MiR-492 is functionally involved in Oxaliplatin resistance in colon cancer cells LS174T via its regulating the expression of CD147.

abstract：:Frequenin is a member of the neuronal Ca(2+) sensor protein family, implicated in being the modulator of the neurotransmitter release, potassium channels, phosphatidylinositol signaling pathway and the Ca(2+)-dependent exocytosis of dense-core granules in the PC12 cells. Frequenin exhibits these biological activities ...

journal_title：Molecular and cellular biochemistry

authors： Fik-Rymarkiewicz E,Duda T,Sharma RK

更新日期：2006-10-01 00:00:00

abstract：:Sildenafil citrate (Viagra) is a potent and specific inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), which exhibits cardioprotective action against ischemia/reperfusion injury in intact and isolated heart. The mechanism of its cardioprotective action is not completely under...

journal_title：Molecular and cellular biochemistry

authors： Fernandes MA,Marques RJ,Vicente JA,Santos MS,Monteiro P,Moreno AJ,Custódio JB

更新日期：2008-02-01 00:00:00

abstract：:Pig coronary artery cultured smooth muscle cells were skinned using saponin. In the presence of an ATP-regenerating system and oxalate, the skinned cells showed an ATP-dependent azide insensitive Ca(2+)-uptake which increased linearly with time for > 1 h. The Ca(2+)-uptake occurred with Km values of 0.20 +/- 0.03 micr...

journal_title：Molecular and cellular biochemistry

authors： Elmoselhi AB,Blennerhassett M,Samson SE,Grover AK

更新日期：1995-10-18 00:00:00

abstract：:Heat shock proteins (Hsps) have been reported to be dominant antigens for the host immune response to various pathogens and thus, have great potential for use in vaccination. In the present study, we evaluated the immunogenicity and protective efficacy of GroEL of Salmonella enterica serovar Typhi against lethal infec...

journal_title：Molecular and cellular biochemistry

authors： Bansal A,Paliwal PK,Sagi SS,Sairam M

更新日期：2010-04-01 00:00:00

abstract：:Poly(ADP-ribose) polymerases or PARPs are a family of NAD(+)-dependent enzymes that modify themselves and other substrate proteins with ADP-ribose polymers. The founding member PARP 1 is localized predominantly in the nucleus and is activated by binding to DNA lesions. Excessive PARP 1 activation following genotoxin t...

journal_title：Molecular and cellular biochemistry

authors： Yeh TY,Sbodio JI,Nguyen MT,Meyer TN,Lee RM,Chi NW

更新日期：2005-08-01 00:00:00

abstract：:Flavonoids are naturally occurring plant compounds with antioxidant properties. Their consumption has been associated with the protective effects of certain diets against some of the complications of atherosclerosis. Low-density lipoprotein (LDL) oxidative modification is currently thought to be a significant event in...

journal_title：Molecular and cellular biochemistry

authors： Filipe P,Lança V,Silva JN,Morlière P,Santus R,Fernandes A

更新日期：2001-05-01 00:00:00

abstract：:Sinomenine, a pure alkaloid extract from Sinomenium acutum, has anti-inflammatory and immunoregulatory functions. This study investigated the efficiency and the signalling pathways involved in the effect of sinomenine on vascular smooth muscle cell (VSMC) dedifferentiation in response to platelet-derived growth factor...

journal_title：Molecular and cellular biochemistry

authors： Zhu L,Hao Y,Guan H,Cui C,Tian S,Yang D,Wang X,Zhang S,Wang L,Jiang H

更新日期：2013-01-01 00:00:00

abstract：:Histone acetylation and deacetylaion play important roles in chromatin remodeling and gene expression. An imbalance of these reactions leads to aberrant behavior of the cells in the cell cycle, which in turn contributes to carcinogenesis. Histone deacetylase (HDAC) inhibitors have been shown to have anti-tumor effects...

journal_title：Molecular and cellular biochemistry

authors： Lee KH,Choi EY,Kim MK,Kim KO,Jang BI,Kim SW,Kim SW,Song SK,Kim JR

更新日期：2010-10-01 00:00:00

abstract：:The role of the subunits of phosphoinositide (PI) 3-kinase in NF-kappaB activation in silica-stimulated RAW 264.7 cells was investigated. Results indicate that PI3-kinase activity was increased in response to silica. The p85alpha subunit of PI3-kinase interacted with tyrosine-phosphorylated I(kappa)B-alpha in silica-s...

journal_title：Molecular and cellular biochemistry

authors： Kang JL,Lee HS,Pack IS,Hur KC,Castranova V

更新日期：2003-06-01 00:00:00

abstract：:Concentrations of 1-4 mumol l-1 isoproterenol cause both in right ventricular papillary muscles and in enzymatically isolated myocytes of the guinea-pig a Ca2+ overload-induced state which is functionally characterized by biphasic (multiphasic) twitches and biphasic (multiphasic) intracellular calcium transients, resp...

