Ca2+ calmodulin-dependent protein kinase activity in the ascomycetes Neurospora crassa.

abstract：:Respiratory muscle injury may result from excessive loading due to a decrease in respiratory muscle strength, an increase in the work of breathing, or an increase in the rate of ventilation. Other conditions such as hypoxemia, hypercapnia, aging, decreased nutrition, and immobilization may potentiate respiratory muscl...

journal_title：Molecular and cellular biochemistry

authors： Reid WD,MacGowan NA

更新日期：1998-02-01 00:00:00

abstract：:Development and repair of the skeletal system and other organs are highly dependent on precise regulation of the bone morphogenetic protein (BMP) pathway. The use of BMPs clinically to induce bone formation has been limited in part by the requirement of much higher doses of recombinant proteins in primates than were n...

journal_title：Molecular and cellular biochemistry

authors： Sangadala S,Yoshioka K,Enyo Y,Liu Y,Titus L,Boden SD

更新日期：2014-01-01 00:00:00

abstract：:Inactivation of the Staphylococcus aureus tricarboxylic acid (TCA) cycle delays the resolution of cutaneous ulcers in a mouse soft tissue infection model. In this study, it was observed that cutaneous lesions in mice infected with wild-type or isogenic aconitase mutant S. aureus strains contained comparable inflammato...

journal_title：Molecular and cellular biochemistry

authors： Massilamany C,Gangaplara A,Gardner DJ,Musser JM,Steffen D,Somerville GA,Reddy J

更新日期：2011-09-01 00:00:00

abstract：:Identifying low-abundance mutations is important for the therapy and diagnose of cancer. Since the potential for tumor heterogeneity, the efficient detection of cancer-relevant mutations largely depends on the sensitivity of the methods employed. To confirm whether the mutation detection platforms affect the perceived...

journal_title：Molecular and cellular biochemistry

authors： Jiang W,Wang W,Fu F,Teng X,Wang H,Wang H,Teng L

更新日期：2012-07-01 00:00:00

abstract：:The roles of TGF-beta and the interaction between TGF-beta and EGFR signaling are critical in Sertoli cell, though the knowledge about them is limited. RT-PCR was used to characterize the status of TGF-beta signaling in clinical testicular specimens with complete Sertoli cell-only syndrome (SCOS). The mouse Sertoli ce...

journal_title：Molecular and cellular biochemistry

authors： Sun T,Xin Z,Jin Z,Wu Y,Gong Y

更新日期：2008-12-01 00:00:00

abstract：:Both reactive oxygen- and nitrogen-derived reactive species play important roles in physiological and pathophysiological conditions. Flavones, luteolin and luteolin-7-O-glucoside along with a rich plant source of both flavones, namely dandelion (Taraxacum officinale) flower extract were studied for antioxidant activit...

journal_title：Molecular and cellular biochemistry

authors： Hu C,Kitts DD

更新日期：2004-10-01 00:00:00

abstract：:Serratia marcescens utilizes two types of quorum-sensing signal molecules: N-acyl homoserine lactones and furanosyl borate diester (AI-2). S-adenosylmethionine synthetase (METK), S-adenosylhomocysteine nucleosidase (PFS), and S-ribosylhomocysteinase (LUXS) are three key enzymes in the biosynthetic pathway leading to A...

journal_title：Molecular and cellular biochemistry

authors： Zhu H,Shen YL,Wei DZ,Zhu JW

更新日期：2008-08-01 00:00:00

abstract：:Progression of prostate cancer is facilitated by growth factors that activate critical signaling cascades thereby promote prostate cancer cell growth, survival, and migration. To investigate the effect of quercetin on insulin-like growth factor signaling and apoptosis in androgen independent prostate cancer cells (PC-...

journal_title：Molecular and cellular biochemistry

authors： Senthilkumar K,Elumalai P,Arunkumar R,Banudevi S,Gunadharini ND,Sharmila G,Selvakumar K,Arunakaran J

更新日期：2010-11-01 00:00:00

abstract：:Susceptibility of four major rat tissues to oxidative damage in terms of lipid peroxidation induced by in vitro by ascorbate-Fe2+ in homogenates and mitochondria has been examined. Lipid peroxidation, as assessed by thiobarbituric acid reactive substances (TBARS) and conjugated dienes was maximum in brain followed by ...

journal_title：Molecular and cellular biochemistry

authors： Pushpendran CK,Subramanian M,Devasagayam TP,Singh BB

更新日期：1998-01-01 00:00:00

abstract：:Reviews on the pathogenic mechanisms of Shigella species show a lacunae in the understanding of the bacterial antioxidant defense system and its regulations. This study was done to investigate the regulation of expression of antioxidant enzymes in clinical isolates of Shigella species, under various growth conditions....

