当前位置： SCI文献检索 > MOLECULAR AND CELLULAR BIOCHEMISTRY期刊下所有文献 > Renal dopamine receptors are involved in the development of cardiac hypertrophy.

Renal dopamine receptors are involved in the development of cardiac hypertrophy.

Abstract：

:The present study examined the effect of fenoldopam, a known dopamine-1 receptor (DA1) agonist in order to understand its involvement in the cardiac hypertrophic process. Male Sprague-Dawley rats underwent abdominal aortic constriction (AB) with placement of a suprarenal ligature while sham operated animals served as controls. The AB groups showed an increase in their heart wt, left ventricular (LV) wt, heart wt/body wt and LV wt/body ratio. Furthermore, the length of these hearts, as measured from the auriculoventricular border to the apex, LV wall and interventricular (IV) septal thickness were increased from control levels. Treatment with SCH 23390, a DA1 antagonist, on the other hand, was able to partially regress the cardiac hypertrophic changes. All these parameters were also increased in control animals treated with fenoldopam (F). Such changes were more striking in the F+AB group which showed a significant acceleration of the cardiac hypertrophic process on superimposing the two treatments. Plasma dopamine and renin activity were increased in all the groups as compared to control. These results indicate that dopamine receptors are implicated in the development of cardiac hypertrophy.

journal_name

Mol Cell Biochem

journal_title

Molecular and cellular biochemistry

authors

Ganguly PK,Mukherjee K,Sahai A

doi

10.1007/BF00926744

subject

Has Abstract

pub_date

1995-03-09 00:00:00

pages

81-4

issue

1

eissn

0300-8177

issn

1573-4919

journal_volume

144

pub_type

杂志文章

相关文献

MOLECULAR AND CELLULAR BIOCHEMISTRY文献大全
  • Sulfhydryl oxidation and Ca2+ release from sarcoplasmic reticulum.

    abstract：:Our interest in the role of sulfhydryl groups (SH) in regulating or altering transport across biological membranes has focused on the significance of a critical SH group associated with the Ca2+-release protein from skeletal muscle sarcoplasmic reticulum (SR). We have shown that binding of heavy metals to this group o...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00242520

    authors： Abramson JJ,Salama G

    更新日期：1988-07-01 00:00:00

  • Functional analysis of CK2beta-derived synthetic fragments.

    abstract：:Synthetic peptides reproducing the amino and carboxyl terminal region of CK2beta subunit have been analyzed for their ability to mimic different properties of full length beta subunit. Peptide beta[1-77], containing both the autophosphorylation site and the down-regulatory domain 55-64, is readily phosphorylated by al...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：

    authors： Meggio F,Marin O,Sarno S,Pinna LA

    更新日期：1999-01-01 00:00:00

  • Expression of calcium-binding protein regucalcin mRNA in rat liver is stimulated by calcitonin: the hormonal effect is mediated through calcium.

    abstract：:The involvement of a hypocalcemic hormone calcitonin (CT) in the expression of hepatic Ca(2+)-binding protein regucalcin mRNA was investigated. The change of regucalcin mRNA levels was analyzed by Northern blotting using liver regucalcin complementary DNA (0.9 kb). A single oral administration of calcium chloride (100...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00931603

    authors： Yamaguchi M,Kanayama Y,Shimokawa N

    更新日期：1994-07-13 00:00:00

  • Involvement of Ad4BP/SF-1, DAX-1, and COUP-TFII transcription factor on steroid production and luteinization in ovarian theca cells.

    abstract：:To examine the essential mechanisms of steroid production in ovarian theca cells, we analyzed the expression of genes associated with steroid production using simple culture system with serum medium. In addition, we examined the involvement of DAX-1, COUP-TFII, and Ad4BP/SF-1 transcription factors on the steroid produ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-008-9764-y

    authors： Murayama C,Miyazaki H,Miyamoto A,Shimizu T

    更新日期：2008-07-01 00:00:00

  • BTF3 is a potential new substrate of protein kinase CK2.

    abstract：:BTF3, initially discovered as a factor required for transcription inititation of RNA polymerase II, is expressed in two isoforms, termed a and b. BTF3b, the transcriptionally inactive isoform, was identified as an interaction partner of protein kinase CK2 subunit beta employing the interaction trap system for screenin...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：

    authors： Grein S,Pyerin W

    更新日期：1999-01-01 00:00:00

  • Whole-cell voltage clamp and intracellular perfusion technique on single smooth muscle cells.

    abstract：:Using freshly isolated single smooth muscle cells prepared by collagenase treatment, membrane currents were recorded by whole-cell voltage clamp. Intracellular constituents were modified by using an intracellular perfusion technique, i.e., pipette solutions were continuously exchanged from control to test solutions du...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00231006

    authors： Ohya Y,Sperelakis N

    更新日期：1988-03-01 00:00:00

  • Notch2 signaling contributes to cell growth, invasion, and migration in salivary adenoid cystic carcinoma.

