Protein kinase C activation and cardioprotective effect of preconditioning with oxidative stress in isolated rat heart.

abstract：:Adipose-derived stem cells (ADSCs) have been considered as the optimal cells for regenerative medicine because ADSCs have the potential of multi-directional differentiation. To study the mechanisms of ADSCs differentiation, we analyzed microarray of GSE37329. GSE37329 was downloaded from Gene Expression Omnibus includ...

journal_title：Molecular and cellular biochemistry

authors： Ren Y,Han C,Wang J,Jia Y,Kong L,Eerdun T,Wu L,Jiang D

更新日期：2015-02-01 00:00:00

abstract：:In order to compare the role of the Ca(2+)-receptive protein (troponin), in the characteristic myofibrillar contractile response of chicken fast and slow skeletal muscles, the troponin in both kinds of myofibrils were partially exchanged, under slightly acidic conditions. The Ca(2+)- or Sr(2+)-activation of the ATPase...

journal_title：Molecular and cellular biochemistry

authors： Kawashima A,Shiraishi F,Ohtsuki I,Yamamoto K

更新日期：1994-03-30 00:00:00

abstract：:Regulation of matrix metalloproteinase-13 (MMP-13) by collagen matrix in the synovial fibroblasts of rheumatoid arthritis (RA) is critical event in the progressive joint destruction. Our previous study indicated that a collagen receptor, discoidin receptor 2 (DDR2), was highly expressed in the synovial fibroblasts of ...

journal_title：Molecular and cellular biochemistry

authors： Su J,Yu J,Ren T,Zhang W,Zhang Y,Liu X,Sun T,Lu H,Miyazawa K,Yao L

更新日期：2009-10-01 00:00:00

abstract：:The underlying molecular mechanism of carcinogenesis in oral squamous cell carcinoma (OSCC) is poorly understood and appears to be controlled on many genetic, environmental, and hormonal factors. Obestatin and ghrelin, two recently discovered hormones, are co-expressed in endocrine cells. The purpose of this investiga...

journal_title：Molecular and cellular biochemistry

authors： Alnema MM,Aydin S,Ozkan Y,Dagli AF,Ozercan HI,Yildirim N,Sahin I,Karaoglu A,Kilic N,Yilmaz M,Ozercan MR,Donder E

更新日期：2010-06-01 00:00:00

abstract：:The effect of Aclacinomycin B (ACM-B), an anthracycline antitumor antibiotic, on the DNA-dependent RNA synthesis using single- and double-stranded DNAs of known base content and sequence is studied. The data show that ACM-B effectively inhibits the double-stranded DNA-directed RNA synthesis with a preference of poly[d...

journal_title：Molecular and cellular biochemistry

authors： Li LH,Yu FL

更新日期：1989-10-05 00:00:00

abstract：:This study aimed to explore the potential contribution of myofibrils to contractile dysfunction in Ca2+-paradox hearts. Isolated rat hearts were perfused with Krebs-Henseleit solution (Control), followed by Ca2+-depletion, and then Ca2+-repletion after Ca2+-depletion (Ca2+-paradox) by Langendorff method. During heart ...

journal_title：Molecular and cellular biochemistry

authors： Kovács Á,Kalász J,Pásztor ET,Tóth A,Papp Z,Dhalla NS,Barta J

更新日期：2017-06-01 00:00:00

abstract：:Activation of either the A(1) adenosine receptor (A(1)R) or the A(3) adenosine receptor (A(3)R), by their specific agonists CCPA and Cl-IB-MECA, respectively, protects cardiac cells in culture against ischemic injury. Yet the full protective mechanism remains unclear. In this study, we therefore examined the involveme...

journal_title：Molecular and cellular biochemistry

authors： Leshem-Lev D,Hochhauser E,Chanyshev B,Isak A,Shainberg A

更新日期：2010-12-01 00:00:00

abstract：:When cells of the thymus or mouse leukemias P288 and L1210 are exposed in vitro to the potent synthetic glucocorticoid, 3H-Triamcinolone acetonide, the steroid enters the cells passively and binds to macromolecules in the cytoplasm. At 37 degrees C this hormone-receptor complex enters the nucleus and associates with t...

journal_title：Molecular and cellular biochemistry

authors： Turnell RW,Burton AF

更新日期：1975-12-31 00:00:00

abstract：:Glycyrrhizin, a major constituent of licorice (Glycyrrhiza glabra) root, has been reported to ameliorate insulin resistance, hyperglycemia, dyslipidemia, and obesity in rats with metabolic syndrome. Liver dysfunction is associated with this syndrome. The objective of this study is to investigate the effect of glycyrrh...

journal_title：Molecular and cellular biochemistry

authors： Sil R,Ray D,Chakraborti AS

更新日期：2015-11-01 00:00:00

abstract：:Both NADPH oxidase (NOX) and inducible nitric oxide synthase (iNOS) are the main sources of reactive oxygen species in kidney. However, their interactions in oxidative stress and contributions to kidney fibrosis during diabetic nephropathy have not been studied. Human mesangial cells were treated with normal glucose (...

