Abstract:
:Plants in the form of food or other remedial forms have been used for the treatment of various human ailments. Diabetes is one such disorder in which various form of plants and herbal remedies have been tried. Brassicajuncea (BJ) seeds (Rai) are consumed in India as a spice in various food items. Previous studies have shown the hypoglycemic effect of this plant in rats. The present study was undertaken to study the hypoglycemic and antihyperglycemic of various strengths (5, 10 and 15%) of BJ seed diet in alloxan and streptozotocin induced diabetes in albino rats. In addition, key enzymes of carbohydrate metabolism (glucokinase--EC 2.7.1.1, hexokinase--EC 2.7.1.1, and phosphofructokinase--EC 2.7.1.11) and hepatic glycogen content was also assessed to understand the mechanism of action. BJ diet (10 and 15%) showed significant antihyperglycemic effect in alloxan (35 mg/kg) but not in STZ (60 mg/kg) rats. It also failed to modulate the hepatic glycogen content and enzyme activities.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Grover JK,Yadav S,Vats Vdoi
10.1023/a:1020814709118keywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
95-101issue
1-2eissn
0300-8177issn
1573-4919journal_volume
241pub_type
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