当前位置： SCI文献检索 > MOLECULAR AND CELLULAR BIOCHEMISTRY期刊下所有文献 > Mechanism of inhibition of ascites tumor growth in mice by curcumin is mediated by NF-kB and caspase activated DNase.

Mechanism of inhibition of ascites tumor growth in mice by curcumin is mediated by NF-kB and caspase activated DNase.

Abstract：

:One of the most clinically relevant biological activities of curcumin is its anti-cancer property, implicating multiple intracellular pathways in the process. In the present report, we investigated the effect of curcumin on the activation of apoptotic and anti-angiogenic pathways in Ehrlich Ascites Tumor (EAT) cells. Treatment with curcumin in vivo resulted in inhibition of proliferation of EAT cells and ascites formation. Further, we demonstrate that the induction of apoptosis in EAT cells showed nuclear condensation, DNA fragmentation and translocation of caspase-activated DNase (CAD) to nucleus upon curcumin treatment. Curcumin-induced apoptosis is mediated through activation of caspase-3, which is specifically inhibited by the caspase-3 inhibitor, Ac-DEVD-CHO. On the other hand, the decreased secretion of ascites by EAT cells is corroborated by reduction in VEGF secretion upon curcumin treatment. Further, CD31 immunohistological staining of peritoneum sections in curcumin-treated mice suggests its efficacy in acting as anti-angiogenic compound in EAT cells by inhibiting proliferation of endothelial cells in mouse peritoneum. However, immunoflurescence studies of NF-kB revealed that the inhibition of nuclear translocation of NF-kB p65, a transcription factor required for VEGF gene expression, in curcumin-treated EAT cells. These results suggest a further possible clinical application of this diet-derived compound curcumin, as both proapoptotic and anti-angiogenic compound in association with conventional chemotherapeutic agents.

journal_name

Mol Cell Biochem

journal_title

Molecular and cellular biochemistry

authors

Belakavadi M,Salimath BP

doi

10.1007/s11010-005-7717-2

keywords:

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

57-67

issue

1-2

eissn

0300-8177

issn

1573-4919

journal_volume

273

pub_type

杂志文章

相关文献

MOLECULAR AND CELLULAR BIOCHEMISTRY文献大全
  • Protein kinase A phosphorylation of the multifunctional protein CAD antagonizes activation by the MAP kinase cascade.

    abstract：:The flux through the de novo pyrimidine biosynthetic pathway is controlled by the multifunctional protein CAD, which catalyzes the first three steps. The cell cycle dependent regulation of pyrimidine biosynthesis is a consequence of sequential phosphorylation of CAD Thr456 and Ser1406 by the MAP kinase and PKA cascade...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-006-9398-x

    authors： Kotsis DH,Masko EM,Sigoillot FD,Di Gregorio R,Guy-Evans HI,Evans DR

    更新日期：2007-07-01 00:00:00

  • Interaction of SIV/SHIV infection and morphine on plasma oxidant/antioxidant balance in macaque.

    abstract：:A homeostatic balance exists between the cellular generation of oxidant species and endogenous antioxidants under normal physiological conditions. Human Immunodeficiency Virus (HIV) infection is known to affect this balance causing oxidative stress. However, the interaction of HIV infection with a substance abuse on c...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-007-9625-0

    authors： Pérez-Casanova A,Husain K,Noel RJ Jr,Rivera-Amill V,Kumar A

    更新日期：2008-01-01 00:00:00

  • The roles of NLRP3 inflammasome-mediated signaling pathways in hyperuricemic nephropathy.

    abstract：:Hyperuricemic nephropathy (HN) is a common clinical complication of hyperuricemia. High-serum uric acid can trigger renal inflammation. The inflammasome family has several members and shows a significant effect on inflammatory responses. NLRP3 (NOD-, LRR-, and pyrin domain-containing 3) senses the stimuli signal of ex...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1007/s11010-020-03997-z

    authors： Wen L,Yang H,Ma L,Fu P

    更新日期：2021-01-03 00:00:00

  • Glutathione homeostasis in response to exercise training and nutritional supplements.

