Abstract:
:The rapid repair of gastric mucosa is critical upon exposure to injurious agents. Intestinal trefoil factor (ITF) is a member of the trefoil factor family domain peptides, which play an important role in the cytoprotection of gastric epithelium. However, the underlying molecular mechanisms that are responsible for ITF-induced gastric epithelial repair remain unclear. In the present study, we demonstrate that ITF enhances the proliferation and migration of GES-1 gastric endothelial cells in a dose- and time-dependent manner through the activation of extracellular signal-regulated kinase 1/2 (ERK1/2). Furthermore, the ITF-mediated protection of GES-1 cells from a NS398 (nonsteroidal anti-inflammatory drug) was dependent on the ERK1/2 signaling pathway. Taken together, the results provide a mechanistic explanation for ITF-mediated protection of gastric epithelial mucosa cells, suggesting that activation of the ERK1/2 signaling pathway may provide a new therapeutic strategy for repairing gastric injury.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Lin J,Sun Z,Zhang W,Liu H,Shao D,Ren Y,Wen Y,Cao L,Wolfram J,Yang Z,Nie Sdoi
10.1007/s11010-015-2386-2subject
Has Abstractpub_date
2015-06-01 00:00:00pages
263-70issue
1-2eissn
0300-8177issn
1573-4919journal_volume
404pub_type
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