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Calcium binding proteins in the sarcoplasmic/endoplasmic reticulum of muscle and nonmuscle cells.

Abstract：

:In this paper we review some of the large quantities of information currently available concerning the identification, structure and function of Ca(2+)-binding proteins of endoplasmic and sarcoplasmic reticulum membranes. The review places particular emphasis on identification and discussion of Ca2+ 'storage' proteins in these membranes. We believe that the evidence reviewed here supports the contention that the Ca(2+)-binding capacity of both calsequestrin and calreticulin favor their contribution as the major Ca(2+)-binding proteins of muscle and nonmuscle cells, respectively. Other Ca(2+)-binding proteins discovered in both endoplasmic reticulum and sarcoplasmic reticulum membranes probably contribute to the overall Ca2+ storage capacity of these membrane organelles, and they also play other important functional role such as posttranslational modification of newly synthesized proteins, a cytoskeletal (structural) function, or movement of Ca2+ within the lumen of the sarcoplasmic/endoplasmic reticulum towards the storage sites.

journal_name

Mol Cell Biochem

journal_title

Molecular and cellular biochemistry

authors

Milner RE,Famulski KS,Michalak M

doi

10.1007/BF00229637

keywords:

subject

Has Abstract

pub_date

1992-05-13 00:00:00

pages

1-13

issue

1

eissn

0300-8177

issn

1573-4919

journal_volume

112

pub_type

杂志文章,评审

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