PPARγ antagonist GW9662 induces functional estrogen receptor in mouse mammary organ culture: potential translational significance.

abstract：:This study was designed to investigate the alterations in the levels of various proteases such as angiotensin converting enzyme (ACE), kallikrein, aminopeptidases, urokinase and plasmin in serum-heart and kidney and to find out whether the changes in the levels of these enzymes could explain the pathogeneses of hypert...

journal_title：Molecular and cellular biochemistry

authors： Rajashree S,Puvanakrishnan R

更新日期：1999-07-01 00:00:00

abstract：:Autism is a prevalent developmental disorder that combines repetitive behaviours, social deficits and language abnormalities. The present study aims to assess the autistic subjects using DSM IV-TR criteria followed with the analysis of neurotransmitters, biochemical parameters, oxidative stress and its ions in two gro...

journal_title：Molecular and cellular biochemistry

authors： Meyyazhagan A,Balasubramanian B,Easwaran M,Alagamuthu KK,Shanmugam S,Kuchi Bhotla H,Pappusamy M,Arumugam VA,Thangaraj A,Kaul T,Keshavarao S,Cacabelos R

更新日期：2020-11-01 00:00:00

abstract：:Patients with non-ketotic hyperglycinemia (NKH) present severe neurological symptoms and brain abnormalities involving cerebellum. Although the pathomechanisms underlying the cerebellum damage have not been studied, high tissue levels of glycine (GLY), the biochemical hallmark of this disorder have been suggested to c...

journal_title：Molecular and cellular biochemistry

authors： Moura AP,Grings M,Marcowich GF,Bumbel AP,Parmeggiani B,de Moura Alvorcem L,Wajner M,Leipnitz G

更新日期：2014-10-01 00:00:00

abstract：:Exogenous growth factors could accelerate the process of wound healing. However, the underlying mechanisms have not been clearly clarified. The aim of the present study was to investigate the effect of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) on the expression of type I collagen (cola1),...

journal_title：Molecular and cellular biochemistry

authors： Shen T,Gao K,Miao Y,Hu Z

更新日期：2018-05-01 00:00:00

abstract：:TGR(mREN2)27 is a transgenic rat harboring the murine Ren-2 gene and exhibit fulminant hypertension and marked heart hypertrophy. In order to study the role of angiotensin II in the increase of cardiac mass, these animals were treated with antihypertensive and non-antihypertensive doses of the angiotensin II receptor ...

journal_title：Molecular and cellular biochemistry

authors： Böhm M,Lippoldt A,Wienen W,Ganten D,Bader M

更新日期：1996-10-01 00:00:00

abstract：:Glycyrrhizin, a major constituent of licorice (Glycyrrhiza glabra) root, has been reported to ameliorate insulin resistance, hyperglycemia, dyslipidemia, and obesity in rats with metabolic syndrome. Liver dysfunction is associated with this syndrome. The objective of this study is to investigate the effect of glycyrrh...

journal_title：Molecular and cellular biochemistry

authors： Sil R,Ray D,Chakraborti AS

更新日期：2015-11-01 00:00:00

abstract：:This review examines the mechanism of translocation of cytoplasmically synthesized proteins into mitochondria. Approximately 10% of the mitochondrial proteins are synthesized within the organelles while most mitochondrial proteins are coded for by nuclear genes and synthesized on cytoplasmic ribosomes. Those mitochond...

journal_title：Molecular and cellular biochemistry

authors： Ades IZ

更新日期：1982-03-19 00:00:00

abstract：:Endothelial dysfunction is one of the most important pathological events during the development of several diabetic complications including stroke. The aim of this work was to investigate the role of actin depolymerizing factor (ADF) in advanced glycation endproducts (AGEs)-induced impairment in mouse brain microvascu...

journal_title：Molecular and cellular biochemistry

authors： Liu X,Zhang R,Di H,Zhao D,Wang J

更新日期：2017-09-01 00:00:00

abstract：:Vascular endothelial and -smooth muscle cells have been shown to use fatty acids as substrates for oxidative phosphorylation. Endothelial cells are more vulnerable to oxidative stress than muscle cells and are prone to loose carnitine early during hypoperfusion. This has been suggested by two observations. The first i...

journal_title：Molecular and cellular biochemistry

authors： Hülsmann WC,Dubelaar ML

更新日期：1992-10-21 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have the potential for self-renewal and multipotential differentiation to regenerate damaged tissues or recover functional absence in diseases. Superparamagnetic iron oxide nanoparticles (SPIONs) are used as contrast agents in magnetic resonance imaging (MRI) for labeling cells in vitro a...

