A novel leupeptin-sensitive serine endopeptidase present in normal and malignant rat mammary tissues.

abstract：:Atherosclerosis is the leading cause of death in North America. It is characterized by thickening of the coronary artery wall by the formation of plaques, resulting in reduced blood flow. Plaque rupture and the consequent thrombosis may lead to sudden blockage of arteries and causing stroke and heart attack. In the la...

journal_title：Molecular and cellular biochemistry

authors： Choy PC,Mymin D,Zhu Q,Dakshinamurti K,O K

更新日期：2000-04-01 00:00:00

abstract：:In the present study we explored glutathione S-transferase (GST) polymorphisms in selected patients who experienced accelerated myocardial injury following open heart surgery and compared these to a control group of patients without postoperative complications. 758 Patients were enrolled from which 132 patients were s...

journal_title：Molecular and cellular biochemistry

authors： Kovacs V,Gasz B,Balatonyi B,Jaromi L,Kisfali P,Borsiczky B,Jancso G,Marczin N,Szabados S,Melegh B,Nasri A,Roth E

更新日期：2014-04-01 00:00:00

abstract：:Cardiosphere-derived cells (CDCs) and bone marrow mesenchymal stem cells (MSCs) are popularly used in stem cell therapy for myocardial regeneration. The cell type that survives and maintains stem cell characteristics in the adverse microenvironment following ischemia-reperfusion injury is presumed to be ideal for tran...

journal_title：Molecular and cellular biochemistry

authors： RajendranNair DS,Karunakaran J,Nair RR

更新日期：2017-01-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH) increases the risk of cardiovascular morbid events in hypertension. TGF-beta1 is involved in pathologic states such as cardiac hypertrophy and cardiac fibrosis; we thus postulate that the TGF-beta1 polymorphism is related to LVH in hypertensives. Six hundred and eighty essential hype...

journal_title：Molecular and cellular biochemistry

authors： Xu HY,Hou XW,Wang LF,Wang NF,Xu J

更新日期：2010-02-01 00:00:00

abstract：:Vascular endothelial and -smooth muscle cells have been shown to use fatty acids as substrates for oxidative phosphorylation. Endothelial cells are more vulnerable to oxidative stress than muscle cells and are prone to loose carnitine early during hypoperfusion. This has been suggested by two observations. The first i...

journal_title：Molecular and cellular biochemistry

authors： Hülsmann WC,Dubelaar ML

更新日期：1992-10-21 00:00:00

abstract：:The action of 7.2 microM cardiotoxin on 0.25% human erythrocytes in a plasma extender solution was studied by the interaction of toxin with intact red blood cells and subsequent hemolysis of the cells. The binding of toxin to cells was completed within 10 min, whereas the membrane rigidity was weakened in a non-lytic ...

journal_title：Molecular and cellular biochemistry

authors： Chen YH,Liou RF,Hu CT,Juan CC,Yang JT

更新日期：1987-01-01 00:00:00

abstract：:The present study is designed to investigate the effect of myocardial preconditioning with oxidative stress induced by pyrogallol or H2O2, on ischaemia-reperfusion induced myocardial injury. Isolated perfused rat heart was subjected to global ischaemia for 30 min followed by reperfusion for 120 min. Coronary effluent ...

journal_title：Molecular and cellular biochemistry

authors： Sharma A,Singh M

更新日期：2001-03-01 00:00:00

abstract：:The present study was oriented to gender specificity of Na,K-ATPase in cerebellum, the crucial enzyme maintaining the intracellular homeostasis of Na ions in healthy and diabetic Wistar rats. The effects of diabetes on properties of the Na,K-ATPase in cerebellum derived from normal and streptozotocin (STZ)-diabetic ra...

journal_title：Molecular and cellular biochemistry

authors： Kaločayová B,Mézešová L,Barteková M,Vlkovičová J,Jendruchová V,Vrbjar N

更新日期：2017-01-01 00:00:00

abstract：:In the eluted fractions of histone-treated crude extracts separated by Sephadex G-200 filtration, multiple protein kinase (PK) activities, including three from brain and two from skeletal muscle, were augmented by both S-100 protein and parvalbumin on the phosphorylation of endogenous substrates. One additional PK act...

journal_title：Molecular and cellular biochemistry

authors： Kuo WN,Blake T,Cheema IR,Dominguez J,Nicholson J,Puente K,Shells P,Lowery J

更新日期：1986-06-01 00:00:00

abstract：:7,12-Dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis is widely preferred to assess the tumor-inhibiting efficacy of the medicinal plants or their constituents. The present study explores the tumor-inhibiting potential of esculetin by utilizing the status of lipid peroxidation by products (...

