Mechanisms of transcriptional activation of cAMP-responsive element-binding protein CREB.

abstract：:Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. However, it is unknown if 17beta-estradiol treatment is sufficient to inhibit prostaglandin E2 (PGE2)-induced cellular motility in human colon cancer cells. Upregulation of cyclooxygenase-2 (...

journal_title：Molecular and cellular biochemistry

authors： Lai TY,Chen LM,Lin JY,Tzang BS,Lin JA,Tsai CH,Lin YM,Huang CY,Liu CJ,Hsu HH

更新日期：2010-09-01 00:00:00

abstract：:Cyclophosphamide (CP) is one of the widely used anticancer agents; however, it has serious deleterious effects on normal host cells due to its nonspecific action. The essential trace element Selenium (Se) is suggested to have chemopreventive and chemotherapeutic efficacy and currently used in pharmaceutical formulatio...

journal_title：Molecular and cellular biochemistry

authors： Bhattacharjee A,Basu A,Biswas J,Sen T,Bhattacharya S

更新日期：2017-01-01 00:00:00

abstract：:Our study evaluated the relationship between the endogenous production of prostacyclin and the antiarrhythmic effect of ischemic preconditioning against ischemic and reperfusion-induced tachyarrhythmia. Langendorff perfused rat hearts underwent 30 min regional ischemia with reperfusion. Preconditioning was induced by ...

journal_title：Molecular and cellular biochemistry

authors： Arad M,Oxman T,Leor R,Rabinowitz B

更新日期：1996-07-01 00:00:00

abstract：:Previous results with p9-RNA, obtained from lymph nodes of animals immunized with the peptide p9 of HIV-1, suggested that its effects on lymphocytes could be mediated by RNA-dependent protein kinase (PKR). Here we report that p9-RNA activates PKR leading to the degradation of the inhibitor I-kappaB alpha and the conco...

journal_title：Molecular and cellular biochemistry

authors： De Lucca FL,Sales VS,Souza LR,Murad JM,Watanabe MA

更新日期：2003-05-01 00:00:00

abstract：:The results of our previous studies demonstrated that acute streptozotocin-induced diabetes in rats evoked a decrease in skin collagen content with little effect on glycosaminoglycans (GAG) content. In our present study we employed the model of chronic diabetes in order to check its effect on skin GAG content. It was ...

journal_title：Molecular and cellular biochemistry

authors： Cechowska-Pasko M,Pałka J,Bańkowski E

更新日期：1996-01-12 00:00:00

abstract：:Pulmonary atresia (PA) with ventricular septal defect (VSD) is an extreme form of tetralogy of Fallot with characteristic right ventricular hypertrophy. To reduce the right ventricular overload, these children have to undergo staged corrective surgery to restore physiological pulmonary perfusion. We studied the degree...

journal_title：Molecular and cellular biochemistry

authors： Peters TH,de Jong PL,Klompe L,Berger RM,Saxena PR,Sharma HS,Bogers AJ

更新日期：2003-09-01 00:00:00

abstract：:Coupling of ATP-generating with ATP-consuming processes is an essential component in the cardiac bioenergetics responsible for optimal myocardial function. Although a number of enzymatic systems have been implicated in securing proper intracellular energy communication, their integrative response in a failing myocardi...

journal_title：Molecular and cellular biochemistry

authors： Dzeja PP,Pucar D,Redfield MM,Burnett JC,Terzic A

更新日期：1999-11-01 00:00:00

abstract：:The regulation of phosphatidylcholine-specific phospholipase D by purine nucleotides and protein kinase A were studied in vitro using an enzyme preparation partially purified from the membranous fraction of 7721 hepatocarcinoma cells. It was found that the enzyme activity was elevated by low concentrations of some pur...

journal_title：Molecular and cellular biochemistry

authors： Huang Y,Zhang XY,Liu F,Chen HL

更新日期：2000-04-01 00:00:00

abstract：:In this study, indirect immunofluorescence labeling was used to examine the cellular dynamic distribution of Thr11 phosphorylated H3 at mitosis in MCF-7 cells. The Thr11 phosphorylation was observed beginning at prophase at centromeres. Upon progression of mitosis, fluorescence signal was enhanced in the central regio...

journal_title：Molecular and cellular biochemistry

authors： Zhou H,Li D,Song L,Liu R,Chen J,Huang X

更新日期：2008-04-01 00:00:00

abstract：:By qualitative and quantitative PCR, we evaluated the expression of three messengers coding for SAT-1, SAT-2 and GalNAcT-1 in human samples of intestinal cancer and some cell lines (breast cancer and melanomas). Qualitative PCR demonstrated, in human tissues but not in the cell lines examined, the presence of an mRNA ...

journal_title：Molecular and cellular biochemistry

authors： Gornati R,Chini V,Rimoldi S,Meregalli M,Schiaffino E,Bernardini G

更新日期：2007-04-01 00:00:00

abstract：:Protein kinase CK2 is a highly conserved and ubiquitous serine-threonine kinase. It is a tetrameric enzyme that is made up of two regulatory CK2beta subunits and two catalytic subunits, either CK2alpha/CK2alpha, CK2alpha/CK2alpha', or CK2alpha'/CK2alpha'. Although the two catalytic subunits diverge in their C termini,...

