Epigenetic regulation of cardiac muscle-specific genes in H9c2 cells by Interleukin-18 and histone deacetylase inhibitor m-carboxycinnamic acid bis-hydroxamide.

abstract：:MicroRNA-125b (miR-125b) reduces myocardial infarct area and restrains myocardial ischemia reperfusion injury (I/R). In this study, we aimed to investigate the effect of bone marrow mesenchymal stem cell (BMSC)-derived exosomes carrying miR-125b on I/R rats. The myocardial I/R model in rats was constructed by ligation...

journal_title：Molecular and cellular biochemistry

authors： Chen Q,Liu Y,Ding X,Li Q,Qiu F,Wang M,Shen Z,Zheng H,Fu G

更新日期：2020-02-01 00:00:00

abstract：:Satb2 is a special AT-rich binding transcription factor essential for osteoblast differentiation and bone formation. Specific microRNAs (miRNAs) have been identified to regulate the complex process of osteogenic differentiation. It remains unclear how miRNA expressions is changed in the Satb2-induced osteogenic differ...

journal_title：Molecular and cellular biochemistry

authors： Gong Y,Lu J,Yu X,Yu Y

更新日期：2016-06-01 00:00:00

abstract：:Src-suppressed C kinase substrate (SSeCKS) plays a role in membrane-cytoskeletal remodeling to regulate mitogenesis, cell differentiation, and motility. Previous study showed that lipopolysaccharide (LPS) induced a selective and strong expression of SSeCKS in the vascular endothelial cells of lung. Here we show that L...

journal_title：Molecular and cellular biochemistry

authors： Cheng C,Liu H,Ge H,Qian J,Qin J,Sun L,Chen M,Yan M,Shen A

更新日期：2007-11-01 00:00:00

abstract：:MicroRNA-1 (miR-1) is approved involved in cardiac hypertrophy, but the underlying molecular mechanisms of miR-1 in cardiac hypertrophy are not well elucidated. The present study aimed to investigate the potential role of miR-1 in modulating CDKs-Rb pathway during cardiomyocyte hypertrophy. A rat model of hypertrophy ...

journal_title：Molecular and cellular biochemistry

authors： Yuan W,Tang C,Zhu W,Zhu J,Lin Q,Fu Y,Deng C,Xue Y,Yang M,Wu S,Shan Z

更新日期：2016-01-01 00:00:00

abstract：:SG2NA is a protein of the striatin family that organizes STRIPAK complexes. It has splice variants expressing differentially in tissues. Its 78 kDa isoform regulates cell cycle, maintains homeostasis in the endoplasmic reticulum, and prevents oxidative injuries. The 35 kDa variant is devoid of the signature WD-40 repe...

journal_title：Molecular and cellular biochemistry

authors： Gupta R,Kumar G,Jain BP,Chandra S,Goswami SK

更新日期：2020-10-20 00:00:00

abstract：:Population data have consistently demonstrated a correlation between circulating branched-chain amino acids (BCAA) and insulin resistance. Most recently valine catabolite, 3-hydroxyisobutyrate, has emerged as a potential cause of BCAA-mediated insulin resistance; however, it is unclear if valine independently promotes...

journal_title：Molecular and cellular biochemistry

authors： Rivera ME,Lyon ES,Johnson MA,Sunderland KL,Vaughan RA

更新日期：2020-05-01 00:00:00

abstract：:There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels i...

journal_title：Molecular and cellular biochemistry

authors： Soundararajan A,Prabu P,Mohan V,Gibert Y,Balasubramanyam M

更新日期：2019-08-01 00:00:00

abstract：:We propose a simple mechanism which enables decrease of the free pool of channelled metabolite in static spatial channelling, when the concentration of the enzyme consuming the channelled metabolite is greater than the concentration of the enzyme producing this metabolite. Spatial channelling occurs between two enzyme...

journal_title：Molecular and cellular biochemistry

authors： Korzeniewski B,Quant PA

更新日期：1997-04-01 00:00:00

abstract：:Cigarette smoking is associated with a number of fatal diseases, including cancer of different organs. A number of oxoaldehydes are found in cigarette smoke, among which methylglyoxal (MG) is known to cause toxicity to cells upon accumulation. In biological systems, MG is converted to s-d-lactoylglutathione by glyoxal...

journal_title：Molecular and cellular biochemistry

authors： Biswas S,Gairola CG,Das SK

更新日期：2002-01-01 00:00:00

abstract：:The results of our previous studies demonstrated that acute streptozotocin-induced diabetes in rats evoked a decrease in skin collagen content with little effect on glycosaminoglycans (GAG) content. In our present study we employed the model of chronic diabetes in order to check its effect on skin GAG content. It was ...

