Maturation of fatty acid and carbohydrate metabolism in the newborn heart.

abstract：:Dual-specificity phosphatases (DSPs), which dephosphorylate proteins at Ser/Thr as well as Tyr residues, are thought to be involved in critical signaling events such as control of MAP kinases (MAPKs). We have isolated the cDNA for a novel DSP and termed it low molecular mass DSP-4 (LDP-4). LDP-4 is composed of 211 ami...

journal_title：Molecular and cellular biochemistry

authors： Takagaki K,Shima H,Tanuma N,Nomura M,Satoh T,Watanabe M,Kikuchi K

更新日期：2007-02-01 00:00:00

abstract：:Adipose-derived stem cells (ADSCs) have been considered as the optimal cells for regenerative medicine because ADSCs have the potential of multi-directional differentiation. To study the mechanisms of ADSCs differentiation, we analyzed microarray of GSE37329. GSE37329 was downloaded from Gene Expression Omnibus includ...

journal_title：Molecular and cellular biochemistry

authors： Ren Y,Han C,Wang J,Jia Y,Kong L,Eerdun T,Wu L,Jiang D

更新日期：2015-02-01 00:00:00

abstract：:Human glomerular mesangial cells (HMCs) have a finite lifespan and eventually enter irreversible growth arrest known as cellular senescence which is thought to contribute to kidney aging and age-related kidney disorders, such as chronic kidney disease. The signal transducer and activator of transcription 1 (STAT1) is ...

journal_title：Molecular and cellular biochemistry

authors： Jiao S,Meng F,Zhang J,Yang X,Zheng X,Wang L

更新日期：2012-06-01 00:00:00

abstract：:Eukaryotic cells respond to different external stimuli by activation of mechanisms of cell signaling. One of the major systems participating in the transduction of signal from the cell membrane to nuclear and other intracellular targets is the highly conserved mitogen-activated protein kinase (MAPK) superfamily. The m...

journal_title：Molecular and cellular biochemistry

authors： Ravingerová T,Barancík M,Strnisková M

更新日期：2003-05-01 00:00:00

abstract：:The aim of our study is to explore the regulation of C1QTNF1-AS1 on its target miR-221-3p/SOCS3 in human hepatocellular carcinoma (HCC). To explore the underlying molecular regulation of non-coding RNA for HCC, differentially expressed patterns of lncRNAs and genes were examined by RNA-seq. GO and KEGG pathway analysi...

journal_title：Molecular and cellular biochemistry

authors： Han W,Yu G,Meng X,Hong H,Zheng L,Wu X,Zhang D,Yan B,Ma Y,Li X,Wang Q

更新日期：2019-10-01 00:00:00

abstract：:The effect of menaquinone-7 (MK-7; vitamin K2) on osteoclast-like cell formation and osteoclastic bone resorption in rat femoral tissues in vitro was investigated. The bone marrow cells were cultured for 7 days in a a-minimal essential medium (alpha-MEM) containing a well-known bone resorbing agent [parathyroid hormon...

journal_title：Molecular and cellular biochemistry

authors： Yamaguchi M,Ma ZJ

更新日期：2001-12-01 00:00:00

abstract：:The tRNA modifying enzyme, S-adenosylmethionine:tRNA(guanine-7-)-methyltransferase, has been extensively purified from Salmonella typhimurium. A rapid and efficient purification method using phosphocellulose chromatography followed by ammonium sulfate precipitation and Sephadex G-100 gel filtration is described. The e...

journal_title：Molecular and cellular biochemistry

authors： Colonna A,Ciliberto G,Santamaria R,Cimino F,Salvatore F

更新日期：1983-01-01 00:00:00

abstract：:The purpose of this study was to determine if selected biochemical parameters representing the contractile and calcium regulating systems of cardiac muscle scaled among mammals having inherently different resting heart rates (RHR). Eight mammalian species with RHR ranging from 51 to 475 beats per minute (bpm) were stu...

journal_title：Molecular and cellular biochemistry

authors： Hamilton N,Ianuzzo CD

更新日期：1991-08-14 00:00:00

abstract：:A literature search has been conducted to see to what extent steady-state kinetics studies in the period 1965-1976 have revealed deviations from Michaelis-Menten kinetics. It was found that over 800 enzymes have been reported as giving complex curves for a variety of reasons and a group by group classification of all ...

journal_title：Molecular and cellular biochemistry

authors： Hill CM,Waight RD,Bardsley WG

更新日期：1977-05-03 00:00:00

abstract：:Both idiopathic restrictive cardiomyopathy (IRCM) and hypertrophic cardiomyopathy (HCM) are part of the same disease spectrum and are due to sarcomeric gene mutations. A patient with restrictive physiology without left ventricular hypertrophy (LVH) would be diagnosed as IRCM, while one with LVH would be diagnosed as H...

