The transcription factor TBX2 regulates melanogenesis in melanocytes by repressing Oca2.

abstract：:The exchange of protons and deuterons by phosphoglucoisomerase during the single passage conversion of D-[2-13C,1-2H]fructose 6-phosphate in H2O or D-[2-13C]fructose 6-phosphate in D2O to D-[2-13C]glucose 6-phosphate, as coupled with the further generation of 6-phospho-D-[2-13C]gluconate in the presence of excess gluc...

journal_title：Molecular and cellular biochemistry

authors： Malaisse WJ,Liemans V,Malaisse-Lagae F,Ottinger R,Willem R

更新日期：1991-05-15 00:00:00

abstract：:Hypoxia impairs the muscle fibre-type shift from fast-to-slow during post-natal development; however, this adaptation could be a consequence of the reduced voluntary physical activity associated with hypoxia exposure rather than the result of hypoxia per se. Moreover, muscle oxidative capacity could be reduced in hypo...

journal_title：Molecular and cellular biochemistry

authors： Chaillou T,Koulmann N,Meunier A,Chapot R,Serrurier B,Beaudry M,Bigard X

更新日期：2014-05-01 00:00:00

abstract：:TGR(mREN2)27 is a transgenic rat harboring the murine Ren-2 gene and exhibit fulminant hypertension and marked heart hypertrophy. In order to study the role of angiotensin II in the increase of cardiac mass, these animals were treated with antihypertensive and non-antihypertensive doses of the angiotensin II receptor ...

journal_title：Molecular and cellular biochemistry

authors： Böhm M,Lippoldt A,Wienen W,Ganten D,Bader M

更新日期：1996-10-01 00:00:00

abstract：UNLABELLED:Since recent findings indicate the involvement of G-proteins in the mechanism of ischaemic preconditioning (PC), the present study was aimed to investigate the role of adrenergic mechanisms, such as G-proteins and stimulation of adrenergic receptors, in this phenomenon. For this purpose, isolated Langendorff...

journal_title：Molecular and cellular biochemistry

authors： Ravingerová T,Pyne NJ,Parratt JR

更新日期：1995-06-07 00:00:00

abstract：:Heme oxygenase-1 (HO-1) responds to a variety of oxidative stresses. We examined whether HO-1 expression influences pro-thrombotic processes, in which the involvement of oxidative stress has been reported. Since HO-1 knockout mice with a C57/BL6J background were not viable, embryonic cells from HO-1 deficient mice (E1...

journal_title：Molecular and cellular biochemistry

authors： Matsumoto H,Ishikawa K,Itabe H,Maruyama Y

更新日期：2006-10-01 00:00:00

abstract：:Chloroplasts from spinach can be separated into at least three different populations by countercurrent distribution using polymer two-phase systems. The chloroplast particles of the three populations differ in protein/chlorophyll ratio, ultrastructure and metabolism. One population, peak I, consists of intact chloropl...

journal_title：Molecular and cellular biochemistry

authors： Albertsson PA,Larsson C

更新日期：1976-06-15 00:00:00

abstract：:Ionizing radiation (IR) treatment results in activation of several DNA damage response molecules, such as ataxia telangiectasia, mutated (ATM), and DNA-dependent protein kinase (DNAPK) in mammals that are increasingly recognized for their potential roles in the sensing of DNA damage and initiating the subsequent prote...

journal_title：Molecular and cellular biochemistry

authors： Dhariwala FA,Narang H,Krishna M

更新日期：2012-04-01 00:00:00

abstract：:To investigate insulin action in muscle and adipose tissue in hepatic cirrhosis, a recently described animal model was used. Dimethylnitrosamine administration induced histologically proven cirrhosis. Contrary to expectation, muscle strips from cirrhotic rats displayed increased insulin sensitivity both with respect t...

journal_title：Molecular and cellular biochemistry

authors： Chowdhury SA,Taylor R

更新日期：1989-08-15 00:00:00

abstract：:Cultured human umbilical vein endothelial cells (HUVECs) are a widely used model to study the regulation of endothelial production of vasoactive substances such as endothelin-1 (ET-1) and prostacyclin (PGI2) in human. As even short term culturing is known to affect the function of many cell types, we studied whether t...

journal_title：Molecular and cellular biochemistry

authors： Ranta V,Orpana A,Mikkola T,Ylikorkala O,Viinikka L

更新日期：1997-12-01 00:00:00

abstract：:Coronary vascular endothelial cells control vascular tone by modulating the local concentration of circulating vasoactive substances (e.g. adenine nucleotides, biogenic amines and bradykinin) and by synthesising and releasing the vasoactive autacoids nitric oxide (NO) and prostacyclin (PGI2). The fluid shear stress ex...

