Mitochondrial biogenesis: inhibitors of mitochondrial protein synthesis.

abstract：:The hexokinase: fumarase ratios of mitochondria isolated from ten tissues of the rat were determined, and compared with the tissue content of phosphoglucomutase and phosphorylase, taken as representatives of enzymes concerned with glycogen metabolism. A generally inverse relationship was found between the mitochondria...

journal_title：Molecular and cellular biochemistry

authors： Wilson JE,Felgner PL

更新日期：1977-11-25 00:00:00

abstract：:A matricellular protein, osteopontin (OPN), is expressed in response to mechanical stress and similar stimuli in the heart, integrates the inter-ECM signal transduction network of component cells, and maintains efficient contractility through quantitative and qualitative control of extracellular matrix (ECM) proteins....

journal_title：Molecular and cellular biochemistry

authors： Okamoto H

更新日期：2007-06-01 00:00:00

abstract：:In mammals, protein kinase CK2 has two isozymic forms of its catalytic subunit, designated CK2alpha and CK2alpha'. CK2alpha and CK2alpha' exhibit extensive similarity within their catalytic domains but have completely unrelated C-terminal sequences. To systematically examine the cellular functions of each CK2 isoform ...

journal_title：Molecular and cellular biochemistry

authors： Litchfield DW,Bosc DG,Canton DA,Saulnier RB,Vilk G,Zhang C

更新日期：2001-11-01 00:00:00

abstract：:Reviews on the pathogenic mechanisms of Shigella species show a lacunae in the understanding of the bacterial antioxidant defense system and its regulations. This study was done to investigate the regulation of expression of antioxidant enzymes in clinical isolates of Shigella species, under various growth conditions....

journal_title：Molecular and cellular biochemistry

authors： Prakash R,Devaraj H,Devaraj SN

更新日期：2004-12-01 00:00:00

abstract：:Plasma membrane fractions from normal, regenerating liver and the AS-30D ascites hepatocarcinoma exhibited a high degree of enrichment when a set of plasma membrane enzyme markers were studied in comparison to the ones associated to the mitochondrial and cytosolic compartments. While the (Ca2+, Mg2+)-ATPase observed f...

journal_title：Molecular and cellular biochemistry

authors： Mas-Oliva J,Pérez-Montfort R,Cárdenas-García M,Rivas-Duro M

更新日期：1991-01-16 00:00:00

abstract：:Cardiac oxidative stress is developed following myocardial infarction (MI) particularly in the first week of MI. The influence of reactive oxygen species (ROS) on gene expression profiling and molecular pathways in the infarcted myocardium remains uncertain and is explored in the present study. Rats with MI were treat...

journal_title：Molecular and cellular biochemistry

authors： Zhao W,Zhao T,Chen Y,Qu Y,Gerling IC,Sun Y

更新日期：2013-07-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) has been thought to play a major role during cardiac fibrosis in the development of diabetic cardiomyopathy, and cardiac fibrosis mainly as a result of an increase of collagen type III occurs in the human hearts with diabetes. Thrombospondin-1 (TSP-1) has been reported to activat...

journal_title：Molecular and cellular biochemistry

authors： Tang M,Zhou F,Zhang W,Guo Z,Shang Y,Lu H,Lu R,Zhang Y,Chen Y,Zhong M

更新日期：2011-01-01 00:00:00

abstract：:SG2NA is a protein of the striatin family that organizes STRIPAK complexes. It has splice variants expressing differentially in tissues. Its 78 kDa isoform regulates cell cycle, maintains homeostasis in the endoplasmic reticulum, and prevents oxidative injuries. The 35 kDa variant is devoid of the signature WD-40 repe...

journal_title：Molecular and cellular biochemistry

authors： Gupta R,Kumar G,Jain BP,Chandra S,Goswami SK

更新日期：2020-10-20 00:00:00

abstract：:The results of our previous studies demonstrated that acute streptozotocin-induced diabetes in rats evoked a decrease in skin collagen content with little effect on glycosaminoglycans (GAG) content. In our present study we employed the model of chronic diabetes in order to check its effect on skin GAG content. It was ...

journal_title：Molecular and cellular biochemistry

authors： Cechowska-Pasko M,Pałka J,Bańkowski E

更新日期：1996-01-12 00:00:00

abstract：:Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important diseases of swine, which is caused by PRRS virus (PRRSV). CD151, one of PRRSV entry mediators, determines the cell susceptibility for PRRSV. Emerging evidence indicates that the host microRNAs (miRNAs) play key roles in modu...

journal_title：Molecular and cellular biochemistry

authors： Wu J,Peng X,Zhou A,Qiao M,Wu H,Xiao H,Liu G,Zheng X,Zhang S,Mei S

更新日期：2014-09-01 00:00:00

abstract：:MicroRNA (miRNAs) is demonstrated to be present in the blood of humans and has been increasingly suggested as a novel biomarker for various pathological processes in the heart, including myocardial infarction, myocardial remodeling and progression to heart failure. In this study, we aim to evaluate the diagnostic and ...

