Abstract:
:In an isolated, normothermic rat heart model (Langendorff, 37 degrees C), dimethylthiourea (DMTU) infusion only during reperfusion reduced both injury and measurable hydrogen peroxide (H2O2) concentrations after global ischemia. Cardiac function was assessed by measurement of ventricular developed pressure (DP). H2O2 was assessed using H2O2 dependent aminotriazole inactivation of myocardial catalase. Depletion of xanthine oxidase by two methods (tungsten or allopurinol inhibition) also improved recovery of function and H2O2 production. The results indicate that XO derived H2O2 contributes to myocardial reperfusion injury.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Brown JM,Terada LS,Grosso MA,Whitman GJ,Velasco SE,Patt A,Harken AH,Repine JEdoi
10.1007/BF00421052subject
Has Abstractpub_date
1988-12-01 00:00:00pages
173-5issue
2eissn
0300-8177issn
1573-4919journal_volume
84pub_type
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