p53 and cell-cycle-regulated protein expression in small intestinal cells after fast-neutron irradiation in mice.

abstract：:Tumor suppressor p53 plays important roles in cell cycle regulation, apoptosis and DNA repair in different cell types including lung cancer. There are different p53 apoptotic pathways in high and low metastatic ability lung cancer cells. However, the exactly mechanism in the pathway is still unclear. Here we found tha...

journal_title：Molecular and cellular biochemistry

authors： Huang Y,Jin Y,Yan CH,Yu Y,Bai J,Chen F,Zhao YZ,Fu SB

更新日期：2008-02-01 00:00:00

abstract：:Interferon-stimulated gene15 (ISG15) is the first characterized ubiquitin-like protein, which is strongly induced by type I interferons (IFN-α/β), bacterial endotoxin, and cellular stress. Up-regulation of ISG15 is observed in several cancer cell types and is associated with cancer progression. As many cytokines can i...

journal_title：Molecular and cellular biochemistry

authors： Chairatvit K,Wongnoppavich A,Choonate S

更新日期：2012-09-01 00:00:00

abstract：:Sodium cyanide (NaCN)-induced chemical hypoxia is known to increase intracellular free calcium concentration and reduce cell survival, but its effect on gene expression has not been studied. In this study, we designed primers to conduct a rapid and reliable assay for the expression of mRNA of inducible nitric oxide sy...

journal_title：Molecular and cellular biochemistry

authors： Kiang JG,Warke VG,Tsokos GC

更新日期：2003-12-01 00:00:00

abstract：:Experiments were designed to determine if cotton bract tannin, a component of cotton mill dust, would promote the phosphorylation of alveolar macrophage proteins in doses potentially achievable in vivo. Rabbit alveolar macrophages were loaded with 32PO4 and challenged with various doses of tannin for time periods rang...

journal_title：Molecular and cellular biochemistry

authors： Hempel SL,Rohrbach MS

更新日期：1989-04-11 00:00:00

abstract：:Biochemical and ultrastructural studies indicate that the atrophy of adrenal cortex in hypoyhysectomized rats involves the following changes: (1) One to two days after hypophysectomy, there is loss of "template activity" resulting from cumulative DNA-damage and heterochromatinization. In vivo ACTH-administration led t...

journal_title：Molecular and cellular biochemistry

authors： Tchen TT,Chan SW,Kuo TH,Mostafapour KM,Drzewiecki VH

更新日期：1977-04-12 00:00:00

abstract：:The pyridine nucleotides have important non-redox activities as cellular effectors and metabolic regulators [1-3]. The enzyme-catalyzed cleavage of the nicotinamide-ribosyl bond of NAD+ and the attendant delivery of the ADPRibosyl moiety to acceptors is central to these many diverse biological activities. Included are...

journal_title：Molecular and cellular biochemistry

authors： Oppenheimer NJ

更新日期：1994-09-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been indicated as important signal mediators for many cell surface receptors. We previously demonstrated that ROS are generated by cross-linking surface receptor CD40 and consequently induce c-Jun N-terminal kinase activation and interleukin-6 secretion in murine B cells. In this stu...

journal_title：Molecular and cellular biochemistry

authors： Lee JR

更新日期：2003-10-01 00:00:00

abstract：:microRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by targeting mRNAs, inhibiting the expression of the associated proteins. Although a role for aberrant miRNA expression in cancer has been postulated, the pathophysiologic role and relevance of aberrantly expressed miRNAs in tumor biology has n...

journal_title：Molecular and cellular biochemistry

authors： Wang C,Bian Z,Wei D,Zhang JG

更新日期：2011-06-01 00:00:00

abstract：:The effects of different dietary fats on peritoneal macrophage plasma membrane fluidity, intracellular cyclic AMP (cAMP) production, GTP hydrolysis and TNF binding and TNF-induced IL1 and IL6 production was investigated. After a four week period, fluidity, as determined by both fluorescence recovery after photobleachi...

journal_title：Molecular and cellular biochemistry

authors： Tappia PS,Ladha S,Clark DC,Grimble RF

更新日期：1997-01-01 00:00:00

abstract：:S-glutathionylation, the formation of mixed disulfides of glutathione with cysteine residues of proteins, is a broadly observed physiological modification that occurs in response to oxidative stress. Since cysteine residues are particularly susceptible to oxidative modification by reactive oxygen species, S-glutathion...

