Identification of an RNA aptamer binding hTERT-derived peptide and inhibiting telomerase activity in MCF7 cells.

abstract：:In an attempt to understand the functional role of individual transcription factors, we have carried out S1 nuclease analyses of in vitro synthesized RNA using partially purified HeLa cell factors and truncated 5S and tDNA. The results indicate that faithful initiation of 5S gene transcription depends on the presence ...

journal_title：Molecular and cellular biochemistry

authors： Shastry BS

更新日期：1993-04-21 00:00:00

abstract：:Thymoquinone (TQ) is a highly perspective chemotherapeutic agent against gliomas and glioblastomas because of its ability to cross the blood-brain barrier and its selective cytotoxicity for glioblastoma cells compared to primary astrocytes. Here, we tested the hypothesis that TQ-induced mild oxidative stress provokes ...

journal_title：Molecular and cellular biochemistry

authors： Krylova NG,Drobysh MS,Semenkova GN,Kulahava TA,Pinchuk SV,Shadyro OI

更新日期：2019-12-01 00:00:00

abstract：:Red blood cells (RBCs) enzymatically produce nitric oxide (NO) by a functional RBC-nitric oxide synthase (RBC-NOS). NO is a vascular key regulatory molecule. In RBCs its generation is complex and influenced by several factors, including insulin, acetylcholine, and calcium. NO availability is reduced in end-stage renal...

journal_title：Molecular and cellular biochemistry

authors： Di Pietro N,Giardinelli A,Sirolli V,Riganti C,Di Tomo P,Gazzano E,Di Silvestre S,Panknin C,Cortese-Krott MM,Csonka C,Kelm M,Ferdinandy P,Bonomini M,Pandolfi A

更新日期：2016-06-01 00:00:00

abstract：:Chronic aristolochic acid (AA) nephropathy (CAAN) caused by intake of AA-containing herbs is difficult to treat. We evaluated the therapeutic effect of bone marrow (BM) mesenchymal stem cells (MSCs) on a rat model of CAAN. Female Wistar rats were fed with decoction of Caulis Aristolochia manshuriensis by intragastric ...

journal_title：Molecular and cellular biochemistry

authors： Li W,Jiang H,Feng JM

更新日期：2012-09-01 00:00:00

abstract：:We report the isolation of a full length cDNA from cardiac muscle that encodes a approximately 73 kDa calcium/calmodulin (CaM) dependent kinase IIbeta isoform (CaMKIIbeta(C)) that was generated by alternative splicing of the CaMKIIbeta gene. Antipeptide antibodies raised to specific regions of the kinase identified a ...

journal_title：Molecular and cellular biochemistry

authors： Singh P,Leddy JJ,Chatzis GJ,Salih M,Tuana BS

更新日期：2005-02-01 00:00:00

abstract：:Heat-shock protein90 (HSP90) plays an essential role in maintaining stability and activity of its clients. HSP90 is involved in cell differentiation and survival in a variety of cell types. To elucidate the possible role of HSP90 in myogenic differentiation and cell survival, we examined the time course of changes in ...

journal_title：Molecular and cellular biochemistry

authors： Wagatsuma A,Shiozuka M,Kotake N,Takayuki K,Yusuke H,Mabuchi K,Matsuda R,Yamada S

更新日期：2011-12-01 00:00:00

abstract：:Long-chain fatty acids (e.g. arachidonic acid) have been implicated in physiological control of insulin secretion. We previously reported histidine phosphorylation of at least two islet proteins (e.g., NDP kinase and the beta subunit of trimeric G-proteins), and suggested that such a signalling step may have regulator...

journal_title：Molecular and cellular biochemistry

authors： Kowluru A

更新日期：2004-11-01 00:00:00

abstract：:Surfactants, which provide a hydrophobic environment, may induce an ordered conformation in polypeptides and proteins that contain a sequence with helix-or beta-forming potential. This hypothesis has been illustrated in circular dichroic studies of oligopeptides and short polypeptides. These peptide-surfactant complex...

journal_title：Molecular and cellular biochemistry

authors： Wu CS,Yang JT

更新日期：1981-10-30 00:00:00

abstract：:Hibernating mammals endure conditions of low body temperature and oxidative stress that would be highly injurious to humans and most other mammals. Stress conditions frequently trigger the production of molecular chaperones; in the endoplasmic reticulum the glucose-regulated protein-78 (GRP78) helps to minimize protei...

journal_title：Molecular and cellular biochemistry

authors： Mamady H,Storey KB

更新日期：2006-11-01 00:00:00

abstract：:Insulin receptor binding was examined in the microvillous membranes of mid-term (20-22 weeks of gestation, MT) and full-term (FT) placentas from patients with gestational diabetes mellitus (GDM) and in normal pregnant control (N). Mid-term placentas were obtained from patients who have had spontaneous abortion. The ma...

