Rapid, high temperature exchange assay for the hepatic glucocorticoid receptor.

abstract：:Parasitic nematodes have recently been found to produce proteins which represent two new classes of fatty acid and retinoid binding protein. The first is the nematode polyprotein allergens/antigens (NPAs) which, as their name suggests, are synthesised as large polyproteins which are subsequently cleaved at regularly s...

journal_title：Molecular and cellular biochemistry

authors： McDermott L,Cooper A,Kennedy MW

更新日期：1999-02-01 00:00:00

abstract：:The inhibitory effect of menaquinone-7 (MK-7; vitamin K2) on osteoclast-like cell formation and osteoclastic bone resorption in vitro is found (Mol Cell Biochem 228: 39-47, 2001). This study, furthermore, was undertaken to determine the effect of MK-7 on the bone-resorbing factor-induced bone resorption using the femo...

journal_title：Molecular and cellular biochemistry

authors： Yamaguchi M,Uchiyama S,Tsukamoto Y

更新日期：2003-03-01 00:00:00

abstract：:Exposure to ambient particulate matter has been reported to be associated with increased rates of lung cancer. Previously we showed that total suspended particulate matter (PM) induces oxidative DNA damage in epithelial lung cells. The aim of the present study was to further investigate the mechanism of PM-induced DNA...

journal_title：Molecular and cellular biochemistry

authors： Knaapen AM,Shi T,Borm PJ,Schins RP

更新日期：2002-05-01 00:00:00

abstract：:Patients with non-ketotic hyperglycinemia (NKH) present severe neurological symptoms and brain abnormalities involving cerebellum. Although the pathomechanisms underlying the cerebellum damage have not been studied, high tissue levels of glycine (GLY), the biochemical hallmark of this disorder have been suggested to c...

journal_title：Molecular and cellular biochemistry

authors： Moura AP,Grings M,Marcowich GF,Bumbel AP,Parmeggiani B,de Moura Alvorcem L,Wajner M,Leipnitz G

更新日期：2014-10-01 00:00:00

abstract：:Techniques routinely utilized in this laboratory for recording currents through single ionic channels of isolated atrial and ventricular rat cardiomyocytes are described. Emphasis is placed in two main areas: first, on methods for obtaining a sufficient yield of Ca++-tolerant myocytes suitable for patch clamp experime...

journal_title：Molecular and cellular biochemistry

authors： Vogel SM

更新日期：1988-03-01 00:00:00

abstract：:Cytokines from the interleukin-6 (IL-6) family have been reported to play an important synergistic role with angiotensin II in the development of pathological cardiac hypertrophy. Whether their expression pattern changes in vivo, in an angiotensin I-dependent hypertrophied myocardium has not been reported. In this stu...

journal_title：Molecular and cellular biochemistry

authors： Kurdi M,Randon J,Cerutti C,Bricca G

更新日期：2005-01-01 00:00:00

abstract：:The aim of the present study was to investigate whether lipid metabolism in the nuclei is affected by changes in the metabolism of free fatty acids in the liver. The experiments were carried out on 3 groups of rats: 1 - control-male, 2 - female, and 3 - male, treated with bezafibrate (a peroxisome proliferator). The r...

journal_title：Molecular and cellular biochemistry

authors： Górski J,Zendzian-Piotrowska M,Wolfrum C,Nawrocki A,Spener F

更新日期：2000-11-01 00:00:00

abstract：:The molecular signaling events leading to protection from oxidative stress-induced apoptosis upon contact inhibition have not been fully investigated. Previous research has indicated a role for mitogen-activated protein kinases (MAPKs) in the regulation of contact inhibition, and these proteins have also been associat...

journal_title：Molecular and cellular biochemistry

authors： Gaballah M,Slisz M,Hutter-Lobo D

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Hypercholesterolemia (HC) has been associated with impairment of vascular and myocardial functions. As HC could generate an alteration in the oxidative status, we studied the effects of a 1-month cholesterol diet on cardiovascular oxidative stress. METHODS AND RESULTS:New Zealand rabbits received cholesterol...

journal_title：Molecular and cellular biochemistry

authors： Collin B,Busseuil D,Zeller M,Perrin C,Barthez O,Duvillard L,Vergely C,Bardou M,Dumas M,Cottin Y,Rochette L

更新日期：2007-01-01 00:00:00

abstract：:Tripeptide aminopeptidase (EC 3.4.11.4) was purified from bovine dental follicles by a series of chromatographies. Purified enzyme had a specific activity of 59.5 units per mg protein with L-prolyl-glycylglycine as substrate. The pH optimum was 8.0. The purified native enzyme had a Mr of 230,000 and was shown to be a ...

