Suppression of NF-kappaB and IRF-1-induced transcription of the murine IL-12 p40 by transforming growth factor-beta Smad pathway in macrophages.

abstract：:Thioredoxin (Trx) is a small ubiquitous protein, which has been shown to be involved in redox-dependent cellular functions. In this article, we demonstrate that the increased level of Trx induces AP-1 DNA binding in a redox-dependent manner by activating JNK subgroup of MAPKs. The majority of AP-1 DNA binding complex ...

journal_title：Molecular and cellular biochemistry

authors： Das KC,Muniyappa H

更新日期：2010-04-01 00:00:00

abstract：:In order to compare the role of the Ca(2+)-receptive protein (troponin), in the characteristic myofibrillar contractile response of chicken fast and slow skeletal muscles, the troponin in both kinds of myofibrils were partially exchanged, under slightly acidic conditions. The Ca(2+)- or Sr(2+)-activation of the ATPase...

journal_title：Molecular and cellular biochemistry

authors： Kawashima A,Shiraishi F,Ohtsuki I,Yamamoto K

更新日期：1994-03-30 00:00:00

abstract：:SAP155 is an essential component of the spliceosome and its phosphorylation is required for splicing catalysis, but little is known concerning its function and regulation during spermatogenesis in postnatal murine testes. We report that inhibition of dual-specificity tyrosine-phosphorylation regulated kinase (DYRK) IA...

journal_title：Molecular and cellular biochemistry

authors： Eto K,Sonoda Y,Abe S

更新日期：2011-09-01 00:00:00

abstract：:This study has examined whether elevated glucose can induce lipid peroxidation and contribute to the inhibition of cell growth in human kidney proximal tubule(HPT) cells. HPT cells were cultured in media containing glucose concentrations of 8 mM (control), 25 mM, and 50 mM. Lipid peroxidation was assessed by the thiob...

journal_title：Molecular and cellular biochemistry

authors： Jain SK,Morshed KM,Kannan K,McMartin KE,Bocchini JA Jr

更新日期：1996-09-06 00:00:00

abstract：:Tyrosine levels are abnormally elevated in tissues and body fluids of patients with inborn errors of tyrosine metabolism. Tyrosinemia type II, which is caused by tyrosine aminotransferase deficiency, provokes eyes, skin, and central nervous system disturbances in affected patients. However, the mechanisms of brain dam...

journal_title：Molecular and cellular biochemistry

authors： Streck EL,De Prá SDT,Ferro PR,Carvalho-Silva M,Gomes LM,Agostini JF,Damiani A,Andrade VM,Schuck PF,Ferreira GC,Scaini G

更新日期：2017-11-01 00:00:00

abstract：:HMGb1 is a DNA-binding protein whose role as an extracellular cytokine in inflammation and tissue regeneration has also been reported. Given the importance of keratinocytes in wound healing, we have studied the mechanism of action of HMGb1 on HaCaT keratinocytes during in vitro scratch wound repair. Western blot and c...

journal_title：Molecular and cellular biochemistry

authors： Ranzato E,Patrone M,Pedrazzi M,Burlando B

更新日期：2009-12-01 00:00:00

abstract：:This study examined the effect of nitric oxide on the production of soluble ECE-1. Activity of ECE-1 in media was measured using a quenched fluorescent substrate assay, and expressed as a percentage of control. Endothelial cells were incubated with the nitric oxide donor Diethylenetriamine NONOate (DETA; 250-800 µM), ...

journal_title：Molecular and cellular biochemistry

authors： Kuruppu S,Rajapakse NW,Dunstan RA,Smith AI

更新日期：2014-11-01 00:00:00

abstract：:Somatostatin has been shown to inhibit the release of various polypeptide hormones including insulin, glucagon, gastrin, thyroid stimulating hormone, and growth hormone. The mechanism by which somatostatin inhibits the release of these various polypeptide hormones has not been fully elucidated. It has been reported th...

journal_title：Molecular and cellular biochemistry

authors： Vesely DL

更新日期：1980-11-20 00:00:00

abstract：:The AP-1 consensus sequences (TGAGTCA) are the major 12-O-tetradecanoylphorbol113-acetate (TPA) responsive elements shared by several TPA inducible genes, such as c-sis, c-fos, c-myc, collagenase, stromelysin, hMTIIA and SV40. However, the role of AP-1 binding sites, which are present in the introns 3, 5, and 11 of OD...

journal_title：Molecular and cellular biochemistry

authors： Tseng CP,Verma AK

更新日期：1995-05-10 00:00:00

abstract：:The purpose of this study was to evaluate the protective effect of a new endotoxin analogue, monophosphoryl lipid A (MLA) in a rabbit model of myocardial ischemia/reperfusion and to show if this protection was mediated via synthesis of 70 kDa heat shock protein (HSP 70). Three groups of New Zealand White rabbits under...