journal_title：Molecular and cellular biochemistry

authors： Prakash R,Devaraj H,Devaraj SN

更新日期：2004-12-01 00:00:00

abstract：:Zonation of ethanol oxidation and metabolic effects along the hepatic acini were investigated in the bivascularly perfused liver of fed rats. Ethanol was infused into the hepatic artery in antegrade and retrograde perfusion. Inhibition of glycolysis by ethanol, expressed as micromol min(-1) (ml accessible cell space)(...

journal_title：Molecular and cellular biochemistry

authors： Lopez CH,Constantin J,Gimenes D,Suzuki-Kemmelmeier F,Bracht A

更新日期：2004-03-01 00:00:00

abstract：:The aim of the study was to find out whether administration of selenium (Se) will protect the immature heart against ischemia/reperfusion.The control pregnant rats were fed laboratory diet (0.237 mg Se/kg diet); experimental rats received 2 ppm Na(2)SeO(3) in the drinking water from the first day of pregnancy until da...

journal_title：Molecular and cellular biochemistry

authors： Ostadalova I,Vobecky M,Chvojkova Z,Mikova D,Hampl V,Wilhelm J,Ostadal B

更新日期：2007-06-01 00:00:00

abstract：:Enhancer of zeste homolog 2 (EZH2) is a highly conserved histone methyltransferase, which is overexpressed in different types of cancers such as breast and prostate cancer. It is reported that EZH2 can directly down-regulate RUNX3 by increasing histone H3 methylation. However, the role of EZH2 in the development and p...

journal_title：Molecular and cellular biochemistry

authors： Lian R,Ma H,Wu Z,Zhang G,Jiao L,Miao W,Jin Q,Li R,Chen P,Shi H,Yu W

更新日期：2018-02-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) has been thought to play a major role during cardiac fibrosis in the development of diabetic cardiomyopathy, and cardiac fibrosis mainly as a result of an increase of collagen type III occurs in the human hearts with diabetes. Thrombospondin-1 (TSP-1) has been reported to activat...

journal_title：Molecular and cellular biochemistry

authors： Tang M,Zhou F,Zhang W,Guo Z,Shang Y,Lu H,Lu R,Zhang Y,Chen Y,Zhong M

更新日期：2011-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a rapidly progressing, incurable cancer that frequently spreads to portal vein and lung. New insights are needed to identify therapeutic targets to prevent or retard HCC metastatic progression. Because microRNAs (miRNA) often act as tumor regulators, we investigated their role in prec...

journal_title：Molecular and cellular biochemistry

authors： Shi X,Teng F

更新日期：2015-10-01 00:00:00

abstract：:Inhibition of synthesis of estradiol 17beta by the addition of inhibitors of aromatase, a key enzyme in the biosynthesis of estradiol 17beta, or addition of tamoxifen - an estrogen receptor antagonist, to human placental minces resulted in an increase in the level of LDL-receptor mRNA. This increase could be blocked b...

journal_title：Molecular and cellular biochemistry

authors： Shanker YG,Shetty UP,Rao AJ

更新日期：1998-10-01 00:00:00

abstract：:Interleukin-18 (IL-18) elicited a robust hypertrophy response in H9c2 cardiomyocytes as judged by their accelerated rates of protein synthesis and increased cell size. Evidently, IL-18 treatment also induced a cardiac hypertrophy-specific program of gene expression in H9c2 cardiomyocytes since they elicited enhanced e...

journal_title：Molecular and cellular biochemistry

authors： Majumdar G,Johnson IM,Kale S,Raghow R

更新日期：2008-05-01 00:00:00

abstract：:Unidirectional promoters dominate among mammalian genomes. However, the mechanism through which the transcriptional directionality of promoters is accomplished remains to be clarified. Insulin-degrading enzyme (IDE) is a ubiquitously expressed zinc metalloprotease, whose promoter contains a CpG island. We previously s...

journal_title：Molecular and cellular biochemistry

authors： Zhang L,Wang P,Ding Q,Wang Z

更新日期：2013-10-01 00:00:00

abstract：:Based on sequence relationships the cytoplasmic fatty acid-binding proteins (FABPs) of mammalian origin are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. Highly conserved sequences of FABPs within the same type correlate with immunological crossreactivities. Isoforms of...

journal_title：Molecular and cellular biochemistry

authors： Spener F,Unterberg C,Börchers T,Grosse R

更新日期：1990-10-15 00:00:00

abstract：:Three antisera were prepared against non-histone protein classes named NHCP1, NHCP2 and dehistonized chromatin (with different affinity to DNA) from hamster liver. Two main antigenic bands of MW 17,000 and 36,000 were specific in the NHCP1 fraction and one antigen of MW 56,000 was specific for the NHCP2 fraction from ...