journal_title：Molecular and cellular biochemistry

authors： al-Attas OS

更新日期：1995-10-04 00:00:00

abstract：:For the past 40 years, anabolic-androgenic steroids have been used by a wide variety of athletes with the hope of improving their training, endurance, and performance. The aim of this study was to examine the chronic effects of nandrolone decanoate (20 mg/kg, s.c, Deca-Durabolin DECA(®)) on oxidative stress biomarkers...

journal_title：Molecular and cellular biochemistry

authors： Nikolic T,Zivkovic V,Jevdjevic M,Djuric M,Srejovic I,Djuric D,Jeremic N,Djuric D,Bolevich S,Jakovljevic V

更新日期：2016-01-01 00:00:00

abstract：:The contractile hyporesponsiveness of the streptozotocin diabetic rat heart in vitro to beta-adrenergic agonists is eliminated when the heart is perfused with N(G)-nitro-L-arginine methyl ester (L-NAME), a non-selective inhibitor of nitric oxide synthase (NOS). The following study evaluated the hypothesis that an incr...

journal_title：Molecular and cellular biochemistry

authors： Smith JM,Sondgeroth KB,Wahler GM

更新日期：2007-06-01 00:00:00

abstract：:Changes in fatty acid composition of myocardial lipids were examined in rats with heart failure following myocardial infarction. Left ventricular systolic pressure (LVSP) was decreased and left ventricular end-diastolic pressure (LVEDP) was elevated 24 h, 1 and 12 weeks after left coronary artery ligation (CAL), sugge...

journal_title：Molecular and cellular biochemistry

authors： Nasa Y,Sakamoto Y,Sanbe A,Sasaki H,Yamaguchi F,Takeo S

更新日期：1997-11-01 00:00:00

abstract：:Bipolar disorder (BD) is a psychiatric disorder characterized by alternating episodes of mania and depression. The intracerebroventricular (i.c.v) administration of ouabain (a Na(+)/K(+)-ATPase inhibitor) in rats has been used as an animal model of mania, because present face, construct and predictive validities. Seve...

journal_title：Molecular and cellular biochemistry

authors： Freitas TP,Rezin GT,Gonçalves CL,Jeremias GC,Gomes LM,Scaini G,Teodorak BP,Valvassori SS,Quevedo J,Streck EL

更新日期：2010-08-01 00:00:00

abstract：:The binding of nuclear factor on the promoter region of the regucalcin gene and the expression of regucalcin in the kidney cortex of rats was investigated. Nuclear extracts from kidney cortex were used for oligonucleotide competition gel mobility shift assay. An oligonucleotide between position -523 and -506 in the 5'...

journal_title：Molecular and cellular biochemistry

authors： Misawa H,Yamaguchi M

更新日期：2001-03-01 00:00:00

abstract：:Hepatocyte cell adhesion molecule (HepaCAM) plays a crucial role in tumor progression and has been recognized as a novel tumor suppressor gene. The high protein expression level of protein kinase Cε (PKCε) has been discovered in many tumor types. In the present study, we determined HepaCAM and PKCε protein levels in h...

journal_title：Molecular and cellular biochemistry

authors： Tan B,Tan J,Du H,Quan Z,Xu X,Jiang X,Luo C,Wu X

更新日期：2014-06-01 00:00:00

abstract：:The normal translocation of nascent polypeptides into the lumen of the endoplasmic reticulum (ER) is thought to be aided in part by a translocon-associated protein (TRAP) complex consisting of 4 protein subunits. The association of mature proteins with the ER and Golgi, or other intracellular locales, such as lysosome...

journal_title：Molecular and cellular biochemistry

authors： Mangos S,Krawetz R,Kelly GM

更新日期：2000-12-01 00:00:00

abstract：:To explore the effect of LYRM1 over-expression on basal and insulin-stimulated glucose uptake in rat skeletal muscle cells, and to understand the underlying mechanisms, Rat myoblasts (L6) transfected with either an empty expression vector (pcDNA3.1Myc/His B) or a LYRM1 expression vector were differentiated into myotub...

journal_title：Molecular and cellular biochemistry

authors： Kou C,Cao X,Qin D,Ji C,Zhu J,Zhang C,Zhu C,Gao C,Chen R,Guo X,Zhang M

更新日期：2011-02-01 00:00:00

abstract：:Oxidative stress is recognized as one of the major wrongdoers in Parkinson's disease (PD) while glutathione S-transferase (GST), an endogenous antioxidant, protects from oxidative stress-induced neurodegeneration. Despite GST-pi (GST-π) encounters the toxic manifestations in PD, its role in zinc (Zn)-induced nigrostri...

journal_title：Molecular and cellular biochemistry

authors： Chauhan AK,Mittra N,Singh BK,Singh C

更新日期：2019-02-01 00:00:00

abstract：:Succinic acid monoethyl ester (EMS) is recently proposed as an insulinotropic agent for the treatment of non-insulin dependent diabetes mellitus. Oxidative stress has been suggested to be a contributory factor in the development and complications of diabetes. In the present study the effect of EMS and Metformin on pla...