    abstract：:Glutathione plays a central role in the maintenance of tissue antioxidant defenses and in the regulation of redox sensitive signal transduction. In muscle cells, the level and redox status of GSH regulates activity of the redox sensitive transcription factor NF-kappaB. Physical exercise may cause oxidation of GSH in t...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：

    authors： Sen CK

    更新日期：1999-06-01 00:00:00

  • Identification of a novel intergenic miRNA located between the human DDC and COBL genes with a potential function in cell cycle arrest.

    abstract：:Frequent abnormalities in 7p12 locus in different tumors like lung cancer candidate this region for novel regulatory elements. MiRNAs as novel regulatory elements encoded within the human genome are potentially oncomiRs or miR suppressors. Here, we have used bioinformatics tools to search for the novel miRNAs embedded...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-017-3242-3

    authors： Hoballa MH,Soltani BM,Mowla SJ,Sheikhpour M,Kay M

    更新日期：2018-07-01 00:00:00

  • Regulation of norepinephrine-induced proliferation in cardiac fibroblasts by interleukin-6 and p42/p44 mitogen activated protein kinase.

    abstract：:Norepinephrine (NE) is involved in many cardiovascular diseases such as congestive heart failure. We have recently reported that NE had a comitogenic effect in isolated cardiac fibroblasts, and that it activated p42/p44 mitogen activated protein kinase (MAPK). This study was designed to characterize a possible mechani...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1021655023870

    authors： Leicht M,Briest W,Zimmer HG

    更新日期：2003-01-01 00:00:00

  • Assessing the cellular transmembrane electrical potential difference on the hepatic uptake of palmitate.

    abstract：:Understanding the driving forces for the hepatic uptake of endogenous and exogenous substrates in isolated cells and organs is fundamental to describing the underlying hepatic physiology/pharmacology. In this study we investigated whether uptake of plasma protein-bound [3H]-palmitate across the hepatocyte wall is gove...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-005-5267-2

    authors： Burczynski FJ,Hung D,Wang GQ,Elmadhoun B,Lewis A,Chang P,Rajaraman G,Robert S

    更新日期：2005-02-01 00:00:00

  • Diabetic cardiomyocyte dysfunction and myocyte insulin resistance: role of glucose-induced PKC activity.

    abstract：:Increased protein kinase C (PKC) activity has been implicated in the pathogenesis of a number of diabetic complications, and high concentrations of glucose have been shown to increase PKC activity. The present study was designed to examine the role of PKC in diabetes-induced (and glucose-induced) cardiomyocyte dysfunc...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/b:mcbi.0000038231.68078.4b

    authors： Davidoff AJ,Davidson MB,Carmody MW,Davis ME,Ren J

    更新日期：2004-07-01 00:00:00

  • Is a dietary n-3 fatty acid supplement able to influence the cardiac effect of the psychological stress?

    abstract：:Epidemiological studies suggest that n-3 polyunsaturated fatty acids (PUFA) are involved in the prevention of cardiovascular disease. Stress is known to increase the incidence of CVD and the present study was realised to evaluate some physiological and biochemical effects of dietary docosahexaenoic acid (DHA) in male ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1006813216815

    authors： Rousseau D,Moreau D,Raederstorff D,Sergiel JP,Rupp H,Muggli R,Grynberg A

    更新日期：1998-01-01 00:00:00

  • Regulation of the level of yeasts citrate synthase by oxygen availability.

    abstract：:The activity of yeasts citrate synthase in cells grown under different hypoxic conditions has been investigated. A linear relationship between the citrate synthase activity and the respiratory capacity of the cells has been found. When Saccharomyces cerevisiae was grown on fermentable substrates the activity decreased...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF01741714

    authors： Nuñez de castro I,Arias de Saavedra JM,Machado A,Mayor F

    更新日期：1976-09-30 00:00:00

  • Effect of valine on myotube insulin sensitivity and metabolism with and without insulin resistance.

