Abstract：
:SRY-related box (Sox) transcription factors are conserved among vertebrate species. These proteins regulate multiple processes including sex determination and testis differentiation of the male embryo. Members of the Sox family have been identified in pre- and postnatal testis and are known to play an important role in sex determination (Sry, Sox9), male gonadal development, and fertility (Sox4, Sox8, Sox30). However, their expression profiles per cell types remain elusive. The objectives of this research were to characterize the expression profiles of Sox family members within adult testes using publically available datasets and to determine whether these findings are consistent with literature as well as immunofluorescence and in situ hybridization results. We have found that Sox4, Sox8, Sox9, and Sox12 are highly expressed in Sertoli cells, whereas Sox5, Sox6, and Sox30 were typically expressed in spermatocytes and spermatids. Spermatogonia were characterized by the expressions of Sox3, Sox4, Sox12, Sox13, and Sox18. Hence, these results suggest that Sox transcription factors may play different roles according to cell types of the adult mammalian testis.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Roumaud P,Haché J,Martin LJdoi
10.1007/s11010-018-3302-3subject
Has Abstractpub_date
2018-10-01 00:00:00pages
175-187issue
1-2eissn
0300-8177issn
1573-4919pii
10.1007/s11010-018-3302-3journal_volume
447pub_type
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