journal_title：Molecular and cellular biochemistry

authors： Cechowska-Pasko M,Pałka J,Bańkowski E

更新日期：1996-01-12 00:00:00

abstract：:Thrombocytopenia is a major hematological concern in oxidative stress-associated pathologies and chronic clinical disorders, where premature platelet destruction severely affects the normal functioning of thrombosis and hemostasis. In addition, frequent exposure of platelets to chemical entities and therapeutic drugs ...

journal_title：Molecular and cellular biochemistry

authors： Jagadish S,Rajeev N,NaveenKumar SK,Sharath Kumar KS,Paul M,Hegde M,Basappa,Sadashiva MP,Girish KS,Rangappa KS

更新日期：2016-03-01 00:00:00

abstract：:The present study was attempted to identify transcriptionally regulated genes of the normal neurocytes responsive to iron availability. Postnatal rat hippocampus cells were primarily cultured either under the iron-loaded or depleted conditions. These cultured cells were applied for the generation of subtracted complem...

journal_title：Molecular and cellular biochemistry

authors： Liu M,Xiao DS,Qian ZM

更新日期：2007-06-01 00:00:00

abstract：:When cells of the thymus or mouse leukemias P288 and L1210 are exposed in vitro to the potent synthetic glucocorticoid, 3H-Triamcinolone acetonide, the steroid enters the cells passively and binds to macromolecules in the cytoplasm. At 37 degrees C this hormone-receptor complex enters the nucleus and associates with t...

journal_title：Molecular and cellular biochemistry

authors： Turnell RW,Burton AF

更新日期：1975-12-31 00:00:00

abstract：:It has been recently hypothesized that in PIH a placental oxidant-antioxidant imbalance might cause the release of lipoperoxidation products into the circulation, with subsequent damage of endothelial cell membranes. In this hypothesis the endothelial cell and further increase in circulating lipoperoxide levels, which...

journal_title：Molecular and cellular biochemistry

authors： Cester N,Staffolani R,Rabini RA,Magnanelli R,Salvolini E,Galassi R,Mazzanti L,Romanini C

更新日期：1994-02-23 00:00:00

abstract：:Fasting is accompanied by a decrease in collagen biosynthesis. The mechanism of this phenomenon involves inhibition of prolidase activity, an enzyme that plays a key role in upregulation of collagen metabolism. The mechanism of fasting-induced inhibition of prolidase activity is not known. Phosphoenolpyruvate (PEP) is...

journal_title：Molecular and cellular biochemistry

authors： Cechowska-Pasko M,Palka J,Bańkowski E

更新日期：2004-10-01 00:00:00

abstract：:A quarter of the human population with European background carries at least one allele of the OPRD1 gene that encodes the delta opioid receptor with cysteine at the amino acid position 27 (hδOR(Cys27)) instead of the evolutionary conserved phenylalanine (hδOR(Phe27)). The two variants have indistinguishable pharmacolo...

journal_title：Molecular and cellular biochemistry

authors： Tuusa JT,Petäjä-Repo UE

更新日期：2011-05-01 00:00:00

abstract：:Cellular adaptation to hypoxia involves regulation of specific genes such as vascular endothelial growth factor (VEGF), erythropoietin (EPO) and hypoxia inducible factor (HIF)-1 . In this study, we have evaluated the protective effect of picroliv (a purified iridoid glycoside fraction from roots of Picrorhiza kurrooa ...

journal_title：Molecular and cellular biochemistry

authors： Gaddipati JP,Madhavan S,Sidhu GS,Singh AK,Seth P,Maheshwari RK

更新日期：1999-04-01 00:00:00

abstract：:The roles of TGF-beta and the interaction between TGF-beta and EGFR signaling are critical in Sertoli cell, though the knowledge about them is limited. RT-PCR was used to characterize the status of TGF-beta signaling in clinical testicular specimens with complete Sertoli cell-only syndrome (SCOS). The mouse Sertoli ce...

journal_title：Molecular and cellular biochemistry

authors： Sun T,Xin Z,Jin Z,Wu Y,Gong Y

更新日期：2008-12-01 00:00:00

abstract：:Advanced glycation end products (AGEs) are formed from the non-enzymatic glycation reaction of reducing sugars or their metabolites with the free amino groups of several biomolecules and are known to play pathophysiological roles in various inflammatory diseases. In an earlier study, it was suggested that tumor necros...

journal_title：Molecular and cellular biochemistry

authors： Watanabe M,Toyomura T,Wake H,Liu K,Teshigawara K,Takahashi H,Nishibori M,Mori S

更新日期：2017-10-01 00:00:00

abstract：:Chemotherapy remains the core of anticancer treatment. However, despite the tremendous strides made in the development of targeted anticancer therapies, emergence of resistance to chemotherapeutic drugs is still a major obstacle in the successful management of resistant tumors. Therefore, profound investigation into t...