journal_title：Molecular and cellular biochemistry

authors： He F,Lv P,Zhao X,Wang X,Ma X,Meng W,Meng X,Dong S

更新日期：2014-09-01 00:00:00

abstract：:Abnormal angiogenesis underlies many pathological conditions and is critical for the growth and maintenance of various types of tumors, including hormone-dependent cancers. Since estrogens are potent carcinogens in humans and rodents, and are involved in regulating angiogenesis, this study was designed to examine the ...

journal_title：Molecular and cellular biochemistry

authors： Banerjee SK,Campbell DR,Weston AP,Banerjee DK

更新日期：1997-12-01 00:00:00

abstract：:The role of the subunits of phosphoinositide (PI) 3-kinase in NF-kappaB activation in silica-stimulated RAW 264.7 cells was investigated. Results indicate that PI3-kinase activity was increased in response to silica. The p85alpha subunit of PI3-kinase interacted with tyrosine-phosphorylated I(kappa)B-alpha in silica-s...

journal_title：Molecular and cellular biochemistry

authors： Kang JL,Lee HS,Pack IS,Hur KC,Castranova V

更新日期：2003-06-01 00:00:00

abstract：:Poly(ADP-ribosyl)ation is a eukaryotic posttranslational protein modification catalyzed by poly(ADP-ribose) polymerase (PARP), a highly conserved nuclear enzyme which uses NAD as substrate. We have previously tested PARP activity in permeabilized mononuclear blood cells (MNC) from 13 mammalian species as a function of...

journal_title：Molecular and cellular biochemistry

authors： Bürkle A,Müller M,Wolf I,Küpper JH

更新日期：1994-09-01 00:00:00

abstract：:Effectiveness of selenium in different forms like sodium selenite, selenocysteine and selenomethionine has been compared in four different doses, namely 4, 6, 8 and 10 ppm of each, in terms of their bioavailability and prolongation of survival of Dalton's lymphoma (DL) bearing mice. Selenomethionine, at a dose of 8 pp...

journal_title：Molecular and cellular biochemistry

authors： Mukhopadhyay-Sardar S,Rana MP,Chatterjee M

更新日期：2000-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNAs that have important roles in cancer. The altered expressions of miRNAs and their target genes are frequently detected in various tumors. In this study, downregulation of miR-15a-16 in nonsmall cell lung cancer (NSCLC) was found to be inversely correlated with Cripto. Results...

journal_title：Molecular and cellular biochemistry

authors： Chen F,Hou SK,Fan HJ,Liu YF

更新日期：2014-06-01 00:00:00

abstract：:The identification of informative biomarkers that could predict the treatment response is particularly important in the triple-negative (TN) breast cancer, which is characterized by biological diversity. The aim of this study was to investigate the impact of vascular endothelial growth factor receptor (VEGFR2) express...

journal_title：Molecular and cellular biochemistry

authors： Babyshkina N,Zavyalova M,Tarabanovskaya N,Dronova T,Krakhmal N,Slonimskaya E,Kzhyshkowska J,Choynzonov E,Cherdyntseva N

更新日期：2018-07-01 00:00:00

abstract：:The aim of the study was to find out whether administration of selenium (Se) will protect the immature heart against ischemia/reperfusion.The control pregnant rats were fed laboratory diet (0.237 mg Se/kg diet); experimental rats received 2 ppm Na(2)SeO(3) in the drinking water from the first day of pregnancy until da...

journal_title：Molecular and cellular biochemistry

authors： Ostadalova I,Vobecky M,Chvojkova Z,Mikova D,Hampl V,Wilhelm J,Ostadal B

更新日期：2007-06-01 00:00:00

abstract：:The present study was aimed to delineate in vivo mechanisms of orally administered fisetin with special reference to mitochondrial dysfunction in lung tissues employing benzo(a)pyrene (B(a)P) as the model lung carcinogen. The recent revival of interest in the study of mitochondria has been stimulated by the evidence t...

journal_title：Molecular and cellular biochemistry

authors： Ravichandran N,Suresh G,Ramesh B,Manikandan R,Choi YW,Vijaiyan Siva G

更新日期：2014-05-01 00:00:00

abstract：:The CREB-CREM transcription factors are the main gene regulatory effectors of the cAMP signaling pathway. The investigations of this family of transcription factors had a profound impact on the understanding of signaling-induced gene transcription. Here we discuss some key aspects of the underlying biology, review tra...

journal_title：Molecular and cellular biochemistry

authors： Haus-Seuffert P,Meisterernst M

更新日期：2000-09-01 00:00:00

abstract：:A quarter of the human population with European background carries at least one allele of the OPRD1 gene that encodes the delta opioid receptor with cysteine at the amino acid position 27 (hδOR(Cys27)) instead of the evolutionary conserved phenylalanine (hδOR(Phe27)). The two variants have indistinguishable pharmacolo...