    abstract：:Population data have consistently demonstrated a correlation between circulating branched-chain amino acids (BCAA) and insulin resistance. Most recently valine catabolite, 3-hydroxyisobutyrate, has emerged as a potential cause of BCAA-mediated insulin resistance; however, it is unclear if valine independently promotes...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-020-03720-y

    authors： Rivera ME,Lyon ES,Johnson MA,Sunderland KL,Vaughan RA

    更新日期：2020-05-01 00:00:00

  • Identification of an HMG-like protein involved in regulation of Na+/H+ exchanger expression.

    abstract：:In this study we characterized regulation of the Na+/H+ exchanger promoter in several tissue types. A conserved poly (dA:dT) region was important in regulation of the promoter. Nuclear extracts from rat myocardium and from mouse proximal tubule cells protected the poly (dA:dT) region of the NHE1 promoter. A protein fr...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：

    authors： Wang H,Yang W,Fliegel L

    更新日期：1997-11-01 00:00:00

  • The utrophin-beta 2 syntrophin complex regulates adipocyte lipid droplet size independent of adipogenesis.

    abstract：:Utrophin is a widely expressed cytoskeleton protein and is associated with lipid droplets (LDs) in adipocytes. The scaffold protein beta 2 syntrophin (SNTB2) controls signaling events by recruiting distinct membrane and cytoskeletal proteins, and binds to utrophin. Here we show that SNTB2 forms a complex with utrophin...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-018-3409-6

    authors： Krautbauer S,Neumeier M,Haberl EM,Pohl R,Feder S,Eisinger K,Rein-Fischboeck L,Buechler C

    更新日期：2019-02-01 00:00:00

  • Morphological study of TNPO3 and SRSF1 interaction during myogenesis by combining confocal, structured illumination and electron microscopy analysis.

    abstract：:Transportin3 (TNPO3) shuttles the SR proteins from the cytoplasm to the nucleus. The SR family includes essential splicing factors, such as SRSF1, that influence alternative splicing, controlling protein diversity in muscle and satellite cell differentiation. Given the importance of alternative splicing in the myogeni...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-020-04023-y

    authors： Costa R,Rodia MT,Zini N,Pegoraro V,Marozzo R,Capanni C,Angelini C,Lattanzi G,Santi S,Cenacchi G

    更新日期：2021-01-15 00:00:00

  • Endocrine disruptors provoke differential modulatory responses on androgen receptor and pregnane and xenobiotic receptor: potential implications in metabolic disorders.

    abstract：:A systematic comparison of the impact of some potential endocrine disruptors (EDs) on modulation of androgen receptor (AR) and pregnane and xenobiotic receptor (PXR) function was conducted in a multi-step analysis. Promoter-reporter-based transcription assays were performed in conjunction with receptor dynamic studies...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-010-0583-6

    authors： Chaturvedi NK,Kumar S,Negi S,Tyagi RK

    更新日期：2010-12-01 00:00:00

  • Transcriptional and antioxidative responses to endogenous polyunsaturated fatty acid accumulation in yeast.

    abstract：:Pathophysiology of polyunsaturated fatty acids (PUFAs) is associated with aberrant lipid and oxygen metabolism. In particular, under oxidative stress, PUFAs are prone to autocatalytic degradation via peroxidation, leading to formation of reactive aldehydes with numerous potentially harmful effects. However, the pathol...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-014-2229-6

    authors： Andrisic L,Collinson EJ,Tehlivets O,Perak E,Zarkovic T,Dawes IW,Zarkovic N,Cipak Gasparovic A

    更新日期：2015-01-01 00:00:00

  • Analgesic-antitumor peptide inhibits angiogenesis by suppressing AKT activation in hepatocellular carcinoma.