journal_title：Molecular and cellular biochemistry

authors： Wojtkowiak Z,Kiliańska Z,Kłyszejko-Stefanowicz L

更新日期：1990-01-18 00:00:00

abstract：:The phosphorylation of rat cardiac microsomal proteins was investigated with special attention to the effects of okadaic acid (an inhibitor of protein phosphatases), inhibitor 2 of protein phosphatase 1 and inhibitor of cyclic AMP-dependent protein kinase (protein kinase A). The results showed that okadaic acid (5 mic...

journal_title：Molecular and cellular biochemistry

authors： Sulakhe PV,Vo XT,Morris TE,Pato MD,Khandelwal RL

更新日期：1997-10-01 00:00:00

abstract：:Effectiveness of selenium in different forms like sodium selenite, selenocysteine and selenomethionine has been compared in four different doses, namely 4, 6, 8 and 10 ppm of each, in terms of their bioavailability and prolongation of survival of Dalton's lymphoma (DL) bearing mice. Selenomethionine, at a dose of 8 pp...

journal_title：Molecular and cellular biochemistry

authors： Mukhopadhyay-Sardar S,Rana MP,Chatterjee M

更新日期：2000-03-01 00:00:00

abstract：:Activating transcription factor 4 (ATF4), which is ubiquitously expressed, plays a crucial role in regulating various stress-responsive genes under pathophysiological conditions. Further, growth arrest and DNA damage-inducible gene 34 (GADD34), a downstream target of ATF4, has been reported to negatively regulate ATF4...

journal_title：Molecular and cellular biochemistry

authors： Oh-Hashi K,Sugiura N,Amaya F,Isobe KI,Hirata Y

更新日期：2018-03-01 00:00:00

abstract：:Elevated levels of triglycerides and very low density lipoproteins (VLDL) are biochemical markers of metabolic syndrome and diabetes. VLDL from hypertriglyceridemic or diabetic patients increased the generation of plasminogen activator inhibitor-1 (PAI-1) from cultured vascular endothelial cells (EC). Susceptibility o...

journal_title：Molecular and cellular biochemistry

authors： Zhao R,Ma X,Shen GX

更新日期：2008-10-01 00:00:00

abstract：:In various peroxynitrite (PN)-treated proteins, the formations of stable 3-nitrotyrosine (nitration) and labile S-nitrosocysteine (S-nitrosation) were observed by employing rapid Western blot in 6 h. The steps of SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and membrane-blotting were performed at 4 degrees C. It ...

journal_title：Molecular and cellular biochemistry

authors： Kuo WN,Kocis JM

更新日期：2002-04-01 00:00:00

abstract：:Transforming Growth Factor-beta (TGF-beta) plays an essential role in differentiation of dental pulp cells into odontoblasts during reparative dentine formation. However, the mechanism by which TGF-beta stimulates dental repair remains rather obscure. Human dental pulp cells were used as an in vitro model in the prese...

journal_title：Molecular and cellular biochemistry

authors： Wang FM,Hu T,Tan H,Zhou XD

更新日期：2006-10-01 00:00:00

abstract：:Extracts of fasted rat diaphragms, previously treated with or without insulin were assayed for glycogen synthase, protein kinase and cyclic [3H]-AMP binding. Treatment with insulin produced an elevation in the % of glycogen synthase I and a concurrent decrease in cyclic AMP-dependent protein kinase activity and cyclic...

journal_title：Molecular and cellular biochemistry

authors： Walkenbach RJ,Hazen R,Larner J

更新日期：1978-02-24 00:00:00

abstract：:The activity of yeasts citrate synthase in cells grown under different hypoxic conditions has been investigated. A linear relationship between the citrate synthase activity and the respiratory capacity of the cells has been found. When Saccharomyces cerevisiae was grown on fermentable substrates the activity decreased...

journal_title：Molecular and cellular biochemistry

authors： Nuñez de castro I,Arias de Saavedra JM,Machado A,Mayor F

更新日期：1976-09-30 00:00:00

abstract：:RGPR-p117 was originally discovered as a novel protein that binds to a nuclear factor I (NFI) consensus motif TTGGC(N)(6)CC, which is present in the 5'-flanking region of the regucalcin gene (rgn). RGPR-p117 has been identified in human, rat, mouse, bovine, rabbit, and chicken livers. Phylogenetic analysis of six vert...

journal_title：Molecular and cellular biochemistry

authors： Yamaguchi M

更新日期：2009-07-01 00:00:00

abstract：:Myocardial infarction is the most common cause of congestive cardiac failure. Free radicals, cytokines, nitric oxide (NO) and antioxidants play a major role both in atherosclerosis and myocardial damage and preservation. In the early stages of atherosclerosis, neutrophils and monocytes infiltrate the intima and genera...

journal_title：Molecular and cellular biochemistry

authors： Das UN

更新日期：2000-12-01 00:00:00