Abstract：
:Recent evidence indicated that endocan may be a potential cell marker and a new target for cancers including acute leukemia since the serum endocan level in patients with acute leukemia was associated with the status of the disease, i.e., endocan was higly expressed in untreated acute leukemia, but decreased after chemotherapy and increased again during bone marrow regeneration. The present study showed that there was high level expression of endocan in cytoplasm of bone marrow blasts of patients with acute myeloid leukemia or acute lymphoblastic leukemia. The expression level of endocan was significantly decreased when the patients underwent remission after chemotherapy and re-bounces back when the acute leukemia relapsed. No obvious change in expression of endocan was observed before and after chemotherapy if the patients showed no remission after chemotherapy. (N-(4-Hydroxyphenyl) retinamide), a potent anti-angiogenic agent, could not only down-regulate the expression of vascular epithelial growth factor, but also decrease endocan transcription and expression in NB4 cells, a human acute promyelocytic leukemia cell line. These observations suggest that endocan could act as a predictor for the severity and the prognosis of acute leukemia. The findings could be used as the basis for future targeted therapy directed against bone marrow angiogenesis in acute leukemia treatment.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Xu Z,Zhang S,Zhou Q,Wang Y,Xia Rdoi
10.1007/s11010-014-2117-0subject
Has Abstractpub_date
2014-10-01 00:00:00pages
117-23issue
1-2eissn
0300-8177issn
1573-4919journal_volume
395pub_type
杂志文章abstract：:Liver glycogen synthase b phosphatase, chromatographically separable from phosphorylase a phosphatase, is decreased in 48-hour alloxan diabetic rats. The phosphatase activities are measured in an in vitro system using exogenous isolated phospho-enzyme as substrates with added phosphatases. Synthase and phosphorylase p...
journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
doi：10.1007/BF00211141
更新日期：1979-05-06 00:00:00
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journal_title：Molecular and cellular biochemistry
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doi：10.1007/BF00421052
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pub_type： 杂志文章
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
doi：10.1007/BF00219260
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章,评审
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更新日期：1998-11-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
doi：10.1007/BF00426336
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
doi：10.1007/BF01793330
更新日期：1977-04-12 00:00:00
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journal_title：Molecular and cellular biochemistry
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doi：10.1007/BF00420901
更新日期：1990-08-10 00:00:00
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
doi：10.1023/a:1013360308946
更新日期：2001-12-01 00:00:00
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
doi：10.1007/s11010-019-03589-6
更新日期：2019-11-01 00:00:00
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
doi：10.1023/a:1010932211745
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pub_type： 杂志文章
doi：10.1007/s11010-010-0537-z
更新日期：2010-11-01 00:00:00
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
doi：10.1007/s11010-011-1004-1
更新日期：2012-01-01 00:00:00
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
doi：10.1007/BF00926832
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pub_type： 杂志文章
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
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