当前位置： SCI文献检索 > MOLECULAR AND CELLULAR BIOCHEMISTRY期刊下所有文献 > Ganglioside GM3 promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling.

Ganglioside GM3 promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling.

Abstract：

:Ganglioside GM3 plays a well-documented and important role in the regulation of tumor cell proliferation, invasion, and metastasis by modulating tyrosine kinase growth factor receptors. However, the effect of GM3 on the hepatocyte growth factor receptor (HGFR, cMet) has not been fully delineated. In the current study, we investigated how GM3 affects cMet signaling and HGF-stimulated cell motility and migration using three hepatic cancer cell lines of mouse (Hca/A2, Hca/16A3, and Hepa1-6). Decreasing GM3 expression with the use of P4, a specific inhibitor for ganglioside synthesis inhibited the HGF-stimulated phosphorylation of cMet and activity of PI3K/Akt signaling pathway. In contrast, the increased expression of GM3 as a result of adding exogenous GM3 enhanced the HGF-stimulated phosphorylation of cMet and activity of PI3K/Akt signaling pathway. Furthermore, HGF-stimulated cell motility and migration in vitro were inhibited by reduced expression of GM3 and enhanced by increased expression of GM3. All the observations indicate that ganglioside GM3 promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling.

journal_name

Mol Cell Biochem

journal_title

Molecular and cellular biochemistry

authors

Li Y,Huang X,Zhong W,Zhang J,Ma K

doi

10.1007/s11010-013-1720-9

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

83-92

issue

1-2

eissn

0300-8177

issn

1573-4919

journal_volume

382

pub_type

杂志文章

相关文献

MOLECULAR AND CELLULAR BIOCHEMISTRY文献大全
  • Adenylate kinase: kinetic behavior in intact cells indicates it is integral to multiple cellular processes.

    abstract：:Monitoring the kinetic behavior of adenylate kinase (AK) and creatine kinase (CK) in intact cells by 18O-phosphoryl oxygen exchange analysis has provided new perspectives from which to more fully define the involvement of these phosphotransferases in cellular bioenergetics. A primary function attributable to both AK a...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：

    authors： Dzeja PP,Zeleznikar RJ,Goldberg ND

    更新日期：1998-07-01 00:00:00

  • Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure.

    abstract：:Protein kinase C isoforms comprise a family of structurally related serine/threonine kinases that are activated by second messenger molecules formed via receptor-dependent activation of phospholipase C. Cardiomyocytes co-express multiple protein kinase C isoforms which play key roles in a spectrum of adaptive and mala...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：

    authors： Sabri A,Steinberg SF

    更新日期：2003-09-01 00:00:00

  • New perspectives in triple-negative breast cancer therapy based on treatments with TGFβ1 siRNA and doxorubicin.

    abstract：:Triple-negative breast cancer (TNBC), which accounts for 10-20% of all breast cancers, has the worst prognosis. Although chemotherapy treatment is a standard for TNBC, it lacks a specific target. Therefore, new therapeutic strategies are required to be investigated. In this study, a combined doxorubicin (DOX) and smal...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-020-03881-w

    authors： Ciocan-Cȃrtiţă CA,Jurj A,Raduly L,Cojocneanu R,Moldovan A,Pileczki V,Pop LA,Budişan L,Braicu C,Korban SS,Berindan-Neagoe I

    更新日期：2020-12-01 00:00:00

  • Saikosaponin-d inhibits proliferation by up-regulating autophagy via the CaMKKβ-AMPK-mTOR pathway in ADPKD cells.

    abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is a common heritable human disease. Recently, the role of repressed autophagy in ADPKD has drawn increasing attention. Here, we investigate the mechanism underlying the effect of Saikosaponin-d (SSd), a sarcoplasmic/endoplasmic reticulum Ca2+ ATPase pump (SERCA) in...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-018-3358-0

    authors： Shi W,Xu D,Gu J,Xue C,Yang B,Fu L,Song S,Liu D,Zhou W,Lv J,Sun K,Chen M,Mei C

    更新日期：2018-12-01 00:00:00

  • Purification and properties of human serum dopamine-beta-hydroxylase.

    abstract：:1. Two different molecular forms of dopamine-beta-hydroxylase were isolated from human serum; a major component (Peak I enzyme) with a molecular weight of 368000 and with a higher specific activity and a minor component (Peak II enzyme) with a molecular weight of 188000 and with a lower specific activity. 2. Both form...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00280277

    authors： Ikeno T,Hashimoto S,Kuzuya H,Nagatsu T

    更新日期：1977-12-29 00:00:00

  • Critical segment of apocytochrome c for its insertion into membrane.

