Sulfhydryl oxidation and Ca2+ release from sarcoplasmic reticulum.

Abstract:

:Our interest in the role of sulfhydryl groups (SH) in regulating or altering transport across biological membranes has focused on the significance of a critical SH group associated with the Ca2+-release protein from skeletal muscle sarcoplasmic reticulum (SR). We have shown that binding of heavy metals to this group or oxidation of this sulfhydryl to a disulfide induces rapid Ca2+ release from SR vesicles and induces contraction in skinned muscle fibers. Several models are described in which oxidation and reduction might control the state of the Ca2+-release channel from SR.

journal_name

Mol Cell Biochem

authors

Abramson JJ,Salama G

doi

10.1007/BF00242520

subject

Has Abstract

pub_date

1988-07-01 00:00:00

pages

81-4

issue

1-2

eissn

0300-8177

issn

1573-4919

journal_volume

82

pub_type

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