Expression of adropin in rat brain, cerebellum, kidneys, heart, liver, and pancreas in streptozotocin-induced diabetes.

abstract：:Cultured endothelial cells have been used in the past as a source of endothelium-derived relaxing factor (EDRF) and of prostacyclin (PGI2). Although cell cultures are essential for observation of prolonged exposure to media or when there is delayed response, they are time consuming and sterile conditions are essential...

journal_title：Molecular and cellular biochemistry

authors： Kibira S,Dudek R,Narayan KS,Bing RJ

更新日期：1991-11-13 00:00:00

abstract：:Interleukin 8 (IL-8) is a chemoattractant associated with ovulation in the mammalian ovary. This chemokine is also involved in the recruitment and activation of neutrophils. Using bovine tissue, we examined the possible role of IL-8 in steroid production by theca cells of the large ovarian follicles. IL-8 promoted pro...

journal_title：Molecular and cellular biochemistry

authors： Shimizu T,Imamura E,Magata F,Murayama C,Miyamoto A

更新日期：2013-02-01 00:00:00

abstract：:Primary cultures of skeletal muscle cells secrete plasminogen activator (PA) activity to the conditioning medium and display membrane-bound PA. Growth of these cells in culture in presence of 10(-7) M dexamethasone resulted in a marked reduction of the membranal and secreted PA activity. The hormone also reduced cytos...

journal_title：Molecular and cellular biochemistry

authors： Mayer M,Finci Z,Chaouat M,Sasson S

更新日期：1986-02-01 00:00:00

abstract：:Fibrates and WY-14643 are widely used as lipid-lowering drugs via modulation of peroxisome proliferator-activated receptor alpha (PPAR α) for the treatment of a wide range of metabolic disorders. Here, to address the question whether PPAR α agonists can affect the enzymatic activity of 11beta-hydroxysteroid dehydrogen...

journal_title：Molecular and cellular biochemistry

authors： Kim CH,Ramu R,Ahn JH,Bae MA,Cho YS

更新日期：2010-11-01 00:00:00

abstract：:Effect of several vanadium salts, sodium orthovanadate, vanadyl sulfate and sodium metavanadate on protein tyrosine phosphorylation and serine/threonine kinases in chinese hamster ovary (CHO) cells overexpressing a normal human insulin receptor was examined. All the compounds stimulated protein tyrosine phosphorylatio...

journal_title：Molecular and cellular biochemistry

authors： Pandey SK,Chiasson JL,Srivastava AK

更新日期：1995-12-06 00:00:00

abstract：:Carbohydrate has been removed from a number of glycoproteins without major effect on the structure or enzyme activity of the protein. Thus carbohydrate has been suggested to underly a non-primary function for proteins, such as in relatively non-specific interactions with other carbohydrates or macromolecules, stabiliz...

journal_title：Molecular and cellular biochemistry

authors： West CM

更新日期：1986-11-01 00:00:00

abstract：:Cardiovascular disease has become the leading cause of death in the world. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays an important role in cardiovascular disease, such as stroke. However, the role of MALAT1 in hypoxia (HYP)-induced vascular endothelial cells (VECs) remains unclear. In the pr...

journal_title：Molecular and cellular biochemistry

authors： Liu H,Shi C,Deng Y

更新日期：2020-03-01 00:00:00

abstract：:ING proteins are tumor suppressors involved in the regulation of gene transcription, cell cycle arrest, apoptosis, and senescence. Here, we show that ING1b expression is upregulated by several DNA-damaging agents, in a p53-independent manner. ING1b stimulates DNA repair of a variety of DNA lesions requiring activation...

journal_title：Molecular and cellular biochemistry

authors： Ceruti JM,Ogara MF,Menéndez C,Palmero I,Cánepa ET

更新日期：2013-06-01 00:00:00

abstract：:7,12-Dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis is widely preferred to assess the tumor-inhibiting efficacy of the medicinal plants or their constituents. The present study explores the tumor-inhibiting potential of esculetin by utilizing the status of lipid peroxidation by products (...

journal_title：Molecular and cellular biochemistry

authors： Selvasundaram R,Manoharan S,Buddhan R,Neelakandan M,Murali Naidu R

更新日期：2018-11-01 00:00:00

abstract：:The treatment of obstructive sleep apnea-hypopnea syndrome targets the narrow anatomic structure of the upper airway (UA) and lacks an effective therapy for UA dilator muscle dysfunction. Long-term hypoxia can cause damage to UA dilator muscles and trigger a vicious cycle. We previously confirmed that hypoxia-inducibl...