journal_title：Molecular and cellular biochemistry

authors： Selvasundaram R,Manoharan S,Buddhan R,Neelakandan M,Murali Naidu R

更新日期：2018-11-01 00:00:00

abstract：:Gram negative sepsis and septic shock continue to be a major medical problem, with a complex physiopathology and it is associated with high mortality. Although secretion of cytokines such as tumor necrosis factor-alpha by macrophages is the principal host mediator of septic shock, other characteristic functions of mac...

journal_title：Molecular and cellular biochemistry

authors： Víctor VM,Miñano M,Guayerbas N,Del Río M,Medina S,De la Fuente M

更新日期：1998-12-01 00:00:00

abstract：:Experiments were designed to determine if cotton bract tannin, a component of cotton mill dust, would promote the phosphorylation of alveolar macrophage proteins in doses potentially achievable in vivo. Rabbit alveolar macrophages were loaded with 32PO4 and challenged with various doses of tannin for time periods rang...

journal_title：Molecular and cellular biochemistry

authors： Hempel SL,Rohrbach MS

更新日期：1989-04-11 00:00:00

abstract：:Recent evidence indicated that endocan may be a potential cell marker and a new target for cancers including acute leukemia since the serum endocan level in patients with acute leukemia was associated with the status of the disease, i.e., endocan was higly expressed in untreated acute leukemia, but decreased after che...

journal_title：Molecular and cellular biochemistry

authors： Xu Z,Zhang S,Zhou Q,Wang Y,Xia R

更新日期：2014-10-01 00:00:00

abstract：:The molecular signaling events leading to protection from oxidative stress-induced apoptosis upon contact inhibition have not been fully investigated. Previous research has indicated a role for mitogen-activated protein kinases (MAPKs) in the regulation of contact inhibition, and these proteins have also been associat...

journal_title：Molecular and cellular biochemistry

authors： Gaballah M,Slisz M,Hutter-Lobo D

更新日期：2012-01-01 00:00:00

abstract：:Under normal and ischemic conditions backdiffusion of radiolabeled non-esterified fatty acids (NEFA) has been demonstrated. In the fasted normal canine heart the extraction fraction (EF) during interventions with glucose or lactate loading, vasodilation, and metabolic level augmentation was determined, and compared wi...

journal_title：Molecular and cellular biochemistry

authors： Duwel CM,Visser FC,van Eenige MJ,Roos JP

更新日期：1989-06-27 00:00:00

abstract：:Human glomerular mesangial cells (HMCs) have a finite lifespan and eventually enter irreversible growth arrest known as cellular senescence which is thought to contribute to kidney aging and age-related kidney disorders, such as chronic kidney disease. The signal transducer and activator of transcription 1 (STAT1) is ...

journal_title：Molecular and cellular biochemistry

authors： Jiao S,Meng F,Zhang J,Yang X,Zheng X,Wang L

更新日期：2012-06-01 00:00:00

abstract：:The expression of 76 sequences, previously isolated as differentially expressed in visceral white adipose tissue (WAT) of female rats, fed with a high-fat diet for 11 days (Lopez et al., Biochem Biophys Res Comm 318: 234-239, 2004), was analyzed in epidydimal WAT of male rats after a feeding period of 65 days with the...

journal_title：Molecular and cellular biochemistry

authors： Lopez IP,Milagro FI,Marti A,Moreno-Aliaga MJ,Martinez JA,De Miguel C

更新日期：2005-07-01 00:00:00

abstract：:Proteins which are major substrates of epidermal transglutaminases can be identified in cultured keratinocytes of human, cow, and new-born rat. Cow and human keratinocytes both contain substrate proteins which are 30 000 to 50 000 daltons in size but dissociable in SDS to 12 000 daltons or less. In both species these ...

journal_title：Molecular and cellular biochemistry

authors： Kubilus J,Baden HP

更新日期：1984-01-01 00:00:00

abstract：:Apocytochrome c has a potent ability to insert spontaneously into membrane. To identify which sequences were critical for this insertion activity, a series of peptides N19, C8, C15 and C21, corresponding to sequences 1-19, 81-88, 74-88 and 68-88 of apocytochrome c, respectively, were synthesized and purified. Insertio...

journal_title：Molecular and cellular biochemistry

authors： Wang X,Han X,Yang F

更新日期：2004-07-01 00:00:00

abstract：:Retinal pigment epithelium (RPE) exerts critical roles in the maintenance of the normal functions of the retina, whereas RPE dysfunction can induce retina neovascularization. p75 neurotrophin receptor (p75(NTR)) has been shown to play essential roles in angiogenesis. However, the function of p75(NTR) in the RPE remain...

