbit reticulocyte lysate and it appeared in these preparations to be still active i...

journal_title：Molecular and cellular biochemistry

authors： Mouat MF,Manchester K

更新日期：1998-06-01 00:00:00

abstract：:The localization of the membrane-bound cyclic 3',5'-AMP phosphodiesterase in cardiac tissues of both, rat and dog was studied by cytochemical method. 40 microm thick slices from glutaraldehyde fixed heart tissue were incubated in the medium with cAMP as a substrate and Pb ions as a capture metal of the reaction produc...

journal_title：Molecular and cellular biochemistry

authors： Okruhlicová L,Tribulová N,Styk J,Eckly A,Lugnier C,Slezk J

更新日期：1997-08-01 00:00:00

abstract：:Cataract is the most common eye disease that causes blindness in patients. Ultraviolet B (UVB) irradiation is considered an important factor leading to cataract by inducing apoptosis in human lens epithelial cells (HLECs), but the mechanism is currently unclear. In this study, we investigated HLECs under different int...

journal_title：Molecular and cellular biochemistry

authors： Ji Y,Cai L,Zheng T,Ye H,Rong X,Rao J,Lu Y

更新日期：2015-03-01 00:00:00

abstract：:HMGb1 is a DNA-binding protein whose role as an extracellular cytokine in inflammation and tissue regeneration has also been reported. Given the importance of keratinocytes in wound healing, we have studied the mechanism of action of HMGb1 on HaCaT keratinocytes during in vitro scratch wound repair. Western blot and c...

journal_title：Molecular and cellular biochemistry

authors： Ranzato E,Patrone M,Pedrazzi M,Burlando B

更新日期：2009-12-01 00:00:00

abstract：:Previously, we isolated and characterized the gene encoding the 3'-Nucleotidase/Nuclease (Ld3'NT/NU) from the human pathogen, Leishmania donovani. This unique cell surface enzyme has been shown to be involved in the salvage of host-derived purines, which are essential for the survival of this important protozoan paras...

journal_title：Molecular and cellular biochemistry

authors： Debrabant A,Bastien P,Dwyer DM

更新日期：2001-04-01 00:00:00

abstract：:Advanced glycation end products (AGE) and its cell-bound receptor called receptor for AGE (RAGE) are implicated in the pathogenesis of numerous diseases. Soluble receptor for AGE (sRAGE) counteracts the adverse effects of AGE-RAGE interaction by competing with RAGE for binding with AGE. Low levels of serum sRAGE have ...

journal_title：Molecular and cellular biochemistry

authors： Prasad K

更新日期：2019-01-01 00:00:00

abstract：:p62/sequestosome-1 is a multifunctional adapter protein implicated in selective autophagy, cell signaling pathways, and tumorigenesis, and plays an important role at the crossroad between autophagy and cancer. But, the connection between autophagy and cancer is complex and in some cases contradictory. Human colorectal...

journal_title：Molecular and cellular biochemistry

authors： Ren F,Shu G,Liu G,Liu D,Zhou J,Yuan L,Zhou J

更新日期：2014-01-01 00:00:00

abstract：:Cardiovascular diseases involve critical mechanisms including impaired nitric oxide (NO) levels and abnormal matrix metalloproteinase (MMP) activity. While NO downregulates MMP expression in some cell types, no previous study has examined whether NO downregulates MMP levels in endothelial cells. We hypothesized that N...

journal_title：Molecular and cellular biochemistry

authors： Meschiari CA,Izidoro-Toledo T,Gerlach RF,Tanus-Santos JE

更新日期：2013-06-01 00:00:00

abstract：:Oxidized LDL is highly atherogenic as it stimulates macrophage cholesterol accumulation and foam cell formation, it is cytotoxic to cells of the arterial wall and it stimulates inflammatory and thrombotic processes. LDL oxidation can lead to its subsequent aggregation, which further increases cellular cholesterol accu...