journal_title：Molecular and cellular biochemistry

authors： Fleming I,Bauersachs J,Busse R

更新日期：1996-04-12 00:00:00

abstract：:Acrolein is a highly reactive alpha, beta-unsaturated aldehyde, and a product of lipid peroxidation reactions. Acrolein is also an environmental pollutant and a key component of cigarette smoke, and has been implicated in multiple respiratory diseases. Lung tissue is a primary target for acrolein toxicity in smokers a...

journal_title：Molecular and cellular biochemistry

authors： Sarkar P,Hayes BE

更新日期：2007-07-01 00:00:00

abstract：:In mammalian cells, increases in calcium concentration cause increases in oxidative phosphorylation. This effect is mediated by the activation of four mitochondrial dehydrogenases by calcium ions; FAD-glycerol 3-phosphate dehydrogenase, pyruvate dehydrogenase, NAD-isocitrate dehydrogenase and oxoglutarate dehydrogenas...

journal_title：Molecular and cellular biochemistry

authors： Nichols BJ,Denton RM

更新日期：1995-08-01 00:00:00

abstract：:The role of the subunits of phosphoinositide (PI) 3-kinase in NF-kappaB activation in silica-stimulated RAW 264.7 cells was investigated. Results indicate that PI3-kinase activity was increased in response to silica. The p85alpha subunit of PI3-kinase interacted with tyrosine-phosphorylated I(kappa)B-alpha in silica-s...

journal_title：Molecular and cellular biochemistry

authors： Kang JL,Lee HS,Pack IS,Hur KC,Castranova V

更新日期：2003-06-01 00:00:00

abstract：:Endothelin-1 (ET-1), a peptide isolated from the culture medium of endothelial cells, mediates a variety of physiological and pathological responses including mitogenesis. We have compared the expression of ET receptors in untransformed versus ras-transformed NIH-3T3 murine fibroblasts and in untransformed versus SV40...

journal_title：Molecular and cellular biochemistry

authors： Nambi P,Mattern MR,Wu HL,Pullen M,Nuthulaganti P,Hofmann GA,Kumar C

更新日期：1997-10-01 00:00:00

abstract：:Histone acetylation and deacetylaion play important roles in chromatin remodeling and gene expression. An imbalance of these reactions leads to aberrant behavior of the cells in the cell cycle, which in turn contributes to carcinogenesis. Histone deacetylase (HDAC) inhibitors have been shown to have anti-tumor effects...

journal_title：Molecular and cellular biochemistry

authors： Lee KH,Choi EY,Kim MK,Kim KO,Jang BI,Kim SW,Kim SW,Song SK,Kim JR

更新日期：2010-10-01 00:00:00

abstract：:Twenty-six days of fat deficiency brought about a decrease of linoleic and an increase of oleic acid in rough endoplasmic reticulum (RER) of guinea pig liver. Arachidonic acid was only slightly decreased in some phospholipids whereas eicose-5,8,11-trienoic acid was not enhanced except in phosphatidyl-inositol. All the...

journal_title：Molecular and cellular biochemistry

authors： Soulages JL,Brenner RR

更新日期：1987-12-01 00:00:00

abstract：:In this article, we discuss our attempts to establish the existence in the cytoplasm of regulatory molecules involved in translational control. Our studies have revealed the presence of cAMP independent protein kinase in the free mRNP complex capable of phosphorylating a Mr = 38 000 polypeptide, also part of the same ...

journal_title：Molecular and cellular biochemistry

authors： Bag J,Sells BH

更新日期：1981-11-13 00:00:00

abstract：:Rat pheochromocytoma PC12 cells have been treated with nerve growth factor (NGF) at final concentrations of 2, 4, 8, and 16 ng/ml, and then were exposed to 60-Hz, sinusoidal magnetic fields (MF) of 12.5, 25, 50, and 100 microT (rms) for 30 min. Transcript levels for both c-fos and glyceraldehyde-3 -phosphate dehydroge...

journal_title：Molecular and cellular biochemistry

authors： Campbell-Beachler M,Ishida-Jones T,Haggren W,Phillips JL

更新日期：1998-12-01 00:00:00

abstract：:The apparent membrane fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene has been reported to be lower in intact erythrocytes than in isolated erythrocyte membranes. Although this difference was once suggested to be caused by the fluidizing effect associated with the loss of erythrocyte proteins during membrane ...

journal_title：Molecular and cellular biochemistry

authors： Dickens BF,Snow TR,Green V,Weglicki WB

更新日期：1988-01-01 00:00:00

abstract：:Carperitide, a synthetic alpha-human atrial natriuretic peptide (ANP) is a newly developed drug for the treatment of heart failure. However, effects of carperitide on susceptibility to ischemia reperfusion injury are left to be determined. Isolated rat hearts were subjected to Langendorff perfusion. Six hearts receive...

