Glioma: what is the role of c-Myc, hsp90 and telomerase?

abstract：:Gentamicin (GM) is an antibiotic whose clinical use is limited by its nephrotoxicity. Experimental evidences suggest a role of reactive oxygen species in GM-induced nephrotoxicity. In this work we explored the effect of diallyl sulfide (DAS), a garlic-derived compound with antioxidant properties, on GM-induced nephrot...

journal_title：Molecular and cellular biochemistry

authors： Pedraza-Chaverrí J,Maldonado PD,Barrera D,Cerón A,Medina-Campos ON,Hernández-Pando R

更新日期：2003-12-01 00:00:00

abstract：:This study investigated the anticancer effects of embelin in human gastric cancer cells and the underlying molecular mechanisms. Gastric cancer cells were treated with embelin and 5-FU for methyl-thiazolyl-tetrazolium bromide cell viability assay and flow cytometric detection of cell viability and apoptosis. Protein p...

journal_title：Molecular and cellular biochemistry

authors： Wang DG,Sun YB,Ye F,Li W,Kharbuja P,Gao L,Zhang DY,Suo J

更新日期：2014-01-01 00:00:00

abstract：:Spray-dried milk enriched with n-3 fatty acids from linseed oil (LSO) or fish oil (FO) were fed to rats to study its influence on liver lipid peroxides, hepatic antioxidant enzyme activities, serum prostaglandins and platelet aggregation. Significant level of alpha linolenic acid, eicosapentaenoic acid and docosahexae...

journal_title：Molecular and cellular biochemistry

authors： Ramaprasad TR,Baskaran V,Krishnakantha TP,Lokesh BR

更新日期：2005-09-01 00:00:00

abstract：:In the present study we explored glutathione S-transferase (GST) polymorphisms in selected patients who experienced accelerated myocardial injury following open heart surgery and compared these to a control group of patients without postoperative complications. 758 Patients were enrolled from which 132 patients were s...

journal_title：Molecular and cellular biochemistry

authors： Kovacs V,Gasz B,Balatonyi B,Jaromi L,Kisfali P,Borsiczky B,Jancso G,Marczin N,Szabados S,Melegh B,Nasri A,Roth E

更新日期：2014-04-01 00:00:00

abstract：:This comparative study investigates the relationship between sarcoplasmic reticulum (SR) calcium(Ca2+)-ATPase transport activity and phospholamban (PLB) phosphorylation in whole cardiac homogenates of spontaneously hypertensive rats (SHR) and their parent, normotensive Wistar Kyoto (WKY) strain during early postnatal ...

journal_title：Molecular and cellular biochemistry

authors： Freestone N,Singh J,Krause EG,Vetter R

更新日期：1996-10-01 00:00:00

abstract：:Autoantibodies (AABs) against the second extracellular loop of the beta1-receptor (beta1(II)-AABs) are found as a pathogenic driver in patients with idiopathic dilated cardiomyopathy, Chagas cardiomyopathy, peripartum cardiomyopathy, and myocarditis, and have been increasingly seen as a treatment target. We recently i...

journal_title：Molecular and cellular biochemistry

authors： Haberland A,Wallukat G,Berg S,Schulz AM,Freyse EJ,Vetter R,Salzsieder E,Müller J,Kreutz R,Schimke I

更新日期：2014-08-01 00:00:00

abstract：:To extend the available information on the significance of the interactions between glycolytic enzymes and the actin component of the cellular ultrastructure, investigations into the compositional characteristics of the actin binding site on one of the major glycolytic enzymes, aldolase, have been undertaken. As the e...

journal_title：Molecular and cellular biochemistry

authors： Don M,Masters C

更新日期：1988-06-01 00:00:00

abstract：:Hydrogen sulfide (H2S) has been investigated widely in recent years. H2S plays a variety of roles in different biological systems, including cardiovascular system. It is the final product of amino acids metabolism, which contains sulfur-cysteine and homocysteine (Hcy). In human plasma, there are several various forms ...

journal_title：Molecular and cellular biochemistry

authors： Olas B,Kontek B

更新日期：2015-06-01 00:00:00

abstract：:Control of mitochondrial respiration depends on ADP availability to the F1-ATPase. An electrochemical gradient of ADP and ATP across the mitochondrial inner membrane is maintained by the adenine nucleotide translocase which provides ADP to the matrix for ATP synthesis and ATP for energy-dependent processes in the cyto...

journal_title：Molecular and cellular biochemistry

authors： McMillin JB,Pauly DF

更新日期：1988-06-01 00:00:00

abstract：:The collagen metabolism alterations triggered by reactive oxygen species are involved in the development of various connective tissue diseases and skin aging. This study was designed to examine whether (E)-anethole possesses a protective effect on H2O2-induced alterations in collagen metabolism as well as whether it c...

