Equal reduction in infarct size by ethylisopropyl-amiloride pretreatment and ischemic preconditioning in the in situ rabbit heart.

abstract：:Autoantibodies (AABs) against the second extracellular loop of the beta1-receptor (beta1(II)-AABs) are found as a pathogenic driver in patients with idiopathic dilated cardiomyopathy, Chagas cardiomyopathy, peripartum cardiomyopathy, and myocarditis, and have been increasingly seen as a treatment target. We recently i...

journal_title：Molecular and cellular biochemistry

authors： Haberland A,Wallukat G,Berg S,Schulz AM,Freyse EJ,Vetter R,Salzsieder E,Müller J,Kreutz R,Schimke I

更新日期：2014-08-01 00:00:00

abstract：:The effect of anti-regucalcin monoclonal antibody on neutral phoshatase activity in rat liver cytosol was investigated. Phosphotyrosine, phosphoserine, and phosphothreonine were used as the substrate toward phosphatase assay. Liver cytosolic phosphatase activity with three phosphoaminoacids was significantly increased...

journal_title：Molecular and cellular biochemistry

authors： Omura M,Yamaguchi M

更新日期：1999-07-01 00:00:00

abstract：:In this study we characterized regulation of the Na+/H+ exchanger promoter in several tissue types. A conserved poly (dA:dT) region was important in regulation of the promoter. Nuclear extracts from rat myocardium and from mouse proximal tubule cells protected the poly (dA:dT) region of the NHE1 promoter. A protein fr...

journal_title：Molecular and cellular biochemistry

authors： Wang H,Yang W,Fliegel L

更新日期：1997-11-01 00:00:00

abstract：:Cellular adaptation to hypoxia involves regulation of specific genes such as vascular endothelial growth factor (VEGF), erythropoietin (EPO) and hypoxia inducible factor (HIF)-1 . In this study, we have evaluated the protective effect of picroliv (a purified iridoid glycoside fraction from roots of Picrorhiza kurrooa ...

journal_title：Molecular and cellular biochemistry

authors： Gaddipati JP,Madhavan S,Sidhu GS,Singh AK,Seth P,Maheshwari RK

更新日期：1999-04-01 00:00:00

abstract：:The present study is to investigate the effect and mechanism of action of interleukin (IL)-17A and its receptor IL-17RA on non-small cell lung cancer (NSCLC). A total of 139 NSCLC patients were included in the study. NSCLC tissues and tumor-adjacent tissues were collected from the patients. Human NSCLC cell lines H157...

journal_title：Molecular and cellular biochemistry

authors： Wu Z,He D,Zhao S,Wang H

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:We reported that urinary L-FABP reflected the progression of chronic kidney disease (CKD). This study is aimed to evaluate the clinical significance of urinary liver type fatty acid binding protein (L-FABP) as a biomarker for monitoring CKD. METHODS:Urinary L-FABP was measured using human L-FABP ELISA kit (...

journal_title：Molecular and cellular biochemistry

authors： Kamijo A,Sugaya T,Hikawa A,Yamanouchi M,Hirata Y,Ishimitsu T,Numabe A,Takagi M,Hayakawa H,Tabei F,Sugimoto T,Mise N,Omata M,Kimura K

更新日期：2006-03-01 00:00:00

abstract：:Insulin stimulated phosphorylation of tyrosine residues by the insulin receptor kinase may be part of a signalling mechanism associated with insulin's action. We report that indomethacin inhibited the phosphorylation of the beta-subunit of the solubilized adipocyte insulin receptor. Indomethacin also inhibited several...

journal_title：Molecular and cellular biochemistry

authors： Malchoff CD,Messina JL,Gordon V,Tamura S,Larner J

更新日期：1985-11-01 00:00:00

abstract：:Human Fibroblast growth factor 1 (FGF1) has been recognized as a valuable protein drug for the treatment of many diseases because of its multiple functions in regulating a variety of biological processes involved in embryonic development, cell growth and differentiation, morphogenesis, tissue repair, and others. The a...

journal_title：Molecular and cellular biochemistry

authors： Zhou Y,Ren L,Zhu J,Yan S,Wang H,Song N,Li L,Ouyang H,Pang D

更新日期：2011-08-01 00:00:00

abstract：:DNA methylation plays an important role in regulation of gene expression and is increasingly being recognized as a determinant of chemosensitivity of human cancers. With the aim of improving the chemotherapeutic efficacy of breast carcinoma, the effect of DNA methyltransferase inhibitor, 5-Aza-2'-deoxycytidine (5-aza-...

journal_title：Molecular and cellular biochemistry

authors： Mirza S,Sharma G,Pandya P,Ralhan R

更新日期：2010-09-01 00:00:00

abstract：:Huge data accumulated in last few years have shown that differential expression of candidate miRNAs in normal versus transformed cell provides important insights into the pathogenesis of cancer including leukemias. In our previous report, we have revealed that miR-196b was significantly down-regulated in both EB-3 cel...