journal_title：Molecular and cellular biochemistry

authors： Okawa H,Horimoto H,Mieno S,Nomura Y,Yoshida M,Shinjiro S

更新日期：2003-06-01 00:00:00

abstract：:Persistent activation of nuclear factor B (NF-κB) is very important in the modulation of macrophages cellular response to microbial infections. The deubiquitinase USP14, which is critical for ubiquitin-mediated proteasomal degradation of proteins, is known to be involved in cancer, neurological diseases, and aging. Ho...

journal_title：Molecular and cellular biochemistry

authors： Liu N,Kong T,Chen X,Hu H,Gu H,Liu S,Chen X,Yang Q,Li A,Xiong X,Zhang Z

更新日期：2017-07-01 00:00:00

abstract：:The capacity of noradrenaline (NA) and its end metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) to modulate the chemotaxis of lymphocytes from a primary immunocompetent organ (thymus) and a secondary one (spleen) was investigated over a range of concentrations from 10(-12) M to 10(-5) M. Lymphocyte chemotaxis was eva...

journal_title：Molecular and cellular biochemistry

authors： García JJ,del Carmen Sáez M,De la Fuente M,Ortega E

更新日期：2003-12-01 00:00:00

abstract：:Coupling of ATP-generating with ATP-consuming processes is an essential component in the cardiac bioenergetics responsible for optimal myocardial function. Although a number of enzymatic systems have been implicated in securing proper intracellular energy communication, their integrative response in a failing myocardi...

journal_title：Molecular and cellular biochemistry

authors： Dzeja PP,Pucar D,Redfield MM,Burnett JC,Terzic A

更新日期：1999-11-01 00:00:00

abstract：:The normal translocation of nascent polypeptides into the lumen of the endoplasmic reticulum (ER) is thought to be aided in part by a translocon-associated protein (TRAP) complex consisting of 4 protein subunits. The association of mature proteins with the ER and Golgi, or other intracellular locales, such as lysosome...

journal_title：Molecular and cellular biochemistry

authors： Mangos S,Krawetz R,Kelly GM

更新日期：2000-12-01 00:00:00

abstract：:Primary cultures of skeletal muscle cells secrete plasminogen activator (PA) activity to the conditioning medium and display membrane-bound PA. Growth of these cells in culture in presence of 10(-7) M dexamethasone resulted in a marked reduction of the membranal and secreted PA activity. The hormone also reduced cytos...

journal_title：Molecular and cellular biochemistry

authors： Mayer M,Finci Z,Chaouat M,Sasson S

更新日期：1986-02-01 00:00:00

abstract：:Several metabolic compounds have been found to be competitive inhibitors of the anomerase activity of phosphoglucose isomerase (EC 5.3.1.9).Ki values for erythrose 4-phosphate, 6-phosphogluconate, and fructose 1,6-bisphosphate for the anomerase reaction are 0.32 muM, 21 muM, and 84 muM respectively at 0 degree and pH ...

journal_title：Molecular and cellular biochemistry

authors： Howell EE,Schray KJ

更新日期：1981-07-07 00:00:00

abstract：:To understand the hypocholesterolemic activity of green tea, our in vitro studies screened the relative efficacy of two structurally distinct green tea catechins, epicatechin (EC) and epigallocatechin gallate (EGCG), on apolipoprotein B-100 (apoB) and lipid production using a well established human hepatoma cell-line,...

journal_title：Molecular and cellular biochemistry

authors： Yee WL,Wang Q,Agdinaoay T,Dang K,Chang H,Grandinetti A,Franke AA,Theriault A

更新日期：2002-01-01 00:00:00

abstract：:NADPH oxidase from stimulated guinea pig granulocytes was extracted with deoxycholate. The solubilized enzyme was stable in 20% glycerol. Solubilized enzyme was free of myeloperoxidase activity. The properties of the deoxycholate solubilized enzyme indicated that it is a high molecular weight complex with a flavoprote...

journal_title：Molecular and cellular biochemistry

authors： Bellavite P,Serra MC,Davoli A,Bannister JV,Rossi F

更新日期：1983-01-01 00:00:00

abstract：:Alterations in lipid metabolism and genetic predisposition are major risk factors for coronary artery disease (CAD). Variations in genes involved in lipid metabolism may act synergistically to confer risk or protection against CAD. The objective of the present study was to determine such interactions in variants of ap...

journal_title：Molecular and cellular biochemistry

authors： Rai TS,Khullar M,Sehrawat BS,Ahuja M,Sharma PK,Vijayvergiya R,Grover A

更新日期：2008-06-01 00:00:00

abstract：:The deiodinases regulate the activation and inactivation of Thyroid hormones (TH), in both physiological and pathological conditions. The three deiodinases, DIO1, DIO2 and DIO3, have different catalytic role and cellular and tissue distribution. Aim of this study is to evaluate a rat model of regional ischemia/reperfu...

journal_title：Molecular and cellular biochemistry

authors： Sabatino L,Kusmic C,Iervasi G

更新日期：2020-12-01 00:00:00