journal_title：Molecular and cellular biochemistry

authors： Zeng G,Wang G,Guan F,Chang K,Jiao H,Gao W,Xi S,Yang B

更新日期：2011-11-01 00:00:00

abstract：:The identification of informative biomarkers that could predict the treatment response is particularly important in the triple-negative (TN) breast cancer, which is characterized by biological diversity. The aim of this study was to investigate the impact of vascular endothelial growth factor receptor (VEGFR2) express...

journal_title：Molecular and cellular biochemistry

authors： Babyshkina N,Zavyalova M,Tarabanovskaya N,Dronova T,Krakhmal N,Slonimskaya E,Kzhyshkowska J,Choynzonov E,Cherdyntseva N

更新日期：2018-07-01 00:00:00

abstract：:Fenugreek and Balanites are two plants commonly used in Egyptian folk medicine as hypoglycemic agents. In the present study, the effects of 21 days oral administration of Fenugreek seed and Balanites fruit extracts (1.5 g/kg bw) on the liver and kidney glycogen content and on some key liver enzymes of carbohydrate met...

journal_title：Molecular and cellular biochemistry

authors： Gad MZ,El-Sawalhi MM,Ismail MF,El-Tanbouly ND

更新日期：2006-01-01 00:00:00

abstract：:Glycogen content as well as glycolytic, gluconeogenic and fatty acid synthesis enzyme activities were monitored in young and adult male rats fed diets differing in fat content: 11% (low), 22% (medium) and 42% (high) of total energy from fat. The results showed significant differences in the responses of young and adul...

journal_title：Molecular and cellular biochemistry

authors： Brooks SP,Lampi BJ

更新日期：1996-06-07 00:00:00

abstract：:Thymol is a phytochemical component present in many plants used as food additive in order to promote animal growth due to its several biological properties. However, possible side effects of thymol remain poorly known limited to few reports. In this sense, we evaluated the enzymes of the purinergic signaling such as, ...

journal_title：Molecular and cellular biochemistry

authors： Baldissera MD,Souza CF,De Matos AFIM,Baldisserotto B,Stefani LM,da Silva AS

更新日期：2019-02-01 00:00:00

abstract：:In liver fibrosis, the quiescent hepatic stellate cells (HSC) are activated to proliferate and express the activated myofibroblast phenotype, losing fat droplets and the stored vitamin A, and depositing more extracellular matrix. Therapeutic strategies for liver fibrosis are focused on HSC. Pentoxifylline (PTF), an an...

journal_title：Molecular and cellular biochemistry

authors： Cardoso CC,Paviani ER,Cruz LA,Guma FC,Borojevic R,Guaragna RM

更新日期：2003-12-01 00:00:00

abstract：:Platelets are involved in hemostasis, wound healing, and tumor growth. Autologous blood products are commonly used to facilitate healing in a variety of clinical surgery applications. Recently, it was shown that platelet-rich plasma (PRP) has more specific growth factors that participate in the healing process. This s...

journal_title：Molecular and cellular biochemistry

authors： Park SI,Lee HR,Kim S,Ahn MW,Do SH

更新日期：2012-02-01 00:00:00

abstract：:Vaccinia virus (VV) and other pathogenic poxviruses encode for a complement control protein. The VV complement control protein or VCP, was one of the first soluble microbial proteins postulated to have an active role in the immunomodulation of the host defense. Since then, 2 other poxviruses, including variola virus a...

journal_title：Molecular and cellular biochemistry

authors： Kotwal GJ,Miller CG,Justus DE

更新日期：1998-08-01 00:00:00

abstract：:Carbohydrate has been removed from a number of glycoproteins without major effect on the structure or enzyme activity of the protein. Thus carbohydrate has been suggested to underly a non-primary function for proteins, such as in relatively non-specific interactions with other carbohydrates or macromolecules, stabiliz...

journal_title：Molecular and cellular biochemistry

authors： West CM

更新日期：1986-11-01 00:00:00

abstract：:We report here a study of the incorporation and metabolism of various long chain fatty acids in SK-Hep-1 cultured hepatoma cells. Medium supplementation with radiolabelled palmitic, stearic, linoleic, alpha-linolenic and eicosa-8,11,14-trienoic acids (1 microM, 24 H) resulted in an active uptake of each of these precu...

journal_title：Molecular and cellular biochemistry

authors： Marra CA,de Alaniz MJ

更新日期：1992-11-18 00:00:00

abstract：:A high molecular weight protein has been isolated as a major polypeptide comprising 85% of the total extractable proteins in the fruit pericarp of the plant Impatiens balsamina. The protein has been purified to homogeneity following fractionation of the crude cell supernatant with ammonium sulphate, chromatography on ...

