Shh signaling, negatively regulated by BMP signaling, inhibits the osteo/dentinogenic differentiation potentials of mesenchymal stem cells from apical papilla.

abstract：:Clinically significant occlusive vascular lesions contain more extracellular matrix (ECM) proteins and lipid deposition than healthy vascular tissue. The events leading to this condition remain unresolved. One possibility is that ECM deposition may exceed ECM degradation which would contribute to the expansion of the ...

journal_title：Molecular and cellular biochemistry

authors： Wilson D,Massaeli H,Russell JC,Pierce GN,Zahradka P

更新日期：2003-07-01 00:00:00

abstract：:The effect of Aclacinomycin B (ACM-B), an anthracycline antitumor antibiotic, on the DNA-dependent RNA synthesis using single- and double-stranded DNAs of known base content and sequence is studied. The data show that ACM-B effectively inhibits the double-stranded DNA-directed RNA synthesis with a preference of poly[d...

journal_title：Molecular and cellular biochemistry

authors： Li LH,Yu FL

更新日期：1989-10-05 00:00:00

abstract：:Lysophosphatidic acid (LPA) signaling through LPA receptors (LPA1 to LPA6) regulates a variety of malignant properties in cancer cells. Recently, we show that LPA2 expression is elevated by long-term cisplatin (CDDP) treatment in melanoma A375 cells. In the present study, we investigated whether LPA2-mediated signalin...

journal_title：Molecular and cellular biochemistry

authors： Minami K,Ueda N,Ishimoto K,Tsujiuchi T

更新日期：2020-06-01 00:00:00

abstract：:The PI-3 kinase signalling pathway is an important pathway in mediating the glucoregulatory effects of insulin and skeletal muscle (SKM) is the major tissue involved in glucose utilization. In diabetes this pathway is impaired, either due to lack of insulin as in Type I diabetes, or due to insulin resistance as in Typ...

journal_title：Molecular and cellular biochemistry

authors： Mohammad A,Bhanot S,McNeill JH

更新日期：2001-07-01 00:00:00

abstract：:Twenty-six days of fat deficiency brought about a decrease of linoleic and an increase of oleic acid in rough endoplasmic reticulum (RER) of guinea pig liver. Arachidonic acid was only slightly decreased in some phospholipids whereas eicose-5,8,11-trienoic acid was not enhanced except in phosphatidyl-inositol. All the...

journal_title：Molecular and cellular biochemistry

authors： Soulages JL,Brenner RR

更新日期：1987-12-01 00:00:00

abstract：:Proton pump inhibitors (PPIs) are widely used to treat hyperacid secretion and stomach ulcers. The study investigated the anti-secretory and anti-ulcer effects of esomeprazole, the S-isomer of omeprazole on dimaprit, histamine and dibutyryl adenosine 3, 5 cyclic monophosphate (dbcAMP)-evoked gastric acid secretion, ac...

journal_title：Molecular and cellular biochemistry

authors： Bastaki SM,Chandranath IS,Singh J

更新日期：2008-02-01 00:00:00

abstract：:To determine the role of 'translocation' vs. 'activation' of Glut1 in the stimulation of glucose transport in response to inhibition of oxidative phosphorylation, we measured the abundance of myc-tagged Glut1 in plasma membrane of stably transfected Clone 9 cells, a rat liver cell line expressing only the Glut1 isofor...

journal_title：Molecular and cellular biochemistry

authors： Koseoglu MH,Beigi FI

更新日期：1999-04-01 00:00:00

abstract：:Pathophysiology of polyunsaturated fatty acids (PUFAs) is associated with aberrant lipid and oxygen metabolism. In particular, under oxidative stress, PUFAs are prone to autocatalytic degradation via peroxidation, leading to formation of reactive aldehydes with numerous potentially harmful effects. However, the pathol...

journal_title：Molecular and cellular biochemistry

authors： Andrisic L,Collinson EJ,Tehlivets O,Perak E,Zarkovic T,Dawes IW,Zarkovic N,Cipak Gasparovic A

更新日期：2015-01-01 00:00:00

abstract：:Endochondral ossification, an important stage of fracture healing, is regulated by a variety of signaling pathways. Transforming growth factor β (TGFβ) superfamily plays important roles and comprises TGFβs, bone morphogenetic proteins (BMPs), and growth differentiation factors. TGFβs primarily regulate cartilage forma...

journal_title：Molecular and cellular biochemistry

authors： Sheu TJ,Zhou W,Fan J,Zhou H,Zuscik MJ,Xie C,Yin G,Berk BC

更新日期：2014-12-01 00:00:00

abstract：:7,12-Dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis is widely preferred to assess the tumor-inhibiting efficacy of the medicinal plants or their constituents. The present study explores the tumor-inhibiting potential of esculetin by utilizing the status of lipid peroxidation by products (...