journal_title：Molecular and cellular biochemistry

authors： Yoshida K,Maaieh MM,Shipley JB,Doloresco M,Bernardo NL,Qian YZ,Elliott GT,Kukreja RC

更新日期：1996-03-09 00:00:00

abstract：:Glycosphingolipid biosynthesis was examined using [3H]-galactose as a precursor as rat L6 myoblasts fused to form multinucleated myotubes. Incorporation of label into neutral glycolipids decreased steadily as the population of myotubes increased, so that final biosynthesis was one-half that observed with myoblasts (p ...

journal_title：Molecular and cellular biochemistry

authors： Leskawa KC,Erwin RE,Buse PE,Hogan EL

更新日期：1988-09-01 00:00:00

abstract：:The present study examined the effect of fenoldopam, a known dopamine-1 receptor (DA1) agonist in order to understand its involvement in the cardiac hypertrophic process. Male Sprague-Dawley rats underwent abdominal aortic constriction (AB) with placement of a suprarenal ligature while sham operated animals served as ...

journal_title：Molecular and cellular biochemistry

authors： Ganguly PK,Mukherjee K,Sahai A

更新日期：1995-03-09 00:00:00

abstract：:Cross-talk between coding RNAs and regulatory non-coding microRNAs, within human genome, has provided compelling evidence for the existence of flexible checkpoint control of T-Cell activation. The present study attempts to demonstrate that the interplay between miR-2909 and its effector KLF4 gene has the inherent capa...

journal_title：Molecular and cellular biochemistry

authors： Kaul D,Malik D,Wani S

更新日期：2019-01-01 00:00:00

abstract：:The OCT4 transcription factor is a crucial stem cells marker and it has been related to the cancer stem cells concept. Moreover, it has also been associated to the multiple drug resistance (MDR) phenotype. Our first results pointed out a straight relation between OCT4 and ABC transporters in K562-derivative MDR (Lucen...

journal_title：Molecular and cellular biochemistry

authors： Oliveira BR,Figueiredo MA,Trindade GS,Marins LF

更新日期：2015-02-01 00:00:00

abstract：:Monitoring the kinetic behavior of adenylate kinase (AK) and creatine kinase (CK) in intact cells by 18O-phosphoryl oxygen exchange analysis has provided new perspectives from which to more fully define the involvement of these phosphotransferases in cellular bioenergetics. A primary function attributable to both AK a...

journal_title：Molecular and cellular biochemistry

authors： Dzeja PP,Zeleznikar RJ,Goldberg ND

更新日期：1998-07-01 00:00:00

abstract：:The insoluble inclusion bodies of soluble leukemia inhibitory factor receptor fusion protein (gp 190 sol DAF) was solubilized in 8 M urea on the unfolding transitions, and several factors on the aggregate formation were indirectly analyzed for the refolding of gp 190 sol DAF. Results indicate that the refolding yield ...

journal_title：Molecular and cellular biochemistry

authors： Liu H,Moreau JF,Gualde N,Fu J

更新日期：1997-04-01 00:00:00

abstract：:The hexokinase: fumarase ratios of mitochondria isolated from ten tissues of the rat were determined, and compared with the tissue content of phosphoglucomutase and phosphorylase, taken as representatives of enzymes concerned with glycogen metabolism. A generally inverse relationship was found between the mitochondria...

journal_title：Molecular and cellular biochemistry

authors： Wilson JE,Felgner PL

更新日期：1977-11-25 00:00:00

abstract：:Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are two hormones produced and secreted by the heart to control blood pressure, body fluid homeostasis and electrolyte balance. Each peptide binds to a common family of 3 receptors (GC-A, GC-B and C-receptor) with varying degrees of affinity. The pro...

journal_title：Molecular and cellular biochemistry

authors： Tse MY,Watson JD,Sarda IR,Flynn TG,Pang SC

更新日期：2001-03-01 00:00:00

abstract：:The aim of the current study was to comparatively investigate the effect of inhibition of nitric oxide (NO) production by N-nitro-L-arginine methyl ester (L-NAME), an isoform non-specific inhibitor of nitric oxide synthase (NOS), after oral mucosal incision on wound tissue NO levels. A standard incision was applied to...

journal_title：Molecular and cellular biochemistry

authors： Coşkun S,Karataş F,Acartürk F,Olmuş H,Selvi M,Erbaş D

更新日期：2005-10-01 00:00:00

abstract：:The RNase hydrolysis of random-coil (alkaline form) poly A follows biphasic kinetics at low salt concentrations. However, its resistance to RNase increases with the ionic strength. Helical (acidic form) poly A is alos susceptible to RNase but its hydrolysis follows first-order kinetics, and its resistance increases as...