journal_title：Molecular and cellular biochemistry

authors： Saravanan R,Pari L

更新日期：2007-02-01 00:00:00

abstract：:The AP-1 consensus sequences (TGAGTCA) are the major 12-O-tetradecanoylphorbol113-acetate (TPA) responsive elements shared by several TPA inducible genes, such as c-sis, c-fos, c-myc, collagenase, stromelysin, hMTIIA and SV40. However, the role of AP-1 binding sites, which are present in the introns 3, 5, and 11 of OD...

journal_title：Molecular and cellular biochemistry

authors： Tseng CP,Verma AK

更新日期：1995-05-10 00:00:00

abstract：:Cytochrome c oxidase (COX), like other multi-subunit components of the respiratory chain, is controlled by both the nuclear and the mitochondrial genome. In order to find wether there is a close relationship between mRNAs encoded by the nucleus and by the mitochondrion, and between these mRNAs and enzyme activity, we ...

journal_title：Molecular and cellular biochemistry

authors： Gagnon J,Kurowski TT,Wiesner RJ,Zak R

更新日期：1991-09-18 00:00:00

abstract：:The T-786C, Glu298Asp, and 27 bp variable number of tandem repeats (27 bp-VNTR-a/b) polymorphsims of the endothelial nitric oxide synthase (eNOS) gene are thought to alter nitric oxide production and contribute to the development of vascular and renal disease risk. The objective of this study is to investigate whether...

journal_title：Molecular and cellular biochemistry

authors： Nath SD,He X,Voruganti VS,Blangero J,MacCluer JW,Comuzzie AG,Arar NH,Abboud HE,Thameem F

更新日期：2009-11-01 00:00:00

abstract：:Liver cytosol from adrenalectomized rats was prebound for 2 hr at 4 degrees C with unlabeled 10(-5) M corticosterone. After treatment of cytosol with dextran-coated charcoal to remove free steroid, samples were incubated at 15-25 degrees C in the presence of 10 mM molybdate plus 5 mM dithiothreitol (followed by a 60 m...

journal_title：Molecular and cellular biochemistry

authors： Hubbard JR,Tanvir,Shirwany A,Kalimi M

更新日期：1985-01-01 00:00:00

abstract：:Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase which participates in many important cellular processes such as cell adhesion and migration. However, the role of FAK in renal tubular epithelial-to-mesenchymal transition (EMT) is still unknown. FAK was knocked down by transfection of specific small interf...

journal_title：Molecular and cellular biochemistry

authors： Deng B,Yang X,Liu J,He F,Zhu Z,Zhang C

更新日期：2010-07-01 00:00:00

abstract：:Gastric cancer (GC) is a malignant tumor with high morbidity and mortality in the world. Circular RNA hsa_circHN1_005 (circ_HN1), also termed as hsa_circ_0045602, is reported as an oncogene in GC. However, the molecular mechanism of circ_HN1 in GC development has not been fully explored. Here, we surveyed the regulato...

journal_title：Molecular and cellular biochemistry

authors： Wang D,Jiang X,Liu Y,Cao G,Zhang X,Kuang Y

更新日期：2020-09-19 00:00:00

abstract：:Coupling of ATP-generating with ATP-consuming processes is an essential component in the cardiac bioenergetics responsible for optimal myocardial function. Although a number of enzymatic systems have been implicated in securing proper intracellular energy communication, their integrative response in a failing myocardi...

journal_title：Molecular and cellular biochemistry

authors： Dzeja PP,Pucar D,Redfield MM,Burnett JC,Terzic A

更新日期：1999-11-01 00:00:00

abstract：:Obesity-induced low-grade inflammation (metaflammation) impairs insulin receptor signaling. This has been implicated in the development of insulin resistance. Insulin signaling in the target tissues is mediated by stress kinases such as p38 mitogen-activated protein kinase, c-Jun NH2-terminal kinase, inhibitor of NF-k...

journal_title：Molecular and cellular biochemistry

authors： Nandipati KC,Subramanian S,Agrawal DK

更新日期：2017-02-01 00:00:00

abstract：:Ovarian cancer is one of the greatest causes of cancer death in women. The association of TMEM49 and ovarian cancer is poorly defined. Here, we reported that TMEM49 was significantly increased in ovarian tumor tissues compared to ovarian normal tissues. Furthermore, down-regulation of TMEM49 through RNA interference i...

journal_title：Molecular and cellular biochemistry

authors： Zheng L,Chen L,Zhang X,Zhan J,Chen J

更新日期：2016-05-01 00:00:00

abstract：:Fenofibrate, a selective (1)PPAR-alpha activator, is prescribed to treat human dyslipidemia. The aim of this study was to delineate the mechanism of fenofibrate-mediated reductions in adiposity, improvements in insulin sensitivity, and lowering of triglycerides (TG) and free fatty acids (FFA) and to investigate if the...

journal_title：Molecular and cellular biochemistry

authors： Srivastava RA,Jahagirdar R,Azhar S,Sharma S,Bisgaier CL

更新日期：2006-04-01 00:00:00