Reversal of the growth inhibitory effect of alpha-difluoromethylornithine by putrescine but not by other divalent cations.

abstract：:A proliferation-inducing ligand (APRIL) is overexpressed in most tumor cells and tissues, especially in tumors of the alimentary system, such as colorectal cancer (CRC), gastric cancer, and liver cancer. RNA interference (RNAi) has been proved to be a powerful tool for gene knockdown and holds great promise for the tr...

journal_title：Molecular and cellular biochemistry

authors： Wang J,Ding W,Sun B,Jing R,Huang H,Shi G,Wang H

更新日期：2012-04-01 00:00:00

abstract：:The mechanism of the effect of beta-hydroxy-beta-methylbutyrate (HMB) on protein degradation induced by lipopolysaccharide (LPS) has been evaluated in murine myotubes. HMB (50 muM) completely attenuated total protein degradation induced by LPS (1-100 ng/ml), formation of reactive oxygen species (ROS) and activation of...

journal_title：Molecular and cellular biochemistry

authors： Russell ST,Tisdale MJ

更新日期：2009-10-01 00:00:00

abstract：:The present study was undertaken to characterize the contractile effects of vanadate on thoracic aorta rings from virgin and term-pregnant rats. Vanadate caused concentration-dependent contraction in rat aortic rings with an EC50 (concentration producing 50% maximum response) of 0.10 mM. Contractions in response to va...

journal_title：Molecular and cellular biochemistry

authors： St-Louis J,Sicotte B,Breton E,Srivastava AK

更新日期：1995-12-06 00:00:00

abstract：:The effect of CK2beta on the activity of CK2alpha and other protein kinases that can bind this regulatory subunit is not fully understood. In an attempt to improve our understanding of this effect, chimeras of CK2alpha and CK1alpha have been constructed. These chimeras contain different portions of the CK2alpha amino ...

journal_title：Molecular and cellular biochemistry

authors： Jedlicki A,Allende CC,Allende JE

更新日期：2008-09-01 00:00:00

abstract：:Brain membrane lipid fatty acid composition and consequently membrane fluidity change with increasing age. Intracellular fatty acid binding proteins (FABPs) such as heart H-FABP and the brain specific B-FABP, detected by immunoblotting of brain tissue, are thought to be involved in fatty acid uptake, metabolism, and d...

journal_title：Molecular and cellular biochemistry

authors： Pu L,Igbavboa U,Wood WG,Roths JB,Kier AB,Spener F,Schroeder F

更新日期：1999-08-01 00:00:00

abstract：:Myocardial hypoxia is a major cause of cardiac dysfunction due to its triggering cell injury and apoptosis. Deregulated microRNAs and their roles in cardiomyocyte apoptosis have attracted much attention. miR-133a is among the most abundant of the miRNAs present in the normal heart, and significant changes in expressio...

journal_title：Molecular and cellular biochemistry

authors： Li AY,Yang Q,Yang K

更新日期：2015-02-01 00:00:00

abstract：:Transmission of extra cellular signals across biological membranes results in the generation of lipid metabolites which in turn influence specific cellular events such as cell growth or differentiation. Many of these lipid messengers can activate protein kinase C (PKC) isozymes of which one function is to perpetuate t...

journal_title：Molecular and cellular biochemistry

authors： Sista P,Edmiston S,Darges JW,Robinson S,Burns DJ

更新日期：1994-12-21 00:00:00

abstract：:Fructose consumption is responsible for the onset of insulin resistance (IR), and metabolic syndrome. It possesses no functional utility in body and its detrimental effects on hepatic metabolic milieu are beyond those produced by glucose. The need of the hour is to identify fructose-induced IR as an unique pathologica...

journal_title：Molecular and cellular biochemistry

authors： Aggarwal H,Nair J,Sharma P,Sehgal R,Naeem U,Rajora P,Mathur R

更新日期：2018-01-01 00:00:00

abstract：:Amida was first isolated from a rat hippocampal cDNA library as an Arc-associated protein. Although previous studies have shown that Amida mRNA is predominantly expressed and developmentally regulated in rat testis and overexpression induces apoptosis, the function of Amida remains unclear. In this study, we found tha...

journal_title：Molecular and cellular biochemistry

authors： Gan Y,Taira E,Irie Y,Fujimoto T,Miki N

更新日期：2003-04-01 00:00:00

abstract：:Pluripotent stem cells within the adipose stromal compartment, termed adipose-derived stromal cells (ASCs), have the potential to differentiate into a variety of cell lineages both in vitro and in vivo. Imaging with expression of exogenous or endogenous green fluorescent protein (GFP) reporters facilitates the detaile...

