Regulatory RNA induces the production of IFN-gamma, but not IL-4 in human lymphocytes: role of RNA-dependent protein kinase (PKR) and NF-kappaB.

abstract：:Many glomerular diseases are associated with changes in the expression and distribution in the components of extracellular matrix. A remarkable feature in acute renal failure induced by mercuric chloride in rats was large fibronectin (Fn) deposits in kidneys 1 h post-HgCl2 injection (5 mg/kg body wt., s.c.). Our study...

journal_title：Molecular and cellular biochemistry

authors： Saball E,Salvarrey M,Serra E,Picó G,Elías MM

更新日期：2001-10-01 00:00:00

abstract：:Eukaryotic protein synthesis initiation factor eIF-2 is usually isolated as a heterotrimer (alphabeta gamma). By use of Sephacryl S-300 fractionation an alpha subunit-deficient form of eIF-2 was identified in impure preparations from rabbit reticulocyte lysate and it appeared in these preparations to be still active i...

journal_title：Molecular and cellular biochemistry

authors： Mouat MF,Manchester K

更新日期：1998-06-01 00:00:00

abstract：:Hyperhomocysteinemia (HHcy) is an independent risk factor of cardiovascular disease, but the mechanisms of tissue injury are poorly understood. In the present study, we investigated the effect of HHcy on rat heart function, activities electron transport chain (ETC) complexes, mitochondrial protein expression, and prot...

journal_title：Molecular and cellular biochemistry

authors： Timkova V,Tatarkova Z,Lehotsky J,Racay P,Dobrota D,Kaplan P

更新日期：2016-01-01 00:00:00

abstract：:As an endo-β (1-4)-D: -glucuronidase, heparanase can specifically cleave carbohydrate chains of heparan sulfate (HS) and has been implicated in development of endothelial cells dsyfunction. The advanced glycation end products (AGEs) play a pivotal role in the pathology of diabetic complications. In the present study, ...

journal_title：Molecular and cellular biochemistry

authors： An XF,Zhou L,Jiang PJ,Yan M,Huang YJ,Zhang SN,Niu YF,Ten SC,Yu JY

更新日期：2011-08-01 00:00:00

abstract：:The conserved N-domain of the STAT proteins has been implicated in several activities crucial to cytokine signaling including receptor recruitment and STAT activation, cooperative DNA binding and STAT-dependent gene expression. We evaluated the role of the STAT3 N-domain in the IL-6 signal transduction pathway leading...

journal_title：Molecular and cellular biochemistry

authors： Zhang L,Badgwell DB,Bevers JJ 3rd,Schlessinger K,Murray PJ,Levy DE,Watowich SS

更新日期：2006-08-01 00:00:00

abstract：:NADPH oxidase from stimulated guinea pig granulocytes was extracted with deoxycholate. The solubilized enzyme was stable in 20% glycerol. Solubilized enzyme was free of myeloperoxidase activity. The properties of the deoxycholate solubilized enzyme indicated that it is a high molecular weight complex with a flavoprote...

journal_title：Molecular and cellular biochemistry

authors： Bellavite P,Serra MC,Davoli A,Bannister JV,Rossi F

更新日期：1983-01-01 00:00:00

abstract：:A relation between fatty acid oxidation capacity and cytosolic FABP content was found in heart and various muscles of the rat. Other tissues do not show such a relation, since they are involved in more or other pathways of fatty acid metabolism. At postnatal development FABP content and fatty acid oxidation capacity r...

journal_title：Molecular and cellular biochemistry

authors： Veerkamp JH,van Moerkerk HT

更新日期：1993-06-09 00:00:00

abstract：:Cardiac glycosides (CGs) are useful drugs to treat cardiac illnesses and have potent cytotoxic and anticancer effects in cultured cells and animal models. Their receptor is the Na+,K+ ATPase, but other plasma membrane proteins might bind CGs as well. Herein, we evaluated the short- and long-lasting cytotoxic effects o...

journal_title：Molecular and cellular biochemistry

authors： Schneider NFZ,Menegaz D,Dagostin ALA,Persich L,Rocha SC,Ramos ACP,Cortes VF,Fontes CFL,de Pádua RM,Munkert J,Kreis W,Braga FC,Barbosa LA,Silva FRMB,Simões CMO

更新日期：2021-01-18 00:00:00

abstract：:Existing kinetic data of cholesteryl ester formation by lecithin:cholesterol acyltransferase in discoidal high-density lipoproteins with 34 mutations of apoA-I that involved all putative helices were grouped by cluster analysis into four noncoincident regions with mutations both without any functional impairment and w...

journal_title：Molecular and cellular biochemistry

authors： Dergunov AD

更新日期：2013-06-01 00:00:00

abstract：:Human glomerular mesangial cells (HMCs) have a finite lifespan and eventually enter irreversible growth arrest known as cellular senescence which is thought to contribute to kidney aging and age-related kidney disorders, such as chronic kidney disease. The signal transducer and activator of transcription 1 (STAT1) is ...

