Synthesis, characterization and bioactivity studies of novel 1,3,4-oxadiazole small molecule that targets basic phospholipase A2 from Vipera russelli.

abstract：:The effects of Mg2+ and Ca2+ deprivation on survival and growth of normal and transformed cultured cells were studied. Normal fibroblast from several origins (mouse, hamster and human) did not grow in 2 microM Mg2+ medium, whereas transformed fibroblasts (mouse and rat) and tumor cells of other types (mouse adrenocort...

journal_title：Molecular and cellular biochemistry

authors： Ribeiro SM,Armelin HA

更新日期：1984-01-01 00:00:00

abstract：:The genome sequence of Mycobacterium tuberculosis revealed the presence of several hydrolases involved in lipid metabolism including the members of Lip gene family. Rv0646c (LipG) is one of them. It is annotated as putative esterase/lipase because of the presence of consensus sequence 'GXSXG.' The gene was cloned, exp...

journal_title：Molecular and cellular biochemistry

authors： Rastogi R,Kumar A,Kaur J,Saini V,Kaur J,Bhatnagar A

更新日期：2018-10-01 00:00:00

abstract：:The present study was addressed to understand the interrelationship between Receptor-Ck activation, mevalonate pathway and primary response genes such as c-fos, c-myc and cyclin 'D' involved in the cell cycle. The results reported here unambiguously revealed that the phosphatidic acid (generated through the activation...

journal_title：Molecular and cellular biochemistry

authors： Kaur M,Kaul D,Sobti RC

更新日期：1998-04-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) derived from dental tissues show promise for use in tooth-related tissue regeneration, but the molecular mechanisms underlying their directed differentiation remain unclear, limiting their usefulness. Sonic Hedgehog (Shh) signaling is a major signaling pathway that regulates cell differen...

journal_title：Molecular and cellular biochemistry

authors： Jiang Q,Du J,Yin X,Shan Z,Ma Y,Ma P,Du J,Fan Z

更新日期：2013-11-01 00:00:00

abstract：:The apparent membrane fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene has been reported to be lower in intact erythrocytes than in isolated erythrocyte membranes. Although this difference was once suggested to be caused by the fluidizing effect associated with the loss of erythrocyte proteins during membrane ...

journal_title：Molecular and cellular biochemistry

authors： Dickens BF,Snow TR,Green V,Weglicki WB

更新日期：1988-01-01 00:00:00

abstract：:A wide variety of metals have been reported to act as mutagenic and carcinogenic agents in both human and animal studies. The underlying mechanisms are being extensively investigated. Recently, a new sub-discipline of molecular carcinogenesis has surfaced and new techniques and instruments are being developed which al...

journal_title：Molecular and cellular biochemistry

authors： Leonard SS,Bower JJ,Shi X

更新日期：2004-01-01 00:00:00

abstract：:Increasing evidence has shown that normal stem cells may act as cancer-initiating cells and contribute to the development and progression of cancer. HBx has a close relationship with hepatocellular carcinoma, however, the role of HBx in hepatic progenitor cells (HPCs) is poorly understood. In this study, we sought to ...

journal_title：Molecular and cellular biochemistry

authors： Shen L,Zhang X,Hu D,Feng T,Li H,Lu Y,Huang J

更新日期：2013-11-01 00:00:00

abstract：:In the present study we investigated if administration of vitamin A could protect rat liver microsomes and mitochondria from in vitro peroxidation. Appreciable decrease of chemiluminescence and lipid peroxidation was measured in microsomal membranes from rats receiving vitamin A, with respect to control animals. In me...

journal_title：Molecular and cellular biochemistry

authors： Palacios A,Piergiacomi VA,Catalá A

更新日期：1996-01-12 00:00:00

abstract：:ING proteins are tumor suppressors involved in the regulation of gene transcription, cell cycle arrest, apoptosis, and senescence. Here, we show that ING1b expression is upregulated by several DNA-damaging agents, in a p53-independent manner. ING1b stimulates DNA repair of a variety of DNA lesions requiring activation...

journal_title：Molecular and cellular biochemistry

authors： Ceruti JM,Ogara MF,Menéndez C,Palmero I,Cánepa ET

更新日期：2013-06-01 00:00:00

abstract：:It has been shown that elevation of plasma methionine (Met) and its metabolites may occur in several genetic abnormalities. In this study we investigated the in vitro and in vivo effects of the Met and methionine sulfoxide (MetO) on oxidative stress parameters in the liver of rats. For in vitro studies, liver homogena...

journal_title：Molecular and cellular biochemistry

authors： Costa MZ,da Silva TM,Flores NP,Schmitz F,da Silva Scherer EB,Viau CM,Saffi J,Barschak AG,de Souza Wyse AT,Spanevello RM,Stefanello FM

更新日期：2013-12-01 00:00:00

abstract：:Osteoblast differentiation is an essential event in the developmental process, which is favoured by the production of extra cellular matrix proteins and various enzymes including discrete ones like acetylcholinesterase (AChE). Despite the fact that AChE facilitates osteoblast differentiation, the significance of its c...