journal_title：Molecular and cellular biochemistry

authors： Lin Y,Tian W,Chen X,Yan Z,Li Z,Qiao J,Liu L,Tang W,Zheng X

更新日期：2005-09-01 00:00:00

abstract：:In this study, the effect of (Boc-Lys (Boc)-Arg-Asp-Ser (tBu)-OtBu), a tetrapeptide derivative (PEP1261) was examined for antiproliferative potency and apoptotic induction. Synovial fibroblasts were isolated from collagen-induced arthritic (CIA) rats and exposed to peptides viz., PEP1261, and parental peptides (KRDS a...

journal_title：Molecular and cellular biochemistry

authors： Kumar DA,Settu K,Raju KV,Kumanan K,Manohar BM,Puvanakrishnan R

更新日期：2006-01-01 00:00:00

abstract：:Oxygen is a diradical and because of its unique electronic configuration, it has the potential to form strong oxidants (e.g. superoxide radical, hydrogen peroxide and hydroxyl radical) called oxygen free radicals or partially reduced forms of oxygen (PRFO). These highly reactive oxygen species can cause cellular injur...

journal_title：Molecular and cellular biochemistry

authors： Singal PK,Dhalla AK,Hill M,Thomas TP

更新日期：1993-12-22 00:00:00

abstract：:We have observed that phospholipids and protein of the catecholamine (CA) storage granules, i.e. the chromaffin granules, interact in an in vitro system to form liposomal particles, which in many respects resemble the intact matrix of the bovine chromaffin granule. A model has been suggested which consists of an aqueo...

journal_title：Molecular and cellular biochemistry

authors： Helle KB,Serck-Hanssen G

更新日期：1975-02-28 00:00:00

abstract：:TGR(mREN2)27 is a transgenic rat harboring the murine Ren-2 gene and exhibit fulminant hypertension and marked heart hypertrophy. In order to study the role of angiotensin II in the increase of cardiac mass, these animals were treated with antihypertensive and non-antihypertensive doses of the angiotensin II receptor ...

journal_title：Molecular and cellular biochemistry

authors： Böhm M,Lippoldt A,Wienen W,Ganten D,Bader M

更新日期：1996-10-01 00:00:00

abstract：:The ubiquitin specific peptidase 22 (USP22) is a positive regulator of the growth of tumors. However, little is known about the impact of USP22 knockdown on the growth of human bladder cells. In the present study, we designed a series of asymmetric interfering RNAs (aiRNAs) and compared the efficacy of aiRNA and conve...

journal_title：Molecular and cellular biochemistry

authors： Lv L,Xiao XY,Gu ZH,Zeng FQ,Huang LQ,Jiang GS

更新日期：2011-01-01 00:00:00

abstract：:Insulin receptor binding was examined in the microvillous membranes of mid-term (20-22 weeks of gestation, MT) and full-term (FT) placentas from patients with gestational diabetes mellitus (GDM) and in normal pregnant control (N). Mid-term placentas were obtained from patients who have had spontaneous abortion. The ma...

journal_title：Molecular and cellular biochemistry

authors： al-Attas OS

更新日期：1995-10-04 00:00:00

abstract：:Coronary vascular endothelial cells control vascular tone by modulating the local concentration of circulating vasoactive substances (e.g. adenine nucleotides, biogenic amines and bradykinin) and by synthesising and releasing the vasoactive autacoids nitric oxide (NO) and prostacyclin (PGI2). The fluid shear stress ex...

journal_title：Molecular and cellular biochemistry

authors： Fleming I,Bauersachs J,Busse R

更新日期：1996-04-12 00:00:00

abstract：:Gap junctional communication during the progression of cell cycle from quiescent G0 to S phase was examined in cultured clone 9 rat liver cells. The transfer of scrape-loaded fluorescent dye was suppressed immediately after the stimulation of cell cycle progression in a synchronized cell population. Northern blot anal...

journal_title：Molecular and cellular biochemistry

authors： Koo SK,Kim DY,Park SD,Kang KW,Joe CO

更新日期：1997-02-01 00:00:00

abstract：:RGPR-p117 was originally discovered as a novel protein that binds to a nuclear factor I (NFI) consensus motif TTGGC(N)(6)CC, which is present in the 5'-flanking region of the regucalcin gene (rgn). RGPR-p117 has been identified in human, rat, mouse, bovine, rabbit, and chicken livers. Phylogenetic analysis of six vert...

journal_title：Molecular and cellular biochemistry

authors： Yamaguchi M

更新日期：2009-07-01 00:00:00

abstract：:The NGF secretion from cultured mouse astrocytes was enhanced by sublethal concentrations of phosphatidic acid (PA), ceramide, or sphingosine (Sph), and concentration dependently by lysophosphatidic acid (LPA), sphingosylphosphorylcholine (SPC), or sphingosine-1-phosphate (S1P), but was unaffected by any concentration...