journal_title：Molecular and cellular biochemistry

authors： Seldin DC,Lou DY,Toselli P,Landesman-Bollag E,Dominguez I

更新日期：2008-09-01 00:00:00

abstract：:XPO5 (Exp5, Exportin-5) is a transporter protein mainly mediating pre-microRNAs' nuclear export. Recent studies have demonstrated that XPO5 may play crucial roles in a few of cancers. However, little is known about XPO5 in hepatocellular carcinoma (HCC). In the present study, we elucidated the expression of XPO5 by qu...

journal_title：Molecular and cellular biochemistry

authors： Li Y,Wang X,He B,Cai H,Gao Y

更新日期：2016-04-01 00:00:00

abstract：:Treatment with alpha-difluoromethylornithine (DFMO), an enzyme-activated irreversible inhibitor of ornithine decarboxylase (ODC), depletes the putrescine and spermidine content, and reduces the growth rate of Ehrlich ascites tumor cells. The addition of putrescine, which is the immediate precursor of spermidine, promp...

journal_title：Molecular and cellular biochemistry

authors： Oredsson SM,Anehus S,Heby O

更新日期：1984-09-01 00:00:00

abstract：:Growth hormone (GH) has been reported to be useful to treat heart failure. To elucidate whether GH has direct beneficial effects on the heart, we examined effects of GH on oxidative stress-induced apoptosis in cardiac myocytes. TUNEL staining and DNA ladder analysis revealed that hydrogen peroxide (H2O2)-induced apopt...

journal_title：Molecular and cellular biochemistry

authors： Gu Y,Zou Y,Aikawa R,Hayashi D,Kudoh S,Yamauchi T,Uozumi H,Zhu W,Kadowaki T,Yazaki Y,Komuro I

更新日期：2001-07-01 00:00:00

abstract：:Nicotinic acid administration, which depletes liver glycogen, leads to an increase of both pyruvate kinase L and phosphoenolypyruvate carboxykinase in liver by a factor of nearly two. The former is not prevented by either cycloheximide or actinomycin D. L-Cysteine, an allosteric inhibitor of pyruvate kinase L, favors ...

journal_title：Molecular and cellular biochemistry

authors： Moreno FJ,Benito M,Sánchez-Medina F,Medina JM,Mayor F

更新日期：1976-11-30 00:00:00

abstract：:This study has examined whether elevated glucose can induce lipid peroxidation and contribute to the inhibition of cell growth in human kidney proximal tubule(HPT) cells. HPT cells were cultured in media containing glucose concentrations of 8 mM (control), 25 mM, and 50 mM. Lipid peroxidation was assessed by the thiob...

journal_title：Molecular and cellular biochemistry

authors： Jain SK,Morshed KM,Kannan K,McMartin KE,Bocchini JA Jr

更新日期：1996-09-06 00:00:00

abstract：:The interaction of glyceraldehyde 3-phosphate dehydrogenase with microtubules has been studied by measurement of the amount of enzyme which co-assembles with in vitro reconstituted microtubules. The binding of glyceraldehyde 3-phosphate dehydrogenase to microtubules is a saturable process; the maximum binding capacity...

journal_title：Molecular and cellular biochemistry

authors： Durrieu C,Bernier-Valentin F,Rousset B

更新日期：1987-03-01 00:00:00

abstract：:Recent studies suggest JAK2 signaling may be a therapeutic target for treatment of gastric cancer (GC). However, the exact roles of JAK2 in gastric carcinogenesis are not very clear. Here, we have targeted JAK2 to be silenced by shRNA and investigated the biological functions and related mechanisms of JAK2 in GC cell ...

journal_title：Molecular and cellular biochemistry

authors： Qian C,Yao J,Wang J,Wang L,Xue M,Zhou T,Liu W,Si J

更新日期：2014-02-01 00:00:00

abstract：:Kawasaki disease is an immune-mediated acute, systemic vasculitis and is the leading cause of acquired heart disease in children in the developed world. Bifidobacterium (BIF) is one of the dominant bacteria in the intestines of humans and many mammals and is able to adjust the intestinal flora disorder. The Caco-2 cel...

journal_title：Molecular and cellular biochemistry

authors： Nie N,Bai C,Song S,Zhang Y,Wang B,Li Z

更新日期：2020-01-01 00:00:00

abstract：:Lipoamidase is found to be able to release various membrane-anchored enzymes from the membrane compartment of pig brain. Released enzymes revealed their intact enzyme activities in the soluble fraction. Lipoamidase could release at least two types of anchored enzymes, i.e. glycosyl-phosphatidylinositol-bonded and myri...

