Release of ischemia in paced rat Langendorff hearts by supply of L-carnitine: role of endogenous long-chain acylcarnitine.

abstract：:Regulation of L-type Ca2+ channels is complex, because many factors, such as phosphorylation, divalent cations, and proteins, specified or unspecified, have been shown to affect the channel activities. An additional complication is that these factors interact with one another to achieve final outcomes. Recent molecula...

journal_title：Molecular and cellular biochemistry

authors： Yamaoka K,Kameyama M

更新日期：2003-11-01 00:00:00

abstract：:Original studies with rat adrenocortical carcinoma identified a 180 kDa cell-surface protein which contained both guanylate cyclase and atrial natriuretic factor (ANF) receptor, representing a potentially new type of bifunctional receptor protein. It is both a receptor and a guanylate cyclase. This critical conclusion...

journal_title：Molecular and cellular biochemistry

authors： Marala RB,Sharma RK

更新日期：1991-01-16 00:00:00

abstract：:The present review is focused on the main achievements realized in the lysozyme research field since the meeting held in 1972 to commemorate the fiftieth anniversary of the discovery of this enzyme. Despite of extensive structural, physico-chemical, crystallographic, genetic, immunological and evolutionary studies dev...

journal_title：Molecular and cellular biochemistry

authors： Jollès P,Jollès J

更新日期：1984-09-01 00:00:00

abstract：:The aim of our study is to explore the regulation of C1QTNF1-AS1 on its target miR-221-3p/SOCS3 in human hepatocellular carcinoma (HCC). To explore the underlying molecular regulation of non-coding RNA for HCC, differentially expressed patterns of lncRNAs and genes were examined by RNA-seq. GO and KEGG pathway analysi...

journal_title：Molecular and cellular biochemistry

authors： Han W,Yu G,Meng X,Hong H,Zheng L,Wu X,Zhang D,Yan B,Ma Y,Li X,Wang Q

更新日期：2019-10-01 00:00:00

abstract：:Activation of extracellular signal-related kinase (ERK) is involved in decreased melanogenesis by sphingosylphosphorylcholine (SPC). In the present study, we confirmed that SPC activated ERK and that a specific inhibitor of the ERK pathway (PD98059) recovered SPC-induced hypopigmentation. Moreover, we found that SPC s...

journal_title：Molecular and cellular biochemistry

authors： Jeong HS,Park KC,Kim DS

更新日期：2012-08-01 00:00:00

abstract：:The fatty acid binding proteins (FAPBs) function as intracellular carriers of fatty acid (FA) and related compounds. During the digestion of lipids, the local concentration of FA exceeds their critical micellar concentration; the excess ratio of FA/FABP can be as high as approximately 1,000/1, consequently building mi...

journal_title：Molecular and cellular biochemistry

authors： Levin LB,Nachliel E,Gutman M,Tsfadia Y

更新日期：2009-06-01 00:00:00

abstract：:The molecular mechanisms potentially responsible for cadmium carcinogenesis were investigated by differential gene expression analysis of Balb/c-3T3 cells morphologically transformed with cadmium chloride. Differential display analysis of gene expression revealed overexpression of mouse Translation Initiation Factor 3...

journal_title：Molecular and cellular biochemistry

authors： Joseph P,Lei YX,Ong TM

更新日期：2004-01-01 00:00:00

abstract：:Methotrexate (MTX), a folic acid antagonist, is widely used as a cytotoxic chemotherapeutic agent. MTX-associated neurotoxicity is an important clinical problem. The aim of this study was to investigate the role of caffeic acid phenethyl ester (CAPE) on cerebellar oxidative stress induced by MTX in rats. A total of 19...

journal_title：Molecular and cellular biochemistry

authors： Uzar E,Koyuncuoglu HR,Uz E,Yilmaz HR,Kutluhan S,Kilbas S,Gultekin F

更新日期：2006-10-01 00:00:00

abstract：:Cultured cardiac myocytes were depleted of ATP by incubation with oligomycin (1 mg/ml). Then the ability of the cells to oxidize various substrates and to restore ATP levels was studied. Following ATP depletion, the cells were found to be able to oxidize glucose given alone, but not palmitate. However, with both subst...

journal_title：Molecular and cellular biochemistry

authors： Tirosh R,Mishor T,Pinson A

更新日期：1996-09-20 00:00:00

abstract：:Rat pheochromocytoma PC12 cells have been treated with nerve growth factor (NGF) at final concentrations of 2, 4, 8, and 16 ng/ml, and then were exposed to 60-Hz, sinusoidal magnetic fields (MF) of 12.5, 25, 50, and 100 microT (rms) for 30 min. Transcript levels for both c-fos and glyceraldehyde-3 -phosphate dehydroge...