    abstract：:Hepatocellular carcinoma (HCC) is one of leading causes of cancer-related death, and its increasing incidence worldwide is a cause for concern. The recombinant analgesic-antitumor peptide (rAGAP), a protein consisting of small ubiquitin-related modifier linked with a hexa-histidine tag, exhibited the antitumor activit...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-018-3475-9

    authors： Cao Q,Lu W,Zhou T,Liu Y,Cai X,Zhu J,Cao P

    更新日期：2019-05-01 00:00:00

  • Hepatitis B virus X (HBx) play an anti-apoptosis role in hepatic progenitor cells by activating Wnt/β-catenin pathway.

    abstract：:Increasing evidence has shown that normal stem cells may act as cancer-initiating cells and contribute to the development and progression of cancer. HBx has a close relationship with hepatocellular carcinoma, however, the role of HBx in hepatic progenitor cells (HPCs) is poorly understood. In this study, we sought to ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-013-1769-5

    authors： Shen L,Zhang X,Hu D,Feng T,Li H,Lu Y,Huang J

    更新日期：2013-11-01 00:00:00

  • Epigenetic regulation of cardiac muscle-specific genes in H9c2 cells by Interleukin-18 and histone deacetylase inhibitor m-carboxycinnamic acid bis-hydroxamide.

    abstract：:Interleukin-18 (IL-18) elicited a robust hypertrophy response in H9c2 cardiomyocytes as judged by their accelerated rates of protein synthesis and increased cell size. Evidently, IL-18 treatment also induced a cardiac hypertrophy-specific program of gene expression in H9c2 cardiomyocytes since they elicited enhanced e...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-008-9720-x

    authors： Majumdar G,Johnson IM,Kale S,Raghow R

    更新日期：2008-05-01 00:00:00

  • Exogenous growth factors enhance the expression of cola1, cola3, and Elastin in fibroblasts via activating MAPK signaling pathway.

    abstract：:Exogenous growth factors could accelerate the process of wound healing. However, the underlying mechanisms have not been clearly clarified. The aim of the present study was to investigate the effect of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) on the expression of type I collagen (cola1),...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-017-3204-9

    authors： Shen T,Gao K,Miao Y,Hu Z

    更新日期：2018-05-01 00:00:00

  • Bone morphogenetic protein 4 (BMP4) is required for migration and invasion of breast cancer.

    abstract：:Bone-morphogenetic proteins (BMPs) play an important role in development and many cellular processes. However, their functional role in the development and progression of breast cancer is not clearly understood. In the present study, we performed a systematic expression analysis of the 14 types of BMPs in 10 human bre...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-011-1170-1

    authors： Guo D,Huang J,Gong J

    更新日期：2012-04-01 00:00:00

  • Flavonoids and urate antioxidant interplay in plasma oxidative stress.

    abstract：:Flavonoids are naturally occurring plant compounds with antioxidant properties. Their consumption has been associated with the protective effects of certain diets against some of the complications of atherosclerosis. Low-density lipoprotein (LDL) oxidative modification is currently thought to be a significant event in...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1010944919952

    authors： Filipe P,Lança V,Silva JN,Morlière P,Santus R,Fernandes A

    更新日期：2001-05-01 00:00:00

  • Cytokine G-protein signaling crosstalk in cardiomyocytes: attenuation of Jak-STAT activation by endothelin-1.

    abstract：:The IL-6-related cytokines, LIF and cardiotrophin-1, are important growth promoting and cardioprotective agents for cardiomyocytes. However, factors that regulate their actions in the heart are poorly understood. In this study, we tested the hypothesis that endothelin-1, a peptide hormone that produces a pattern of ca...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1020648425895

    authors： Booz GW,Day JN,Speth R,Baker KM

    更新日期：2002-11-01 00:00:00

  • Premature aging in uremia.