journal_title：Molecular and cellular biochemistry

authors： Gao L,Huang W,Li J

更新日期：2013-10-01 00:00:00

abstract：:In order to initiate the study of the functional differences between myosin alkali light chain isoforms and to investigate the mechanisms of their differential expression, we have isolated cDNA clones for two human alkali light chain isoforms. Here we report DNA sequence and RNA blotting analyses that demonstrate that...

journal_title：Molecular and cellular biochemistry

authors： Wade R,Feldman D,Gunning P,Kedes L

更新日期：1989-06-01 00:00:00

abstract：:Hyperlipidemia is a well-known risk factor for atherosclerosis and statins are widely used to treat patients with elevated levels of lipids in their plasma. Notwithstanding the proven benefits of statin drugs on both primary and secondary prevention of heart disease, the high cost of statin treatment, in addition to p...

journal_title：Molecular and cellular biochemistry

authors： Man RY,Lynn EG,Cheung F,Tsang PS,O K

更新日期：2002-04-01 00:00:00

abstract：:Angiotensin II has previously been reported to have in vivo and in vitro cardiac hypertrophic effects. We used the salt-sensitive Dahl rat genetic strain to separate mechanical (pressure overload) vs. hormonal (renin-angiotensin system) input in cardiac hypertrophy. Blood pressure was significantly increased and left ...

journal_title：Molecular and cellular biochemistry

authors： Peeler TC,Baker KM,Esmurdoc CF,Chernin MI

更新日期：1991-05-29 00:00:00

abstract：:The results of our experiments demonstrated that one hour of ischemia followed by one hour of reflow in the kidney caused a reduction in (Na+K+)ATPase activity and microsomal sulfhydryl content as well as an increase in microsomal lipid peroxidation. Renal venous malondialdehyde concentration was increased soon after ...

journal_title：Molecular and cellular biochemistry

authors： Kato M,Kako KJ

更新日期：1987-12-01 00:00:00

abstract：:Prolonged ischemia-reperfusion results in various damages in skeletal muscle. Following reperfusion, although the damaged muscles undergo regeneration, the precise process and mechanism of regeneration have not yet been fully understood. Here, we show the altered levels of plasma biochemical markers of muscle damage, ...

journal_title：Molecular and cellular biochemistry

authors： Itoh M,Shimokawa N,Tajika Y,Murakami T,Aotsuka N,Lesmana R,Farenia R,Iwasaki T,Okda J,Yorifuji H,Koibuchi N

更新日期：2013-01-01 00:00:00

abstract：:This study focuses on two inflammatory diseases, viz., "diabetes mellitus (DM)" that causes serious complications such as retinopathy, nephropathy, and neuropathy, and "ischemic colitis" which is evoked by DM. Ischemic colitis originates from the reduction in mesenteric blood flow to the colon with existence of the oc...

journal_title：Molecular and cellular biochemistry

authors： Ozel Y,Elcioglu HK,Cevikelli ZA,Kudas I,Ahmad S,Uzun H,Topal C,Aktas S,Kabasakal L

更新日期：2018-02-01 00:00:00

abstract：:Hyperhomocysteinemia is associated with various pathologies including cardiovascular disease, stroke, and cognitive dysfunctions. Systemic administration of homocysteine can trigger seizures in animals, and patients with homocystinuria suffer from epileptic seizures. Available data suggest that homocysteine can be har...

journal_title：Molecular and cellular biochemistry

authors： Rasić-Marković A,Stanojlović O,Hrncić D,Krstić D,Colović M,Susić V,Radosavljević T,Djuric D

更新日期：2009-07-01 00:00:00

abstract：:Adenylate kinases (AK, EC 2.7.4.3) have been considered important enzymes for energy homeostasis and metabolic signaling. To gain a better understanding of their cell-specific significance we studied the structural and functional aspects of products of one adenylate kinase gene, AK1, in mouse tissues. By combined comp...

journal_title：Molecular and cellular biochemistry

authors： Janssen E,Kuiper J,Hodgson D,Zingman LV,Alekseev AE,Terzic A,Wieringa B

更新日期：2004-01-01 00:00:00

abstract：:Frequent abnormalities in 7p12 locus in different tumors like lung cancer candidate this region for novel regulatory elements. MiRNAs as novel regulatory elements encoded within the human genome are potentially oncomiRs or miR suppressors. Here, we have used bioinformatics tools to search for the novel miRNAs embedded...

journal_title：Molecular and cellular biochemistry

authors： Hoballa MH,Soltani BM,Mowla SJ,Sheikhpour M,Kay M

更新日期：2018-07-01 00:00:00

abstract：:Recently it has been demonstrated that hydroxylamine is an activator of triglyceride catabolism. We have studied the effect of hydroxylamine on isocitrate lyase activity and lipid catabolism and have noted a stimulation of isocitrate lyase biosynthesis by 5 mM hydroxylamine. The specificity of this effect was tested w...

