当前位置： SCI文献检索 > MOLECULAR AND CELLULAR BIOCHEMISTRY期刊下所有文献 > Inhibitor of growth 1 (ING1) acts at early steps of multiple DNA repair pathways.

Inhibitor of growth 1 (ING1) acts at early steps of multiple DNA repair pathways.

Abstract：

:ING proteins are tumor suppressors involved in the regulation of gene transcription, cell cycle arrest, apoptosis, and senescence. Here, we show that ING1b expression is upregulated by several DNA-damaging agents, in a p53-independent manner. ING1b stimulates DNA repair of a variety of DNA lesions requiring activation of multiple DNA repair pathways. Moreover, Ing1(-/-) cells showed impaired genomic DNA repair after H2O2 and neocarzinostatin treatment and this defect was reverted by overexpression of ING1b. Two tumor-derived ING1 mutants failed to promote DNA repair highlighting the physiological importance of the integrity of the PHD domain for ING1b DNA repair activity and suggesting a role in the prevention of tumor progression. Ing(-/-) cells showed higher basal levels of γ-H2AX and, upon DNA damage, γ-H2AX increase was greater and with faster kinetics compared to wild-type cells. Chromatin relaxation by Trichostatin A led to an exacerbated damage signal in both types of cells, but this effect was dependent on Ing1 status, and more pronounced in wild-type cells. Our results suggest that ING1 acts at early stages of the DNA damage response activating a variety of repair mechanisms and that this function of ING1 is targeted in tumors.

journal_name

Mol Cell Biochem

journal_title

Molecular and cellular biochemistry

authors

Ceruti JM,Ogara MF,Menéndez C,Palmero I,Cánepa ET

doi

10.1007/s11010-013-1601-2

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

117-26

issue

1-2

eissn

0300-8177

issn

1573-4919

journal_volume

378

pub_type

杂志文章

相关文献

MOLECULAR AND CELLULAR BIOCHEMISTRY文献大全
  • D-glucose metabolism in normal dispersed islet cells and tumoral INS-1 cells.

    abstract：:The metabolism of D-glucose was characterized in both normal dispersed rat islet cells and the 2-mercaptoethanol-dependent insulin-secreting cells of the INS-1 line. The normal and tumoral islet cells differed from one another by the relative magnitude, concentration dependency and hierarchy of the increase in the pro...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1007106529644

    authors： Nadi AB,Olivares E,Malaisse WJ

    更新日期：2000-07-01 00:00:00

  • Protein-DNA array-based identification of transcription factor activities differentially regulated in skeletal muscle of normal and dystrophin-deficient mdx mice.

    abstract：:Inactivation of dystrophin gene is the primary cause of Duchenne muscular dystrophy (DMD) in humans and mdx mice. However, the underpinning mechanisms, which govern the pathogenesis of dystrophin-deficient skeletal muscle, remain poorly understood. We have previously reported activation of mitogen-activated protein ki...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-008-9716-6

    authors： Dogra C,Srivastava DS,Kumar A

    更新日期：2008-05-01 00:00:00

  • c-Jun-NH2 terminal kinase (JNK)-mediates AP-1 activation by thioredoxin: phosphorylation of cJun, JunB, and Fra-1.

    abstract：:Thioredoxin (Trx) is a small ubiquitous protein, which has been shown to be involved in redox-dependent cellular functions. In this article, we demonstrate that the increased level of Trx induces AP-1 DNA binding in a redox-dependent manner by activating JNK subgroup of MAPKs. The majority of AP-1 DNA binding complex ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-009-0285-0

    authors： Das KC,Muniyappa H

    更新日期：2010-04-01 00:00:00

  • Knockdown of p62/sequestosome 1 attenuates autophagy and inhibits colorectal cancer cell growth.

    abstract：:p62/sequestosome-1 is a multifunctional adapter protein implicated in selective autophagy, cell signaling pathways, and tumorigenesis, and plays an important role at the crossroad between autophagy and cancer. But, the connection between autophagy and cancer is complex and in some cases contradictory. Human colorectal...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-013-1818-0

    authors： Ren F,Shu G,Liu G,Liu D,Zhou J,Yuan L,Zhou J

    更新日期：2014-01-01 00:00:00

  • Regulatory RNA induces the production of IFN-gamma, but not IL-4 in human lymphocytes: role of RNA-dependent protein kinase (PKR) and NF-kappaB.

    abstract：:Previous results with p9-RNA, obtained from lymph nodes of animals immunized with the peptide p9 of HIV-1, suggested that its effects on lymphocytes could be mediated by RNA-dependent protein kinase (PKR). Here we report that p9-RNA activates PKR leading to the degradation of the inhibitor I-kappaB alpha and the conco...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1024107512419

    authors： De Lucca FL,Sales VS,Souza LR,Murad JM,Watanabe MA

    更新日期：2003-05-01 00:00:00

  • Increased superoxide anion production is associated with early atherosclerosis and cardiovascular dysfunctions in a rabbit model.