    abstract：:Apocytochrome c has a potent ability to insert spontaneously into membrane. To identify which sequences were critical for this insertion activity, a series of peptides N19, C8, C15 and C21, corresponding to sequences 1-19, 81-88, 74-88 and 68-88 of apocytochrome c, respectively, were synthesized and purified. Insertio...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/b:mcbi.0000038216.13105.08

    authors： Wang X,Han X,Yang F

    更新日期：2004-07-01 00:00:00

  • Molecular dynamics study of the interaction between fatty acid binding proteins with palmitate mini-micelles.

    abstract：:The fatty acid binding proteins (FAPBs) function as intracellular carriers of fatty acid (FA) and related compounds. During the digestion of lipids, the local concentration of FA exceeds their critical micellar concentration; the excess ratio of FA/FABP can be as high as approximately 1,000/1, consequently building mi...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-008-0010-4

    authors： Levin LB,Nachliel E,Gutman M,Tsfadia Y

    更新日期：2009-06-01 00:00:00

  • Multifunctional actions of vanadium compounds on insulin signaling pathways: evidence for preferential enhancement of metabolic versus mitogenic effects.

    abstract：:The pathophysiologic importance of insulin resistance in diseases such as obesity and diabetes mellitus has led to great interest in defining the mechanism of insulin action as well as the means to overcome the biochemical defects responsible for the resistance. Vanadium compounds have been discovered to mimic many of...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：

    authors： Fantus IG,Tsiani E

    更新日期：1998-05-01 00:00:00

  • Peroxisome distribution along the crypt-villus axis of the guinea pig small intestine.

    abstract：:Peroxisomes and peroxisomal enzyme expression were investigated biochemically and morphometrically in guinea pig intestinal epithelial cells at different stages of their migration along the crypt-villus axis. Epithelial cells were sequentially isolated along the axis and the specific activities of the peroxisomal enzy...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1007052003143

    authors： Phipps AN,Connock MJ,Johnson P,Burdett K

    更新日期：2000-01-01 00:00:00

  • Characterization of cholinesterase molecular forms in the mucosal cells along the intestine of the chicken.

    abstract：:The presence of a butyrylcholinesterase (BuChE, EC 3.1.1.8) in the musocal cells of the chicken intestine was demonstrated by histochemical and biochemical methods. The study of its distribution, along the intestine from duodenum to rectum, showed that the jejuno-ileum possesses the highest activity. Sucrose gradient ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00223513

    authors： Sine JP,Ferrand R,Colas B

    更新日期：1989-01-23 00:00:00

  • The role of neurofibromin in N-Ras mediated AP-1 regulation in malignant peripheral nerve sheath tumors.

    abstract：:Plexiform neurofibromas commonly found in patients with Neurofibromatosis type I (NF1) have a 5% risk of being transformed into malignant peripheral nerve sheath tumors (MPNST). Germline mutations in the NF1 gene coding for neurofibromin, which is a Ras GTPase activating protein (RasGAP) and a negative regulator of Ra...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-010-0551-1

    authors： Kraniak JM,Sun D,Mattingly RR,Reiners JJ Jr,Tainsky MA

    更新日期：2010-11-01 00:00:00

  • Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3).

    abstract：:Progression of prostate cancer is facilitated by growth factors that activate critical signaling cascades thereby promote prostate cancer cell growth, survival, and migration. To investigate the effect of quercetin on insulin-like growth factor signaling and apoptosis in androgen independent prostate cancer cells (PC-...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-010-0540-4

    authors： Senthilkumar K,Elumalai P,Arunkumar R,Banudevi S,Gunadharini ND,Sharmila G,Selvakumar K,Arunakaran J

    更新日期：2010-11-01 00:00:00

  • Analgesic-antitumor peptide inhibits angiogenesis by suppressing AKT activation in hepatocellular carcinoma.

    abstract：:Hepatocellular carcinoma (HCC) is one of leading causes of cancer-related death, and its increasing incidence worldwide is a cause for concern. The recombinant analgesic-antitumor peptide (rAGAP), a protein consisting of small ubiquitin-related modifier linked with a hexa-histidine tag, exhibited the antitumor activit...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-018-3475-9

    authors： Cao Q,Lu W,Zhou T,Liu Y,Cai X,Zhu J,Cao P

    更新日期：2019-05-01 00:00:00

  • Calcium and smooth muscle contraction.