journal_title：Molecular and cellular biochemistry

authors： Peng L,Zhu H,Wang J,Sui H,Zhang H,Jin C,Li L,Xu T,Miao R

更新日期：2015-07-01 00:00:00

abstract：:Many studies have explored whether the Notch signaling pathway has a tumor-suppressive or an oncogenic role in various tumors; however, the role of the Notch signaling pathway in salivary adenoid cystic carcinoma (SACC) is still unknown. In this study, we attempt to define the role of Notch2 signaling in cell growth, ...

journal_title：Molecular and cellular biochemistry

authors： Qu J,Song M,Xie J,Huang XY,Hu XM,Gan RH,Zhao Y,Lin LS,Chen J,Lin X,Zheng DL,Lu YG

更新日期：2016-01-01 00:00:00

abstract：:GD3, a minor ganglioside in most normal tissues, is involved in important biological events and its expression could increase in pathological conditions. Organism integrity requires a tight balance between the anabolic and catabolic processes, thus it is important to control the intracellular expression of those "key"...

journal_title：Molecular and cellular biochemistry

authors： Rimoldi S,Papis E,Bernardini G,Prati M,Gornati R

更新日期：2007-07-01 00:00:00

abstract：:Modulation of Ca(2+) homoeostasis in cardiac myocytes plays a major role in beat-to-beat regulation of heart function. Previous studies suggest that sphingosine-1-phosphate (S1P), a biologically active sphingomyelin metabolite, regulates Ca(2+) handling in cardiac myocytes, but the underlying mechanism is unclear. In ...

journal_title：Molecular and cellular biochemistry

authors： Egom EE,Bae JS,Capel R,Richards M,Ke Y,Pharithi RB,Maher V,Kruzliak P,Lei M

更新日期：2016-08-01 00:00:00

abstract：:It is well established that severe hypertrophy induces metabolic and structural changes in the heart which result in enhanced susceptibility to ischemic damage during cardioplegic arrest while much less is known about the effect of cardioplegic arrest on moderately hypertrophied hearts. The aim of this study was to el...

journal_title：Molecular and cellular biochemistry

authors： Smolenski RT,Jayakumar J,Seymour AM,Yacoub MH

更新日期：1998-03-01 00:00:00

abstract：:In mammals, protein kinase CK2 has two isozymic forms of its catalytic subunit, designated CK2alpha and CK2alpha'. CK2alpha and CK2alpha' exhibit extensive similarity within their catalytic domains but have completely unrelated C-terminal sequences. To systematically examine the cellular functions of each CK2 isoform ...

journal_title：Molecular and cellular biochemistry

authors： Litchfield DW,Bosc DG,Canton DA,Saulnier RB,Vilk G,Zhang C

更新日期：2001-11-01 00:00:00

abstract：:Under normal environmental conditions, L-glutamine is well oxidized but fails to stimulate insulin release in rat pancreatic islets. However, a marked stimulation of insulin release by L-glutamine, without alteration in its oxidation rate occurs when the intracellular pH of the islet cells is decreased and/or when the...

journal_title：Molecular and cellular biochemistry

authors： Sener A,Malaisse WJ

更新日期：1980-12-16 00:00:00

abstract：:Glomerular mesangial cells play an important role in the development of glomerulosclerosis. Mesangial cell apoptosis has been shown to be involved in different stages of development of glomerulonephritis. The aim of the present study was to evaluate the effect of inhibition of serine/threonine phosphatases by okadaic ...

journal_title：Molecular and cellular biochemistry

authors： Parameswaran N,Spielman WS,Brooks DP,Nambi P

更新日期：2004-05-01 00:00:00

abstract：:Adipose-derived stem cells (ADSCs) have been considered as the optimal cells for regenerative medicine because ADSCs have the potential of multi-directional differentiation. To study the mechanisms of ADSCs differentiation, we analyzed microarray of GSE37329. GSE37329 was downloaded from Gene Expression Omnibus includ...

journal_title：Molecular and cellular biochemistry

authors： Ren Y,Han C,Wang J,Jia Y,Kong L,Eerdun T,Wu L,Jiang D

更新日期：2015-02-01 00:00:00

abstract：:The identification of informative biomarkers that could predict the treatment response is particularly important in the triple-negative (TN) breast cancer, which is characterized by biological diversity. The aim of this study was to investigate the impact of vascular endothelial growth factor receptor (VEGFR2) express...

journal_title：Molecular and cellular biochemistry

authors： Babyshkina N,Zavyalova M,Tarabanovskaya N,Dronova T,Krakhmal N,Slonimskaya E,Kzhyshkowska J,Choynzonov E,Cherdyntseva N

更新日期：2018-07-01 00:00:00

abstract：:The homeodomain-containing Msx3 gene, the newest member of the Msx family, encodes two mRNAs, with an unknown relationship to each other. To elucidate how Msx3 gene generates the two transcripts, we cloned their corresponding cDNAs from an E10.5 mouse embryo cDNA library. The alignment of sequences of the two Msx3-spe...

journal_title：Molecular and cellular biochemistry

authors： Matsui H,Takahashi T,Raghow R

更新日期：2004-12-01 00:00:00