    abstract：OBJECTIVE:Hypercholesterolemia (HC) has been associated with impairment of vascular and myocardial functions. As HC could generate an alteration in the oxidative status, we studied the effects of a 1-month cholesterol diet on cardiovascular oxidative stress. METHODS AND RESULTS:New Zealand rabbits received cholesterol...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-006-9263-y

    authors： Collin B,Busseuil D,Zeller M,Perrin C,Barthez O,Duvillard L,Vergely C,Bardou M,Dumas M,Cottin Y,Rochette L

    更新日期：2007-01-01 00:00:00

  • Leishmania donovani: in vitro culture and [1H] NMR characterization of amastigote-like forms.

    abstract：:When Leishmania donovani promastigote forms, were cultured in TC-199 medium at 28 degrees C and subsequently incubated at 38 degrees C, they turned into aflagellate (amastigote-like) forms. A return of the incubation-culture temperature to 28 degrees C these amastigote-like forms to revert to promastigotes. The amasti...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00928929

    authors： Castilla JJ,Sanchez-Moreno M,Mesa C,Osuna A

    更新日期：1995-01-26 00:00:00

  • Heme oxygenase and antioxidant status in cultured aortic endothelial cells isolated from atherosclerosis-susceptible and -resistant Japanese quail.

    abstract：:We have investigated heme oxygenase (HO) and antioxidant status in the novel isolation and characterization of aortic endothelial cells (AECs) from a random bred wild-type strain (WILD) and selectively bred atherosclerosis-susceptible (SUS) and -resistant (RES) strains of Japanese quail. Cultured AECs expressed acetyl...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1025555525661

    authors： Hoekstra KA,Godin DV,Kurtu J,Cheng KM

    更新日期：2003-10-01 00:00:00

  • Modulation of cAMP level by tedisamil in guinea pig heart.

    abstract：:Tedisamil is antiarrhythmic class III drug with antifibrillating/defibrillating potency linked to enhancement of intermyocyte gap junctional electrical coupling most likely via its sympathomimetic cAMP-related mechanisms. This study was designed to examine the effect of tedisamil on cAMP level in guinea pig hearts in ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1007133322295

    authors： Tribulova N,Ravingerova T,Okruhlicova L,Gabauer I,Fickova M,Pancza D,Slezak J,Manoach M

    更新日期：2000-07-01 00:00:00

  • Cloning and characterization of the rat TIS11 gene.

    abstract：:The TIS11 gene is an immediate early gene that is induced rapidly and transiently by phorbol 12-myristate 13-acetate and various growth factors. To study transcriptional regulation of the gene, a genomic clone of rat TIS11 was isolated, and the organization of exon-intron structure and transcriptional initiation site ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1007172316657

    authors： Kaneda N,Murata T,Niimi Y,Minamiyama M

    更新日期：2000-10-01 00:00:00

  • Messenger RNA in regenerating liver: implications for the understanding of regulated growth.

    abstract：:The application of nucleic acid hybridization techniques to the study of liver regeneration has led to a revision of some well-established ideas about the patterns of gene expression during regenerative growth. This paper focuses on two broad problems: a) the extent to which mRNA populations in regenerating liver diff...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1007/BF00231309

    authors： Fausto N

    更新日期：1984-01-01 00:00:00

  • Heart glycogen content and isoprenaline-induced myocardial lesions.

    abstract：:The role of glycogen content in the heart for the development of isoprenaline-induced myocardial lesions (IML) was studied in Wistar rats and in two inbred rat strains: In IR rats (resistant to the development of IML) and in IS rats (sensitive to IML development). Glycogen content in the heart can be dramatically lowe...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00408651

    authors： Mráz M,Hynie S

    更新日期：1996-10-01 00:00:00

  • Monophosphoryl lipid A induces pharmacologic 'preconditioning' in rabbit hearts without concomitant expression of 70-kDa heat shock protein.

    abstract：:The purpose of this study was to evaluate the protective effect of a new endotoxin analogue, monophosphoryl lipid A (MLA) in a rabbit model of myocardial ischemia/reperfusion and to show if this protection was mediated via synthesis of 70 kDa heat shock protein (HSP 70). Three groups of New Zealand White rabbits under...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00239312

    authors： Yoshida K,Maaieh MM,Shipley JB,Doloresco M,Bernardo NL,Qian YZ,Elliott GT,Kukreja RC