journal_title：Molecular and cellular biochemistry

authors： Zhang J,Zhao J,Bai Y,Huang L,Yu W,Li X

更新日期：2015-01-01 00:00:00

abstract：:The contribution of anti-inflammatory property of celecoxib in the improvement of metabolic disorders in cancer is unknown. The purpose of this study was to compare the effects of celecoxib and ibuprofen, non-steroidal anti-inflammatory drugs (NSAIDs), on several metabolic changes observed in Walker-256 tumor-bearing ...

journal_title：Molecular and cellular biochemistry

authors： de Souza CO,Kurauti MA,de Fatima Silva F,de Morais H,Borba-Murad GR,de Andrade FG,de Souza HM

更新日期：2015-01-01 00:00:00

abstract：:Treatment with alpha-difluoromethylornithine (DFMO), an enzyme-activated irreversible inhibitor of ornithine decarboxylase (ODC), depletes the putrescine and spermidine content, and reduces the growth rate of Ehrlich ascites tumor cells. The addition of putrescine, which is the immediate precursor of spermidine, promp...

journal_title：Molecular and cellular biochemistry

authors： Oredsson SM,Anehus S,Heby O

更新日期：1984-09-01 00:00:00

abstract：:The ability of the gap junction phosphoprotein connexin-43 (Cx43) to inhibit DNA synthesis in primary cardiomyocytes is regulated by serine (S) 262, a protein kinase C phosphorylation site that also affects metabolic coupling. We have now examined if the S262-regulated growth suppression is operating in transformed ce...

journal_title：Molecular and cellular biochemistry

authors： Dang X,Jeyaraman M,Kardami E

更新日期：2006-09-01 00:00:00

abstract：:Autoantibodies (AABs) against the second extracellular loop of the beta1-receptor (beta1(II)-AABs) are found as a pathogenic driver in patients with idiopathic dilated cardiomyopathy, Chagas cardiomyopathy, peripartum cardiomyopathy, and myocarditis, and have been increasingly seen as a treatment target. We recently i...

journal_title：Molecular and cellular biochemistry

authors： Haberland A,Wallukat G,Berg S,Schulz AM,Freyse EJ,Vetter R,Salzsieder E,Müller J,Kreutz R,Schimke I

更新日期：2014-08-01 00:00:00

abstract：:Cancer cell aggregation has been long known to facilitate metastatic potential of cancer cells. In addition, the presence of nitric oxide (NO) in cancer area may have a significant impact on aggregation behavior of the cells. We show herein that lung cancer H460 cells possessing high ability of anoikis resistance form...

journal_title：Molecular and cellular biochemistry

authors： Powan P,Chanvorachote P

更新日期：2014-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that have been suggested to play an essential role in tumorigenesis. Reduced expression of miR-338 has been reported in several types of cancers; however, the role of miR-338 in oral squamous cell carcinoma (OSCC) has not been elucidated. In this study, we demonstrated that...

journal_title：Molecular and cellular biochemistry

authors： Liu C,Wang Z,Wang Y,Gu W

更新日期：2015-01-01 00:00:00

abstract：:Acute kidney injury (AKI) occurs in 30%-70% of critically ill patients. Multiple organ failure (MOF), which is most often secondary to hypotension and septicemia, is a global public health problem. The prognosis of patients is poor. Currently, there is no specific therapeutic method. Finding new therapeutic targets is...

journal_title：Molecular and cellular biochemistry

authors： Yang X,Li B,Guan Y,Jiang HM

更新日期：2021-01-11 00:00:00

abstract：:Increasing evidence has shown that normal stem cells may act as cancer-initiating cells and contribute to the development and progression of cancer. HBx has a close relationship with hepatocellular carcinoma, however, the role of HBx in hepatic progenitor cells (HPCs) is poorly understood. In this study, we sought to ...

journal_title：Molecular and cellular biochemistry

authors： Shen L,Zhang X,Hu D,Feng T,Li H,Lu Y,Huang J

更新日期：2013-11-01 00:00:00

abstract：:Lipoamidase is found to be able to release various membrane-anchored enzymes from the membrane compartment of pig brain. Released enzymes revealed their intact enzyme activities in the soluble fraction. Lipoamidase could release at least two types of anchored enzymes, i.e. glycosyl-phosphatidylinositol-bonded and myri...

journal_title：Molecular and cellular biochemistry

authors： Oizumi J,Hayakawa K

更新日期：1992-09-22 00:00:00

abstract：:We have previously documented that naked antisense CK2alpha ODN can potently induce apoptosis in cancer cells in culture and in mouse xenograft human prostate cancer. The effects of the antisense CK2alpha are related to downregulation of CK2alpha message and rapid loss of the CK2 from the nuclear compartment. Here we ...

journal_title：Molecular and cellular biochemistry

authors： Wang G,Unger G,Ahmad KA,Slaton JW,Ahmed K

更新日期：2005-06-01 00:00:00