journal_title：Molecular and cellular biochemistry

authors： Selvasundaram R,Manoharan S,Buddhan R,Neelakandan M,Murali Naidu R

更新日期：2018-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that have been suggested to play an essential role in tumorigenesis. Reduced expression of miR-338 has been reported in several types of cancers; however, the role of miR-338 in oral squamous cell carcinoma (OSCC) has not been elucidated. In this study, we demonstrated that...

journal_title：Molecular and cellular biochemistry

authors： Liu C,Wang Z,Wang Y,Gu W

更新日期：2015-01-01 00:00:00

abstract：:We have identified by immunoblotting and ADP-ribosylation by cholera toxin and pertussis toxin the presence of Mr 43 and 46 KDa Gs alpha, and 39 and 41 KDa Gi alpha subunits in rat parotid gland plasma membranes but not in granule membranes. A Mr 28 KDa polypeptide that served as substrate for ADP-ribosylation by both...

journal_title：Molecular and cellular biochemistry

authors： Ali N,Agrawal DK,Cheung P

更新日期：1992-10-07 00:00:00

abstract：:Evidence suggests that endothelial cell layer heparan sulfate proteoglycans include a variety of different sized molecules which most likely contain different protein cores. In the present report, approximately half of endothelial cell surface associated heparan sulfate proteoglycan is shown to be releasable with solu...

journal_title：Molecular and cellular biochemistry

authors： Lowe-Krentz LJ,Thompson K,Patton WA 2nd

更新日期：1992-01-15 00:00:00

abstract：:β-Adrenergic receptor (β-AR) stimulation induces cardiac myocyte apoptosis and plays an important role in myocardial remodeling. Here we investigated expression of various apoptosis-related genes affected by β-AR stimulation, and examined first time the role of ataxia telangiectasia mutated kinase (ATM) in cardiac myo...

journal_title：Molecular and cellular biochemistry

authors： Foster CR,Singh M,Subramanian V,Singh K

更新日期：2011-07-01 00:00:00

abstract：:Rat Langendorff hearts perfused with media that do not contain erythrocytes or fluorocarbon as oxygen carriers are borderline aerobic during 5 Hz pacing. This follows from the release of catabolic products measured: lactate, urate and Iysophosphatidyl-choline (IysoPC). Addition of L-carnitine to the perfusion medium r...

journal_title：Molecular and cellular biochemistry

authors： Hulsmann WC,Peschechera A,Serafini F,Ferrari LE

更新日期：1996-03-09 00:00:00

abstract：:MERRF (myoclonic epilepsy with ragged-red fibers) is a severe, multisystem disorder characterized by myoclonus, seizures, progressive cerebellar syndrome, muscle weakness, and the presence of ragged-red fibers in the muscle biopsy. MERRF is associated with heteroplasmic point mutations, either A8344G or T8356C, in the...

journal_title：Molecular and cellular biochemistry

authors： Masucci JP,Schon EA,King MP

更新日期：1997-09-01 00:00:00

abstract：:1. Glucokinase is one of four glucose phosphorylating enzymes present in rat liver. Its distinctive features are a high K-m for glucose (high-K-m isozyme) and a rather narrow substrate specificity. In contrast, the other three enzymes, collectively called hexokinases or low-K-m isozymes, exhibit low K-m values for glu...

journal_title：Molecular and cellular biochemistry

authors： Niemeyer H,Ureta T,Clark-Turri L

更新日期：1975-02-28 00:00:00

abstract：:Changes in the ecto-5'-nucleotidase activity-an extracellular nucleotide catabolic enzyme may lead to the inflammation and endothelial dysfunction. We investigated the effect of CD73 deletion on the endothelial function and L-arginine metabolism in various age groups of mice. 1-,3-,6-, and 12-month-old, male C57BL/6 J...

journal_title：Molecular and cellular biochemistry

authors： Mierzejewska P,Zabielska MA,Kutryb-Zajac B,Tomczyk M,Koszalka P,Smolenski RT,Slominska EM

更新日期：2019-08-01 00:00:00

abstract：:Fenugreek and Balanites are two plants commonly used in Egyptian folk medicine as hypoglycemic agents. In the present study, the effects of 21 days oral administration of Fenugreek seed and Balanites fruit extracts (1.5 g/kg bw) on the liver and kidney glycogen content and on some key liver enzymes of carbohydrate met...

journal_title：Molecular and cellular biochemistry

authors： Gad MZ,El-Sawalhi MM,Ismail MF,El-Tanbouly ND

更新日期：2006-01-01 00:00:00

abstract：:Angiotensin receptor blockers provide cardiovascular protection in heart failure patients. We have studied the effect of 8 weeks treatment with telmisartan (5 mg kg(-1) day(-1)) on cardiovascular complications associated with streptozotocin (STZ) diabetic rats. Wistar rats were made diabetic with STZ (45 mg kg(-1), iv...

