Rat red blood cell hexokinase purification, properties and age-dependence.

abstract：:Ovarian cancer has the highest mortality in gynecologic malignancies. LncRNA BLACAT1 serves crucial functions in various cancers, but its role in ovarian cancer has not been investigated. In this article, our team explored the role and the potential regulatory mechanism of BLACAT1 in ovarian cancer. Quantitative RT-PC...

journal_title：Molecular and cellular biochemistry

authors： Yang H,Qi Y,Wang XL,Gu JJ,Shi TM

更新日期：2020-04-01 00:00:00

abstract：:Triplex forming oligonucleotides (TFO) are known to be potential agents for modifying gene function. In most instances they are utilized for repression of transcription. However hybrid molecules containing cis-acting elements in a duplex DNA in a hairpin form contiguously with the TFO can bind transcription factors in...

journal_title：Molecular and cellular biochemistry

authors： Ghosh MK,Katyal A,Chandra R,Brahmachari V

更新日期：2005-10-01 00:00:00

abstract：:Frequent abnormalities in 7p12 locus in different tumors like lung cancer candidate this region for novel regulatory elements. MiRNAs as novel regulatory elements encoded within the human genome are potentially oncomiRs or miR suppressors. Here, we have used bioinformatics tools to search for the novel miRNAs embedded...

journal_title：Molecular and cellular biochemistry

authors： Hoballa MH,Soltani BM,Mowla SJ,Sheikhpour M,Kay M

更新日期：2018-07-01 00:00:00

abstract：:Many recent studies have suggested that bergapten (BP), a class of native compound with numerous biological activities such as anti-resorptive properties, may exert protective effects against postmenopausal bone loss. However, it remains unknown whether BP regulates or improves the osteogenic function of bone marrow s...

journal_title：Molecular and cellular biochemistry

authors： Xiao JJ,Zhao WJ,Zhang XT,Zhao WL,Wang XX,Yin SH,Jiang F,Zhao YX,Chen FN,Li SL

更新日期：2015-11-01 00:00:00

abstract：:Formation of lanthionine, a dehydroalanine crosslink, is associated with aging of the human lens and cataractogenesis. In this study we investigated whether modification of lens proteins by glutathione could proceed through an alternative pathway: that is, by the formation of a nonreducible thioether bond between prot...

journal_title：Molecular and cellular biochemistry

authors： Linetsky M,LeGrand RD

更新日期：2005-04-01 00:00:00

abstract：:In this review we analyze the concepts and the experimental data on the mechanisms of the regulation of energy metabolism in muscle cells. Muscular energetics is based on the force-length relationship, which in the whole heart is expressed as a Frank-Starling law, by which the alterations of left ventricle diastolic v...

journal_title：Molecular and cellular biochemistry

authors： Saks VA,Kuznetsov AV,Vendelin M,Guerrero K,Kay L,Seppet EK

更新日期：2004-01-01 00:00:00

abstract：:delta-Crystallin is a major structural protein of avian and reptilian lenses that is absent from the lenses of fish, amphibia and mammals. It appears to be a tetrameric protein with a native molecular weight near 200 000 (200K) and polypeptide molecular weight near 50K and 48K) (see Note added in proof). The alpha-cry...

journal_title：Molecular and cellular biochemistry

authors： Piatigorsky J

更新日期：1984-01-01 00:00:00

abstract：:p90 ribosomal S6 kinase (p90RSK) constitutes a family of serine/threonine kinases that have been shown to be involved in cell proliferation of various malignancies via direct or indirect effects on the cell-cycle machinery. We investigated the role of p90RSK in lung adenocarcinomas and whether the inhibition of p90RSK...

journal_title：Molecular and cellular biochemistry

authors： Abdulrahman N,Jaballah M,Poomakkoth N,Riaz S,Abdelaziz S,Issa A,Mraiche F

更新日期：2016-07-01 00:00:00

abstract：:In addition to the classical genomic steroid actions on modulation of transcription and protein synthesis, rapid, nongenomic effects have been described for various steroids. These effects on cellular signaling and function are supposed to be transmitted by membrane binding sites unrelated to the classical intracellul...

journal_title：Molecular and cellular biochemistry

authors： Falkenstein E,Eisen C,Schmieding K,Krautkrämer M,Stein C,Lösel R,Wehling M

更新日期：2001-02-01 00:00:00

abstract：:Previously, we isolated and characterized the gene encoding the 3'-Nucleotidase/Nuclease (Ld3'NT/NU) from the human pathogen, Leishmania donovani. This unique cell surface enzyme has been shown to be involved in the salvage of host-derived purines, which are essential for the survival of this important protozoan paras...