journal_title：Molecular and cellular biochemistry

authors： Galicka A,Krętowski R,Nazaruk J,Cechowska-Pasko M

更新日期：2014-09-01 00:00:00

abstract：:Pre-purified preparations of myoinositol-1-phosphate synthase (E.C. 5.5.1.4) from rat testes can be purified to homogeneity by first crystallizing the enzyme according to JAKOBY and then recrystallizing it at a pH value close to the isoelectric point while slowly increasing the temperature from 0 to 15 degrees C. This...

journal_title：Molecular and cellular biochemistry

authors： Pittner F,Hoffmann-Ostenhof O

更新日期：1979-12-14 00:00:00

abstract：:XPO5 (Exp5, Exportin-5) is a transporter protein mainly mediating pre-microRNAs' nuclear export. Recent studies have demonstrated that XPO5 may play crucial roles in a few of cancers. However, little is known about XPO5 in hepatocellular carcinoma (HCC). In the present study, we elucidated the expression of XPO5 by qu...

journal_title：Molecular and cellular biochemistry

authors： Li Y,Wang X,He B,Cai H,Gao Y

更新日期：2016-04-01 00:00:00

abstract：:The results of our experiments demonstrated that one hour of ischemia followed by one hour of reflow in the kidney caused a reduction in (Na+K+)ATPase activity and microsomal sulfhydryl content as well as an increase in microsomal lipid peroxidation. Renal venous malondialdehyde concentration was increased soon after ...

journal_title：Molecular and cellular biochemistry

authors： Kato M,Kako KJ

更新日期：1987-12-01 00:00:00

abstract：:Cardiac hypertrophy in rats was produced by aortic banding for 6 weeks and regression of hypertrophy in these experimental animals was induced by administration of angiotensin converting enzyme inhibitor, enalapril (10 mg/kg/day) for 6 weeks. The left ventricular muscle mass and systolic pressure were decrease upon tr...

journal_title：Molecular and cellular biochemistry

authors： Makino N,Matsui H,Masutomo K,Hata T,Yanaga T

更新日期：1993-02-17 00:00:00

abstract：:Angiotensin II induces the expression of platelet-derived growth factor A-chain and B-chain in cultured vascular smooth muscle cells at the level of transcription. The renin-angiotensin system has also been implicated in the increased expression of platelet-derived growth factor in the mechanically-injured artery wall...

journal_title：Molecular and cellular biochemistry

authors： Khachigian LM,Takuwa Y,Collins T

更新日期：2000-09-01 00:00:00

abstract：:Understanding the driving forces for the hepatic uptake of endogenous and exogenous substrates in isolated cells and organs is fundamental to describing the underlying hepatic physiology/pharmacology. In this study we investigated whether uptake of plasma protein-bound [3H]-palmitate across the hepatocyte wall is gove...

journal_title：Molecular and cellular biochemistry

authors： Burczynski FJ,Hung D,Wang GQ,Elmadhoun B,Lewis A,Chang P,Rajaraman G,Robert S

更新日期：2005-02-01 00:00:00

abstract：:When Leishmania donovani promastigote forms, were cultured in TC-199 medium at 28 degrees C and subsequently incubated at 38 degrees C, they turned into aflagellate (amastigote-like) forms. A return of the incubation-culture temperature to 28 degrees C these amastigote-like forms to revert to promastigotes. The amasti...

journal_title：Molecular and cellular biochemistry

authors： Castilla JJ,Sanchez-Moreno M,Mesa C,Osuna A

更新日期：1995-01-26 00:00:00

abstract：:In order to establish the distribution with time of proteins microinjected into mammalian cells, horseradish peroxidase (HRP) was microinjected into baby hamster kidney (BHK) cells using chicken erythrocyte ghosts. At time intervals following initiation of fusion between ghosts and target cells, samples were fixed wit...

journal_title：Molecular and cellular biochemistry

authors： McClung JK,Ulrich RG,Kletzien RF

更新日期：1987-01-01 00:00:00

abstract：:Targeting angiogenesis is considered an effective strategy for treating the expansion and metastasis of tumors. The aim of this study is to assess the effects of perifosine, an inhibitor of Akt, on cell proliferation, apoptosis, angiogenesis, and VEGF-induced cell migration in cultured human umbilical vein endothelial...

journal_title：Molecular and cellular biochemistry

authors： Wang FZ,Fei HR,Li XQ,Shi R,Wang de C

更新日期：2012-09-01 00:00:00

abstract：:Chronic exposure to many heavy metals and metal-derivatives is associated with an increased risk of cancer, although the mechanisms of tumorigenesis are largely unknown. Approximately 125 scientists attended the 3rd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis and presented the latest resear...