journal_title：Molecular and cellular biochemistry

authors： Iqbal ZM

更新日期：1975-10-31 00:00:00

abstract：:Glutathione acts as a protein disulphide reductant, which detoxifies herbicides by conjugation, either spontaneously or by the activity of one of a number of glutathione-S-transferases (GSTs), and regulates gene expression in response to environmental stress and pathogen attack. GSTs play roles in both normal cellular...

journal_title：Molecular and cellular biochemistry

authors： Banerjee S,Goswami R

更新日期：2010-03-01 00:00:00

abstract：:We have identified by immunoblotting and ADP-ribosylation by cholera toxin and pertussis toxin the presence of Mr 43 and 46 KDa Gs alpha, and 39 and 41 KDa Gi alpha subunits in rat parotid gland plasma membranes but not in granule membranes. A Mr 28 KDa polypeptide that served as substrate for ADP-ribosylation by both...

journal_title：Molecular and cellular biochemistry

authors： Ali N,Agrawal DK,Cheung P

更新日期：1992-10-07 00:00:00

abstract：:Peroxisomes and peroxisomal enzyme expression were investigated biochemically and morphometrically in guinea pig intestinal epithelial cells at different stages of their migration along the crypt-villus axis. Epithelial cells were sequentially isolated along the axis and the specific activities of the peroxisomal enzy...

journal_title：Molecular and cellular biochemistry

authors： Phipps AN,Connock MJ,Johnson P,Burdett K

更新日期：2000-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of leading causes of cancer-related death, and its increasing incidence worldwide is a cause for concern. The recombinant analgesic-antitumor peptide (rAGAP), a protein consisting of small ubiquitin-related modifier linked with a hexa-histidine tag, exhibited the antitumor activit...

journal_title：Molecular and cellular biochemistry

authors： Cao Q,Lu W,Zhou T,Liu Y,Cai X,Zhu J,Cao P

更新日期：2019-05-01 00:00:00

abstract：:Tedisamil is antiarrhythmic class III drug with antifibrillating/defibrillating potency linked to enhancement of intermyocyte gap junctional electrical coupling most likely via its sympathomimetic cAMP-related mechanisms. This study was designed to examine the effect of tedisamil on cAMP level in guinea pig hearts in ...

journal_title：Molecular and cellular biochemistry

authors： Tribulova N,Ravingerova T,Okruhlicova L,Gabauer I,Fickova M,Pancza D,Slezak J,Manoach M

更新日期：2000-07-01 00:00:00

abstract：:Basal and trypsin-stimulated adenosine triphosphatase activities of Escherichia coli K 12 have been characterized at pH 7.5 in the membrane-bound state and in a soluble form of the enzyme. The saturation curve for Mg2+/ATP = 1/2 was hyperbolic with the membrane-bound enzyme and sigmoidal with the soluble enzyme. Tryps...

journal_title：Molecular and cellular biochemistry

authors： Carreira J,Muñoz E

更新日期：1975-11-14 00:00:00

abstract：:Cryptotanshinone (CPT) is a natural compound extracted from herbal medicine that has been previously shown to possess antitumor properties in various types of human cancer cells. In the present study, we examined the potential role of CPT in the treatment of colorectal cancer. Using SW480, HCT116, and LOVO colorectal ...

journal_title：Molecular and cellular biochemistry

authors： Li W,Saud SM,Young MR,Colburn NH,Hua B

更新日期：2015-08-01 00:00:00

abstract：:The characterization of mutations in Japanese patients with lipidosis, particularly in metachromatic leukodystrophy (MLD) and Gaucher disease has been studied in detail. Metachromatic leukodystrophy is characterized by an accumulation of sulfatide in nervous tissues and kidney due to a deficiency of arylsulfatase A (A...

journal_title：Molecular and cellular biochemistry

authors： Eto Y,Kawame H,Hasegawa Y,Ohashi T,Ida H,Tokoro T

更新日期：1993-02-17 00:00:00

abstract：UNLABELLED:Carnosic acid is a well-known antioxidant. Recently, it has been identified as modulator of nuclear factor erythroid 2-related factor 2 (Nrf2). The effect of carnosic acid in the context of cardiovascular disorders has not been studied. In the present study, we investigated the beneficial effect and the unde...

journal_title：Molecular and cellular biochemistry

authors： Sahu BD,Putcha UK,Kuncha M,Rachamalla SS,Sistla R

更新日期：2014-09-01 00:00:00

abstract：:In this review we analyze the concepts and the experimental data on the mechanisms of the regulation of energy metabolism in muscle cells. Muscular energetics is based on the force-length relationship, which in the whole heart is expressed as a Frank-Starling law, by which the alterations of left ventricle diastolic v...

journal_title：Molecular and cellular biochemistry

authors： Saks VA,Kuznetsov AV,Vendelin M,Guerrero K,Kay L,Seppet EK

更新日期：2004-01-01 00:00:00