journal_title：Molecular and cellular biochemistry

authors： Debrabant A,Bastien P,Dwyer DM

更新日期：2001-04-01 00:00:00

abstract：:Zonation of ethanol oxidation and metabolic effects along the hepatic acini were investigated in the bivascularly perfused liver of fed rats. Ethanol was infused into the hepatic artery in antegrade and retrograde perfusion. Inhibition of glycolysis by ethanol, expressed as micromol min(-1) (ml accessible cell space)(...

journal_title：Molecular and cellular biochemistry

authors： Lopez CH,Constantin J,Gimenes D,Suzuki-Kemmelmeier F,Bracht A

更新日期：2004-03-01 00:00:00

abstract：:Using a synthetic peptide that encompasses the zinc finger domain of the eukaryotic transcription factor Sp1, we produced a number of monoclonal antibodies that specifically reacted with the target antigen. Analysis by competitive inhibition assay of five of the monoclonal antibodies revealed that they all recognized ...

journal_title：Molecular and cellular biochemistry

authors： Katai H,Terato K,Raghow R

更新日期：1991-02-27 00:00:00

abstract：:Insulin alone at concentrations of less than 1 to 5 uU/ml increased the enzyme activities of glycogen synthase, synthase phosphatase, phosphorylase, and phosphorylase phosphatase in hepatoma H4 cells in culture in the presence and absence of serum. Increase in total and active forms of glycogen synthase and phosphoryl...

journal_title：Molecular and cellular biochemistry

authors： Goheer MA,Larner J,Curnow RT

更新日期：1987-06-01 00:00:00

abstract：:The capacity of noradrenaline (NA) and its end metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) to modulate the chemotaxis of lymphocytes from a primary immunocompetent organ (thymus) and a secondary one (spleen) was investigated over a range of concentrations from 10(-12) M to 10(-5) M. Lymphocyte chemotaxis was eva...

journal_title：Molecular and cellular biochemistry

authors： García JJ,del Carmen Sáez M,De la Fuente M,Ortega E

更新日期：2003-12-01 00:00:00

abstract：:Cellular FLICE-like inhibitory protein (Flip) is a negative regulator of nuclear factor κB signaling which has been shown previously to complicate with cardiac hypertrophy. In the present study, we tested the hypothesis that the knockout of Flip would increase cardiac hypertrophy in vivo and in vitro. The effects of F...

journal_title：Molecular and cellular biochemistry

authors： Huang Y,Wu L,Wu J,Li Y,Hou L

更新日期：2014-12-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are two hormones produced and secreted by the heart to control blood pressure, body fluid homeostasis and electrolyte balance. Each peptide binds to a common family of 3 receptors (GC-A, GC-B and C-receptor) with varying degrees of affinity. The pro...

journal_title：Molecular and cellular biochemistry

authors： Tse MY,Watson JD,Sarda IR,Flynn TG,Pang SC

更新日期：2001-03-01 00:00:00

abstract：:Acute kidney injury (AKI) occurs in 30%-70% of critically ill patients. Multiple organ failure (MOF), which is most often secondary to hypotension and septicemia, is a global public health problem. The prognosis of patients is poor. Currently, there is no specific therapeutic method. Finding new therapeutic targets is...

journal_title：Molecular and cellular biochemistry

authors： Yang X,Li B,Guan Y,Jiang HM

更新日期：2021-01-11 00:00:00

abstract：:Cysteine-rich secretory protein 3 (CRISP-3) is upregulated in prostate cancer as compared to the normal prostate tissue. Higher expression of CRISP-3 has been linked to poor prognosis and hence it has been thought to act as a prognostic marker for prostate cancer. It is proposed to have a role in innate immunity but i...

journal_title：Molecular and cellular biochemistry

authors： Pathak BR,Breed AA,Apte S,Acharya K,Mahale SD

更新日期：2016-01-01 00:00:00

abstract：:Effects of iloprost, which is a stable prostacyclin analogue, on the ischemic myocardium were examined in the open-chest dog heart in terms of biochemical parameters. Ischemia was initiated by ligating the left anterior descending coronary artery. When the coronary artery was ligated for 3 min, the levels or glycogen,...

journal_title：Molecular and cellular biochemistry

authors： Ichihara K,Yamamoto K,Abiko Y

更新日期：1993-02-17 00:00:00

abstract：:Endothelial dysfunction (ED) has a high incidence in chronic kidney disease (CKD) and is identified as a precursor to cardiovascular events. Recent studies suggest that leptin may be the missing link between ED and CKD. The objective of this study was to investigate the mechanism by which leptin causes ED and the conn...

journal_title：Molecular and cellular biochemistry

authors： Liu B,Qiao J,Hu J,Fan M,Zhao Y,Su H,Wang Z,Yu Q,Ma Q,Li Y,Lv Z,Wang R

更新日期：2020-10-01 00:00:00

abstract：:In an isolated, normothermic rat heart model (Langendorff, 37 degrees C), dimethylthiourea (DMTU) infusion only during reperfusion reduced both injury and measurable hydrogen peroxide (H2O2) concentrations after global ischemia. Cardiac function was assessed by measurement of ventricular developed pressure (DP). H2O2 ...