    abstract：:The fact that smooth muscle exists in almost every hollow organ and is involved in a large number of disease states has led to a vast increase in smooth muscle research, covering areas from testing response to antagonists and agonists to measuring the molecular force generated by a single actin filament. Yet, the exac...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1007/BF00925956

    authors： Jiang H,Stephens NL

    更新日期：1994-06-15 00:00:00

  • Atypical PKC phosphorylates microtubule affinity-regulating kinase 4 in vitro.

    abstract：:MAP/Microtubule affinity-regulating kinase 4 (MARK4), a Ser/Thr protein kinases, is related to the Par-1 (partitioning-defective) gene products, and is the human ortholog of Par-1. MARK4 shows its role in the cell polarity at the time of embryonic development. It is mostly located at the basal region of cells, providi...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-015-2555-3

    authors： Naz F,Islam A,Ahmad F,Hassan MI

    更新日期：2015-12-01 00:00:00

  • A mannose-binding glycoprotein found in the 4 day post coital rat uterus is involved in pregnancy.

    abstract：:Experiments were conducted to study the functional implication of a mannose-binding glycoprotein found in the day 4 post coital (p.c.) rat uterus, using a mono-specific polyclonal antibody raised against the glycoprotein. Western Blot and immunohistochemical techniques were employed to study the distribution of the gl...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1006901206170

    authors： Mehta M,Chowdhury M

    更新日期：1999-05-01 00:00:00

  • Antioxidant effect of doxycycline decreases MMP activity and blood pressure in SHR.

    abstract：:Increased matrix metalloproteinase (MMP) levels are involved in vascular remodeling of hypertension. In this study, we hypothesized that doxycycline (a MMP inhibitor) could exert antioxidant effects, reverse establish vascular remodeling, and lower blood pressure in spontaneously hypertensive rats (SHR). SHR and Wista...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-013-1848-7

    authors： Antonio RC,Ceron CS,Rizzi E,Coelho EB,Tanus-Santos JE,Gerlach RF

    更新日期：2014-01-01 00:00:00

  • Conference overview: molecular mechanisms of metal toxicity and carcinogenesis.

    abstract：:Chronic exposure to many heavy metals and metal-derivatives is associated with an increased risk of cancer, although the mechanisms of tumorigenesis are largely unknown. Approximately 125 scientists attended the 3rd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis and presented the latest resear...

    journal_title：Molecular and cellular biochemistry

    pub_type：

    doi：10.1007/s11010-005-8210-7

    authors： Bower JJ,Leonard SS,Shi X

    更新日期：2005-11-01 00:00:00

  • Role of antioxidant systems, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis.

    abstract：:In this study we assessed activities of antioxidant enzymes, lipid peroxidation end-products, and nitric oxide (NO) levels in women with postmenopausal osteoporosis (PMO). Relationship between oxidative stress parameters and NO levels with bone mineral density (BMD) and clinical variables influencing bone mass and hea...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-006-9270-z

    authors： Ozgocmen S,Kaya H,Fadillioglu E,Aydogan R,Yilmaz Z

    更新日期：2007-01-01 00:00:00

  • Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro.

    abstract：:Hepatic stellate cells (HSCs) play an important role in the development of hepatic fibrosis. Heat shock protein 90 (Hsp90) is essential for the maturation and activity of a varied group of proteins involved in signal transduction and cell cycle regulation. In this study, we found that two Hsp90 inhibitors, VER-49009 a...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-009-0131-4

    authors： Sun X,Zhang XD,Cheng G,Hu YH,Wang HY

    更新日期：2009-10-01 00:00:00

  • Effect of n-3 and n-6 fatty acids on hepatic microsomal lipid metabolism: a time course study.

    abstract：:The present study examines the time dependent effects of n-6 and n-3 polyunsaturated fatty acids on liver microsomal lipid metabolism in FVB mice fed a diet supplemented with a mixture of free fatty acids (mainly 18:3n-6 and 20:5n-3) at 25 mg/g diet. Significant changes in the fatty acid composition of total liver and...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00299394

    authors： de Antueno RJ,Cantrill RC,Huang YS,Raha SK,Elliot M,Horrobin DF

    更新日期：1992-12-16 00:00:00

  • Role of antioxidant treatment on DNA and lipid damage in the brain of rats subjected to a chemically induced chronic model of tyrosinemia type II.