journal_title：Molecular and cellular biochemistry

authors： Bower JJ,Leonard SS,Shi X

更新日期：2005-11-01 00:00:00

abstract：:The effect of ginsenoside Rg1 (Rg1) on hepatic damage caused by concanavalin A (Con A) has not been fully elucidated. This study was designed to evaluate the protective effect of Rg1 on Con A-induced hepatitis in mice and explore the potential mechanisms of this effect. C57BL/6 mice were divided randomly into the foll...

journal_title：Molecular and cellular biochemistry

authors： Cao L,Zou Y,Zhu J,Fan X,Li J

更新日期：2013-08-01 00:00:00

abstract：:Shin et al. (Biochim Biophys Acta 444: 794-801, 1976) described the subcellular location of [3H]folic acid after injection into rats. The microsomal fraction of the liver contained relatively large amounts of tracer initially but lower amounts at later times. Because of the heterogeneous nature of the microsomal fract...

journal_title：Molecular and cellular biochemistry

authors： Brody T,Stokstad EL

更新日期：1990-09-03 00:00:00

abstract：:Eukaryotic protein synthesis initiation factor eIF-2 is usually isolated as a heterotrimer (alphabeta gamma). By use of Sephacryl S-300 fractionation an alpha subunit-deficient form of eIF-2 was identified in impure preparations from rabbit reticulocyte lysate and it appeared in these preparations to be still active i...

journal_title：Molecular and cellular biochemistry

authors： Mouat MF,Manchester K

更新日期：1998-06-01 00:00:00

abstract：:The activity of yeasts citrate synthase in cells grown under different hypoxic conditions has been investigated. A linear relationship between the citrate synthase activity and the respiratory capacity of the cells has been found. When Saccharomyces cerevisiae was grown on fermentable substrates the activity decreased...

journal_title：Molecular and cellular biochemistry

authors： Nuñez de castro I,Arias de Saavedra JM,Machado A,Mayor F

更新日期：1976-09-30 00:00:00

abstract：:Peroxisome proliferator activated receptor gamma coactivator 1α (PGC-1α) induced by hypoxia regulates mitochondrial biogenesis and oxidative stress. However, the potential role of PGC-1α in hypoxia-promoted proliferation of pulmonary arterial vascular smooth muscle cells (PASMCs) is completely unknown. In this study, ...

journal_title：Molecular and cellular biochemistry

authors： Rao J,Li J,Liu Y,Lu P,Sun X,Sugumaran PK,Zhu D

更新日期：2012-08-01 00:00:00

abstract：:Osteoblast differentiation is an essential event in the developmental process, which is favoured by the production of extra cellular matrix proteins and various enzymes including discrete ones like acetylcholinesterase (AChE). Despite the fact that AChE facilitates osteoblast differentiation, the significance of its c...

journal_title：Molecular and cellular biochemistry

authors： Chinnadurai RK,Saravanaraman P,Boopathy R

更新日期：2018-03-01 00:00:00

abstract：:A multi-component solution, containing α-ketoglutaric acid (α-KG), 5-hydroxymethylfurfural (5-HMF), N-acetyl-seleno-L-methionine (NASeLM), and N-acetyl-L-methionine (NALM) as active ingredients, has been tested considering its supposed antioxidative effect with respect to heart transplantations. Oxidative stress was i...

journal_title：Molecular and cellular biochemistry

authors： Russ M,Jauk S,Wintersteiger R,Andrä M,Brcic I,Ortner A

更新日期：2019-11-01 00:00:00

abstract：UNLABELLED:Inhibition of Na+/H+ exchange with amiloride analogues has been shown to provide functional protection during ischemia and reperfusion and to reduce infarct size in isolated rat hearts. In rat hearts, treatment with ethylisopropyl-amiloride (EIPA, a selective Na+/H- exchange inhibitor) was additive to the pr...

journal_title：Molecular and cellular biochemistry

authors： Munch-Ellingsen J,Løkebø JE,Bugge E,Ytrehus K

更新日期：1998-09-01 00:00:00

abstract：:The aim of the present study was to investigate whether lipid metabolism in the nuclei is affected by changes in the metabolism of free fatty acids in the liver. The experiments were carried out on 3 groups of rats: 1 - control-male, 2 - female, and 3 - male, treated with bezafibrate (a peroxisome proliferator). The r...

journal_title：Molecular and cellular biochemistry

authors： Górski J,Zendzian-Piotrowska M,Wolfrum C,Nawrocki A,Spener F

更新日期：2000-11-01 00:00:00

abstract：:Cofilin is an actin-binding protein of low molecular weight which is widely distributed in eukaryotes and is deeply involved in the dynamics of actin assembly in the cytoplasm. The actin-binding ability of cofilin is inhibited by inositol phosphates (PIP2), and the PIP2- and actin-binding site(s) has been localized in...

journal_title：Molecular and cellular biochemistry

authors： Kusano K,Abe H,Obinata T

更新日期：1999-01-01 00:00:00