Abstract:
:Protein kinase CK2 is a highly conserved and ubiquitous serine-threonine kinase. It is a tetrameric enzyme that is made up of two regulatory CK2beta subunits and two catalytic subunits, either CK2alpha/CK2alpha, CK2alpha/CK2alpha', or CK2alpha'/CK2alpha'. Although the two catalytic subunits diverge in their C termini, their enzymatic activities are similar. To identify the specific function of the two catalytic subunits in development, we have deleted them individually from the mouse genome by homologous recombination. We have previously reported that CK2alpha' is essential for male germ cell development, and we now demonstrate that CK2alpha has an essential role in embryogenesis, as mice lacking CK2alpha die in mid-embryogenesis, with cardiac and neural tube defects.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Seldin DC,Lou DY,Toselli P,Landesman-Bollag E,Dominguez Idoi
10.1007/s11010-008-9811-8subject
Has Abstractpub_date
2008-09-01 00:00:00pages
141-7issue
1-2eissn
0300-8177issn
1573-4919journal_volume
316pub_type
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