journal_title：Molecular and cellular biochemistry

authors： Tuusa JT,Petäjä-Repo UE

更新日期：2011-05-01 00:00:00

abstract：:This study was focused to evaluate protection of indigenous antioxidant system of mice against gamma radiation-induced oxidative stress using a semiquinone (SQGD)-rich fraction isolated from Bacillus sp. INM-1. Male C57bl/6 mice were administered SQGD (50 mg/kgb.w.i.p.) 2 h before irradiation (10 Gy) and modulation in...

journal_title：Molecular and cellular biochemistry

authors： Mishra S,Reddy DS,Jamwal VS,Bansal DD,Patel DD,Malhotra P,Gupta AK,Singh PK,Jawed S,Kumar R

更新日期：2013-07-01 00:00:00

abstract：:Oxidative stress in cells caused by excessive production of reactive oxygen species (ROS) and decreased antioxidant defense is implicated in the cytotoxicity of xenobiotics including drugs and environmental chemicals. Endosulfan, a highly toxic organochlorine insecticide, causes cytotoxic cell death by inducing oxidat...

journal_title：Molecular and cellular biochemistry

authors： Murali M,Carvalho MS,Shivanandappa T

更新日期：2020-05-01 00:00:00

abstract：:We have previously demonstrated that Cationic Arginine-Rich Peptides (CARPs) and in particular poly-arginine-18 (R18; 18-mer of arginine) exhibit potent neuroprotective properties in both in vitro and in vivo neuronal injury models. Based on the current literature, there is a consensus that arginine residues by virtue...

journal_title：Molecular and cellular biochemistry

authors： MacDougall G,Anderton RS,Ouliel E,Gao J,Redmond SL,Knuckey NW,Meloni BP

更新日期：2020-01-01 00:00:00

abstract：:Lysosomes are defined traditionally with the marker enzyme acid phosphatase. We showed recently that lysosomes from human fibroblasts can be separated into a light and dense fraction as well as prelysosomal population. We now provide evidence that although acid phosphatase is enriched in all three fractions, the marke...

journal_title：Molecular and cellular biochemistry

authors： Kelly BM,Waheed A,Van Etten R,Chang PL

更新日期：1989-06-01 00:00:00

abstract：:Human telomerase reverse transcriptase is an essential rate-limiting component of telomerase complex. hTERT protein in association with other proteins and the human telomerase RNA (hTR) shows telomerase activity, essential for maintaining genomic integrity in proliferating cells. hTERT binds hTR through a decapeptide ...

journal_title：Molecular and cellular biochemistry

authors： Varshney A,Bala J,Santosh B,Bhaskar A,Kumar S,Yadava PK

更新日期：2017-03-01 00:00:00

abstract：:The effects of infusing superoxide dismutase (SOD) and catalase (CAT) into the coronary circulation were investigated in isolated, working rat hearts prior to and during a 15 minute episode of regional ischemia followed by 30 minutes reperfusion. Aortic output, left ventricular pressure and dP/dT were recorded. Compar...

journal_title：Molecular and cellular biochemistry

authors： Koke JR,Christodoulides NJ,Chudej LL,Bittar N

更新日期：1990-08-10 00:00:00

abstract：:The accessibility of pyridoxal 5'-phosphates of the phosphorylase ab hybrid to resolution by imidazole citrate and cysteine was studied and compared with that of the b and a forms. Promotion of resolution of phosphorylated forms by raising the temperature or in the presence of glycogen indicates that the resistance of...

journal_title：Molecular and cellular biochemistry

authors： Vereb G,Pallagi E,Gergely P

更新日期：1992-03-25 00:00:00

abstract：:Transmission of extra cellular signals across biological membranes results in the generation of lipid metabolites which in turn influence specific cellular events such as cell growth or differentiation. Many of these lipid messengers can activate protein kinase C (PKC) isozymes of which one function is to perpetuate t...

journal_title：Molecular and cellular biochemistry

authors： Sista P,Edmiston S,Darges JW,Robinson S,Burns DJ

更新日期：1994-12-21 00:00:00

abstract：:Phospholipase C-beta (PLCbeta) isozymes (PLCbeta(1) and PLCbeta(3)) have been extensively characterized in cardiac tissue, but no data are available for the PLCbeta(4) isozyme. In this study, PLCbeta((1-4)) isozymes mRNA relative expression was studied by real-time PCR (RT-PCR) in human, rat, and murine left ventricle...

journal_title：Molecular and cellular biochemistry

authors： Otaegui D,Querejeta R,Arrieta A,Lazkano A,Bidaurrazaga A,Arriandiaga JR,Aldazabal P,Garro MA

更新日期：2010-04-01 00:00:00