当前位置： SCI文献检索 > MOLECULAR AND CELLULAR BIOCHEMISTRY期刊下所有文献 > Lysophosphatidic acid receptor-2 (LPA2)-mediated signaling enhances chemoresistance in melanoma cells treated with anticancer drugs.

Lysophosphatidic acid receptor-2 (LPA2)-mediated signaling enhances chemoresistance in melanoma cells treated with anticancer drugs.

Abstract：

:Lysophosphatidic acid (LPA) signaling through LPA receptors (LPA1 to LPA6) regulates a variety of malignant properties in cancer cells. Recently, we show that LPA2 expression is elevated by long-term cisplatin (CDDP) treatment in melanoma A375 cells. In the present study, we investigated whether LPA2-mediated signaling is involved in the modulation of chemoresistance in A375 cells. In cell survival assay, cells were treated with CDDP and dacarbazine (DTIC) every 24 h for 2 days. The cell survival rates to CDDP and DTIC were markedly increased by an LPA2 agonist, GRI-977143. To validate the effects of LPA2 on cell survival, LPA2 knockdown cells were generated from A375 cells. The cell survival rates elevated by GRI-977143 were suppressed by LPA2 knockdown. To evaluate the roles of LPA2-mediated signaling in cell survival, cells were pretreated with a Gi protein inhibitor, pertussis toxin (PTX). In the presence of GRI-977143, the cell survival rates to CDDP and DTIC were significantly lower in PTX-treated cells than in untreated cells. In addition, pretreatment of an adenylyl cyclase inhibitor, SQ22536, increased the cell survival of A375 cells treated with CDDP and DTIC. These results suggest that LPA2-mediated signaling plays an important role in the enhancement of chemoresistance of A375 cells treated with anticancer drugs.

journal_name

Mol Cell Biochem

journal_title

Molecular and cellular biochemistry

authors

Minami K,Ueda N,Ishimoto K,Tsujiuchi T

doi

10.1007/s11010-020-03730-w

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

89-95

issue

1-2

eissn

0300-8177

issn

1573-4919

pii

10.1007/s11010-020-03730-w

journal_volume

469

pub_type

杂志文章

相关文献

MOLECULAR AND CELLULAR BIOCHEMISTRY文献大全
  • Quantization of chloroplast DNA using dot blot filter hybridization with double-stranded probes.

    abstract：:Hybridization characteristics of purified chloroplast DNA, immobilized in 'dot blots' on nitrocellulose filters using radiolabeled chloroplast DNA restriction fragments or recombinant DNA probes were investigated. Conditions are described which proved a near linear relationship between amounts of hybridization and amo...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00285223

    authors： Smith MA

    更新日期：1984-09-01 00:00:00

  • Crosstalk between Noxa, Bcl-2, and ceramide in mediating p53-dependent apoptosis in Molt-4 human T-cell leukemia.

    abstract：:Ionizing radiation induces apoptosis in human Molt-4 leukemia cells in a p53-dependent manner. The tumor suppressor p53 stimulates various downstream targets that presumably trigger, individually or in concert, de novo ceramide synthesis and intrinsic apoptosis via mitochondrial outer membrane permeabilization (MOMP)....

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-020-03874-9

    authors： Kobeissy H,Hage-Sleiman R,Dakdouk Z,Kozhaya L,Dbaibo G

    更新日期：2020-12-01 00:00:00

  • Synthesis and characterization of a DNA complementary to Xenopus laevis albumin mRNA.

    abstract：:Albumin complementary DNA (cDNA) was transcribed from purified albumin mRNA from the liver of Xenopus laevis. The resultant cDNA was an almost full length copy as defined by denaturing gel electrophoresis; was hybridized specifically to albumin mRNA with pseudo-first-order reaction kinetics and the mRNA . cDNA hybrid ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00224922

    authors： Dimitriadis GJ,Zongza-Dimitriadis V

    更新日期：1983-01-01 00:00:00

  • Sequence-specific apolipoprotein A-I effects on lecithin:cholesterol acyltransferase activity.

    abstract：:Existing kinetic data of cholesteryl ester formation by lecithin:cholesterol acyltransferase in discoidal high-density lipoproteins with 34 mutations of apoA-I that involved all putative helices were grouped by cluster analysis into four noncoincident regions with mutations both without any functional impairment and w...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-013-1619-5

    authors： Dergunov AD

    更新日期：2013-06-01 00:00:00

  • Excitation-contraction coupling in heart muscle.