journal_title：Molecular and cellular biochemistry

authors： Lu Y,Mao J,Han X,Zhang W,Li Y,Liu Y,Li Q

更新日期：2021-01-03 00:00:00

abstract：:There is a wealth of information regarding the import and export of nuclear proteins in general. Nevertheless, the available data that deals with the nucleocytoplasmic movement of steroid hormone receptors remains highly limited. Some research findings reported during the past five years have succeeded in identifying ...

journal_title：Molecular and cellular biochemistry

authors： Sebastian T,Sreeja S,Thampan RV

更新日期：2004-05-01 00:00:00

abstract：:This study examined the effect of nitric oxide on the production of soluble ECE-1. Activity of ECE-1 in media was measured using a quenched fluorescent substrate assay, and expressed as a percentage of control. Endothelial cells were incubated with the nitric oxide donor Diethylenetriamine NONOate (DETA; 250-800 µM), ...

journal_title：Molecular and cellular biochemistry

authors： Kuruppu S,Rajapakse NW,Dunstan RA,Smith AI

更新日期：2014-11-01 00:00:00

abstract：:In rat adipocytes, the insulin stimulation of the rate of glucose uptake is due, at least partially, to the recruitment of glucose transporter proteins from an intracellular compartment to the plasma membrane. Vanadate is a known insulin mimetic agent and causes an increase in the rate of glucose transport in rat adip...

journal_title：Molecular and cellular biochemistry

authors： Päquet MR,Romanek RJ,Sargeant RJ

更新日期：1992-02-12 00:00:00

abstract：:Chemotherapy remains the core of anticancer treatment. However, despite the tremendous strides made in the development of targeted anticancer therapies, emergence of resistance to chemotherapeutic drugs is still a major obstacle in the successful management of resistant tumors. Therefore, profound investigation into t...

journal_title：Molecular and cellular biochemistry

authors： Peng L,Zhu H,Wang J,Sui H,Zhang H,Jin C,Li L,Xu T,Miao R

更新日期：2015-07-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of metal-catalyzed oxidation by H(2)O(2) on the structure, oligomerization, and chaperone function of alphaA- and alphaB-crystallins. Recombinant alphaA-and alphaB-crystallins were prepared by expressing them in E. coli and purifying by size-exclusion chromatogra...

journal_title：Molecular and cellular biochemistry

authors： Rajan S,Horn C,Abraham EC

更新日期：2006-08-01 00:00:00

abstract：:The fatty acid binding proteins (FAPBs) function as intracellular carriers of fatty acid (FA) and related compounds. During the digestion of lipids, the local concentration of FA exceeds their critical micellar concentration; the excess ratio of FA/FABP can be as high as approximately 1,000/1, consequently building mi...

journal_title：Molecular and cellular biochemistry

authors： Levin LB,Nachliel E,Gutman M,Tsfadia Y

更新日期：2009-06-01 00:00:00

abstract：:The identification of informative biomarkers that could predict the treatment response is particularly important in the triple-negative (TN) breast cancer, which is characterized by biological diversity. The aim of this study was to investigate the impact of vascular endothelial growth factor receptor (VEGFR2) express...

journal_title：Molecular and cellular biochemistry

authors： Babyshkina N,Zavyalova M,Tarabanovskaya N,Dronova T,Krakhmal N,Slonimskaya E,Kzhyshkowska J,Choynzonov E,Cherdyntseva N

更新日期：2018-07-01 00:00:00

abstract：:Glutathione acts as a protein disulphide reductant, which detoxifies herbicides by conjugation, either spontaneously or by the activity of one of a number of glutathione-S-transferases (GSTs), and regulates gene expression in response to environmental stress and pathogen attack. GSTs play roles in both normal cellular...

journal_title：Molecular and cellular biochemistry

authors： Banerjee S,Goswami R

更新日期：2010-03-01 00:00:00

abstract：:The effect of menaquinone-7 (MK-7; vitamin K2) on osteoclast-like cell formation and osteoclastic bone resorption in rat femoral tissues in vitro was investigated. The bone marrow cells were cultured for 7 days in a a-minimal essential medium (alpha-MEM) containing a well-known bone resorbing agent [parathyroid hormon...

journal_title：Molecular and cellular biochemistry

authors： Yamaguchi M,Ma ZJ

更新日期：2001-12-01 00:00:00

abstract：:Induction and activation of the p53 tumour suppressor protein occurs in response to a number of cellular stresses, including disruption of RNA polymerase II-mediated transcription. Both p53 itself and its principle negative regulator, the E3 ubiquitin ligase Mdm2, are substrates for phosphorylation by the protein kina...