    abstract：:Many studies have explored whether the Notch signaling pathway has a tumor-suppressive or an oncogenic role in various tumors; however, the role of the Notch signaling pathway in salivary adenoid cystic carcinoma (SACC) is still unknown. In this study, we attempt to define the role of Notch2 signaling in cell growth, ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-015-2575-z

    authors： Qu J,Song M,Xie J,Huang XY,Hu XM,Gan RH,Zhao Y,Lin LS,Chen J,Lin X,Zheng DL,Lu YG

    更新日期：2016-01-01 00:00:00

  • Involvement of nuclear factor-1 (NF1) binding motif in the regucalcin gene expression of rat kidney cortex: the expression is suppressed by cisplatin administration.

    abstract：:The binding of nuclear factor on the promoter region of the regucalcin gene and the expression of regucalcin in the kidney cortex of rats was investigated. Nuclear extracts from kidney cortex were used for oligonucleotide competition gel mobility shift assay. An oligonucleotide between position -523 and -506 in the 5'...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1011040805597

    authors： Misawa H,Yamaguchi M

    更新日期：2001-03-01 00:00:00

  • Regulation of connexin-43-mediated growth inhibition by a phosphorylatable amino-acid is independent of gap junction-forming ability.

    abstract：:The ability of the gap junction phosphoprotein connexin-43 (Cx43) to inhibit DNA synthesis in primary cardiomyocytes is regulated by serine (S) 262, a protein kinase C phosphorylation site that also affects metabolic coupling. We have now examined if the S262-regulated growth suppression is operating in transformed ce...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-006-9162-2

    authors： Dang X,Jeyaraman M,Kardami E

    更新日期：2006-09-01 00:00:00

  • Sequence-dependent conformations of short polypeptides in a hydrophobic environment.

    abstract：:Surfactants, which provide a hydrophobic environment, may induce an ordered conformation in polypeptides and proteins that contain a sequence with helix-or beta-forming potential. This hypothesis has been illustrated in circular dichroic studies of oligopeptides and short polypeptides. These peptide-surfactant complex...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00224754

    authors： Wu CS,Yang JT

    更新日期：1981-10-30 00:00:00

  • Magnesium: effects on reperfusion arrhythmias and membrane potential in isolated rat hearts.

    abstract：:The effects of Mg2+ concentration (Mg2+o, 0, 1.2, 2.4, and 4.8 mM) on the incidence of reperfusion arrhythmias and on the cellular electrical activity were studied in spontaneously beating rat hearts. The surface electrogram and the membrane potential were recorded in control conditions, during 10 min of regional isch...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1006863311967

    authors： Ponce Zumino A,Risler NR,Schanne OF,Ruiz Petrich E,Carrión A

    更新日期：1997-06-01 00:00:00

  • Reduction of cardiac hypertrophy in TGR(mREN2)27 by angiotensin II receptor blockade.

    abstract：:TGR(mREN2)27 is a transgenic rat harboring the murine Ren-2 gene and exhibit fulminant hypertension and marked heart hypertrophy. In order to study the role of angiotensin II in the increase of cardiac mass, these animals were treated with antihypertensive and non-antihypertensive doses of the angiotensin II receptor ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00408661

    authors： Böhm M,Lippoldt A,Wienen W,Ganten D,Bader M

    更新日期：1996-10-01 00:00:00

  • Modulation of the c-Jun N-terminal kinase activity in the embryonic heart in response to anoxia-reoxygenation: involvement of the Ca2+ and mitoKATP channels.

    abstract：:Whether the response of the fetal heart to ischemia-reperfusion is associated with activation of the c-Jun N-terminal kinase (JNK) pathway is not known. In contrast, involvement of the sarcolemmal L-type Ca2+ channel (LCC) and the mitochondrial KATP (mitoKATP) channel has been established. This work aimed at investiga...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-008-9750-4

    authors： Sarre A,Gardier S,Maurer F,Bonny C,Raddatz E

    更新日期：2008-06-01 00:00:00

  • Nitric oxide attenuates matrix metalloproteinase-9 production by endothelial cells independent of cGMP- or NFκB-mediated mechanisms.

    abstract：:Cardiovascular diseases involve critical mechanisms including impaired nitric oxide (NO) levels and abnormal matrix metalloproteinase (MMP) activity. While NO downregulates MMP expression in some cell types, no previous study has examined whether NO downregulates MMP levels in endothelial cells. We hypothesized that N...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-013-1602-1

    authors： Meschiari CA,Izidoro-Toledo T,Gerlach RF,Tanus-Santos JE

    更新日期：2013-06-01 00:00:00

  • The mitochondrial Nod-like receptor NLRX1 modifies apoptosis through SARM1.

