Abstract：
:In this review we analyze the concepts and the experimental data on the mechanisms of the regulation of energy metabolism in muscle cells. Muscular energetics is based on the force-length relationship, which in the whole heart is expressed as a Frank-Starling law, by which the alterations of left ventricle diastolic volume change linearly both the cardiac work and oxygen consumption. The second basic characteristics of the heart is the metabolic stability--almost constant levels of high energy phosphates, ATP and phosphocreatine, which are practically independent of the workload and the rate of oxygen consumption, in contrast to the fast-twitch skeletal muscle with no metabolic stability and rapid fatigue. Analysis of the literature shows that an increase in the rate of oxygen consumption by order of magnitude, due to Frank-Starling law, is observed without any significant changes in the intracellular calcium transients. Therefore, parallel activation of contraction and mitochondrial respiration by calcium ions may play only a minor role in regulation of respiration in the cells. The effective regulation of the respiration under the effect of Frank-Starling law and metabolic stability of the heart are explained by the mechanisms of functional coupling within supramolecular complexes in mitochondria, and at the subcellular level within the intracellular energetic units. Such a complex structural and functional organisation of heart energy metabolism can be described quantitatively by mathematical models.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Saks VA,Kuznetsov AV,Vendelin M,Guerrero K,Kay L,Seppet EKdoi
10.1023/b:mcbi.0000009868.92189.fbkeywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
185-99issue
1-2eissn
0300-8177issn
1573-4919journal_volume
256-257pub_type
杂志文章abstract：:Rat erythrocytes, in contrast to red blood cells from other mammals, have been shown to contain only one hexokinase isozymic form identified as type I by chromatographic and kinetic properties. Rat reticulocytes contain 3.6-times the hexokinase activity found in mature erythrocytes but exactly the same isozyme. By a c...
journal_title：Molecular and cellular biochemistry
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journal_title：Molecular and cellular biochemistry
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更新日期：1997-07-01 00:00:00
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