    abstract：:We have investigated the links between electrical excitation and contraction in mammalian heart muscle. Using isolated single cells from adult rat ventricle, a whole-cell voltage-clamp technique and quantitative fluorescence microscopy, we have measured simultaneously calcium current (ICa) and [Ca2+]i (with fura-2). W...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00220762

    authors： Lederer WJ,Cannell MB,Cohen NM,Berlin JR

    更新日期：1989-09-07 00:00:00

  • The 27-bp repeat polymorphism in intron 4 (27 bp-VNTR) of endothelial nitric oxide synthase (eNOS) gene is associated with albumin to creatinine ratio in Mexican Americans.

    abstract：:The T-786C, Glu298Asp, and 27 bp variable number of tandem repeats (27 bp-VNTR-a/b) polymorphsims of the endothelial nitric oxide synthase (eNOS) gene are thought to alter nitric oxide production and contribute to the development of vascular and renal disease risk. The objective of this study is to investigate whether...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-009-0159-5

    authors： Nath SD,He X,Voruganti VS,Blangero J,MacCluer JW,Comuzzie AG,Arar NH,Abboud HE,Thameem F

    更新日期：2009-11-01 00:00:00

  • Is a dietary n-3 fatty acid supplement able to influence the cardiac effect of the psychological stress?

    abstract：:Epidemiological studies suggest that n-3 polyunsaturated fatty acids (PUFA) are involved in the prevention of cardiovascular disease. Stress is known to increase the incidence of CVD and the present study was realised to evaluate some physiological and biochemical effects of dietary docosahexaenoic acid (DHA) in male ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1006813216815

    authors： Rousseau D,Moreau D,Raederstorff D,Sergiel JP,Rupp H,Muggli R,Grynberg A

    更新日期：1998-01-01 00:00:00

  • Involvement of PARP and poly(ADP-ribosyl)ation in the early stages of apoptosis and DNA replication.

    abstract：:We have focused on the roles of PARP and poly(ADP-ribosyl)ation early in apoptosis, as well as during the early stages of differentiation-linked DNA replication. In both nuclear processes, a transient burst of PAR synthesis and PARP expression occurs early, prior to internucleosomal DNA cleavage before commitment to a...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：

    authors： Simbulan-Rosenthal CM,Rosenthal DS,Iyer S,Boulares H,Smulson ME

    更新日期：1999-03-01 00:00:00

  • Differential binding of rat pituitary-specific nuclear factors to the 5'-flanking region of pituitary and placental members of the human growth hormone gene family.

    abstract：:Placental chorionic somatomammotropin (hCS-A or B) and growth hormone variant (hGH-V) are members of the human growth hormone family, and are related by structure and function to pituitary growth hormone (hGH-N). However, while the hGH-N gene is expressed specifically in the anterior pituitary, hGH-V and hCS are produ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00230184

    authors： Nickel BE,Nachtigal MW,Bock ME,Cattini PA

    更新日期：1991-08-14 00:00:00

  • Perifosine as potential anti-cancer agent inhibits proliferation, migration, and tube formation of human umbilical vein endothelial cells.

    abstract：:Targeting angiogenesis is considered an effective strategy for treating the expansion and metastasis of tumors. The aim of this study is to assess the effects of perifosine, an inhibitor of Akt, on cell proliferation, apoptosis, angiogenesis, and VEGF-induced cell migration in cultured human umbilical vein endothelial...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-011-0986-z

    authors： Wang FZ,Fei HR,Li XQ,Shi R,Wang de C

    更新日期：2012-09-01 00:00:00

  • Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264.7 cells.

    abstract：:Both reactive oxygen- and nitrogen-derived reactive species play important roles in physiological and pathophysiological conditions. Flavones, luteolin and luteolin-7-O-glucoside along with a rich plant source of both flavones, namely dandelion (Taraxacum officinale) flower extract were studied for antioxidant activit...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/b:mcbi.0000044364.73144.fe

    authors： Hu C,Kitts DD

    更新日期：2004-10-01 00:00:00

  • A single step purification of a sialic acid binding lectin (AchatininH) from Achatina fulica snail.

    abstract：:A sialic acid binding lectin, AchatininH, was purified in single step from the hemolymph of the land snail, Achatina fulica, by the affinity chromatography on sheep submaxillary mucin coupled to Sepharose 4B. The yield of the lectin was found to be 3 mg from 100 ml of hemolymph. The homogeneity of the lectin was estab...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00214774

    authors： Basu S,Sarkar M,Mandal C

    更新日期：1986-08-01 00:00:00

  • Point mutations in the mitochondrial tRNA(Lys) gene: implications for pathogenesis and mechanism.

    abstract：:MERRF (myoclonic epilepsy with ragged-red fibers) is a severe, multisystem disorder characterized by myoclonus, seizures, progressive cerebellar syndrome, muscle weakness, and the presence of ragged-red fibers in the muscle biopsy. MERRF is associated with heteroplasmic point mutations, either A8344G or T8356C, in the...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：

    authors： Masucci JP,Schon EA,King MP

    更新日期：1997-09-01 00:00:00

  • Purification and characterization of liver cytochrome P-446 isolated from protein energy malnourished rats.