journal_title：Molecular and cellular biochemistry

authors： Rai TS,Ahmad S,Ahluwalia TS,Ahuja M,Bahl A,Saikia UN,Singh B,Talwar KK,Khullar M

更新日期：2009-11-01 00:00:00

abstract：:Recently it has been demonstrated that hydroxylamine is an activator of triglyceride catabolism. We have studied the effect of hydroxylamine on isocitrate lyase activity and lipid catabolism and have noted a stimulation of isocitrate lyase biosynthesis by 5 mM hydroxylamine. The specificity of this effect was tested w...

journal_title：Molecular and cellular biochemistry

authors： Vanni P,Vincenzini MT,Vincieri F,Baccari V

更新日期：1977-04-12 00:00:00

abstract：:In our recently published study, we provided in vitro as well as in vivo data demonstrating the involvement of TRM2/RNC1 in homologous recombination based repair (HRR) of DNA double strand breaks (DSBs), in support of such claims reported earlier. To further validate its role in DNA DSB processing, our present study r...

journal_title：Molecular and cellular biochemistry

authors： Choudhury SA,Asefa B,Kauler P,Chow TY

更新日期：2007-10-01 00:00:00

abstract：:Knowledge of transcription and translation has advanced our understanding of cardiac diseases. Here, we present the hypothesis that the stability of mRNA mediated by the 3'-untranslated region (3'-UTR) plays a role in changing gene expression in cardiovascular pathophysiology. Several proteins that bind to sequences i...

journal_title：Molecular and cellular biochemistry

authors： Misquitta CM,Iyer VR,Werstiuk ES,Grover AK

更新日期：2001-08-01 00:00:00

abstract：:Cardiac oxidative stress is developed following myocardial infarction (MI) particularly in the first week of MI. The influence of reactive oxygen species (ROS) on gene expression profiling and molecular pathways in the infarcted myocardium remains uncertain and is explored in the present study. Rats with MI were treat...

journal_title：Molecular and cellular biochemistry

authors： Zhao W,Zhao T,Chen Y,Qu Y,Gerling IC,Sun Y

更新日期：2013-07-01 00:00:00

abstract：:Airways inflammation, a pathological hallmark of asthma, is associated with the recruitment of pro-inflammatory and inflammatory cells like eosinophils, polymorphonuclear leucocytes cells, mononuclear cells, macrophages, epithelial desquamation, and airways remodeling with sub-epithelial fibrosis. Activated inflammato...

journal_title：Molecular and cellular biochemistry

authors： Khanduja KL,Kaushik G,Khanduja S,Pathak CM,Laldinpuii J,Behera D

更新日期：2011-01-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor (PPAR) family of transcription factors play a key role in lipid metabolism and have been implicated in a number of disease states, most notably of which is obesity. Controlled regulation of lipid metabolism is a key ingredient for successful hibernation. Partial cDNA sequ...

journal_title：Molecular and cellular biochemistry

authors： Eddy SF,Morin P Jr,Storey KB

更新日期：2005-01-01 00:00:00

abstract：:Dendritic cells (DC) and myeloid-derived suppressor cells (MDSC) are important cells involved in immune response. DC can be generated from mouse bone marrow (BM) in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-4. Recent studies have revealed that combined treatment of bone marrow MD...

journal_title：Molecular and cellular biochemistry

authors： Liu C,Zhang C,Lu H,Cai J,Wang Z,Chen J,Liu F,Wu Z,Liu X,Sun W

更新日期：2011-12-01 00:00:00

abstract：:In the search for MBP phosphorylating activities in Dictyostelium discoideum, we have found a proteolysis-activated protein kinase. This activity which is distributed between the soluble and the particulate fractions of the cell, uses MBP and histone as substrate and has a molecular mass of 140 kDa as detected in an '...

journal_title：Molecular and cellular biochemistry

authors： Nuñez A,Fernández-Renart M

更新日期：1997-10-01 00:00:00

abstract：:A sialic acid binding lectin, AchatininH, was purified in single step from the hemolymph of the land snail, Achatina fulica, by the affinity chromatography on sheep submaxillary mucin coupled to Sepharose 4B. The yield of the lectin was found to be 3 mg from 100 ml of hemolymph. The homogeneity of the lectin was estab...

journal_title：Molecular and cellular biochemistry

authors： Basu S,Sarkar M,Mandal C

更新日期：1986-08-01 00:00:00

abstract：:When Leishmania donovani promastigote forms, were cultured in TC-199 medium at 28 degrees C and subsequently incubated at 38 degrees C, they turned into aflagellate (amastigote-like) forms. A return of the incubation-culture temperature to 28 degrees C these amastigote-like forms to revert to promastigotes. The amasti...

