Expression of fatty acid binding proteins is altered in aged mouse brain.

abstract：:Amida was first isolated from a rat hippocampal cDNA library as an Arc-associated protein. Although previous studies have shown that Amida mRNA is predominantly expressed and developmentally regulated in rat testis and overexpression induces apoptosis, the function of Amida remains unclear. In this study, we found tha...

journal_title：Molecular and cellular biochemistry

authors： Gan Y,Taira E,Irie Y,Fujimoto T,Miki N

更新日期：2003-04-01 00:00:00

abstract：:The involvement of a hypocalcemic hormone calcitonin (CT) in the expression of hepatic Ca(2+)-binding protein regucalcin mRNA was investigated. The change of regucalcin mRNA levels was analyzed by Northern blotting using liver regucalcin complementary DNA (0.9 kb). A single oral administration of calcium chloride (100...

journal_title：Molecular and cellular biochemistry

authors： Yamaguchi M,Kanayama Y,Shimokawa N

更新日期：1994-07-13 00:00:00

abstract：:The flux through the de novo pyrimidine biosynthetic pathway is controlled by the multifunctional protein CAD, which catalyzes the first three steps. The cell cycle dependent regulation of pyrimidine biosynthesis is a consequence of sequential phosphorylation of CAD Thr456 and Ser1406 by the MAP kinase and PKA cascade...

journal_title：Molecular and cellular biochemistry

authors： Kotsis DH,Masko EM,Sigoillot FD,Di Gregorio R,Guy-Evans HI,Evans DR

更新日期：2007-07-01 00:00:00

abstract：:Physiological, pharmacological, histochemical and biochemical studies indicate that dopamine receptors are heterogenous in the central nervous system with each individual functions. This review describes pharmacological and biochemical characteristics of dopamine receptors, particularly in canine caudate nucleus, whic...

journal_title：Molecular and cellular biochemistry

authors： Maeno H

更新日期：1982-03-19 00:00:00

abstract：:Hypertension and related oxidative stress are involved in the pathogenesis of any renal diseases. Angiotensin-converting enzyme inhibitors have multi-directional renoprotective effects. In this study, we aimed to investigate whether lisinopril treatment has any biochemical alterations on renal tissue in L-NAME (Nε-nit...

journal_title：Molecular and cellular biochemistry

authors： Oktem F,Kirbas A,Armagan A,Kuybulu AE,Yilmaz HR,Ozguner F,Uz E

更新日期：2011-06-01 00:00:00

abstract：:Plasma membrane fractions from normal, regenerating liver and the AS-30D ascites hepatocarcinoma exhibited a high degree of enrichment when a set of plasma membrane enzyme markers were studied in comparison to the ones associated to the mitochondrial and cytosolic compartments. While the (Ca2+, Mg2+)-ATPase observed f...

journal_title：Molecular and cellular biochemistry

authors： Mas-Oliva J,Pérez-Montfort R,Cárdenas-García M,Rivas-Duro M

更新日期：1991-01-16 00:00:00

abstract：:The activities of the hexose monophosphate dehydrogenases increased in adipose tissue, remained unchanged in liver and decreased in mammary gland following the weaning of rats at mid-lactation (day 14). When dietary intake was restricted at mid-lactation, the activities of the hexose monophosphate dehydrogenases incre...

journal_title：Molecular and cellular biochemistry

authors： Martins RN,Stokes GB

更新日期：1987-08-01 00:00:00

abstract：:In hypertensive animals and patients, oxidative stress represents the primary risk factor for progression of left ventricular hypertrophy. Recently, it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals and peroxynitrite anion to exert therapeutic antioxidant activity...

journal_title：Molecular and cellular biochemistry

authors： Yu YS,Zheng H

更新日期：2012-06-01 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) and renin-angiotensin system (RAS) play critical roles in the process of renal diseases, but their interaction has not been comprehensively discussed. In the present studies, we investigated the renoprotective effects of MPAK inhibitors on renal diseases in type 1 diabetic mouse...

journal_title：Molecular and cellular biochemistry

authors： Hong Z,Hong Z,Wu D,Nie H

更新日期：2016-08-01 00:00:00

abstract：:The (Ca2+ + Mg2+) ATPase which serves as a Ca2+ pump in the kidney basolateral membranes is essential to the maintenance of an intracellular Ca2+ concentration optimal for kidney function. Since atrial natriuretic peptide (ANP) is known to participate in the Ca2+ homeostasis mechanism, altered levels of ANP in diabete...

journal_title：Molecular and cellular biochemistry

authors： Sahai A,Ganguly PK

更新日期：1991-06-26 00:00:00

abstract：:The present study was designed to induce massive accumulation of calcium in the myocardium and to evaluate the effect of calcium overload on myocardial contractile function and biochemical activity of cardiac subcellular membranes. Rats were treated with an oral administration of 500,000 units/kg of vitamin D3 for 3 c...