journal_title：Molecular and cellular biochemistry

authors： Löhn M,Szymanski G,Markwardt F

更新日期：1996-07-01 00:00:00

abstract：:Sustained cardiac hypertrophy (CH) is related to a variety of physiological as well as pathological stimuli and eventually increases the risk of heart failure. HOTAIR has been identified as a competing endogenous RNA in multiple human biological processes. Whether lncRNA-HOTAIR is involved in the progress of CH and ho...

journal_title：Molecular and cellular biochemistry

authors： Lai Y,He S,Ma L,Lin H,Ren B,Ma J,Zhu X,Zhuang S

更新日期：2017-08-01 00:00:00

abstract：:A quarter of the human population with European background carries at least one allele of the OPRD1 gene that encodes the delta opioid receptor with cysteine at the amino acid position 27 (hδOR(Cys27)) instead of the evolutionary conserved phenylalanine (hδOR(Phe27)). The two variants have indistinguishable pharmacolo...

journal_title：Molecular and cellular biochemistry

authors： Tuusa JT,Petäjä-Repo UE

更新日期：2011-05-01 00:00:00

abstract：:Epidemiological studies suggest that n-3 polyunsaturated fatty acids (PUFA) are involved in the prevention of cardiovascular disease. Stress is known to increase the incidence of CVD and the present study was realised to evaluate some physiological and biochemical effects of dietary docosahexaenoic acid (DHA) in male ...

journal_title：Molecular and cellular biochemistry

authors： Rousseau D,Moreau D,Raederstorff D,Sergiel JP,Rupp H,Muggli R,Grynberg A

更新日期：1998-01-01 00:00:00

abstract：:MAP/Microtubule affinity-regulating kinase 4 (MARK4), a Ser/Thr protein kinases, is related to the Par-1 (partitioning-defective) gene products, and is the human ortholog of Par-1. MARK4 shows its role in the cell polarity at the time of embryonic development. It is mostly located at the basal region of cells, providi...

journal_title：Molecular and cellular biochemistry

authors： Naz F,Islam A,Ahmad F,Hassan MI

更新日期：2015-12-01 00:00:00

abstract：:Endochondral ossification, an important stage of fracture healing, is regulated by a variety of signaling pathways. Transforming growth factor β (TGFβ) superfamily plays important roles and comprises TGFβs, bone morphogenetic proteins (BMPs), and growth differentiation factors. TGFβs primarily regulate cartilage forma...

journal_title：Molecular and cellular biochemistry

authors： Sheu TJ,Zhou W,Fan J,Zhou H,Zuscik MJ,Xie C,Yin G,Berk BC

更新日期：2014-12-01 00:00:00

abstract：:1. Glucokinase is one of four glucose phosphorylating enzymes present in rat liver. Its distinctive features are a high K-m for glucose (high-K-m isozyme) and a rather narrow substrate specificity. In contrast, the other three enzymes, collectively called hexokinases or low-K-m isozymes, exhibit low K-m values for glu...

journal_title：Molecular and cellular biochemistry

authors： Niemeyer H,Ureta T,Clark-Turri L

更新日期：1975-02-28 00:00:00

abstract：:Cataract is the most common eye disease that causes blindness in patients. Ultraviolet B (UVB) irradiation is considered an important factor leading to cataract by inducing apoptosis in human lens epithelial cells (HLECs), but the mechanism is currently unclear. In this study, we investigated HLECs under different int...

journal_title：Molecular and cellular biochemistry

authors： Ji Y,Cai L,Zheng T,Ye H,Rong X,Rao J,Lu Y

更新日期：2015-03-01 00:00:00

abstract：:The effect of CK2beta on the activity of CK2alpha and other protein kinases that can bind this regulatory subunit is not fully understood. In an attempt to improve our understanding of this effect, chimeras of CK2alpha and CK1alpha have been constructed. These chimeras contain different portions of the CK2alpha amino ...

journal_title：Molecular and cellular biochemistry

authors： Jedlicki A,Allende CC,Allende JE

更新日期：2008-09-01 00:00:00

abstract：:Myostatin (MSTN) is primarily expressed in muscle and plays an important role in muscle and fat development in pigs. However, there is little information about the regulation of pig MSTN. In order to elucidate whether pig MSTN could be regulated by muscle- and fat-related factors, the porcine MSTN promoter was amplifi...

journal_title：Molecular and cellular biochemistry

authors： Deng B,Wen J,Ding Y,Gao Q,Huang H,Ran Z,Qian Y,Peng J,Jiang S

更新日期：2012-04-01 00:00:00

abstract：:The marine blood clam species Anadara granosa (L) belong to arcidae, a family with some extraordinary haematological features. The plasma of this species exhibited strong haemagglutinating activities, from which a galactosyl binding lectin, Anadarin P, was purified in a single step affinity chromatography using Sephar...