journal_title：Molecular and cellular biochemistry

authors： Hiraoka BY,Harada M

更新日期：1993-12-08 00:00:00

abstract：:A literature search has been conducted to see to what extent steady-state kinetics studies in the period 1965-1976 have revealed deviations from Michaelis-Menten kinetics. It was found that over 800 enzymes have been reported as giving complex curves for a variety of reasons and a group by group classification of all ...

journal_title：Molecular and cellular biochemistry

authors： Hill CM,Waight RD,Bardsley WG

更新日期：1977-05-03 00:00:00

abstract：:Workers who are exposed to extreme heat or work in hot environments may be at risk of heat stress. Exposure to extreme heat can result in occupational illnesses and injuries. On the other hand, local and regional heat therapy has been used for the treatment of some cancers, such as liver cancer, lung cancer, and kidne...

journal_title：Molecular and cellular biochemistry

authors： Han J,Xu X,Qin H,Liu A,Fan Z,Kang L,Fu J,Liu J,Ye Q

更新日期：2013-06-01 00:00:00

abstract：:A relation between fatty acid oxidation capacity and cytosolic FABP content was found in heart and various muscles of the rat. Other tissues do not show such a relation, since they are involved in more or other pathways of fatty acid metabolism. At postnatal development FABP content and fatty acid oxidation capacity r...

journal_title：Molecular and cellular biochemistry

authors： Veerkamp JH,van Moerkerk HT

更新日期：1993-06-09 00:00:00

abstract：:Lipids form an essential part of the biomembrane and it is of paramount importance to study their conformational aspects. It is found that the present methods of nomenclature for lipids are totally inadequate for describing these diverse amphipathic molecules. Further the existing methods are incompatible in terms of ...

journal_title：Molecular and cellular biochemistry

authors： Chandrasekhur I,Sasisekharan V

更新日期：1989-11-23 00:00:00

abstract：:It is well known that mitochondria are only partly an autonomous system since they are subjected to nuclear control. For this reason, in studying mitochondrial genes one has to consider constantly the integration of mitochondrial and nuclear genetic systems. This fact makes experimental approaches still more sophistic...

journal_title：Molecular and cellular biochemistry

authors： Neifakh SA

更新日期：1977-02-04 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. However, the immune tolerance limits the effect of chemotherapeutic drugs. Therefore, the mechanism of cisplatin in promoting PD-L1 expression by YAP1 was investigated in the present study, and we found that cisplatin increased the expres...

journal_title：Molecular and cellular biochemistry

authors： Li S,Ji J,Zhang Z,Peng Q,Hao L,Guo Y,Zhou W,Cui Q,Shi X

更新日期：2020-12-01 00:00:00

abstract：:Changes in the ecto-5'-nucleotidase activity-an extracellular nucleotide catabolic enzyme may lead to the inflammation and endothelial dysfunction. We investigated the effect of CD73 deletion on the endothelial function and L-arginine metabolism in various age groups of mice. 1-,3-,6-, and 12-month-old, male C57BL/6 J...

journal_title：Molecular and cellular biochemistry

authors： Mierzejewska P,Zabielska MA,Kutryb-Zajac B,Tomczyk M,Koszalka P,Smolenski RT,Slominska EM

更新日期：2019-08-01 00:00:00

abstract：:Metabolic syndrome (MetS) is associated with alterations in coronary vascular smooth muscle and endothelial function. The current study examined the contractile response of the isolated coronary arterioles to serotonin in pigs with and without MetS and investigated the signaling pathways responsible for serotonin-indu...

journal_title：Molecular and cellular biochemistry

authors： Lawandy I,Liu Y,Shi G,Zhang Z,Scrimgeour LA,Pavlov V,Jaworski R,Sellke FW,Feng J

更新日期：2019-11-01 00:00:00

abstract：:We have previously documented that naked antisense CK2alpha ODN can potently induce apoptosis in cancer cells in culture and in mouse xenograft human prostate cancer. The effects of the antisense CK2alpha are related to downregulation of CK2alpha message and rapid loss of the CK2 from the nuclear compartment. Here we ...

journal_title：Molecular and cellular biochemistry

authors： Wang G,Unger G,Ahmad KA,Slaton JW,Ahmed K

更新日期：2005-06-01 00:00:00

abstract：:Evidence suggests that functional atrial natriuretic peptide (ANP) receptors occur in surface gastric mucosal epithelial cells. To evaluate functional aspects of ANP in a model of these cells we examined the expression of natriuretic peptide receptors (NPR) subtypes A and C in the non-transformed rat gastric mucosal e...

journal_title：Molecular and cellular biochemistry

authors： Gower WR Jr,Carter GM,McAfee Q,Solivan SM

更新日期：2006-12-01 00:00:00

abstract：:Infrared spectroscopy which has traditionally been utilized by chemists and physicists for characterization and identification of the structural properties of chemical compounds is now becoming more relevant as a biodiagnostic tool. Recent reports suggest that arthritis and Alzheimer's disease can be diagnosed by usin...