journal_title：Molecular and cellular biochemistry

authors： Leonberg AK,Chai YC

更新日期：2007-10-01 00:00:00

abstract：:The collagen metabolism alterations triggered by reactive oxygen species are involved in the development of various connective tissue diseases and skin aging. This study was designed to examine whether (E)-anethole possesses a protective effect on H2O2-induced alterations in collagen metabolism as well as whether it c...

journal_title：Molecular and cellular biochemistry

authors： Galicka A,Krętowski R,Nazaruk J,Cechowska-Pasko M

更新日期：2014-09-01 00:00:00

abstract：:Colchicine has been demonstrated to suppress the release of fibroblast growth factors, retard collagen formation and augment collagenase activity. Trials with colchicine in patients with hepatic fibrosis have suggested clinical benefit. The development of impaired myocardial function in the spontaneously hypertensive ...

journal_title：Molecular and cellular biochemistry

authors： Cicogna AC,Brooks WW,Hayes JA,Robinson KG,Sen S,Conrad CH,Bing OH

更新日期：1997-01-01 00:00:00

abstract：:Secretory phospholipase A2 (sPLA2) is a key enzyme participating in the inflammatory cascade followed by the action of cyclooxygenase-2 and lipoxygenases. Therefore, inhibitors of sPLA2 could be used as potent anti-inflammatory agents to treat the early phase of inflammation. In this study, we have prepared the fenopr...

journal_title：Molecular and cellular biochemistry

authors： Kameshwar VH,R KJ,Priya BS,Swamy SN

更新日期：2017-02-01 00:00:00

abstract：:Existing kinetic data of cholesteryl ester formation by lecithin:cholesterol acyltransferase in discoidal high-density lipoproteins with 34 mutations of apoA-I that involved all putative helices were grouped by cluster analysis into four noncoincident regions with mutations both without any functional impairment and w...

journal_title：Molecular and cellular biochemistry

authors： Dergunov AD

更新日期：2013-06-01 00:00:00

abstract：:Oxidants and inflammatory mediators such as tumour necrosis factor-alpha (TNF-alpha) activate nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1) transcription factors, and enhance the expression of both pro-inflammatory and protective antioxidant genes. Remodelling of chromatin within the nucleus, contr...

journal_title：Molecular and cellular biochemistry

authors： Rahman I,Gilmour PS,Jimenez LA,MacNee W

更新日期：2002-05-01 00:00:00

abstract：:Glucocorticoids inhibit transcription of the genes encoding rRNA (rDNA) in P1798 lymphoma cells. This is due to a decrease in the amount or activity of a transcription factor, called TFIC. TFIC has been purified to apparent homogeneity and the properties of this protein have been investigated in detail. TFIC is tightl...

journal_title：Molecular and cellular biochemistry

authors： Mahajan PB,Thompson EA

更新日期：1991-05-29 00:00:00

abstract：:Endothelial progenitor cell (EPC) transplantation has shown advantages in the treatment of myocardial infarction (MI) in animal models and clinical trials through mechanisms of direct intercellular contacts, autocrine, and paracrine. However, the effects of EPC transplantation for MI treatment remain controversial and...

journal_title：Molecular and cellular biochemistry

authors： Zhou W,Zheng X,Cheng C,Guo G,Zhong Y,Liu W,Liu K,Chen Y,Liu S,Liu S

更新日期：2020-10-23 00:00:00

abstract：:In this paper we review our experiments on the light-induced Ca2+ release and proton uptake at the rod outer segment (ROS) disk membrane using flash-spectrophotometry and the indicating dyes arsenazo III and bromcresol purple. We used three different ROS preparations in order to locate the intracellular site of Ca2+ r...

journal_title：Molecular and cellular biochemistry

authors： Schnetkamp PP,Kaupp UB

更新日期：1983-01-01 00:00:00

abstract：:Glioblastoma is the most common and deadly type of brain cancer. The poor prognosis may be largely attributed to inadequate disease response to current chemotherapeutic agents. Activation of p38 is associated with deleterious outcomes in glioblastoma patients, as its signaling mediates chemoresistance mechanisms. Anti...

journal_title：Molecular and cellular biochemistry

authors： Su BC,Chen JY

更新日期：2020-01-01 00:00:00

abstract：:Endochondral ossification, an important stage of fracture healing, is regulated by a variety of signaling pathways. Transforming growth factor β (TGFβ) superfamily plays important roles and comprises TGFβs, bone morphogenetic proteins (BMPs), and growth differentiation factors. TGFβs primarily regulate cartilage forma...