    abstract：:A liver cytochrome P-450 isozyme has been purified to homogeneity from protein-energy malnourished rats induced with beta-naphthoflavone (beta-NF). The purification steps included chromatography on DEAE-Sephadex-A-25, DEAE-cellulose (DE-53), hydroxylapatite (HA) and carboxymethyl-sephadex (CM) columns. The reduced car...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00229392

    authors： Gil L,Vasquez H,Orellana M,Selkirk J,Wold F,Strobel H

    更新日期：1988-01-01 00:00:00

  • Role of miRNA-210, miRNA-21 and miRNA-126 as diagnostic biomarkers in colorectal carcinoma: impact of HIF-1α-VEGF signaling pathway.

    abstract：:Colorectal cancer (CRC) is a major cause of death worldwide. Novel non-invasive, high diagnostic value screening test is urgently needed to improve survival rate, treatment and prognosis. Stable, small, circulating microRNA (miRNA) offers unique opportunities for the early diagnosis of several diseases. It acts as tum...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-018-3462-1

    authors： Sabry D,El-Deek SEM,Maher M,El-Baz MAH,El-Bader HM,Amer E,Hassan EA,Fathy W,El-Deek HEM

    更新日期：2019-04-01 00:00:00

  • Differential effects of etomoxir treatment on cardiac Na+-K+ ATPase subunits in diabetic rats.

    abstract：:Etomoxir, an inhibitor of mitochondrial carnitine palmitoyltransferase-1, is known to attenuate the changes in myosin isoforms and sarcoplasmic reticular function that occur in diabetic rat hearts. In the present study, we tested the hypothesis that etomoxir also prevents the diabetes-induced depression of sarcolemmal...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1014841216418

    authors： Kato K,Lukas A,Chapman DC,Rupp H,Dhalla NS

    更新日期：2002-03-01 00:00:00

  • TBP-associated factor 1 overexpression induces tolerance to Doxorubicin in confluent H9c2 cells by an increase in cdk2 activity and cyclin E expression.

    abstract：:Doxorubicin (DOX) is a DNA topoisomerase II inhibitor widely used in anticancer treatment, however, it can lead to irreversible cardiac damage with severe debilitation. TBP-binding associated factor 1 (TAF1) is increased in DOX damaged hearts in vivo and in cardiomyocytes in vitro. To identify the functional role for ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/b:mcbi.0000021347.65073.10

    authors： Servant N,Marcantonio D,Th'ng JP,Chalifour LE

    更新日期：2004-04-01 00:00:00

  • PKC phosphorylation disrupts gap junctional communication at G0/S phase in clone 9 cells.

    abstract：:Gap junctional communication during the progression of cell cycle from quiescent G0 to S phase was examined in cultured clone 9 rat liver cells. The transfer of scrape-loaded fluorescent dye was suppressed immediately after the stimulation of cell cycle progression in a synchronized cell population. Northern blot anal...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1006831114120

    authors： Koo SK,Kim DY,Park SD,Kang KW,Joe CO

    更新日期：1997-02-01 00:00:00

  • Action of oligomycin on cultured mammalian cells. Permeabilization to translation inhibitors.

    abstract：:Oligomycin, an inhibitor of ATP synthesis, has been used as a model to study the effects of ATP depletion on macromolecular synthesis and modification of membrane permeability. Protein synthesis is totally blocked by the antibiotic, whereas RNA and DNA synthesis are less inhibited. Different concentrations of monovale...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00222495

    authors： Otero MJ,Carrasco L

    更新日期：1984-01-01 00:00:00

  • Synergistic effect between apolipoprotein E and apolipoprotein A1 gene polymorphisms in the risk for coronary artery disease.

    abstract：:Alterations in lipid metabolism and genetic predisposition are major risk factors for coronary artery disease (CAD). Variations in genes involved in lipid metabolism may act synergistically to confer risk or protection against CAD. The objective of the present study was to determine such interactions in variants of ap...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-008-9751-3

    authors： Rai TS,Khullar M,Sehrawat BS,Ahuja M,Sharma PK,Vijayvergiya R,Grover A

    更新日期：2008-06-01 00:00:00

  • Structural and functional aspects of tumor cell sialomucins.

    abstract：:Sialomucins are abundant on the surfaces of certain ascites tumor cells and have been implicated in the escape of tumors from immune destruction and metastasis. They are large, highly glycosylated glycoproteins which are rich in serine and threonine and have a variety of 0-linked oligosaccharides. The sialomucin (ASGP...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00230639

    authors： Carraway KL,Spielman J

    更新日期：1986-11-01 00:00:00

  • Metal-induced toxicity, carcinogenesis, mechanisms and cellular responses.