journal_title：Molecular and cellular biochemistry

authors： Goyal BR,Mesariya P,Goyal RK,Mehta AA

更新日期：2008-07-01 00:00:00

abstract：:The involvement of the p53 gene in apoptosis of many cell types towards y-radiation is well established. However, little information is available on the relationship between p53 status and cells' ability to undergo apoptosis following exposure to fast neutrons. The aim of this study was to characterize the apoptotic p...

journal_title：Molecular and cellular biochemistry

authors： Jee YH,Jeong WI,Kim TH,Hwang IS,Ahn MJ,Joo HG,Hong SH,Jeong KS

更新日期：2005-02-01 00:00:00

abstract：:In order to initiate the study of the functional differences between myosin alkali light chain isoforms and to investigate the mechanisms of their differential expression, we have isolated cDNA clones for two human alkali light chain isoforms. Here we report DNA sequence and RNA blotting analyses that demonstrate that...

journal_title：Molecular and cellular biochemistry

authors： Wade R,Feldman D,Gunning P,Kedes L

更新日期：1989-06-01 00:00:00

abstract：:The effects of DOCA-salt hypertensive treatment on hepatic glutathione-dependent defense system, antioxidant enzymes, lipid peroxidation, mixed function oxidase and UDP-glucuronyl transferase activities were investigated in male Sprague Dawley rats. Compared with controls, DOCA-salt hypertensive rats had lower body we...

journal_title：Molecular and cellular biochemistry

authors： Nicod L,Rodriguez S,Letang JM,Viollon-Abadie C,Jacqueson A,Berthelot A,Richert L

更新日期：2000-01-01 00:00:00

abstract：:Adipocytes from 26-week-old Zucker rats (greater than 600 g) and controls of the same strain and age (greater than 400 g) served as models of insulin resistance and obesity. Adipocytes from fatty rats demonstrated insulin resistance of glucose metabolism and resistance to the antilipolytic effect of insulin which was ...

journal_title：Molecular and cellular biochemistry

authors： Stevens J,Green MH,Kaiser DL,Pohl SL

更新日期：1981-07-01 00:00:00

abstract：:One of the most clinically relevant biological activities of curcumin is its anti-cancer property, implicating multiple intracellular pathways in the process. In the present report, we investigated the effect of curcumin on the activation of apoptotic and anti-angiogenic pathways in Ehrlich Ascites Tumor (EAT) cells. ...

journal_title：Molecular and cellular biochemistry

authors： Belakavadi M,Salimath BP

更新日期：2005-05-01 00:00:00

abstract：:Telocytes (TCs) are a novel cell type identified among interstitial cells in various organs. TCs are characterized by very long cell processes (tens to hundreds micrometres) named telopodes (Tps) with uneven calibre: dilations (podoms) and very thin segments (podomers). However, little is known about the factors which...

journal_title：Molecular and cellular biochemistry

authors： Enciu AM,Popescu LM

更新日期：2015-12-01 00:00:00

abstract：:Well-documented evidence suggests that environmental and occupational exposure of toxic metals or metal-containing compounds can cause a number of human diseases, including inflammation and cancer, through DNA damage, protein modifications, or lipid peroxidation. This mini-review addresses the mechanisms of cell death...

journal_title：Molecular and cellular biochemistry

authors： Chen F,Vallyathan V,Castranova V,Shi X

更新日期：2001-06-01 00:00:00

abstract：:Cultured human umbilical vein endothelial cells (HUVECs) are a widely used model to study the regulation of endothelial production of vasoactive substances such as endothelin-1 (ET-1) and prostacyclin (PGI2) in human. As even short term culturing is known to affect the function of many cell types, we studied whether t...

journal_title：Molecular and cellular biochemistry

authors： Ranta V,Orpana A,Mikkola T,Ylikorkala O,Viinikka L

更新日期：1997-12-01 00:00:00

abstract：:Murine erythroleukemia cell lines derived from Friend virus infected mice can be induced to differentiate in vitro by numerous agents. Among these compounds are certain naturally occurring purines such as hypoxanthine or 1-methylhypoxanthine. We have extended these studies to other modified oxypurines and have identif...

journal_title：Molecular and cellular biochemistry

authors： Kerr SJ

更新日期：1990-01-18 00:00:00

abstract：:The molecular mechanisms potentially responsible for cadmium carcinogenesis were investigated by differential gene expression analysis of Balb/c-3T3 cells morphologically transformed with cadmium chloride. Differential display analysis of gene expression revealed overexpression of mouse Translation Initiation Factor 3...

journal_title：Molecular and cellular biochemistry

authors： Joseph P,Lei YX,Ong TM

更新日期：2004-01-01 00:00:00