journal_title：Molecular and cellular biochemistry

authors： Brown JM,Terada LS,Grosso MA,Whitman GJ,Velasco SE,Patt A,Harken AH,Repine JE

更新日期：1988-12-01 00:00:00

abstract：:Oxidized LDL is highly atherogenic as it stimulates macrophage cholesterol accumulation and foam cell formation, it is cytotoxic to cells of the arterial wall and it stimulates inflammatory and thrombotic processes. LDL oxidation can lead to its subsequent aggregation, which further increases cellular cholesterol accu...

journal_title：Molecular and cellular biochemistry

authors： Aviram M,Fuhrman B

更新日期：1998-11-01 00:00:00

abstract：:Spray-dried milk enriched with n-3 fatty acids from linseed oil (LSO) or fish oil (FO) were fed to rats to study its influence on liver lipid peroxides, hepatic antioxidant enzyme activities, serum prostaglandins and platelet aggregation. Significant level of alpha linolenic acid, eicosapentaenoic acid and docosahexae...

journal_title：Molecular and cellular biochemistry

authors： Ramaprasad TR,Baskaran V,Krishnakantha TP,Lokesh BR

更新日期：2005-09-01 00:00:00

abstract：:Acyl-CoA: lysolecithin and lysolecithin: lysolecithin acyltransferases, as well as acyl-CoA hydrolase are important enzymes in lung lipid metabolism. They use amphiphylic lipids as substrates and differ in subcellular localization. In this sense, lipid-protein interactions can be an essential factor in their activity....

journal_title：Molecular and cellular biochemistry

authors： Pérez-Gil J,Estrada P,Acebal C,Arche R

更新日期：1990-05-10 00:00:00

abstract：:Our interest in the role of sulfhydryl groups (SH) in regulating or altering transport across biological membranes has focused on the significance of a critical SH group associated with the Ca2+-release protein from skeletal muscle sarcoplasmic reticulum (SR). We have shown that binding of heavy metals to this group o...

journal_title：Molecular and cellular biochemistry

authors： Abramson JJ,Salama G

更新日期：1988-07-01 00:00:00

abstract：:Interactions of cytochrome P450 2B1 were probed using 8-anilino-1-naphthalenesulfonic acid (ANS), a well known and frequently used reporter group for hydrophobic interactions. Titration of cytochrome P450 2B1 with ANS revealed 6.6 +/- 0.2 ANS binding sites per molecule of P450 2B1 with a Kd value of 42 +/- 2 microM. I...

journal_title：Molecular and cellular biochemistry

authors： Yu XC,Strobel HW

更新日期：1996-09-20 00:00:00

abstract：:Saccharomyces cerevisiae contains vacuoles corresponding to lysosomes in higher eukaryotes. Lysosomes are dynamic (not silent) organelles in which enzymes can be easily integrated or released when exposed to stressful conditions. Changes in lysosomal enzymes have been observed due to oxidative stress, resulting in an ...

journal_title：Molecular and cellular biochemistry

authors： Yoon J,Sekhon SS,Kim YH,Min J

更新日期：2016-06-01 00:00:00

abstract：:A membrane-bound L-asparaginase (EC 3.5.1.1) of Tetrahymena pyriformis was purified to homogeneity. The purified enzyme is a lipoprotein, since it is inactivated by phospholipase C and its activity is restored by the addition of naturally occurring lipids, such as phosphatidylcholine, triolein and oleyl acetate. The r...

journal_title：Molecular and cellular biochemistry

authors： Tsirka SA,Kyriakidis DA

更新日期：1988-10-01 00:00:00

abstract：:Iron ions play a central role in .OH radicals formation and induction of oxidative stress in living organisms. Iron-catalyzed .OH radical formation degrades deoxyribose to thiobarbituric acid reactive substances (TBA-RS). This paper analyzes kinetic properties of the Fe(III)-EDTA-catalyzed deoxyribose degradation in t...

journal_title：Molecular and cellular biochemistry

authors： Hermes-Lima M,Wang EM,Schulman HM,Storey KB,Ponka P

更新日期：1994-08-17 00:00:00

abstract：:Lysophosphatidic acid (LPA) signaling through LPA receptors (LPA1 to LPA6) regulates a variety of malignant properties in cancer cells. Recently, we show that LPA2 expression is elevated by long-term cisplatin (CDDP) treatment in melanoma A375 cells. In the present study, we investigated whether LPA2-mediated signalin...

journal_title：Molecular and cellular biochemistry

authors： Minami K,Ueda N,Ishimoto K,Tsujiuchi T

更新日期：2020-06-01 00:00:00