    abstract：:NLRX1, the mitochondrial NOD-like receptor (NLR), modulates apoptosis in response to both intrinsic and extrinsic cues. Insights into the mechanism of how NLRX1 influences apoptosis remain to be determined. Here, we demonstrate that NLRX1 associates with SARM1, a protein with a toll/interleukin-1 receptor (TIR)-contai...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-018-3444-3

    authors： Killackey SA,Rahman MA,Soares F,Zhang AB,Abdel-Nour M,Philpott DJ,Girardin SE

    更新日期：2019-03-01 00:00:00

  • Regulation of phospholamban and troponin-I phosphorylation in the intact rat cardiomyocytes by adrenergic and cholinergic stimuli: roles of cyclic nucleotides, calcium, protein kinases and phosphatases and depolarization.

    abstract：:Protein phosphorylation was investigated in [32P]-labeled cardiomyocytes isolated from adult rat heart ventricles. The beta-adrenergic stimulation (by isoproterenol, ISO) increased the phosphorylation of inhibitory subunit of troponin (TN-I), C-protein and phospholamban (PLN). Such stimulation was largely mediated by ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1007/BF01076569

    authors： Sulakhe PV,Vo XT

    更新日期：1995-08-01 00:00:00

  • JIP3 localises to exocytic vesicles and focal adhesions in the growth cones of differentiated PC12 cells.

    abstract：:The JNK-interacting protein 3 (JIP3) is a molecular scaffold, expressed predominantly in neurons, that serves to coordinate the activation of the c-Jun N-terminal kinase (JNK) by binding to JNK and the upstream kinases involved in its activation. The JNK pathway is involved in the regulation of many cellular processes...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-017-3222-7

    authors： Caswell PT,Dickens M

    更新日期：2018-07-01 00:00:00

  • CK2alpha-protein phosphatase 2A molecular complex: possible interaction with the MAP kinase pathway.

    abstract：:Despite its wide range of known substrates, the signaling function of protein kinase CK2 is still enigmatic. Mounting evidence suggests that CK2alpha, the catalytic subunit of holoenzymic CK2, may exist free of its usual regulatory partner CK2beta, raising the possibility that 'free' CK2alpha has regulation and functi...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：

    authors： Lebrin F,Bianchini L,Rabilloud T,Chambaz EM,Goldberg Y

    更新日期：1999-01-01 00:00:00

  • Effect of temperature and duration of hyperthermia on HSP72 induction in rat tissues.

    abstract：:The aim of the present study was to determine whether heat shock protein 72 (HSP72) is induced in a heated rat model at rectal temperatures below 42 degrees C. Rats were divided into a control group and six groups (n = 6) heated to different rectal temperatures: 39 degrees C for 1 h (39), 40.0 degrees C for either 15 ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/b:mcbi.0000049382.63841.e4

    authors： Ruell PA,Hoffman KM,Chow CM,Thompson MW

    更新日期：2004-12-01 00:00:00

  • Clinical significance of cathepsin L and cathepsin B in dilated cardiomyopathy.

    abstract：:Dysregulated expression of lysosomal cysteine cathepsins is associated with adverse cardiac remodeling, a characteristic of several cardiovascular diseases. However, the information regarding the role of cysteine cathepsin L (CTSL) and cathepsin B (CTSB) in dilated cardiomyopathy (DCM) is limited. The present study wa...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-016-2924-6

    authors： Mehra S,Kumar M,Manchanda M,Singh R,Thakur B,Rani N,Arava S,Narang R,Arya DS,Chauhan SS

    更新日期：2017-04-01 00:00:00

  • Identification of an atypical form of 30 kDa SOD--a possible virulence factor in clinical isolates of Shigella spp.

    abstract：:Reviews on the pathogenic mechanisms of Shigella species show a lacunae in the understanding of the bacterial antioxidant defense system and its regulations. This study was done to investigate the regulation of expression of antioxidant enzymes in clinical isolates of Shigella species, under various growth conditions....