journal_title：Molecular and cellular biochemistry

authors： Castilla JJ,Sanchez-Moreno M,Mesa C,Osuna A

更新日期：1995-01-26 00:00:00

abstract：:Arjunolic acid, a new triterpene and a potent principle from the bark of Terminalia arjuna, has been shown to provide significant cardiac protection in isoproterenol induced myocardial necrosis in rats. To further explore the mechanism of action of arjunolic acid, antiplatelet activity, anticoagulant assays, electroca...

journal_title：Molecular and cellular biochemistry

authors： Sumitra M,Manikandan P,Kumar DA,Arutselvan N,Balakrishna K,Manohar BM,Puvanakrishnan R

更新日期：2001-08-01 00:00:00

abstract：:Lens epithelial cells are the metabolic unit of the lens and antioxidant enzymes are mainly concentrated here. The purpose of this study was to maintain human lens epithelial cells (HLEC) in culture and examine the status of antioxidant enzymes (glutathione peroxidase (GSHPx), catalase (CAT), glutathione-S-transferase...

journal_title：Molecular and cellular biochemistry

authors： Mohanty I,Joshi S,Trivedi D,Srivastava S,Tandon R,Gupta SK

更新日期：2002-09-01 00:00:00

abstract：:Using freshly isolated single smooth muscle cells prepared by collagenase treatment, membrane currents were recorded by whole-cell voltage clamp. Intracellular constituents were modified by using an intracellular perfusion technique, i.e., pipette solutions were continuously exchanged from control to test solutions du...

journal_title：Molecular and cellular biochemistry

authors： Ohya Y,Sperelakis N

更新日期：1988-03-01 00:00:00

abstract：:The natriuretic peptide receptor-A (NPR-A) is involved in blood pressure and body fluid regulation in order to help maintain cardiovascular homeostasis. It has been shown that these biological effects are mediated through the natriuretic peptide family of hormones, which bind NPR-A according to the rank order ANP>BNP>...

journal_title：Molecular and cellular biochemistry

authors： Marquis M,Fenrick R,Pedro L,Bouvier M,De Léan A

更新日期：1999-04-01 00:00:00

abstract：:In this paper we review our experiments on the light-induced Ca2+ release and proton uptake at the rod outer segment (ROS) disk membrane using flash-spectrophotometry and the indicating dyes arsenazo III and bromcresol purple. We used three different ROS preparations in order to locate the intracellular site of Ca2+ r...

journal_title：Molecular and cellular biochemistry

authors： Schnetkamp PP,Kaupp UB

更新日期：1983-01-01 00:00:00

abstract：:This paper investigated the effects of ox-LDL on PCSK9, and the molecular mechanisms of PCSK9 siRNA-inhibited apoptosis induced by ox-LDL in human umbilical vein endothelial cells (HUVECs), to clarify the role of PCSK9 in atherosclerogenesis. HUVECs were incubated with ox-LDL for 24 h. The apoptosis was observed by Ho...

journal_title：Molecular and cellular biochemistry

authors： Wu CY,Tang ZH,Jiang L,Li XF,Jiang ZS,Liu LS

更新日期：2012-01-01 00:00:00

abstract：:Chemical and enzymatic properties of four collagenases newly isolated from anaerobic Clostridium histolyticum, aerobic Achromobacter iophagus, and from two lower eucaryotes, the fungus Entomophthora coronata and the insect Hypoderma lineatum are reviewed. The problems of their biosynthesis and precursors, namely the e...

journal_title：Molecular and cellular biochemistry

authors： Keil B

更新日期：1979-01-26 00:00:00

abstract：:Insulin elicits its divergent metabolic and mitogenic effects by binding to its specific receptor, which belongs to the family of receptor tyrosine kinases. The activated insulin receptor phosphorylates the intracellular substrate IRS-1, which then binds various signalling molecules that contain SRC homology 2 domains...

journal_title：Molecular and cellular biochemistry

authors： Ogawa W,Matozaki T,Kasuga M

更新日期：1998-05-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are known as crucial regulators in the development of OC. In the current study, we aim to explore the function and molecular mechanism of lncRNA DLEU1 in OC. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to determine the expression of DLEU1, miR-429, and TFAP2A i...

journal_title：Molecular and cellular biochemistry

authors： Xu H,Wang L,Jiang X

更新日期：2020-11-10 00:00:00

abstract：:The clinical benefit of selective BRAF inhibitor therapies is limited by the emergence of drug resistance. Here, we investigated the molecular basis underlying the acquired resistance to a BRAF inhibitor by comparing the signaling pathways in the parental A375P cells and the resistant subline (A375P/Mdr). We demonstra...

journal_title：Molecular and cellular biochemistry

authors： Ahn JH,Lee M

更新日期：2014-07-01 00:00:00