journal_title：Molecular and cellular biochemistry

authors： Furukawa A,Kita K,Toyomoto M,Fujii S,Inoue S,Hayashi K,Ikeda K

更新日期：2007-11-01 00:00:00

abstract：:L-asparaginase EC 3.5.1.1 was purified to homogeneity from Thermus thermophilus. The apparent molecular mass of L-asparaginase by SDS-PAGE was found to be 33 kDa, whereas by its mobility on Sephacryl S-300 superfine column was around 200 kDa, indicating that the enzyme at the native stage acts as hexamer. The purified...

journal_title：Molecular and cellular biochemistry

authors： Pritsa AA,Kyriakidis DA

更新日期：2001-01-01 00:00:00

abstract：:Early responses of lungs to a single radiation dose of 30 Gy were marked by an inflammatory reaction and the onset of pneumonitis within 4 weeks following hemithorax radiation in the rat. Superoxide dismutase reduced the severity of radiation lesions in lungs. ...

journal_title：Molecular and cellular biochemistry

authors： Malaker K,Das RM

更新日期：1988-12-01 00:00:00

abstract：:Tyrosine hydroxylase is considered to be the rate-limiting enzyme in the synthesis of catecholamines in both the central and peripheral nervous system. Increased or decreased neuronal activity, stress, lesions, drug effects, endocrinological manipulations and experimental models of hypertension are associated with alt...

journal_title：Molecular and cellular biochemistry

authors： Masserano JM,Weiner N

更新日期：1983-01-01 00:00:00

abstract：:Genistein is often used as an inhibitor of tyrosine kinases. A less studied side effect of genistein is an inhibition of cyclic AMP-phosphodiesterase (cAMP-PDE) activity resulting in increased cAMP accumulation. The effect of genistein on intracellular cAMP-levels, basal and forskolin-induced, was studied in A549 huma...

journal_title：Molecular and cellular biochemistry

authors： Burvall KM,Palmberg L,Larsson K

更新日期：2002-11-01 00:00:00

abstract：:Glutathione acts as a protein disulphide reductant, which detoxifies herbicides by conjugation, either spontaneously or by the activity of one of a number of glutathione-S-transferases (GSTs), and regulates gene expression in response to environmental stress and pathogen attack. GSTs play roles in both normal cellular...

journal_title：Molecular and cellular biochemistry

authors： Banerjee S,Goswami R

更新日期：2010-03-01 00:00:00

abstract：:Human glomerular mesangial cells (HMCs) have a finite lifespan and eventually enter irreversible growth arrest known as cellular senescence which is thought to contribute to kidney aging and age-related kidney disorders, such as chronic kidney disease. The signal transducer and activator of transcription 1 (STAT1) is ...

journal_title：Molecular and cellular biochemistry

authors： Jiao S,Meng F,Zhang J,Yang X,Zheng X,Wang L

更新日期：2012-06-01 00:00:00

abstract：:We firstly characterized zinc uptake phenomenon across basolateral membrane vesicles (BLMVs) isolated from normal rat kidney. The process was found to be time, temperature, and substrate concentration dependent, and displayed saturability. Zn(2+) uptake was competitively inhibited in the presence of 2 mM Cd with Ki of...

journal_title：Molecular and cellular biochemistry

authors： Kaur J,Sharma N,Attri S,Gogia L,Prasad R

更新日期：2006-02-01 00:00:00

abstract：:Transport characteristics of essential trace elements as zinc, copper, selenium and iron have been studied in maternal-fetal direction in normal pregnancies, using in vitro perfusion of human placental lobules. Solutions of trace elements corresponding to twice the physiological concentrations were injected (100 micro...

journal_title：Molecular and cellular biochemistry

authors： Nandakumaran M,Dashti HM,Al-Saleh E,Al-Zaid NS

更新日期：2003-10-01 00:00:00

abstract：:This article is a review on the organization and function of myofibrillar creatine kinase in striated muscle. The first part describes myofibrillar creatine kinase as an integral structural part of the complex organization of myofibrils in striated muscle. The second part considers the intrinsic biochemical and mechan...

journal_title：Molecular and cellular biochemistry

authors： Ventura-Clapier R,Veksler V,Hoerter JA

更新日期：1994-04-01 00:00:00

abstract：:Modulation of Ca(2+) homoeostasis in cardiac myocytes plays a major role in beat-to-beat regulation of heart function. Previous studies suggest that sphingosine-1-phosphate (S1P), a biologically active sphingomyelin metabolite, regulates Ca(2+) handling in cardiac myocytes, but the underlying mechanism is unclear. In ...

journal_title：Molecular and cellular biochemistry

authors： Egom EE,Bae JS,Capel R,Richards M,Ke Y,Pharithi RB,Maher V,Kruzliak P,Lei M

更新日期：2016-08-01 00:00:00