journal_title：Molecular and cellular biochemistry

authors： Bhatia S,Kaul D,Varma N

更新日期：2011-01-01 00:00:00

abstract：:The characterization of mutations in Japanese patients with lipidosis, particularly in metachromatic leukodystrophy (MLD) and Gaucher disease has been studied in detail. Metachromatic leukodystrophy is characterized by an accumulation of sulfatide in nervous tissues and kidney due to a deficiency of arylsulfatase A (A...

journal_title：Molecular and cellular biochemistry

authors： Eto Y,Kawame H,Hasegawa Y,Ohashi T,Ida H,Tokoro T

更新日期：1993-02-17 00:00:00

abstract：:Transport characteristics of essential trace elements as zinc, copper, selenium and iron have been studied in maternal-fetal direction in normal pregnancies, using in vitro perfusion of human placental lobules. Solutions of trace elements corresponding to twice the physiological concentrations were injected (100 micro...

journal_title：Molecular and cellular biochemistry

authors： Nandakumaran M,Dashti HM,Al-Saleh E,Al-Zaid NS

更新日期：2003-10-01 00:00:00

abstract：:The action of micrococcal nuclease, DNase I and DNase II on mouse TLT hepatoma chromatin revealing the periodicity of its structure as visualized by denaturing and non-denaturing gel electrophoresis, was consistent with the action of these enzymes on other chromatins. Micrococcal nuclease showed a complex subnucleosom...

journal_title：Molecular and cellular biochemistry

authors： Duerksen JD,Connor KW

更新日期：1978-04-11 00:00:00

abstract：:Fenugreek and Balanites are two plants commonly used in Egyptian folk medicine as hypoglycemic agents. In the present study, the effects of 21 days oral administration of Fenugreek seed and Balanites fruit extracts (1.5 g/kg bw) on the liver and kidney glycogen content and on some key liver enzymes of carbohydrate met...

journal_title：Molecular and cellular biochemistry

authors： Gad MZ,El-Sawalhi MM,Ismail MF,El-Tanbouly ND

更新日期：2006-01-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is a common heritable human disease. Recently, the role of repressed autophagy in ADPKD has drawn increasing attention. Here, we investigate the mechanism underlying the effect of Saikosaponin-d (SSd), a sarcoplasmic/endoplasmic reticulum Ca2+ ATPase pump (SERCA) in...

journal_title：Molecular and cellular biochemistry

authors： Shi W,Xu D,Gu J,Xue C,Yang B,Fu L,Song S,Liu D,Zhou W,Lv J,Sun K,Chen M,Mei C

更新日期：2018-12-01 00:00:00

abstract：:Pre-purified preparations of myoinositol-1-phosphate synthase (E.C. 5.5.1.4) from rat testes can be purified to homogeneity by first crystallizing the enzyme according to JAKOBY and then recrystallizing it at a pH value close to the isoelectric point while slowly increasing the temperature from 0 to 15 degrees C. This...

journal_title：Molecular and cellular biochemistry

authors： Pittner F,Hoffmann-Ostenhof O

更新日期：1979-12-14 00:00:00

abstract：:In myocardial cells (MCs), endothelin-1 (ET-1) exerts various effects such as hypertrophy, and causes cellular injury. Long-term treatment with an endothelin-A (ET(A)) receptor antagonist improves the survival of rats with heart failure, suggesting that myocardial endothelin system contributes to the progression of he...

journal_title：Molecular and cellular biochemistry

authors： Ueyama T,Kawashima S,Sakoda T,Rikitake Y,Ishida T,Kawai M,Namiki M,Yokoyama M

更新日期：1999-09-01 00:00:00

abstract：:Carnitine is associated with lipid synthesis and its deficiency may lead to cardiomegaly with parenchymal lipid in the heart, kidney and liver. In our study we found that pretreatment of peripheral blood mononuclear cells (PBMC) with serial dilutions of L-Carnitine (100 micrograms/ml-1 pg/ml) inhibits, in a dose-depen...

journal_title：Molecular and cellular biochemistry

authors： Conti P,Reale M,Stuard S,Spoto G,Picerno F,Ferrara T,Placido FC,Barbacane RC,Albertazzi A,Errichi BM

更新日期：1994-02-09 00:00:00

abstract：:Recently it has been demonstrated that hydroxylamine is an activator of triglyceride catabolism. We have studied the effect of hydroxylamine on isocitrate lyase activity and lipid catabolism and have noted a stimulation of isocitrate lyase biosynthesis by 5 mM hydroxylamine. The specificity of this effect was tested w...

journal_title：Molecular and cellular biochemistry

authors： Vanni P,Vincenzini MT,Vincieri F,Baccari V

更新日期：1977-04-12 00:00:00

abstract：:Using rat liver mitochondria, as model systems, we have examined the ability of the natural compound and the food-flavoring agent, vanillin to protect membranes against oxidative damage induced by photosensitization at concentrations normally used in food preparations. Vanillin, at a concentration of 2.5 mmol/L, has a...