    abstract：:Guanidinosuccinic acid is an aberrant metabolite isolated 40 years ago in the blood and urine of uremic subjects and a suspect in the toxicity associated with renal failure. It plays a minor role in the bleeding diathesis of uremia, contributes to the methyl group deficiency of dialysis patients, and is a factor in th...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-006-9351-z

    authors： Cohen BD

    更新日期：2007-04-01 00:00:00

  • Effect of pyridine on the expression of cytochrome P450 isozymes in primary rat hepatocyte culture.

    abstract：:In vivo administration of pyridine has been shown to increase the activity and content of several forms of cytochrome P450 by transcriptional and posttranscriptional mechanisms. The effect of pyridine on CYP1A and CYP2E1 isozymes was studied in a rat hepatocyte culture model. Hepatocytes were isolated from non-induced...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1006831811622

    authors： Wu D,Ramin SA,Cederbaum AI

    更新日期：1997-08-01 00:00:00

  • Modulation of fatty acid-binding capacity of heart fatty acid-binding protein by oxygen-derived free radicals.

    abstract：:In this study, we examined the effects of exposure of heart fatty acid-binding protein (h-FABP) to chemically generated O2- or OH. with respect to its oleate binding and to its electrophoretic properties. Purified rat h-FABP at 40 microM scavenged as much as 30% O2- and 85% OH.. On the other hand, when 2 nmol (4 micro...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00231380

    authors： Jones RM,Prasad MR,Das DK

    更新日期：1990-10-15 00:00:00

  • Patch clamp analysis of chemically activated and modulated ionic channels in isolated mammalian cardiomyocytes.

    abstract：:Techniques routinely utilized in this laboratory for recording currents through single ionic channels of isolated atrial and ventricular rat cardiomyocytes are described. Emphasis is placed in two main areas: first, on methods for obtaining a sufficient yield of Ca++-tolerant myocytes suitable for patch clamp experime...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00231002

    authors： Vogel SM

    更新日期：1988-03-01 00:00:00

  • Circadian gene Clock participates in mitochondrial apoptosis pathways by regulating mitochondrial membrane potential, mitochondria out membrane permeablization and apoptosis factors in AML12 hepatocytes.

    abstract：:Circadian rhythms help organisms adapt to changes of external environment by regulating energy metabolism and remaining the balance of homeostasis. Numerous researches have proved that the physiological function of liver was precisely controlled by circadian rhythms. Clock, one of core circadian genes, has been demons...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-020-03701-1

    authors： Yang S,Liu Y,Guo Y,Liu R,Qi F,Li X,Yu H,Cheng S,Wang Z

    更新日期：2020-04-01 00:00:00

  • Modulation of the c-Jun N-terminal kinase activity in the embryonic heart in response to anoxia-reoxygenation: involvement of the Ca2+ and mitoKATP channels.

    abstract：:Whether the response of the fetal heart to ischemia-reperfusion is associated with activation of the c-Jun N-terminal kinase (JNK) pathway is not known. In contrast, involvement of the sarcolemmal L-type Ca2+ channel (LCC) and the mitochondrial KATP (mitoKATP) channel has been established. This work aimed at investiga...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-008-9750-4

    authors： Sarre A,Gardier S,Maurer F,Bonny C,Raddatz E

    更新日期：2008-06-01 00:00:00

  • Changes in motochondrial calcium metabolism after treating mastocytoma cells with N6,O2'-dibutyryladenosine 3',5' cyclic monophosphate.

    abstract：:Comparison of Ca2+ uptake by isolated mouse liver mitochondria, and mitochondria prepared from mastocytoma cells grown with and without N6,O2'-dibutyryladenosine 3',5' cyclic monophosphate (DB cyclic AMP) and theophylline showed several differences in their capacity to take up and retain calcium. In particular mitocho...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00215305

    authors： McHardy JE,Ralph RK

    更新日期：1980-03-20 00:00:00