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/b:mcbi.0000049369.78195.b1

    authors： Prakash R,Devaraj H,Devaraj SN

    更新日期：2004-12-01 00:00:00

  • Action of oligomycin on cultured mammalian cells. Permeabilization to translation inhibitors.

    abstract：:Oligomycin, an inhibitor of ATP synthesis, has been used as a model to study the effects of ATP depletion on macromolecular synthesis and modification of membrane permeability. Protein synthesis is totally blocked by the antibiotic, whereas RNA and DNA synthesis are less inhibited. Different concentrations of monovale...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00222495

    authors： Otero MJ,Carrasco L

    更新日期：1984-01-01 00:00:00

  • Mitochondrial bioenergetics, uncoupling protein-2 activity, and reactive oxygen species production in the small intestine of a TNBS-induced colitis rat model.

    abstract：:Inflammatory bowel disease (IBD) is often associated with a decrease in energy-dependent nutrient uptake across the jejunum that serves as the main site for absorption in the small intestine. This association has prompted us to investigate the bioenergetics underlying the alterations in jejunal absorption in 2,4,6-tri...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-020-03749-z

    authors： Al Ojaimi Y,Khachab M,Bazzi S,Bahr GM,Echtay KS

    更新日期：2020-07-01 00:00:00

  • ANRIL regulates the proliferation of human colorectal cancer cells in both two- and three-dimensional culture.

    abstract：:ANRIL is a long noncoding RNA transcribed from the INK4 locus that encodes three tumor suppressor genes, p15, p16, and ARF. Previous studies demonstrated that ANRIL represses p15 and p16, which positively regulate the pRB pathway, leading to repression of cellular senescence of human normal fibroblasts. However, the r...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-015-2618-5

    authors： Naemura M,Tsunoda T,Inoue Y,Okamoto H,Shirasawa S,Kotake Y

    更新日期：2016-01-01 00:00:00

  • Vanadate induces apoptosis in epidermal JB6 P+ cells via hydrogen peroxide-mediated reactions.

    abstract：:Apoptosis is a physiological mechanism for the control of DNA integrity in mammalian cells. Vanadium induces both DNA damage and apoptosis. It is suggested that vanadium-induced apoptosis serves to eliminate DNA-damaged cells. This study is designed to clarify a role of reactive oxygen species in the mechanism of apop...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1007078915585

    authors： Ye J,Ding M,Leonard SS,Robinson VA,Millecchia L,Zhang X,Castranova V,Vallyathan V,Shi X

    更新日期：1999-12-01 00:00:00

  • Inhibitors of cytoplasmic protein synthesis purified from rat liver mitochondria.

    abstract：:Purified mitochondria from rat liver were found to contain protein synthesis inhibitors, that could be extracted by disruption of mitochondrial membranes and fractionated by gel filtration into two fractions of low and high molecular weight. Small size inhibitors were also released from the latter peak by high ionic s...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00223302

    authors： Pérez JL,Dorta B,González-Cadavid N

    更新日期：1984-06-01 00:00:00

  • The relation between the action potential duration, the increase in resting tension, and ATP content during metabolic inhibition in guinea pig ventricular muscles.

    abstract：:To investigate whether the action potential duration (APD) or resting tension was dependent on global ATP content, and whether they were preferentially dependent on glycolytic ATP, APD and resting tension were measured under various metabolic inhibition with corresponding measurement of ATP content in guinea pig ventr...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1006938714384

    authors： Hayashi H,Terada H,McDonald TF

    更新日期：1999-04-01 00:00:00

  • The content of lipoperoxidation products in normal and atherosclerotic human aorta.

    abstract：:To evaluate the role of lipid oxidation in atherogenesis the levels of lipid- and protein-bound products of peroxidation in normal and atherosclerotic areas of human aorta were investigated. The level of fluorescent (360/430 nm) lipid products was measured in chloroform-methanol extracts of aortic tissue. Normal intim...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1012267520932

    authors： Tertov VV,Kaplun VV,Mikhailova IA,Suprun IV,Orekhov AN

    更新日期：2001-09-01 00:00:00

  • Reduced human lymphocyte blastogenesis and enhancement of adenosine triphosphate (ATP) by L-carnitine.

    abstract：:Carnitine is associated with lipid synthesis and its deficiency may lead to cardiomegaly with parenchymal lipid in the heart, kidney and liver. In our study we found that pretreatment of peripheral blood mononuclear cells (PBMC) with serial dilutions of L-Carnitine (100 micrograms/ml-1 pg/ml) inhibits, in a dose-depen...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF01075718

    authors： Conti P,Reale M,Stuard S,Spoto G,Picerno F,Ferrara T,Placido FC,Barbacane RC,Albertazzi A,Errichi BM

    更新日期：1994-02-09 00:00:00

  • Expression of Sp7 in Satb2-induced osteogenic differentiation of mouse bone marrow stromal cells is regulated by microRNA-27a.

    abstract：:Satb2 is a special AT-rich binding transcription factor essential for osteoblast differentiation and bone formation. Specific microRNAs (miRNAs) have been identified to regulate the complex process of osteogenic differentiation. It remains unclear how miRNA expressions is changed in the Satb2-induced osteogenic differ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-016-2709-y

    authors： Gong Y,Lu J,Yu X,Yu Y

    更新日期：2016-06-01 00:00:00