journal_title：Molecular and cellular biochemistry

authors： Campbell-Beachler M,Ishida-Jones T,Haggren W,Phillips JL

更新日期：1998-12-01 00:00:00

abstract：:When cells of the thymus or mouse leukemias P288 and L1210 are exposed in vitro to the potent synthetic glucocorticoid, 3H-Triamcinolone acetonide, the steroid enters the cells passively and binds to macromolecules in the cytoplasm. At 37 degrees C this hormone-receptor complex enters the nucleus and associates with t...

journal_title：Molecular and cellular biochemistry

authors： Turnell RW,Burton AF

更新日期：1975-12-31 00:00:00

abstract：:Partially purified D-aspartate oxidase from beef kidney has been tested in the presence of butanedione or phenylglyoxal, which specifically modify the arginine molecule. The results obtained clearly indicate that arginine residues are involved in the binding of the substrate to the active site of the enzyme. ...

journal_title：Molecular and cellular biochemistry

authors： Crifò C,Santoro L,Rinaldi A,De Marco C

更新日期：1977-08-19 00:00:00

abstract：:Diabetes is associated with increased oxidative stress and impaired antioxidant defenses. Thioredoxin-1 (TRX-1) is a cytosolic thiol antioxidant and redox-active protein which plays a vital role in the maintenance of reduced intracellular redox state. In this study, the authors examined whether 4-week treatments with ...

journal_title：Molecular and cellular biochemistry

authors： Atalay M,Bilginoglu A,Kokkola T,Oksala N,Turan B

更新日期：2011-05-01 00:00:00

abstract：:Hyperhomocysteinemia (HHcy) is an independent risk factor of cardiovascular disease, but the mechanisms of tissue injury are poorly understood. In the present study, we investigated the effect of HHcy on rat heart function, activities electron transport chain (ETC) complexes, mitochondrial protein expression, and prot...

journal_title：Molecular and cellular biochemistry

authors： Timkova V,Tatarkova Z,Lehotsky J,Racay P,Dobrota D,Kaplan P

更新日期：2016-01-01 00:00:00

abstract：:Pig intestinal brush borders (BB) were radiolabeled by iodination using the lactoperoxidase-hydrogen peroxide procedure. The BB were then detergent solubilized, centrifuged to remove particulate material, and chromatographed on Sepharose CL-4B. The fractions were incubated with K88+ E. coli using an in vitro binding a...

journal_title：Molecular and cellular biochemistry

authors： Staley TE,Wilson IB

更新日期：1983-01-01 00:00:00

abstract：:Prolonged ischemia-reperfusion results in various damages in skeletal muscle. Following reperfusion, although the damaged muscles undergo regeneration, the precise process and mechanism of regeneration have not yet been fully understood. Here, we show the altered levels of plasma biochemical markers of muscle damage, ...

journal_title：Molecular and cellular biochemistry

authors： Itoh M,Shimokawa N,Tajika Y,Murakami T,Aotsuka N,Lesmana R,Farenia R,Iwasaki T,Okda J,Yorifuji H,Koibuchi N

更新日期：2013-01-01 00:00:00

abstract：:Two forms of the regulatory subunit of the type II cAMP-dependent protein kinase (RII55 and RII52) were identified from bovine heart by gel electrophoretic behaviour. After autophosphorylation the RII55 isoform migrated more slowly (RII55/57) while the migration of RII52 isoform did not shift. Both isoforms showed dif...

journal_title：Molecular and cellular biochemistry

authors： González-Nicolás J,Jiménez JS,Moreno FJ

更新日期：1990-07-17 00:00:00

abstract：:Recruitment of the protein kinase C (PKC) family of isozymes is an integral component of the signaling events that direct cardiac phenotype expressed during postnatal development and in response to pathologic stimuli. Hyperglycemia is a potent activating signal for cardiac PKC isozymes and induces the apoptosis progra...

journal_title：Molecular and cellular biochemistry

authors： Malhotra A,Kang BP,Hashmi S,Meggs LG

更新日期：2005-01-01 00:00:00

abstract：:1. Two different molecular forms of dopamine-beta-hydroxylase were isolated from human serum; a major component (Peak I enzyme) with a molecular weight of 368000 and with a higher specific activity and a minor component (Peak II enzyme) with a molecular weight of 188000 and with a lower specific activity. 2. Both form...

journal_title：Molecular and cellular biochemistry

authors： Ikeno T,Hashimoto S,Kuzuya H,Nagatsu T

更新日期：1977-12-29 00:00:00

abstract：:Vasoactive peptides such as angiotensin II (AII), atrial natriuretic peptide (ANP) and vasopressin play an important role in the regulation of blood pressure. We have recently shown an augmentation of Gi alpha levels in heart and aorta from genetic and experimentally-induced hypertensive rats, which may be attributed ...