    abstract：:A wide variety of metals have been reported to act as mutagenic and carcinogenic agents in both human and animal studies. The underlying mechanisms are being extensively investigated. Recently, a new sub-discipline of molecular carcinogenesis has surfaced and new techniques and instruments are being developed which al...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1023/b:mcbi.0000007255.72746.a6

    authors： Leonard SS,Bower JJ,Shi X

    更新日期：2004-01-01 00:00:00

  • Alteration of antioxidant status following sympathectomy: differential effects of modified plasma levels of adrenaline and noradrenaline.

    abstract：:The influence of altered levels of endogenous catecholamines following adrenalectomy or 6-hydroxydopamine (6-OH) treatment (alone or in combination) on enzymatic (glutathione reductase, catalase, glutathione peroxidase and Cu, Zn superoxide dismutase) and non-enzymatic (glutathione) antioxidant components of heart, li...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：

    authors： Toleikis PM,Godin DV

    更新日期：1995-11-08 00:00:00

  • Dopamine receptors in canine caudate nucleus.

    abstract：:Physiological, pharmacological, histochemical and biochemical studies indicate that dopamine receptors are heterogenous in the central nervous system with each individual functions. This review describes pharmacological and biochemical characteristics of dopamine receptors, particularly in canine caudate nucleus, whic...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00423094

    authors： Maeno H

    更新日期：1982-03-19 00:00:00

  • Purification of xanthine oxidase from the fat-globule membrane of bovine milk by electrofocusing.

    abstract：:Xanthine oxidase was purified from bovine milk-fat globule membrane by extraction with butan-1-ol, precipitation with ammonium sulphate, separation by preparative electrofocusing and chromatography on Concanavalin-A/Agarose. The enzyme had an A280/A450 ratio of 4.8 and a specific activity of 3.09. At least five to sev...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00573841

    authors： Sullivan CH,Mather IH,Greenwalt DE,Madara PJ

    更新日期：1982-04-16 00:00:00

  • Long term regulation of glycogen metabolizing enzymes by insulin in H4 hepatoma cells.

    abstract：:Insulin alone at concentrations of less than 1 to 5 uU/ml increased the enzyme activities of glycogen synthase, synthase phosphatase, phosphorylase, and phosphorylase phosphatase in hepatoma H4 cells in culture in the presence and absence of serum. Increase in total and active forms of glycogen synthase and phosphoryl...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00229902

    authors： Goheer MA,Larner J,Curnow RT

    更新日期：1987-06-01 00:00:00

  • Antioxidant properties of dehydrozingerone and curcumin in rat brain homogenates.

    abstract：:The present study investigates the inhibition of lipid peroxidation by dehydrozingerone and curcumin in rat brain homogenates. Both the test compounds inhibited the formation of conjugated dienes and spontaneous lipid peroxidation. These compounds also inhibited lipid peroxidation induced by ferrous ions, ferric-ascor...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00928368

    authors： Rajakumar DV,Rao MN

    更新日期：1994-11-09 00:00:00

  • Alterations in atrial natriuretic peptide and its receptors in streptozotocin-induced diabetic rat kidneys.

    abstract：:In this study the effect of diabetes mellitus on atrial natriuretic peptide (ANP) receptors in streptozotocin- (STZ-) induced diabetic rat kidneys was studied. Moreover, plasma ANP concentration was evaluated in diabetic and control rats by using radioimmunoassay. In addition, the expression of ANP in the kidneys of c...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/b:mcbi.0000028732.15710.c2

    authors： Obineche EN,Adeghate E,Chandranath IS,Benedict S,Al Gafri LS,Adem A

    更新日期：2004-06-01 00:00:00

  • Molecular dynamics study of the interaction between fatty acid binding proteins with palmitate mini-micelles.

    abstract：:The fatty acid binding proteins (FAPBs) function as intracellular carriers of fatty acid (FA) and related compounds. During the digestion of lipids, the local concentration of FA exceeds their critical micellar concentration; the excess ratio of FA/FABP can be as high as approximately 1,000/1, consequently building mi...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-008-0010-4

    authors： Levin LB,Nachliel E,Gutman M,Tsfadia Y

    更新日期：2009-06-01 00:00:00

  • Thr11 phosphorylated H3 is associated with centromere DNA during mitosis in MCF-7 cells.

    abstract：:In this study, indirect immunofluorescence labeling was used to examine the cellular dynamic distribution of Thr11 phosphorylated H3 at mitosis in MCF-7 cells. The Thr11 phosphorylation was observed beginning at prophase at centromeres. Upon progression of mitosis, fluorescence signal was enhanced in the central regio...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-007-9692-2

    authors： Zhou H,Li D,Song L,Liu R,Chen J,Huang X

    更新日期：2008-04-01 00:00:00