journal_title：Molecular and cellular biochemistry

authors： Jiao S,Meng F,Zhang J,Yang X,Zheng X,Wang L

更新日期：2012-06-01 00:00:00

abstract：:Activation of extracellular signal-related kinase (ERK) is involved in decreased melanogenesis by sphingosylphosphorylcholine (SPC). In the present study, we confirmed that SPC activated ERK and that a specific inhibitor of the ERK pathway (PD98059) recovered SPC-induced hypopigmentation. Moreover, we found that SPC s...

journal_title：Molecular and cellular biochemistry

authors： Jeong HS,Park KC,Kim DS

更新日期：2012-08-01 00:00:00

abstract：:SRY-related box (Sox) transcription factors are conserved among vertebrate species. These proteins regulate multiple processes including sex determination and testis differentiation of the male embryo. Members of the Sox family have been identified in pre- and postnatal testis and are known to play an important role i...

journal_title：Molecular and cellular biochemistry

authors： Roumaud P,Haché J,Martin LJ

更新日期：2018-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a rapidly progressing, incurable cancer that frequently spreads to portal vein and lung. New insights are needed to identify therapeutic targets to prevent or retard HCC metastatic progression. Because microRNAs (miRNA) often act as tumor regulators, we investigated their role in prec...

journal_title：Molecular and cellular biochemistry

authors： Shi X,Teng F

更新日期：2015-10-01 00:00:00

abstract：:The effect of alloxan-induced diabetes was studied on the activity of monoamine oxidase (MAO), the oxidative deaminating enzyme of monoamine neurotransmitters. MAO was assayed from discrete brain regions like medial preoptic area and median eminence--arcuate region of hypothalamus, septum, amygdala, thalamus, hippocam...

journal_title：Molecular and cellular biochemistry

authors： Lakhman SS,Kaur G

更新日期：1997-12-01 00:00:00

abstract：:To understand the hypocholesterolemic activity of green tea, our in vitro studies screened the relative efficacy of two structurally distinct green tea catechins, epicatechin (EC) and epigallocatechin gallate (EGCG), on apolipoprotein B-100 (apoB) and lipid production using a well established human hepatoma cell-line,...

journal_title：Molecular and cellular biochemistry

authors： Yee WL,Wang Q,Agdinaoay T,Dang K,Chang H,Grandinetti A,Franke AA,Theriault A

更新日期：2002-01-01 00:00:00

abstract：:Liver cytosol from adrenalectomized rats was prebound for 2 hr at 4 degrees C with unlabeled 10(-5) M corticosterone. After treatment of cytosol with dextran-coated charcoal to remove free steroid, samples were incubated at 15-25 degrees C in the presence of 10 mM molybdate plus 5 mM dithiothreitol (followed by a 60 m...

journal_title：Molecular and cellular biochemistry

authors： Hubbard JR,Tanvir,Shirwany A,Kalimi M

更新日期：1985-01-01 00:00:00

abstract：:Diabetic peripheral neuropathy (DPN) is one of the most important complications in diabetes mellitus (DM), which has been reported to be modulated by long non-coding RNAs (lncRNAs). The purpose of the current study is to explore the regulatory mechanism of lncRNA HCG18 on DPN in vitro. The expression of lncRNA HCG18, ...

journal_title：Molecular and cellular biochemistry

authors： Ren W,Xi G,Li X,Zhao L,Yang K,Fan X,Gao L,Xu H,Guo J

更新日期：2020-09-29 00:00:00

abstract：:Pre-steady-state and steady-state kinetics for the p.p. elastase-catalysed hydrolysis of ZAlaONp, one of the most favourable substrates for this serine protease, have been studied between pH 4.0 and 8.0. The results are consistent with the minimum three-step mechanism: (formula; see text) Under pre-steady-state condit...

journal_title：Molecular and cellular biochemistry

authors： Ascenzi P,Menegatti E,Guarneri M,Antonini E

更新日期：1983-01-01 00:00:00

abstract：:The involvement of a hypocalcemic hormone calcitonin (CT) in the expression of hepatic Ca(2+)-binding protein regucalcin mRNA was investigated. The change of regucalcin mRNA levels was analyzed by Northern blotting using liver regucalcin complementary DNA (0.9 kb). A single oral administration of calcium chloride (100...

journal_title：Molecular and cellular biochemistry

authors： Yamaguchi M,Kanayama Y,Shimokawa N

更新日期：1994-07-13 00:00:00

abstract：:Glycyrrhizin, a major constituent of licorice (Glycyrrhiza glabra) root, has been reported to ameliorate insulin resistance, hyperglycemia, dyslipidemia, and obesity in rats with metabolic syndrome. Liver dysfunction is associated with this syndrome. The objective of this study is to investigate the effect of glycyrrh...

