Abstract:
:Regulation of L-type Ca2+ channels is complex, because many factors, such as phosphorylation, divalent cations, and proteins, specified or unspecified, have been shown to affect the channel activities. An additional complication is that these factors interact with one another to achieve final outcomes. Recent molecular technologies have helped to shed light on the mechanisms governing the activity of L-type Ca2+ channels. In this review article, three major topics concerning regulation of L-type Ca2+ channels in the heart are discussed, i.e. c-AMP dependent channel phosphorylation, role of magnesium (Mg2+), and the phenomenon of channel run-down.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Yamaoka K,Kameyama Mdoi
10.1023/a:1026036931170keywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
3-13issue
1-2eissn
0300-8177issn
1573-4919journal_volume
253pub_type
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