journal_title：Molecular and cellular biochemistry

authors： Dam TK,Sarkar M,Ghosal J,Choudhury A

更新日期：1992-11-04 00:00:00

abstract：:Hibernating mammals endure conditions of low body temperature and oxidative stress that would be highly injurious to humans and most other mammals. Stress conditions frequently trigger the production of molecular chaperones; in the endoplasmic reticulum the glucose-regulated protein-78 (GRP78) helps to minimize protei...

journal_title：Molecular and cellular biochemistry

authors： Mamady H,Storey KB

更新日期：2006-11-01 00:00:00

abstract：:Saccharomyces cerevisiae contains vacuoles corresponding to lysosomes in higher eukaryotes. Lysosomes are dynamic (not silent) organelles in which enzymes can be easily integrated or released when exposed to stressful conditions. Changes in lysosomal enzymes have been observed due to oxidative stress, resulting in an ...

journal_title：Molecular and cellular biochemistry

authors： Yoon J,Sekhon SS,Kim YH,Min J

更新日期：2016-06-01 00:00:00

abstract：:The purpose of this investigation was to determine whether fibronectin preparations from both chicken plasma and cell surface of fibroblasts can promote phagocytosis of gelatin-coated latex particles. Chicken plasma fibronectin was isolated (a) by ammonium sulfate fractionation, chromatography on Sepharose-4B followed...

journal_title：Molecular and cellular biochemistry

authors： Marquette D,Molnar J,Yamada K,Schlesinger D,Darby S,Van Alten P

更新日期：1981-05-26 00:00:00

abstract：:Induction and activation of the p53 tumour suppressor protein occurs in response to a number of cellular stresses, including disruption of RNA polymerase II-mediated transcription. Both p53 itself and its principle negative regulator, the E3 ubiquitin ligase Mdm2, are substrates for phosphorylation by the protein kina...

journal_title：Molecular and cellular biochemistry

authors： Allende-Vega N,McKenzie L,Meek D

更新日期：2008-09-01 00:00:00

abstract：:The effects of DOCA-salt hypertensive treatment on hepatic glutathione-dependent defense system, antioxidant enzymes, lipid peroxidation, mixed function oxidase and UDP-glucuronyl transferase activities were investigated in male Sprague Dawley rats. Compared with controls, DOCA-salt hypertensive rats had lower body we...

journal_title：Molecular and cellular biochemistry

authors： Nicod L,Rodriguez S,Letang JM,Viollon-Abadie C,Jacqueson A,Berthelot A,Richert L

更新日期：2000-01-01 00:00:00

abstract：:Oxidative stress in cells caused by excessive production of reactive oxygen species (ROS) and decreased antioxidant defense is implicated in the cytotoxicity of xenobiotics including drugs and environmental chemicals. Endosulfan, a highly toxic organochlorine insecticide, causes cytotoxic cell death by inducing oxidat...

journal_title：Molecular and cellular biochemistry

authors： Murali M,Carvalho MS,Shivanandappa T

更新日期：2020-05-01 00:00:00

abstract：:Peroxisomes and peroxisomal enzyme expression were investigated biochemically and morphometrically in guinea pig intestinal epithelial cells at different stages of their migration along the crypt-villus axis. Epithelial cells were sequentially isolated along the axis and the specific activities of the peroxisomal enzy...

journal_title：Molecular and cellular biochemistry

authors： Phipps AN,Connock MJ,Johnson P,Burdett K

更新日期：2000-01-01 00:00:00

abstract：:Glycosphingolipid biosynthesis was examined using [3H]-galactose as a precursor as rat L6 myoblasts fused to form multinucleated myotubes. Incorporation of label into neutral glycolipids decreased steadily as the population of myotubes increased, so that final biosynthesis was one-half that observed with myoblasts (p ...

journal_title：Molecular and cellular biochemistry

authors： Leskawa KC,Erwin RE,Buse PE,Hogan EL

更新日期：1988-09-01 00:00:00

abstract：:The present study was aimed to delineate in vivo mechanisms of orally administered fisetin with special reference to mitochondrial dysfunction in lung tissues employing benzo(a)pyrene (B(a)P) as the model lung carcinogen. The recent revival of interest in the study of mitochondria has been stimulated by the evidence t...

journal_title：Molecular and cellular biochemistry

authors： Ravichandran N,Suresh G,Ramesh B,Manikandan R,Choi YW,Vijaiyan Siva G

更新日期：2014-05-01 00:00:00

abstract：:The T-box transcription factor TBX2 is known for its role as a critical regulator of melanoma cell proliferation, but its role in regulating melanogenesis has not been widely studied. Here we use a series of experiments to show in primary and immortalized mouse melanocytes that TBX2 acts as regulator of melanogenesis ...

journal_title：Molecular and cellular biochemistry

authors： Chen Y,Pan L,Su Z,Wang J,Li H,Ma X,Liu Y,Lu F,Qu J,Hou L

更新日期：2016-04-01 00:00:00