journal_title：Molecular and cellular biochemistry

authors： Takeo S,Tanonaka R,Tanonaka K,Miyake K,Hisayama H,Ueda N,Kawakami K,Tsumura H,Katsushika S,Taniguchi Y

更新日期：1991-10-16 00:00:00

abstract：:To define metabolic influences on cardiac myosin expression and sarcoplasmic reticulum (SR) Ca(2+)-stimulated ATPase streptozotocin-diabetic rats were treated for 9-10 wk with etomoxir, an inhibitor of carnitine palmitoyl transferase I (CPT-1) and fatty acid synthesis, or an antilipolytic drug, acipimox. Etomoxir redu...

journal_title：Molecular and cellular biochemistry

authors： Rupp H,Elimban V,Dhalla NS

更新日期：1994-03-16 00:00:00

abstract：:A quarter of the human population with European background carries at least one allele of the OPRD1 gene that encodes the delta opioid receptor with cysteine at the amino acid position 27 (hδOR(Cys27)) instead of the evolutionary conserved phenylalanine (hδOR(Phe27)). The two variants have indistinguishable pharmacolo...

journal_title：Molecular and cellular biochemistry

authors： Tuusa JT,Petäjä-Repo UE

更新日期：2011-05-01 00:00:00

abstract：:In this study, we have characterized the negative regulation of the IL-12 p40 expression by TGF-beta in macrophages. Although murine IL-12 p40 promoter contains a putative TGF-beta inhibitory element (TIE), neither mutation nor deletion of the TIE had any effect on the inhibitory activity of TGF-beta. The NF-kappaB p6...

journal_title：Molecular and cellular biochemistry

authors： Ogawa K,Funaba M,Tsujimoto M

更新日期：2008-01-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important diseases of swine, which is caused by PRRS virus (PRRSV). CD151, one of PRRSV entry mediators, determines the cell susceptibility for PRRSV. Emerging evidence indicates that the host microRNAs (miRNAs) play key roles in modu...

journal_title：Molecular and cellular biochemistry

authors： Wu J,Peng X,Zhou A,Qiao M,Wu H,Xiao H,Liu G,Zheng X,Zhang S,Mei S

更新日期：2014-09-01 00:00:00

abstract：:Accumulating data have shown that microRNAs are involved in the pathogenesis of cancer. miR-202 has been confirmed to be downregulated in several types of human cancer. However, the expression and biological role of miR-202 in osteosarcoma (OS) carcinogenesis and progression remain unclear. In this study, we demonstra...

journal_title：Molecular and cellular biochemistry

authors： Sun Z,Zhang T,Hong H,Liu Q,Zhang H

更新日期：2014-12-01 00:00:00

abstract：:Apoptosis-inducing agents have been reported to cause rapid shedding of tumor necrosis factor receptor 1 (TNFR1) in endothelial cells (EC). Oxidized LDL (oxLDL) has also been known to induce apoptosis of EC and to inhibit proliferation of EC. In the present study, we show that oxLDL also causes shedding of TNFR1 in EC...

journal_title：Molecular and cellular biochemistry

authors： Sugano M,Tsuchida K,Makino N

更新日期：2004-03-01 00:00:00

abstract：:Cardiac glycosides (CGs) are useful drugs to treat cardiac illnesses and have potent cytotoxic and anticancer effects in cultured cells and animal models. Their receptor is the Na+,K+ ATPase, but other plasma membrane proteins might bind CGs as well. Herein, we evaluated the short- and long-lasting cytotoxic effects o...

journal_title：Molecular and cellular biochemistry

authors： Schneider NFZ,Menegaz D,Dagostin ALA,Persich L,Rocha SC,Ramos ACP,Cortes VF,Fontes CFL,de Pádua RM,Munkert J,Kreis W,Braga FC,Barbosa LA,Silva FRMB,Simões CMO

更新日期：2021-01-18 00:00:00

abstract：:Pulmonary atresia (PA) with ventricular septal defect (VSD) is an extreme form of tetralogy of Fallot with characteristic right ventricular hypertrophy. To reduce the right ventricular overload, these children have to undergo staged corrective surgery to restore physiological pulmonary perfusion. We studied the degree...

journal_title：Molecular and cellular biochemistry

authors： Peters TH,de Jong PL,Klompe L,Berger RM,Saxena PR,Sharma HS,Bogers AJ

更新日期：2003-09-01 00:00:00

abstract：:The development and growth of the prostate gland depends on androgen stimulation. Dihydrotestosterone (DHT) is the primary androgen responsible for prostate development and also for the pathogenesis of benign prostatic hyperplasia (BPH). The incidence of prostate cancer (PCa) and benign prostatic hypertrophy (BPH) con...