journal_title：Molecular and cellular biochemistry

authors： Sheu TJ,Zhou W,Fan J,Zhou H,Zuscik MJ,Xie C,Yin G,Berk BC

更新日期：2014-12-01 00:00:00

abstract：:In the present study it was investigated if Vitamin A supplementation could protect rat kidney microsomes and mitochondria from in vitro lipoperoxidation. After incubation of rat kidney microsomes and mitochondria in an ascorbate-Fe+2 system, at 37 degrees C during 60 min, it was observed that the total cpm/mg protein...

journal_title：Molecular and cellular biochemistry

authors： Piergiacomi VA,Palacios A,Catalá A

更新日期：1996-12-20 00:00:00

abstract：:delta-Crystallin is a major structural protein of avian and reptilian lenses that is absent from the lenses of fish, amphibia and mammals. It appears to be a tetrameric protein with a native molecular weight near 200 000 (200K) and polypeptide molecular weight near 50K and 48K) (see Note added in proof). The alpha-cry...

journal_title：Molecular and cellular biochemistry

authors： Piatigorsky J

更新日期：1984-01-01 00:00:00

abstract：:Those genes which are transcribed by RNA polymerase III continue to give surprising results with respect to their cis-acting elements and transacting factors. As a result, a broader view of class III promoters has emerged and the internal promoters are not universal in classical polymerase III genes. The involvement o...

journal_title：Molecular and cellular biochemistry

authors： Shastry BS

更新日期：1993-07-07 00:00:00

abstract：:Increased matrix metalloproteinase (MMP) levels are involved in vascular remodeling of hypertension. In this study, we hypothesized that doxycycline (a MMP inhibitor) could exert antioxidant effects, reverse establish vascular remodeling, and lower blood pressure in spontaneously hypertensive rats (SHR). SHR and Wista...

journal_title：Molecular and cellular biochemistry

authors： Antonio RC,Ceron CS,Rizzi E,Coelho EB,Tanus-Santos JE,Gerlach RF

更新日期：2014-01-01 00:00:00

abstract：:Partially purified D-aspartate oxidase from beef kidney has been tested in the presence of butanedione or phenylglyoxal, which specifically modify the arginine molecule. The results obtained clearly indicate that arginine residues are involved in the binding of the substrate to the active site of the enzyme. ...

journal_title：Molecular and cellular biochemistry

authors： Crifò C,Santoro L,Rinaldi A,De Marco C

更新日期：1977-08-19 00:00:00

abstract：:Evidence suggests that functional atrial natriuretic peptide (ANP) receptors occur in surface gastric mucosal epithelial cells. To evaluate functional aspects of ANP in a model of these cells we examined the expression of natriuretic peptide receptors (NPR) subtypes A and C in the non-transformed rat gastric mucosal e...

journal_title：Molecular and cellular biochemistry

authors： Gower WR Jr,Carter GM,McAfee Q,Solivan SM

更新日期：2006-12-01 00:00:00

abstract：:To investigate the involvement of transforming growth factor-β1 (TGF-β1) and tissue inhibitor of metalloproteinase 4 (TIMP-4) in influencing the severity of atrial fibrosis in rheumatic heart disease (RHD) patients with atrial fibrillation (AF). The degree of myocardial fibrosis was evaluated using Masson staining. Th...

journal_title：Molecular and cellular biochemistry

authors： Sun Y,Huang ZY,Wang ZH,Li CP,Meng XL,Zhang YJ,Su F,Ma N

更新日期：2015-08-01 00:00:00

abstract：:Several peptides derived from microtubule-associated tau protein, have been tested as substrates for glycogen synthase kinase 3 (GSK 3). In the absence of cofactors, GSK 3 can modify serines or threonines followed by prolines. In other cases, a phosphorylation in position +4 is required for the phosphorylation of thre...

journal_title：Molecular and cellular biochemistry

authors： Moreno FJ,Muñoz-Montaño JR,Avila J

更新日期：1996-12-06 00:00:00

abstract：:Experiments were conducted to study the functional implication of a mannose-binding glycoprotein found in the day 4 post coital (p.c.) rat uterus, using a mono-specific polyclonal antibody raised against the glycoprotein. Western Blot and immunohistochemical techniques were employed to study the distribution of the gl...

journal_title：Molecular and cellular biochemistry

authors： Mehta M,Chowdhury M

更新日期：1999-05-01 00:00:00

abstract：:Partial obstruction of the rabbit bladder outlet induces a rapid hypertrophy characterized by increased bladder mass, increased smooth muscle content, and increased collagen deposition. In addition, partial outlet obstruction induces decreased contractile responses to both field stimulation and postsynaptic receptor s...

journal_title：Molecular and cellular biochemistry

authors： Zhao Y,Chacko S,Levin RM

更新日期：1994-01-12 00:00:00