Abstract：
:Dendritic cells (DC) and myeloid-derived suppressor cells (MDSC) are important cells involved in immune response. DC can be generated from mouse bone marrow (BM) in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-4. Recent studies have revealed that combined treatment of bone marrow MDSC with LPS plus IFN-γ inhibited the DC development but enhanced MDSC functions, such as NO release and T cell suppression. In our study, bone marrow precursor cells cultures in GM-CSF and IL-4 were treated with poly(I:C) through the culture, Gr1(+)CD11b(+) cells with MDSC functions, such as NO release and T cell suppression were accumulated in the culture system. Then the similar phenomenon was observed in the vesicular stomatitis virus infection in vivo. In conclusion, we demonstrated that the bone marrow precursor cells in the presence of GM-CSF and IL-4 can differentiate into MDSC, which is dependent on the dynamic of interaction with poly(I:C).
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Liu C,Zhang C,Lu H,Cai J,Wang Z,Chen J,Liu F,Wu Z,Liu X,Sun Wdoi
10.1007/s11010-011-0982-3subject
Has Abstractpub_date
2011-12-01 00:00:00pages
317-23issue
1-2eissn
0300-8177issn
1573-4919journal_volume
358pub_type
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