    更新日期：1996-03-09 00:00:00

  • Transient Ca2+ changes in endothelial cells induced by low doses of reactive oxygen species: role of hydrogen peroxide.

    abstract：:Cultured human and rat endothelial cells were used to study cellular toxicity and Ca2+ signalling upon exposure to reactive oxygen species. Superoxide and hydrogen peroxide (O2.-/H2O2) were produced by the hypoxanthine/xanthine oxidase system (HX/XO) and caused intracellular Ca2+ concentration ([Ca2+]i) to rise steadi...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1006886215193

    authors： Volk T,Hensel M,Kox WJ

    更新日期：1997-06-01 00:00:00

  • Transcriptional directionality of the human insulin-degrading enzyme promoter.

    abstract：:Unidirectional promoters dominate among mammalian genomes. However, the mechanism through which the transcriptional directionality of promoters is accomplished remains to be clarified. Insulin-degrading enzyme (IDE) is a ubiquitously expressed zinc metalloprotease, whose promoter contains a CpG island. We previously s...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-013-1739-y

    authors： Zhang L,Wang P,Ding Q,Wang Z

    更新日期：2013-10-01 00:00:00

  • Human tau protein forms complex with PrP and some GSS- and fCJD-related PrP mutants possess stronger binding activities with tau in vitro.

    abstract：:Microtubule associated protein tau is considered to play roles in some types of human transmissible spongiform encephalopathies (TSE). In this study, the full-length and several truncated human tau proteins were expressed from E. coli and purified. Using GST pull down, co-immunoprecipitation assay and tau-coated ELISA...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-007-9664-6

    authors： Wang XF,Dong CF,Zhang J,Wan YZ,Li F,Huang YX,Han L,Shan B,Gao C,Han J,Dong XP

    更新日期：2008-03-01 00:00:00

  • Inhibitory effect of menaquinone-7 (vitamin K2) on the bone-resorbing factors-induced bone resorption in elderly female rat femoral tissues in vitro.

    abstract：:The inhibitory effect of menaquinone-7 (MK-7; vitamin K2) on osteoclast-like cell formation and osteoclastic bone resorption in vitro is found (Mol Cell Biochem 228: 39-47, 2001). This study, furthermore, was undertaken to determine the effect of MK-7 on the bone-resorbing factor-induced bone resorption using the femo...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1022818111655

    authors： Yamaguchi M,Uchiyama S,Tsukamoto Y

    更新日期：2003-03-01 00:00:00

  • Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents.

    abstract：:Molecular hydrogen (H2) is an agent with potential applications in oxidative stress-related and/or inflammatory disorders. H2 is usually administered by inhaling H2-containing air (HCA) or by oral intake of H2-rich water (HRW). Despite mounting evidence, the molecular mechanism underlying the therapeutic effects and t...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-015-2353-y

    authors： Sobue S,Yamai K,Ito M,Ohno K,Ito M,Iwamoto T,Qiao S,Ohkuwa T,Ichihara M

    更新日期：2015-05-01 00:00:00

  • The membrane fatty acid-binding protein is not identical to mitochondrial glutamic oxaloacetic transaminase (mGOT).

    abstract：:For evaluation whether the membrane fatty acid-binding protein is related to mGOT, studies on the structure and function of both purified proteins were performed. Physicochemical characterization revealed that both proteins are different: the membrane fatty acid-binding protein has a molecular weight of 40 kD and a pI...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00231384

    authors： Stremmel W,Diede HE,Rodilla-Sala E,Vyska K,Schrader M,Fitscher B,Passarella S

    更新日期：1990-10-15 00:00:00

  • Compensated cardiac hypertrophy is characterised by a decline in palmitate oxidation.

    abstract：:Cardiac hypertrophy is an independent risk factor in the development of heart failure. However, the cellular mechanisms underlying the transition from compensated hypertrophy to heart failure are incompletely understood. The aim of this study was to investigate changes in myocardial substrate utilisation and function ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-008-9711-y

    authors： Akki A,Smith K,Seymour AM

    更新日期：2008-04-01 00:00:00

  • MALAT1 affects hypoxia-induced vascular endothelial cell injury and autophagy by regulating miR-19b-3p/HIF-1α axis.

    abstract：:Cardiovascular disease has become the leading cause of death in the world. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays an important role in cardiovascular disease, such as stroke. However, the role of MALAT1 in hypoxia (HYP)-induced vascular endothelial cells (VECs) remains unclear. In the pr...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-020-03684-z

    authors： Liu H,Shi C,Deng Y

    更新日期：2020-03-01 00:00:00

  • Quantization of chloroplast DNA using dot blot filter hybridization with double-stranded probes.