journal_title：Molecular and cellular biochemistry

authors： Oizumi J,Hayakawa K

更新日期：1992-09-22 00:00:00

abstract：:The simultaneous administration of the DNA topoisomerase II inhibitor etoposide (0.15 mM) and 1,25-dihydroxyvitamin D3 (VD3) (10 nM) synergistically induced the differentiation of HL-60 human promyelocytic leukemia cells. Similar results were obtained using U-937 human promonocytic cells, or the topoisomerase II inhib...

journal_title：Molecular and cellular biochemistry

authors： Torres R,Calle C,Aller P,Mata F

更新日期：2000-05-01 00:00:00

abstract：:The regulation patterns of gastric acid secretion in rats were investigated. Pentagastrin and histamine stimulate gastric acid secretion, but the inhibitors of DNA-dependent synthesis of RNA and of proteins prevent only the pentagastrin action. It has been found that pentagastrin induces histidine decarboxylase in gas...

journal_title：Molecular and cellular biochemistry

authors： Salganik RI,Bersimbaev RI,Argutinskaya SV,Kiseleva EV,Khristolyubova NB,Deribas VI

更新日期：1976-09-30 00:00:00

abstract：:The role of the subunits of phosphoinositide (PI) 3-kinase in NF-kappaB activation in silica-stimulated RAW 264.7 cells was investigated. Results indicate that PI3-kinase activity was increased in response to silica. The p85alpha subunit of PI3-kinase interacted with tyrosine-phosphorylated I(kappa)B-alpha in silica-s...

journal_title：Molecular and cellular biochemistry

authors： Kang JL,Lee HS,Pack IS,Hur KC,Castranova V

更新日期：2003-06-01 00:00:00

abstract：:A number of acute and chronic neurodegenerative disorders are caused due to misfolding and aggregation of many intra- and extracellular proteins. Protein misfolding and aggregation processes in cells are strongly regulated by cellular molecular chaperones known as heat-shock proteins (Hsps) that include Hsp60, Hsp70, ...

journal_title：Molecular and cellular biochemistry

authors： Paul S,Mahanta S

更新日期：2014-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNAs that have important roles in cancer. The altered expressions of miRNAs and their target genes are frequently detected in various tumors. In this study, downregulation of miR-15a-16 in nonsmall cell lung cancer (NSCLC) was found to be inversely correlated with Cripto. Results...

journal_title：Molecular and cellular biochemistry

authors： Chen F,Hou SK,Fan HJ,Liu YF

更新日期：2014-06-01 00:00:00

abstract：:Peroxisomes and peroxisomal enzyme expression were investigated biochemically and morphometrically in guinea pig intestinal epithelial cells at different stages of their migration along the crypt-villus axis. Epithelial cells were sequentially isolated along the axis and the specific activities of the peroxisomal enzy...

journal_title：Molecular and cellular biochemistry

authors： Phipps AN,Connock MJ,Johnson P,Burdett K

更新日期：2000-01-01 00:00:00

abstract：:We have investigated how diabetes affects the expression of adropin (ADR) in rat brain, cerebellum, kidneys, heart, liver, and pancreas tissues. The rats in the diabetic group were administered an intraperitoneal (i.p.) injection of a single dose of 60 mg/kg streptozotocin (STZ) dissolved in a 0.1 M phosphate-citrate ...

journal_title：Molecular and cellular biochemistry

authors： Aydin S,Kuloglu T,Aydin S,Eren MN,Yilmaz M,Kalayci M,Sahin I,Kocaman N,Citil C,Kendir Y

更新日期：2013-08-01 00:00:00

abstract：:The expression of calcium-binding protein regucalcin mRNA in the kidney cortex of rats ingested with saline was investigated. The alteration in regucalcin mRNA levels was analyzed by Northern blotting using liver regucalcin complementary DNA (0.9 kb of open reading frame). Rats were freely given saline as drinking wat...

journal_title：Molecular and cellular biochemistry

authors： Shinya N,Yamaguchi M

更新日期：1998-01-01 00:00:00

abstract：:Gentamicin (GM) is an antibiotic whose clinical use is limited by its nephrotoxicity. Experimental evidences suggest a role of reactive oxygen species in GM-induced nephrotoxicity. In this work we explored the effect of diallyl sulfide (DAS), a garlic-derived compound with antioxidant properties, on GM-induced nephrot...

journal_title：Molecular and cellular biochemistry

authors： Pedraza-Chaverrí J,Maldonado PD,Barrera D,Cerón A,Medina-Campos ON,Hernández-Pando R

更新日期：2003-12-01 00:00:00

abstract：:The uptake of glucose and gluconate is under inductive control in Pseudomonas putida. Glucose, gluconate, and 2-ketogluconate were each good nutritional inducers of these transport abilities. Glucose and gluconate uptake obeyed saturation kinetics: the apparent Km for glucose was 6 mM and that for gluconate was 0.5 mM...

journal_title：Molecular and cellular biochemistry

authors： Vicente M,Pedro MA,Torrontegui G,Cánovas JL

更新日期：1975-04-30 00:00:00