journal_title：Molecular and cellular biochemistry

authors： Aviram M,Fuhrman B

更新日期：1998-11-01 00:00:00

abstract：:High level of dietary fiber has been epidemiologically linked to protection against the risk for developing colon cancer. The mechanisms of this protection are not clear. Fermentation of dietary fiber in the colon results in production of for example butyrate that has drawn attention as a chemopreventive agent. Polyde...

journal_title：Molecular and cellular biochemistry

authors： Putaala H,Mäkivuokko H,Tiihonen K,Rautonen N

更新日期：2011-11-01 00:00:00

abstract：:In this study, we examined changes in the biochemical and inotropic events of the alpha(1)-adrenoceptor signaling pathway in hypothyroid rat hearts. Hypothyroidism was induced by treating experimental animals with 0.05% 6-n-propyl-2-thiouracil (PTU) in drinking water for 7 weeks. A significant decrease of beta- and an...

journal_title：Molecular and cellular biochemistry

authors： Jalali S,Durston M,Panagia V,Mesaeli N

更新日期：2006-02-01 00:00:00

abstract：:ING proteins are tumor suppressors involved in the regulation of gene transcription, cell cycle arrest, apoptosis, and senescence. Here, we show that ING1b expression is upregulated by several DNA-damaging agents, in a p53-independent manner. ING1b stimulates DNA repair of a variety of DNA lesions requiring activation...

journal_title：Molecular and cellular biochemistry

authors： Ceruti JM,Ogara MF,Menéndez C,Palmero I,Cánepa ET

更新日期：2013-06-01 00:00:00

abstract：:To help resolve the controversy as to whether or not Na(+)-H+ exchange is functioning during reperfusion of the ischemic myocardium we assessed the effects of dimethylamiloride (DMA, an amiloride analogue possessing selectivity for inhibition of the Na(+)-H+ exchanger) on cardiac function and intracellular pH during i...

journal_title：Molecular and cellular biochemistry

authors： Docherty JC,Yang L,Pierce GN,Deslauriers R

更新日期：1997-11-01 00:00:00

abstract：:The interaction of glyceraldehyde 3-phosphate dehydrogenase with microtubules has been studied by measurement of the amount of enzyme which co-assembles with in vitro reconstituted microtubules. The binding of glyceraldehyde 3-phosphate dehydrogenase to microtubules is a saturable process; the maximum binding capacity...

journal_title：Molecular and cellular biochemistry

authors： Durrieu C,Bernier-Valentin F,Rousset B

更新日期：1987-03-01 00:00:00

abstract：:It is well known that mitochondria are only partly an autonomous system since they are subjected to nuclear control. For this reason, in studying mitochondrial genes one has to consider constantly the integration of mitochondrial and nuclear genetic systems. This fact makes experimental approaches still more sophistic...

journal_title：Molecular and cellular biochemistry

authors： Neifakh SA

更新日期：1977-02-04 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) has been thought to play a major role during cardiac fibrosis in the development of diabetic cardiomyopathy, and cardiac fibrosis mainly as a result of an increase of collagen type III occurs in the human hearts with diabetes. Thrombospondin-1 (TSP-1) has been reported to activat...

journal_title：Molecular and cellular biochemistry

authors： Tang M,Zhou F,Zhang W,Guo Z,Shang Y,Lu H,Lu R,Zhang Y,Chen Y,Zhong M

更新日期：2011-01-01 00:00:00

abstract：:Evidence suggests that functional atrial natriuretic peptide (ANP) receptors occur in surface gastric mucosal epithelial cells. To evaluate functional aspects of ANP in a model of these cells we examined the expression of natriuretic peptide receptors (NPR) subtypes A and C in the non-transformed rat gastric mucosal e...

journal_title：Molecular and cellular biochemistry

authors： Gower WR Jr,Carter GM,McAfee Q,Solivan SM

更新日期：2006-12-01 00:00:00