    abstract：:Hybridization characteristics of purified chloroplast DNA, immobilized in 'dot blots' on nitrocellulose filters using radiolabeled chloroplast DNA restriction fragments or recombinant DNA probes were investigated. Conditions are described which proved a near linear relationship between amounts of hybridization and amo...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00285223

    authors： Smith MA

    更新日期：1984-09-01 00:00:00

  • Characterization of the purified rat heart plasma membrane Ca2+/Mg2+ ATPase.

    abstract：:The purified Ca2+/Mg2+ ATPase from rat heart plasma membrane was activated by Ca2+ and Mg2+ with Ka values of 1.47 mM and 2.51 mM, respectively; other divalent cations also activated the enzyme but to a lesser extent. Divalent cations like Cu2+, Zn2+, Ni2+, Cd2+ were potent inhibitors of the enzyme activity in the pre...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00225518

    authors： Zhao D,Elimban V,Dhalla NS

    更新日期：1991-10-16 00:00:00

  • MiR-96 downregulates RECK to promote growth and motility of non-small cell lung cancer cells.

    abstract：:MicroRNAs play critical roles in the development and progression of non-small cell lung cancer (NSCLC). miR-96 acts as an oncogene in some malignancies, while its role in NSCLC is unclear. Here, we validated that miR-96 was significantly increased in both human NSCLC tissues and cell lines. Inhibition of miR-96 expres...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-014-1966-x

    authors： Guo H,Li Q,Li W,Zheng T,Zhao S,Liu Z

    更新日期：2014-05-01 00:00:00

  • Effects of 5'-azacytidine and alendronate on a hepatocellular carcinoma cell line: a proteomics perspective.

    abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer related deaths around the world. Due to late diagnosis and development of drug resistance in patients suffering from HCC, development of more effective therapeutic strategies is inevitable. The aim of this study was to evaluate the combined apoptotic ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-015-2395-1

    authors： Ilyas A,Hashim Z,Zarina S

    更新日期：2015-07-01 00:00:00

  • The role of stratifin in fibroblast-keratinocyte interaction.

    abstract：:Stratifin is a member of 14-3-3 protein family, a highly conserved group of proteins constituted by seven isoforms. They are involved in numerous crucial intracellular functions such as cell cycle and apoptosis, regulation of signal transduction pathways, cellular trafficking, cell proliferation and differentiation, c...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1007/s11010-007-9538-y

    authors： Medina A,Ghaffari A,Kilani RT,Ghahary A

    更新日期：2007-11-01 00:00:00

  • Effect of anti-regucalcin antibody on neutral phosphatase activity in rat liver cytosol: involvement of endogenous regucalcin.

    abstract：:The effect of anti-regucalcin monoclonal antibody on neutral phoshatase activity in rat liver cytosol was investigated. Phosphotyrosine, phosphoserine, and phosphothreonine were used as the substrate toward phosphatase assay. Liver cytosolic phosphatase activity with three phosphoaminoacids was significantly increased...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1006979606225

    authors： Omura M,Yamaguchi M

    更新日期：1999-07-01 00:00:00

  • Remote renal preconditioning-induced cardioprotection: a key role of hypoxia inducible factor-prolyl 4-hydroxylases.

    abstract：:Remote preconditioning is a unique phenomenon in which brief episodes of ischemia and reperfusion to remote organ protect the target organ against sustained ischemia-reperfusion (I/R)-induced injury. Protective effects of remote renal preconditioning (RRPC) are well established in heart, but their mechanisms still rem...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-008-9717-5

    authors： Kant R,Diwan V,Jaggi AS,Singh N,Singh D

    更新日期：2008-05-01 00:00:00

  • Effects of p75 neurotrophin receptor on regulating hypoxia-induced angiogenic factors in retinal pigment epithelial cells.

    abstract：:Retinal pigment epithelium (RPE) exerts critical roles in the maintenance of the normal functions of the retina, whereas RPE dysfunction can induce retina neovascularization. p75 neurotrophin receptor (p75(NTR)) has been shown to play essential roles in angiogenesis. However, the function of p75(NTR) in the RPE remain...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-014-2212-2

    authors： Zhang J,Zhao J,Bai Y,Huang L,Yu W,Li X

    更新日期：2015-01-01 00:00:00

  • The roles of NLRP3 inflammasome-mediated signaling pathways in hyperuricemic nephropathy.

    abstract：:Hyperuricemic nephropathy (HN) is a common clinical complication of hyperuricemia. High-serum uric acid can trigger renal inflammation. The inflammasome family has several members and shows a significant effect on inflammatory responses. NLRP3 (NOD-, LRR-, and pyrin domain-containing 3) senses the stimuli signal of ex...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1007/s11010-020-03997-z

    authors： Wen L,Yang H,Ma L,Fu P

    更新日期：2021-01-03 00:00:00