journal_title：Molecular and cellular biochemistry

authors： Kamat JP,Ghosh A,Devasagayam TP

更新日期：2000-06-01 00:00:00

abstract：:The phosphorylation of rat cardiac microsomal proteins was investigated with special attention to the effects of okadaic acid (an inhibitor of protein phosphatases), inhibitor 2 of protein phosphatase 1 and inhibitor of cyclic AMP-dependent protein kinase (protein kinase A). The results showed that okadaic acid (5 mic...

journal_title：Molecular and cellular biochemistry

authors： Sulakhe PV,Vo XT,Morris TE,Pato MD,Khandelwal RL

更新日期：1997-10-01 00:00:00

abstract：:Control of mitochondrial respiration depends on ADP availability to the F1-ATPase. An electrochemical gradient of ADP and ATP across the mitochondrial inner membrane is maintained by the adenine nucleotide translocase which provides ADP to the matrix for ATP synthesis and ATP for energy-dependent processes in the cyto...

journal_title：Molecular and cellular biochemistry

authors： McMillin JB,Pauly DF

更新日期：1988-06-01 00:00:00

abstract：:Surfactants, which provide a hydrophobic environment, may induce an ordered conformation in polypeptides and proteins that contain a sequence with helix-or beta-forming potential. This hypothesis has been illustrated in circular dichroic studies of oligopeptides and short polypeptides. These peptide-surfactant complex...

journal_title：Molecular and cellular biochemistry

authors： Wu CS,Yang JT

更新日期：1981-10-30 00:00:00

abstract：BACKGROUND:It has been reported that long intergenic non-protein-coding RNA 324 (LINC00324) promotes liver cancer by upregulating Fas ligand (FasL), which is a major player in intervertebral disk degeneration (IDD), indicating the involvement of LINC00324 in IDD. This study was carried out to investigate the interactio...

journal_title：Molecular and cellular biochemistry

authors： Chen Y,Wu Y,Chen R,Xu C,Chen Q

更新日期：2021-01-28 00:00:00

abstract：:Cardiac hypertrophy is an independent risk factor in the development of heart failure. However, the cellular mechanisms underlying the transition from compensated hypertrophy to heart failure are incompletely understood. The aim of this study was to investigate changes in myocardial substrate utilisation and function ...

journal_title：Molecular and cellular biochemistry

authors： Akki A,Smith K,Seymour AM

更新日期：2008-04-01 00:00:00

abstract：:The molecular mechanisms potentially responsible for cadmium carcinogenesis were investigated by differential gene expression analysis of Balb/c-3T3 cells morphologically transformed with cadmium chloride. Differential display analysis of gene expression revealed overexpression of mouse Translation Initiation Factor 3...

journal_title：Molecular and cellular biochemistry

authors： Joseph P,Lei YX,Ong TM

更新日期：2004-01-01 00:00:00

abstract：:Thioredoxin (Trx) is a small ubiquitous protein, which has been shown to be involved in redox-dependent cellular functions. In this article, we demonstrate that the increased level of Trx induces AP-1 DNA binding in a redox-dependent manner by activating JNK subgroup of MAPKs. The majority of AP-1 DNA binding complex ...

journal_title：Molecular and cellular biochemistry

authors： Das KC,Muniyappa H

更新日期：2010-04-01 00:00:00

abstract：:Glycosaminoglycans were extracted from normal, inflamed and phenytoin induced overgrowth of human gingival tissue by proteolysis and alcohol precipitation. Extracts were run in a Dowex-1 column and the fractions were treated with mucopolysaccharidases. Cellulose acetate electrophoresis was carried out with or without ...

journal_title：Molecular and cellular biochemistry

authors： Suresh R,Puvanakrishnan R,Dhar SC

更新日期：1992-10-07 00:00:00

abstract：:Gastrointestinal symptoms are fairly common in diabetes mellitus. Glimepride, is a latest second generation sulfonylurea used for the treatment of type II diabetes mellitus, is a insulin secrectagogue; indirectly, it also increases insulin secretion and its specific effect on pancreatic ATP-dependent K(+) channel inhi...

journal_title：Molecular and cellular biochemistry

authors： Phadatare PD,Chandrashekhar VM

更新日期：2011-08-01 00:00:00

abstract：:Persistent activation of nuclear factor B (NF-κB) is very important in the modulation of macrophages cellular response to microbial infections. The deubiquitinase USP14, which is critical for ubiquitin-mediated proteasomal degradation of proteins, is known to be involved in cancer, neurological diseases, and aging. Ho...

journal_title：Molecular and cellular biochemistry

authors： Liu N,Kong T,Chen X,Hu H,Gu H,Liu S,Chen X,Yang Q,Li A,Xiong X,Zhang Z

更新日期：2017-07-01 00:00:00