journal_title：Molecular and cellular biochemistry

authors： Chinnadurai RK,Saravanaraman P,Boopathy R

更新日期：2018-03-01 00:00:00

abstract：:In liver fibrosis, the quiescent hepatic stellate cells (HSC) are activated to proliferate and express the activated myofibroblast phenotype, losing fat droplets and the stored vitamin A, and depositing more extracellular matrix. Therapeutic strategies for liver fibrosis are focused on HSC. Pentoxifylline (PTF), an an...

journal_title：Molecular and cellular biochemistry

authors： Cardoso CC,Paviani ER,Cruz LA,Guma FC,Borojevic R,Guaragna RM

更新日期：2003-12-01 00:00:00

abstract：:The optical properties, copper content, catalytic activity and quaternary structure of many preparations of ascorbate oxidase purified with two different methods were examined. Fresh samples appeared identical and were characterized by optical ratios A280/A610 = 25 +/- 1 and A330/A610 = 0.8 +/- 0.05, by specific activ...

journal_title：Molecular and cellular biochemistry

authors： Avigliano L,Vecchini P,Sirianni P,Marcozzi G,Marchesini A,Mondovi B

更新日期：1983-01-01 00:00:00

abstract：:Human telomerase reverse transcriptase is an essential rate-limiting component of telomerase complex. hTERT protein in association with other proteins and the human telomerase RNA (hTR) shows telomerase activity, essential for maintaining genomic integrity in proliferating cells. hTERT binds hTR through a decapeptide ...

journal_title：Molecular and cellular biochemistry

authors： Varshney A,Bala J,Santosh B,Bhaskar A,Kumar S,Yadava PK

更新日期：2017-03-01 00:00:00

abstract：:1. Glucokinase is one of four glucose phosphorylating enzymes present in rat liver. Its distinctive features are a high K-m for glucose (high-K-m isozyme) and a rather narrow substrate specificity. In contrast, the other three enzymes, collectively called hexokinases or low-K-m isozymes, exhibit low K-m values for glu...

journal_title：Molecular and cellular biochemistry

authors： Niemeyer H,Ureta T,Clark-Turri L

更新日期：1975-02-28 00:00:00

abstract：:p90 ribosomal S6 kinase (p90RSK) constitutes a family of serine/threonine kinases that have been shown to be involved in cell proliferation of various malignancies via direct or indirect effects on the cell-cycle machinery. We investigated the role of p90RSK in lung adenocarcinomas and whether the inhibition of p90RSK...

journal_title：Molecular and cellular biochemistry

authors： Abdulrahman N,Jaballah M,Poomakkoth N,Riaz S,Abdelaziz S,Issa A,Mraiche F

更新日期：2016-07-01 00:00:00

abstract：:Apoptosis-inducing agents have been reported to cause rapid shedding of tumor necrosis factor receptor 1 (TNFR1) in endothelial cells (EC). Oxidized LDL (oxLDL) has also been known to induce apoptosis of EC and to inhibit proliferation of EC. In the present study, we show that oxLDL also causes shedding of TNFR1 in EC...

journal_title：Molecular and cellular biochemistry

authors： Sugano M,Tsuchida K,Makino N

更新日期：2004-03-01 00:00:00

abstract：:Poly(ADP-ribosyl)ation is a eukaryotic posttranslational protein modification catalyzed by poly(ADP-ribose) polymerase (PARP), a highly conserved nuclear enzyme which uses NAD as substrate. We have previously tested PARP activity in permeabilized mononuclear blood cells (MNC) from 13 mammalian species as a function of...

journal_title：Molecular and cellular biochemistry

authors： Bürkle A,Müller M,Wolf I,Küpper JH

更新日期：1994-09-01 00:00:00

abstract：:Hepatocyte cell adhesion molecule (HepaCAM) plays a crucial role in tumor progression and has been recognized as a novel tumor suppressor gene. The high protein expression level of protein kinase Cε (PKCε) has been discovered in many tumor types. In the present study, we determined HepaCAM and PKCε protein levels in h...

journal_title：Molecular and cellular biochemistry

authors： Tan B,Tan J,Du H,Quan Z,Xu X,Jiang X,Luo C,Wu X

更新日期：2014-06-01 00:00:00

abstract：:It has been reported that HER2 level is strongly correlated with the expression of MMP-7 in some carcinomas. HER2 is a preferred heterodimerization partner of EGFR, HER3, and HER4. HER2 overexpression is believed to enhance the signaling from these receptors in response to binding of their specific ligands. In this st...

journal_title：Molecular and cellular biochemistry

authors： Yuan G,Qian L,Song L,Shi M,Li D,Yu M,Hu M,Shen B,Guo N

更新日期：2008-11-01 00:00:00

abstract：:The characterization of mutations in Japanese patients with lipidosis, particularly in metachromatic leukodystrophy (MLD) and Gaucher disease has been studied in detail. Metachromatic leukodystrophy is characterized by an accumulation of sulfatide in nervous tissues and kidney due to a deficiency of arylsulfatase A (A...