journal_title：Molecular and cellular biochemistry

authors： Allende-Vega N,McKenzie L,Meek D

更新日期：2008-09-01 00:00:00

abstract：:Incubation of MC-1010 cells with the spin-trapping agent 5,5-dimethyl-1-pyrroline 1-oxide (DMPO) followed by brief treatment with the solid oxidant lead dioxide (PbO2) yielded, after filtration, a cell-free solution that contained two nitroxyl adducts. The first was the hydroxyl radical adduct, 5,5-dimethyl-2-hydroxyp...

journal_title：Molecular and cellular biochemistry

authors： Bernofsky C,Bandara BM

更新日期：1995-07-19 00:00:00

abstract：:Hypertrophic scarring (HSc) which frequently develops in patients following severe thermal injury is characterized by accumulation of extracellular matrix (ECM) proteins including type I and type III collagen. In this study, we examined the presence and quantity of IGF-1 mRNA transcripts in post-burn HSc. The results ...

journal_title：Molecular and cellular biochemistry

authors： Ghahary A,Shen YJ,Nedelec B,Scott PG,Tredget EE

更新日期：1995-07-05 00:00:00

abstract：:There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels i...

journal_title：Molecular and cellular biochemistry

authors： Soundararajan A,Prabu P,Mohan V,Gibert Y,Balasubramanyam M

更新日期：2019-08-01 00:00:00

abstract：:Genistein is often used as an inhibitor of tyrosine kinases. A less studied side effect of genistein is an inhibition of cyclic AMP-phosphodiesterase (cAMP-PDE) activity resulting in increased cAMP accumulation. The effect of genistein on intracellular cAMP-levels, basal and forskolin-induced, was studied in A549 huma...

journal_title：Molecular and cellular biochemistry

authors： Burvall KM,Palmberg L,Larsson K

更新日期：2002-11-01 00:00:00

abstract：:Glucocorticoids have been used in the treatment of a number of diseases where immunological intolerance plays a predominant role. Since immunological intolerance points to the involvement of lysosomal enzymes and glucocorticoids are known to affect their activities, we have attempted to study the effect of these stero...

journal_title：Molecular and cellular biochemistry

authors： Rajashree S,Puvanakrishnan R

更新日期：1996-01-26 00:00:00

abstract：:This study focuses on two inflammatory diseases, viz., "diabetes mellitus (DM)" that causes serious complications such as retinopathy, nephropathy, and neuropathy, and "ischemic colitis" which is evoked by DM. Ischemic colitis originates from the reduction in mesenteric blood flow to the colon with existence of the oc...

journal_title：Molecular and cellular biochemistry

authors： Ozel Y,Elcioglu HK,Cevikelli ZA,Kudas I,Ahmad S,Uzun H,Topal C,Aktas S,Kabasakal L

更新日期：2018-02-01 00:00:00

abstract：:Flavonoids are naturally occurring plant compounds with antioxidant properties. Their consumption has been associated with the protective effects of certain diets against some of the complications of atherosclerosis. Low-density lipoprotein (LDL) oxidative modification is currently thought to be a significant event in...

journal_title：Molecular and cellular biochemistry

authors： Filipe P,Lança V,Silva JN,Morlière P,Santus R,Fernandes A

更新日期：2001-05-01 00:00:00

abstract：:A sialic acid binding lectin, AchatininH, was purified in single step from the hemolymph of the land snail, Achatina fulica, by the affinity chromatography on sheep submaxillary mucin coupled to Sepharose 4B. The yield of the lectin was found to be 3 mg from 100 ml of hemolymph. The homogeneity of the lectin was estab...

journal_title：Molecular and cellular biochemistry

authors： Basu S,Sarkar M,Mandal C

更新日期：1986-08-01 00:00:00

abstract：:Sertoli and peritubular myoid cells, the somatic cells of the seminiferous tubule, support growth and differentiation of developing germ cells. This action strictly depends on the availability of in situ synthesized retinoic acid and we have previously documented the ability of Sertoli, but not peritubular cell extrac...

journal_title：Molecular and cellular biochemistry

authors： Cavazzini D,Catizone A,Galdieri M,Ottonello S

更新日期：2003-10-01 00:00:00

abstract：:Angiotensin receptor blockers provide cardiovascular protection in heart failure patients. We have studied the effect of 8 weeks treatment with telmisartan (5 mg kg(-1) day(-1)) on cardiovascular complications associated with streptozotocin (STZ) diabetic rats. Wistar rats were made diabetic with STZ (45 mg kg(-1), iv...

journal_title：Molecular and cellular biochemistry

authors： Goyal BR,Mesariya P,Goyal RK,Mehta AA

更新日期：2008-07-01 00:00:00