    abstract：:Tyrosine levels are abnormally elevated in tissues and body fluids of patients with inborn errors of tyrosine metabolism. Tyrosinemia type II, which is caused by tyrosine aminotransferase deficiency, provokes eyes, skin, and central nervous system disturbances in affected patients. However, the mechanisms of brain dam...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-017-3070-5

    authors： Streck EL,De Prá SDT,Ferro PR,Carvalho-Silva M,Gomes LM,Agostini JF,Damiani A,Andrade VM,Schuck PF,Ferreira GC,Scaini G

    更新日期：2017-11-01 00:00:00

  • Periodicity and fragment size of DNA from mouse TLT hepatoma chromatin and chromatin fractions using endogenous and exogenous nucleases.

    abstract：:The action of micrococcal nuclease, DNase I and DNase II on mouse TLT hepatoma chromatin revealing the periodicity of its structure as visualized by denaturing and non-denaturing gel electrophoresis, was consistent with the action of these enzymes on other chromatins. Micrococcal nuclease showed a complex subnucleosom...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00232599

    authors： Duerksen JD,Connor KW

    更新日期：1978-04-11 00:00:00

  • Energy metabolism and mechanical recovery after cardioplegia in moderately hypertrophied rats.

    abstract：:It is well established that severe hypertrophy induces metabolic and structural changes in the heart which result in enhanced susceptibility to ischemic damage during cardioplegic arrest while much less is known about the effect of cardioplegic arrest on moderately hypertrophied hearts. The aim of this study was to el...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：

    authors： Smolenski RT,Jayakumar J,Seymour AM,Yacoub MH

    更新日期：1998-03-01 00:00:00

  • Characterization of gastrin binding to colonic mucosal membranes of guinea pigs.

    abstract：:Gastrin has significant growth and metabolic effects on colonic mucosal cells. It is, however, not known if gastrin receptors are present on colonic mucosal cells that may directly mediate the reported biological effects of gastrin. In the present studies, the presence of specific gastrin binding sites on colonic muco...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00227573

    authors： Narayan S,Chicione L,Singh P

    更新日期：1992-06-26 00:00:00

  • Curcumin amends Ca2+ dysregulation in microglia by suppressing the activation of P2X7 receptor.

    abstract：:Curcumin (Cur) is widely used as an anti-inflammation agent and has anti-depression potential. Neuroinflammation mediated by Ca2+ channel activation is closely associated with the progression of post-stroke depression (PSD). In the current study, the role of P2X7 receptor (P2X7R) in the anti-PSD function of Cur was ex...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-019-03668-8

    authors： Wang Z,Ren W,Zhao F,Han Y,Liu C,Jia K

    更新日期：2020-02-01 00:00:00

  • Cellular responses in exertion-induced skeletal muscle injury.

    abstract：:Muscle injury is a common result of muscle exertion caused by overload and over-activity. In this presentation, an attempt was made to discuss models of muscle injury which involve exertion but not excessive strain, although most functional activities of the extremities require some eccentric muscle actions. Muscle in...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1023/a:1006832509488

    authors： Stauber WT,Smith CA

    更新日期：1998-02-01 00:00:00

  • Activation of rat erythrocyte phosphofructokinase by AMP and by non-physiological concentrations of cyclic AMP.

    abstract：:Cyclic AMP (300 micron) activates phosphofructokinase from dialyzed haemolysates of mature rat erythrocytes. The main conclusions are: a) Cyclic AMP, at pH 7.1 and low concentrations of fructose-6-phosphate, is able to reverse the inhibition produced by different amounts of ATP (up to 1.5 mM). b) The cyclic nucleotide...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF01734111

    authors： Pinilla M,Luque J

    更新日期：1977-05-03 00:00:00

  • An inverse relation between mitochondrial hexokinase content and phosphoglucomutase activity of rat tissues.

    abstract：:The hexokinase: fumarase ratios of mitochondria isolated from ten tissues of the rat were determined, and compared with the tissue content of phosphoglucomutase and phosphorylase, taken as representatives of enzymes concerned with glycogen metabolism. A generally inverse relationship was found between the mitochondria...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00215278

    authors： Wilson JE,Felgner PL

    更新日期：1977-11-25 00:00:00

  • Changes in motochondrial calcium metabolism after treating mastocytoma cells with N6,O2'-dibutyryladenosine 3',5' cyclic monophosphate.

    abstract：:Comparison of Ca2+ uptake by isolated mouse liver mitochondria, and mitochondria prepared from mastocytoma cells grown with and without N6,O2'-dibutyryladenosine 3',5' cyclic monophosphate (DB cyclic AMP) and theophylline showed several differences in their capacity to take up and retain calcium. In particular mitocho...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00215305

    authors： McHardy JE,Ralph RK

    更新日期：1980-03-20 00:00:00