journal_title：Molecular and cellular biochemistry

authors： Anand-Srivastava MB,Palaparti A,Pion J

更新日期：1997-11-01 00:00:00

abstract：:Total cellular creatine content is an important bioenergetic parameter in skeletal muscle. To understand its regulation we investigated creatine transport and accumulation in the G8 cultured skeletal myoblast line. Like other cell types, these contain a creatine transporter, whose activity, measured using a radiolabel...

journal_title：Molecular and cellular biochemistry

authors： Odoom JE,Kemp GJ,Radda GK

更新日期：1996-05-24 00:00:00

abstract：:Dendritic cells (DC) and myeloid-derived suppressor cells (MDSC) are important cells involved in immune response. DC can be generated from mouse bone marrow (BM) in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-4. Recent studies have revealed that combined treatment of bone marrow MD...

journal_title：Molecular and cellular biochemistry

authors： Liu C,Zhang C,Lu H,Cai J,Wang Z,Chen J,Liu F,Wu Z,Liu X,Sun W

更新日期：2011-12-01 00:00:00

abstract：:Spray-dried milk enriched with n-3 fatty acids from linseed oil or fish oil were fed to rats to study its influence on liver lipid peroxides, hepatic antioxidant enzyme activities, serum prostaglandins and platelet aggregation. Significant level of alpha linolenic acid, eicosapentaenoic acid and docosahexaenoic acid w...

journal_title：Molecular and cellular biochemistry

authors： Ramaprasad TR,Baskaran V,Krishnakantha TP,Lokesh BR

更新日期：2005-12-01 00:00:00

abstract：:The interaction of glyceraldehyde 3-phosphate dehydrogenase with microtubules has been studied by measurement of the amount of enzyme which co-assembles with in vitro reconstituted microtubules. The binding of glyceraldehyde 3-phosphate dehydrogenase to microtubules is a saturable process; the maximum binding capacity...

journal_title：Molecular and cellular biochemistry

authors： Durrieu C,Bernier-Valentin F,Rousset B

更新日期：1987-03-01 00:00:00

abstract：:Many recent studies have suggested that bergapten (BP), a class of native compound with numerous biological activities such as anti-resorptive properties, may exert protective effects against postmenopausal bone loss. However, it remains unknown whether BP regulates or improves the osteogenic function of bone marrow s...

journal_title：Molecular and cellular biochemistry

authors： Xiao JJ,Zhao WJ,Zhang XT,Zhao WL,Wang XX,Yin SH,Jiang F,Zhao YX,Chen FN,Li SL

更新日期：2015-11-01 00:00:00

abstract：:We have investigated how diabetes affects the expression of adropin (ADR) in rat brain, cerebellum, kidneys, heart, liver, and pancreas tissues. The rats in the diabetic group were administered an intraperitoneal (i.p.) injection of a single dose of 60 mg/kg streptozotocin (STZ) dissolved in a 0.1 M phosphate-citrate ...

journal_title：Molecular and cellular biochemistry

authors： Aydin S,Kuloglu T,Aydin S,Eren MN,Yilmaz M,Kalayci M,Sahin I,Kocaman N,Citil C,Kendir Y

更新日期：2013-08-01 00:00:00

abstract：:Primary cultures of skeletal muscle cells secrete plasminogen activator (PA) activity to the conditioning medium and display membrane-bound PA. Growth of these cells in culture in presence of 10(-7) M dexamethasone resulted in a marked reduction of the membranal and secreted PA activity. The hormone also reduced cytos...

journal_title：Molecular and cellular biochemistry

authors： Mayer M,Finci Z,Chaouat M,Sasson S

更新日期：1986-02-01 00:00:00

abstract：:This comparative study investigates the relationship between sarcoplasmic reticulum (SR) calcium(Ca2+)-ATPase transport activity and phospholamban (PLB) phosphorylation in whole cardiac homogenates of spontaneously hypertensive rats (SHR) and their parent, normotensive Wistar Kyoto (WKY) strain during early postnatal ...

journal_title：Molecular and cellular biochemistry

authors： Freestone N,Singh J,Krause EG,Vetter R

更新日期：1996-10-01 00:00:00

abstract：:To extend the available information on the significance of the interactions between glycolytic enzymes and the actin component of the cellular ultrastructure, investigations into the compositional characteristics of the actin binding site on one of the major glycolytic enzymes, aldolase, have been undertaken. As the e...

journal_title：Molecular and cellular biochemistry

authors： Don M,Masters C

更新日期：1988-06-01 00:00:00

abstract：:Beta-arrestin-2 is an adaptor protein that terminates G protein activation and seems to be involved in the modulation of the inflammatory response. Small hyaluronan (HA) fragments, such as 4-mer HA oligosaccharides, are known to interact with the toll-like receptor-4 (TLR-4) with consequent activation of the nuclear f...

journal_title：Molecular and cellular biochemistry

authors： Campo GM,Avenoso A,D'Ascola A,Scuruchi M,Calatroni A,Campo S

更新日期：2015-01-01 00:00:00