journal_title：Molecular and cellular biochemistry

authors： Pal M,Biswas S

更新日期：1994-01-26 00:00:00

abstract：:Acetylcholine-induced, endothelium-dependent relaxation of norepinephrine-precontracted aortic strips, was severely impaired after exposure to a hypoxanthine/xanthine oxidase reaction generating oxygen radicals. This effect was more evident in aortic strips of aging rats (24 months old) in comparison to young rats (3 ...

journal_title：Molecular and cellular biochemistry

authors： Guarnieri C,Giordano E,Muscari C,Grossi L,Caldarera CM

更新日期：1996-04-12 00:00:00

abstract：:Chloroplasts from spinach can be separated into at least three different populations by countercurrent distribution using polymer two-phase systems. The chloroplast particles of the three populations differ in protein/chlorophyll ratio, ultrastructure and metabolism. One population, peak I, consists of intact chloropl...

journal_title：Molecular and cellular biochemistry

authors： Albertsson PA,Larsson C

更新日期：1976-06-15 00:00:00

abstract：:Targeting angiogenesis is considered an effective strategy for treating the expansion and metastasis of tumors. The aim of this study is to assess the effects of perifosine, an inhibitor of Akt, on cell proliferation, apoptosis, angiogenesis, and VEGF-induced cell migration in cultured human umbilical vein endothelial...

journal_title：Molecular and cellular biochemistry

authors： Wang FZ,Fei HR,Li XQ,Shi R,Wang de C

更新日期：2012-09-01 00:00:00

abstract：:Frequenin is a member of the neuronal Ca(2+) sensor protein family, implicated in being the modulator of the neurotransmitter release, potassium channels, phosphatidylinositol signaling pathway and the Ca(2+)-dependent exocytosis of dense-core granules in the PC12 cells. Frequenin exhibits these biological activities ...

journal_title：Molecular and cellular biochemistry

authors： Fik-Rymarkiewicz E,Duda T,Sharma RK

更新日期：2006-10-01 00:00:00

abstract：:To identify PBMC-expressed genes significant for RA, and to ascertain their upstream regulatory factors, as well as downstream functional effects relevant to RA pathogenesis. We performed peripheral blood mononuclear cells (PBMCs) transcriptome-wide mRNA expression profiling in a case-control discovery sample. Differe...

journal_title：Molecular and cellular biochemistry

authors： He P,Wu LF,Bing PF,Xia W,Wang L,Xie FF,Lu X,Lei SF,Deng FY

更新日期：2019-06-01 00:00:00

abstract：:A number of acute and chronic neurodegenerative disorders are caused due to misfolding and aggregation of many intra- and extracellular proteins. Protein misfolding and aggregation processes in cells are strongly regulated by cellular molecular chaperones known as heat-shock proteins (Hsps) that include Hsp60, Hsp70, ...

journal_title：Molecular and cellular biochemistry

authors： Paul S,Mahanta S

更新日期：2014-01-01 00:00:00

abstract：:The uptake of glucose and gluconate is under inductive control in Pseudomonas putida. Glucose, gluconate, and 2-ketogluconate were each good nutritional inducers of these transport abilities. Glucose and gluconate uptake obeyed saturation kinetics: the apparent Km for glucose was 6 mM and that for gluconate was 0.5 mM...

journal_title：Molecular and cellular biochemistry

authors： Vicente M,Pedro MA,Torrontegui G,Cánovas JL

更新日期：1975-04-30 00:00:00

abstract：:A literature search has been conducted to see to what extent steady-state kinetics studies in the period 1965-1976 have revealed deviations from Michaelis-Menten kinetics. It was found that over 800 enzymes have been reported as giving complex curves for a variety of reasons and a group by group classification of all ...

journal_title：Molecular and cellular biochemistry

authors： Hill CM,Waight RD,Bardsley WG

更新日期：1977-05-03 00:00:00

abstract：:The present study is designed to investigate the effect of myocardial preconditioning with oxidative stress induced by pyrogallol or H2O2, on ischaemia-reperfusion induced myocardial injury. Isolated perfused rat heart was subjected to global ischaemia for 30 min followed by reperfusion for 120 min. Coronary effluent ...

journal_title：Molecular and cellular biochemistry

authors： Sharma A,Singh M

更新日期：2001-03-01 00:00:00

abstract：:The aim of this study was to determine the effect of magnesium deficiency on small intestinal morphology and function. Rats were assigned to 4 groups and placed on magnesium sufficient or deficient diet for 1 or 3 weeks. Infiltration of neutrophils and mucosal injury were assessed in stained sections of small intestin...

journal_title：Molecular and cellular biochemistry

authors： Scanlan BJ,Tuft B,Elfrey JE,Smith A,Zhao A,Morimoto M,Chmielinska JJ,Tejero-Taldo MI,Mak IuT,Weglicki WB,Shea-Donohue T

更新日期：2007-12-01 00:00:00