journal_title：Molecular and cellular biochemistry

authors： Vanni P,Vincenzini MT,Vincieri F,Baccari V

更新日期：1977-04-12 00:00:00

abstract：:NAD kinase (NADK, EC 2.7.1.23) is the sole NADP(+)-biosynthetic enzyme that catalyzes phosphorylation of NAD(+) to yield NADP(+) using ATP as a phosphoryl donor, and thus, plays a vital role in the cell and represents a potentially powerful antimicrobial drug target. Although methods for expression and purification of...

journal_title：Molecular and cellular biochemistry

authors： Ohashi K,Kawai S,Koshimizu M,Murata K

更新日期：2011-09-01 00:00:00

abstract：:The PPAR-gamma receptor agonists, as a relatively new and perhaps still not very widely used class of antidiabetic agent in the Caribbean and particularly the Trinidadian context, possess pharmacologic properties that certainly have been shown to have impact on many of the inflammatory, metabolic, biochemical and stru...

journal_title：Molecular and cellular biochemistry

authors： Smith SI

更新日期：2004-08-01 00:00:00

abstract：:Plants in the form of food or other remedial forms have been used for the treatment of various human ailments. Diabetes is one such disorder in which various form of plants and herbal remedies have been tried. Brassicajuncea (BJ) seeds (Rai) are consumed in India as a spice in various food items. Previous studies have...

journal_title：Molecular and cellular biochemistry

authors： Grover JK,Yadav S,Vats V

更新日期：2002-12-01 00:00:00

abstract：:3H-1,2-Dithiole-3-thione (D3T), a potent member of dithiolethiones, induces phase 2 enzymes by activating an Nrf2/Keap1-dependent signaling pathway. It was proposed that interaction between D3T and two adjacent sulfhydryl groups of Keap1 might cause dissociation of Keap1 from Nrf2, leading to Nrf2 activation. This stu...

journal_title：Molecular and cellular biochemistry

authors： Jia Z,Zhu H,Trush MA,Misra HP,Li Y

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:To assess the oxidative effects of raloxifene use in postmenopausal women by investigating protein carbonyl levels in the plasma. METHODS:Nineteen osteoporotic postmenopausal women treated with raloxifene for 12 months were included in the study. Another seventeen postmenopausal women matched for age and po...

journal_title：Molecular and cellular biochemistry

authors： Korucuoğlu U,Ciftçi B,Gülbahar O,Biri A,Nas T,Gürsoy R,Aricioğlu A

更新日期：2006-10-01 00:00:00

abstract：:Lipoprotein(a) [Lp(a)] is a highly atherogenic lipoprotein, whose metabolism is poorly understood. Efficient and secure drugs that can lower elevated plasma Lp(a) concentrations are currently lacking. Fibroblast growth factor-21 (FGF-21), a member of the FGFS super family, regulates glucose and lipid metabolism in hep...

journal_title：Molecular and cellular biochemistry

authors： Lin X,Li G,He X,Ma X,Zhang K,Zhang H,Zeng G,Wang Z

更新日期：2014-08-01 00:00:00

abstract：:Myostatin (MSTN) is primarily expressed in muscle and plays an important role in muscle and fat development in pigs. However, there is little information about the regulation of pig MSTN. In order to elucidate whether pig MSTN could be regulated by muscle- and fat-related factors, the porcine MSTN promoter was amplifi...

journal_title：Molecular and cellular biochemistry

authors： Deng B,Wen J,Ding Y,Gao Q,Huang H,Ran Z,Qian Y,Peng J,Jiang S

更新日期：2012-04-01 00:00:00

abstract：:From pharmacological investigations and clinical studies, it is known that angiotensin converting enzyme (ACE) inhibitors exhibit additional local actions, which are not related to hemodynamic changes and which cannot be explained only by interference with the renin angiotensin system (RAS) by means of an inhibition o...

journal_title：Molecular and cellular biochemistry

authors： Linz W,Wiemer G,Schaper J,Zimmermann R,Nagasawa K,Gohlke P,Unger T,Schölkens BA

更新日期：1995-06-07 00:00:00

abstract：:Glioblastomas are the most malignant and most frequent brain tumors and exciting targets of gene and immunotherapy. Despite rapid development of experimental therapy little is known about the cellular behaviour of therapeutic oligodeoxynucleotides (ODNs). Here we designed uptake, cellular distribution and cellular bin...

journal_title：Molecular and cellular biochemistry

authors： Zhang Z,Weinschenk T,Schluesener HJ

更新日期：2005-04-01 00:00:00

abstract：:Our study evaluated the relationship between the endogenous production of prostacyclin and the antiarrhythmic effect of ischemic preconditioning against ischemic and reperfusion-induced tachyarrhythmia. Langendorff perfused rat hearts underwent 30 min regional ischemia with reperfusion. Preconditioning was induced by ...

journal_title：Molecular and cellular biochemistry

authors： Arad M,Oxman T,Leor R,Rabinowitz B

更新日期：1996-07-01 00:00:00