journal_title：Molecular and cellular biochemistry

authors： Eto Y,Kawame H,Hasegawa Y,Ohashi T,Ida H,Tokoro T

更新日期：1993-02-17 00:00:00

abstract：:Using a synthetic peptide that encompasses the zinc finger domain of the eukaryotic transcription factor Sp1, we produced a number of monoclonal antibodies that specifically reacted with the target antigen. Analysis by competitive inhibition assay of five of the monoclonal antibodies revealed that they all recognized ...

journal_title：Molecular and cellular biochemistry

authors： Katai H,Terato K,Raghow R

更新日期：1991-02-27 00:00:00

abstract：:This study aims to investigate the unclear molecular relationship involved in the activation of intrinsic pathway of apoptosis and NSAID-activated gene-1 (NAG-1) induction as a putative target in NSAIDs-mediated chemoprevention of colorectal cancer. Male Sprague-Dawley rats were administered with a colon-specific pro-...

journal_title：Molecular and cellular biochemistry

authors： Vaish V,Piplani H,Rana C,Vaiphei K,Sanyal SN

更新日期：2013-06-01 00:00:00

abstract：:Mitoapocynin is a triphenylphosphonium conjugated derivative of apocynin that specifically locates to the mitochondria. It has been developed as a mitochondrially targeted therapeutic antioxidant. We attempted to attenuate the mitochondrial ROS induced in H9c2 cardiac myoblast cells treated with norepinephrine. Mitoap...

journal_title：Molecular and cellular biochemistry

authors： Mahmood A,Bisoyi P,Banerjee R,Yousuf M,Goswami SK

更新日期：2021-01-30 00:00:00

abstract：:Retinol (vitamin A) is involved in several cellular processes, like cell division, differentiation, transformation and apoptosis. Although it has been shown that retinol is a limitant factor for all these processes, the precise mechanisms by which retinol acts are still unknown. In the present study we hypothesised th...

journal_title：Molecular and cellular biochemistry

authors： de Oliveira RB,Klamt F,Castro MA,Polydoro M,Zanotto Filho A,Gelain DP,Dal-Pizzol F,Moreira JC

更新日期：2005-03-01 00:00:00

abstract：:Overexpressed cysteine-rich protein 61 (Cyr61) is believed to enhance osteosarcoma (OS) cell metastasis, but the mechanism of Cyr61 overexpression in OS is not clear so far. In this study 33 OS samples were analyzed by immunostaining and focused on two parts: the correlation between overexpression of Cyr61 and OS meta...

journal_title：Molecular and cellular biochemistry

authors： Chen J,Song Y,Yang J,Gong L,Zhao P,Zhang Y,Su H

更新日期：2013-12-01 00:00:00

abstract：:Inactivation of the Staphylococcus aureus tricarboxylic acid (TCA) cycle delays the resolution of cutaneous ulcers in a mouse soft tissue infection model. In this study, it was observed that cutaneous lesions in mice infected with wild-type or isogenic aconitase mutant S. aureus strains contained comparable inflammato...

journal_title：Molecular and cellular biochemistry

authors： Massilamany C,Gangaplara A,Gardner DJ,Musser JM,Steffen D,Somerville GA,Reddy J

更新日期：2011-09-01 00:00:00

abstract：:We have examined a possibility whether or not severity and extent of coronary atherosclerosis may associate with degree of local inflammation in relation to endothelial dysfunction as is indicated by reduced NO formation. Blood samples were obtained from aortic root (Ao) and coronary sinus (CS) of 39 patients who unde...

journal_title：Molecular and cellular biochemistry

authors： Matsubara T,Ishibashi T,Hori T,Ozaki K,Mezaki T,Tsuchida K,Nasuno A,Kubota K,Tanaka T,Miida T,Aizawa Y,Nishio M

更新日期：2003-07-01 00:00:00

abstract：:Fasting is accompanied by a decrease in collagen biosynthesis. The mechanism of this phenomenon involves inhibition of prolidase activity, an enzyme that plays a key role in upregulation of collagen metabolism. The mechanism of fasting-induced inhibition of prolidase activity is not known. Phosphoenolpyruvate (PEP) is...

journal_title：Molecular and cellular biochemistry

authors： Cechowska-Pasko M,Palka J,Bańkowski E

更新日期：2004-10-01 00:00:00

abstract：:Heat-shock protein90 (HSP90) plays an essential role in maintaining stability and activity of its clients. HSP90 is involved in cell differentiation and survival in a variety of cell types. To elucidate the possible role of HSP90 in myogenic differentiation and cell survival, we examined the time course of changes in ...

journal_title：Molecular and cellular biochemistry

authors： Wagatsuma A,Shiozuka M,Kotake N,Takayuki K,Yusuke H,Mabuchi K,Matsuda R,Yamada S

更新日期：2011-12-01 00:00:00