journal_title：Molecular and cellular biochemistry

authors： Torres JM,Gómez-Capilla JA,Ruiz E,Ortega E

更新日期：2003-08-01 00:00:00

abstract：:Coronary vascular endothelial cells control vascular tone by modulating the local concentration of circulating vasoactive substances (e.g. adenine nucleotides, biogenic amines and bradykinin) and by synthesising and releasing the vasoactive autacoids nitric oxide (NO) and prostacyclin (PGI2). The fluid shear stress ex...

journal_title：Molecular and cellular biochemistry

authors： Fleming I,Bauersachs J,Busse R

更新日期：1996-04-12 00:00:00

abstract：:Glomerular mesangial cells play an important role in the development of glomerulosclerosis. Mesangial cell apoptosis has been shown to be involved in different stages of development of glomerulonephritis. The aim of the present study was to evaluate the effect of inhibition of serine/threonine phosphatases by okadaic ...

journal_title：Molecular and cellular biochemistry

authors： Parameswaran N,Spielman WS,Brooks DP,Nambi P

更新日期：2004-05-01 00:00:00

abstract：:The apparent membrane fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene has been reported to be lower in intact erythrocytes than in isolated erythrocyte membranes. Although this difference was once suggested to be caused by the fluidizing effect associated with the loss of erythrocyte proteins during membrane ...

journal_title：Molecular and cellular biochemistry

authors： Dickens BF,Snow TR,Green V,Weglicki WB

更新日期：1988-01-01 00:00:00

abstract：:delta-Crystallin is a major structural protein of avian and reptilian lenses that is absent from the lenses of fish, amphibia and mammals. It appears to be a tetrameric protein with a native molecular weight near 200 000 (200K) and polypeptide molecular weight near 50K and 48K) (see Note added in proof). The alpha-cry...

journal_title：Molecular and cellular biochemistry

authors： Piatigorsky J

更新日期：1984-01-01 00:00:00

abstract：:The role of C-X-C chemokine receptor type 4 (CXCR4) in umbilical mesenchymal stem cells (UMSCs) as therapy for liver disease is ill understood. The aim of the study was to evaluate rat UMSCs (rUMSCs) on CXCR4 expression and homing to injured liver tissue. rUMSCs were isolated from umbilical cords of pregnant rats. Acu...

journal_title：Molecular and cellular biochemistry

authors： Deng C,Qin A,Zhao W,Feng T,Shi C,Liu T

更新日期：2014-11-01 00:00:00

abstract：:In recent years, there has been growing interest in estimating the degree of heating caused by the diagnostic ultrasound in clinical practice. Both theoretical and experimental methods have been suggested for estimating the heating potential, or thermal hazard, of diagnostic ultrasound. Aim of this study was to evalua...

journal_title：Molecular and cellular biochemistry

authors： Karagöz I,Biri A,Babacan F,Kavutçu M

更新日期：2007-01-01 00:00:00

abstract：:Muscle injury is a common result of muscle exertion caused by overload and over-activity. In this presentation, an attempt was made to discuss models of muscle injury which involve exertion but not excessive strain, although most functional activities of the extremities require some eccentric muscle actions. Muscle in...

journal_title：Molecular and cellular biochemistry

authors： Stauber WT,Smith CA

更新日期：1998-02-01 00:00:00

abstract：:Cancer stem cells (CSCs) are believed to be responsible for tumor metastasis, recurrence, and high mortality of cancer patients due to their high tumorigenicity resistance to chemo-radiotherapy. Morusin possesses anti-cancer activity through attenuation of NF-κB activity, which is up-regulated in cancer stem cells. Th...

journal_title：Molecular and cellular biochemistry

authors： Wang L,Guo H,Yang L,Dong L,Lin C,Zhang J,Lin P,Wang X

更新日期：2013-07-01 00:00:00

abstract：:A crude preparation of heavy sarcoplasmic reticulum (HSR) was isolated using 1 gram of muscle obtained from swine susceptible to malignant hyperthermia (MH) and from control swine. The caffeine and ATP concentration-dependency of Ca-release was determined using suction filtration with radioisotopic 45Ca as a tracer. R...

journal_title：Molecular and cellular biochemistry

authors： O'Brien PJ

更新日期：1990-03-05 00:00:00

abstract：:In the eluted fractions of histone-treated crude extracts separated by Sephadex G-200 filtration, multiple protein kinase (PK) activities, including three from brain and two from skeletal muscle, were augmented by both S-100 protein and parvalbumin on the phosphorylation of endogenous substrates. One additional PK act...

journal_title：Molecular and cellular biochemistry

authors： Kuo WN,Blake T,Cheema IR,Dominguez J,Nicholson J,Puente K,Shells P,Lowery J

更新日期：1986-06-01 00:00:00