journal_title：Molecular and cellular biochemistry

authors： Das RM,Ahmed MK,Mantsch HH,Scott JE

更新日期：1995-04-12 00:00:00

abstract：:Whereas in rat liver mitochondria the hyperthyroid state causes an increase both in fatty acid unsaturation and in the Ea of D-3-hydroxybutyrate dehydrogenase and a decrease in phase transition temperature, in hyperthyroid rat heart mitochondria these changes are negligible. D-3-hydroxybutyrate dehydrogenase in both t...

journal_title：Molecular and cellular biochemistry

authors： Lippolis R,Morini P,Conserva AR,Casalino E,Landriscina C

更新日期：1990-03-27 00:00:00

abstract：:Advanced glycation end products (AGEs) are formed from the non-enzymatic glycation reaction of reducing sugars or their metabolites with the free amino groups of several biomolecules and are known to play pathophysiological roles in various inflammatory diseases. In an earlier study, it was suggested that tumor necros...

journal_title：Molecular and cellular biochemistry

authors： Watanabe M,Toyomura T,Wake H,Liu K,Teshigawara K,Takahashi H,Nishibori M,Mori S

更新日期：2017-10-01 00:00:00

abstract：:Photoreactive probes for the hydrophobic pocket of the liver fatty acid-binding protein, 11-(5'-azido-salicylamido)-undecanoic acid (5' ASU) and its acetyl ester (Ac5' ASU), were synthesized and their interaction with the protein was assessed. Fatty acid-binding proteins are closely related proteins which are abundant...

journal_title：Molecular and cellular biochemistry

authors： Atlasovich F,Santomé JA,Fernández HN

更新日期：1993-03-10 00:00:00

abstract：:Lithostathine may play a physiological role in preventing the precipitation of excess calcium in the pancreatic juice. The hypothesis has been advanced that in chronic calcifying pancreatitis the abnormal biosynthesis of lithostathine might be the original defect to which genetic proneness to the disease may be ascrib...

journal_title：Molecular and cellular biochemistry

authors： Cavallini G,Bovo P,Bianchini E,Carsana A,Costanzo C,Merola M,Sgarbi D,Frulloni L,Di Francesco V,Libonati M,Palmieri M

更新日期：1998-08-01 00:00:00

abstract：:In order to understand the molecular basis of cold adaptation, we have used directed evolution to transform a thermophilic lipase LipR1 into its psychrophilic counterpart. A single round of random mutagenesis followed by screening for improved variants yielded a mutant with single-point mutation LipR1M1 (S130T), with ...

journal_title：Molecular and cellular biochemistry

authors： Sharma M,Kumar R,Singh R,Kaur J

更新日期：2017-06-01 00:00:00

abstract：:The purification and functional characterization of protein kinase A catalytic subunit (PKAcat) from bovine lens cytosol has been described. Purification to homogeneity has been achieved by using 100 kDa cut-off membrane filtration followed by Sephacryl S-300 chromatography and finally fractionating on High Q anion ex...

journal_title：Molecular and cellular biochemistry

authors： Samanta B,Nagdas SK,Das K,Sen PC

更新日期：2007-10-01 00:00:00

abstract：:The effects of the microtubular inhibitor, podophyllotoxin, on mitochondrial respiration were determined using isolated, digitonin-permeabilized hepatocytes and isolated mitochondria. In hepatocytes, podophyllotoxin (1.5 mM) inhibited coupled and uncoupled respiration of both FAD and NAD-linked substrates. In mitochon...

journal_title：Molecular and cellular biochemistry

authors： Horrum MA,Jennett RB,Ecklund RE,Tobin RB

更新日期：1986-06-01 00:00:00

abstract：:Autism is a prevalent developmental disorder that combines repetitive behaviours, social deficits and language abnormalities. The present study aims to assess the autistic subjects using DSM IV-TR criteria followed with the analysis of neurotransmitters, biochemical parameters, oxidative stress and its ions in two gro...

journal_title：Molecular and cellular biochemistry

authors： Meyyazhagan A,Balasubramanian B,Easwaran M,Alagamuthu KK,Shanmugam S,Kuchi Bhotla H,Pappusamy M,Arumugam VA,Thangaraj A,Kaul T,Keshavarao S,Cacabelos R

更新日期：2020-11-01 00:00:00

abstract：:The possibility of amino acids biosynthesis from sucrose, metabolites of Krebs cycle or glyoxylate and ammonium by intact bacteroids has been studied. The suspension of intact Rhizobium lupini bacteroids in phosphate buffer solution pH 7.8 was shown to catalyse the biosynthesis from sucrose and ammonium of some amino ...

journal_title：Molecular and cellular biochemistry

authors： Kretovich WL,Kariakina TI,Kazakova OV,Sidelnikova LI,Kaloshina GS,Shaposhnikov GL

更新日期：1983-01-01 00:00:00