journal_title：Molecular and cellular biochemistry

authors： Sil R,Ray D,Chakraborti AS

更新日期：2015-11-01 00:00:00

abstract：:The existence and expression of gene encoding the Ca(2+)-binding protein regucalcin in various species and tissues were investigated with Southern and Northern hybridization analyses using regucalcin cDNA (0.9 kb of open reading frame). Genomic Southern hybridization analysis demonstrated that regucalcin gene was wide...

journal_title：Molecular and cellular biochemistry

authors： Shimokawa N,Isogai M,Yamaguchi M

更新日期：1995-02-09 00:00:00

abstract：:The aim of this study was to elucidate the effects of natural vanadium-containing Jeju ground water on glucose uptake in L6 myotubes and adipogensesis in 3T3 L1 cells. The Jeju ground water samples containing vanadium components were designated as S1 (8.0 ± 0.9 μg/l), S2 (24.0 ± 2.0 μg/l), and S3 (26.0 ± 2.0 μg/l), re...

journal_title：Molecular and cellular biochemistry

authors： Hwang SL,Chang HW

更新日期：2012-01-01 00:00:00

abstract：:Endothelial cells are known to produce reactive oxygen species by several mechanisms. Functional consequences of increased production of reactive oxygen species were investigated in vitro after stimulation with several proinflammatory cytokines. Time dependent increases in DCF-fluorescence as a measure of reactive oxy...

journal_title：Molecular and cellular biochemistry

authors： Volk T,Hensel M,Schuster H,Kox WJ

更新日期：2000-03-01 00:00:00

abstract：:Plexiform neurofibromas commonly found in patients with Neurofibromatosis type I (NF1) have a 5% risk of being transformed into malignant peripheral nerve sheath tumors (MPNST). Germline mutations in the NF1 gene coding for neurofibromin, which is a Ras GTPase activating protein (RasGAP) and a negative regulator of Ra...

journal_title：Molecular and cellular biochemistry

authors： Kraniak JM,Sun D,Mattingly RR,Reiners JJ Jr,Tainsky MA

更新日期：2010-11-01 00:00:00

abstract：:The regulation of phosphatidylcholine-specific phospholipase D by purine nucleotides and protein kinase A were studied in vitro using an enzyme preparation partially purified from the membranous fraction of 7721 hepatocarcinoma cells. It was found that the enzyme activity was elevated by low concentrations of some pur...

journal_title：Molecular and cellular biochemistry

authors： Huang Y,Zhang XY,Liu F,Chen HL

更新日期：2000-04-01 00:00:00

abstract：:Experiments were designed to determine if cotton bract tannin, a component of cotton mill dust, would promote the phosphorylation of alveolar macrophage proteins in doses potentially achievable in vivo. Rabbit alveolar macrophages were loaded with 32PO4 and challenged with various doses of tannin for time periods rang...

journal_title：Molecular and cellular biochemistry

authors： Hempel SL,Rohrbach MS

更新日期：1989-04-11 00:00:00

abstract：:The constitutive androstane receptor (CAR) has been reported to decrease insulin resistance along with obesity. 6,7-dimethylesculetin (DE) is an active component of Yin Zhi Huang which is a traditional Asian medicine used to treat neonatal jaundice via CAR. In this study, we examined whether DE could affect the expres...

journal_title：Molecular and cellular biochemistry

authors： Masuyama H,Mitsui T,Maki J,Tani K,Nakamura K,Hiramatsu Y

更新日期：2016-08-01 00:00:00

abstract：:In the search for MBP phosphorylating activities in Dictyostelium discoideum, we have found a proteolysis-activated protein kinase. This activity which is distributed between the soluble and the particulate fractions of the cell, uses MBP and histone as substrate and has a molecular mass of 140 kDa as detected in an '...

journal_title：Molecular and cellular biochemistry

authors： Nuñez A,Fernández-Renart M

更新日期：1997-10-01 00:00:00

abstract：:Tumor necrosis factor receptor-associated factor 6 (TRAF6), a regulator of NF-κB signaling, has been discovered recently to be probably related to osteoarthritis, while the function of TRAF6 in lumbar facet joint osteoarthritis(FJOA)still remains unknown. The aim of this study was to probe the specific function of TRA...

journal_title：Molecular and cellular biochemistry

authors： Jiang J,Zhang J,Wu C,Chen C,Bao G,Xu G,Xue P,Zhou Y,Sun Y,Cui Z

更新日期：2021-01-27 00:00:00

abstract：:Reactive oxygen species (ROS) have been indicated as important signal mediators for many cell surface receptors. We previously demonstrated that ROS are generated by cross-linking surface receptor CD40 and consequently induce c-Jun N-terminal kinase activation and interleukin-6 secretion in murine B cells. In this stu...

journal_title：Molecular and cellular biochemistry

authors： Lee JR

更新日期：2003-10-01 00:00:00